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1. 发明授权

EP2439191B1 METHOD FOR PRODUCING N-SUBSTITUTED CARBAMIC ACID ESTER, METHOD FOR PRODUCING ISOCYANATE USING N-SUBSTITUTED CARBAMIC ACID ESTER, AND COMPOSITION FOR TRANSFERRING AND STORING N-SUBSTITUTED CARBAMIC ACID ESTER CONTAINING N-SUBSTITUTED CARBAMIC ACID ESTER AND AROMATIC HYDROXY COMPOUND 有权
标题翻译：用于制备N-取代氨基，PROCESS FOR PRODUCING异氰酸酯与N-取代输送用和储藏的氨基和组合物的N-取代氨基与N-取代氨基和芳族羟基
公开(公告)号：EP2439191B1
公开(公告)日：2017-01-25
申请号：EP09833912.0
申请日：2009-09-29
申请人： Asahi Kasei Kabushiki Kaisha
发明人： SHINOHATA, Maasaki , MIYAKE, Nobuhisa
IPC分类号： C07C263/04 , C07C265/14 , C07C269/04 , C07C271/42 , C07C269/00 , C07C271/54 , C07C271/56 , C07C271/58 , C07C275/40
CPC分类号： C07C275/40 , C07C263/04 , C07C269/00 , C07C269/04 , C07C271/54 , C07C271/56 , C07C271/58 , C07C2601/14 , C07C265/14 , C07C271/52

2. 发明授权

EP2322501B1 4-dedimethylamino tetracycline compounds 有权
标题翻译： 4-去二甲基氨基四环素化合物
公开(公告)号：EP2322501B1
公开(公告)日：2015-08-05
申请号：EP10183340.8
申请日：2003-01-06
申请人： Paratek Pharmaceuticals, Inc.
发明人： Nelson, Mark L. , Ohemeng, Kwasi
IPC分类号： C07C235/70 , C07C235/32 , C07D209/02 , C07D265/30 , C07D333/50 , C07D419/00 , A61K31/65 , A61P31/04
CPC分类号： A61K31/65 , C07C235/70 , C07C237/26 , C07C251/48 , C07C255/41 , C07C271/22 , C07C271/54 , C07C271/58 , C07C275/42 , C07C275/54 , C07C279/18 , C07C311/06 , C07C311/08 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07D295/185 , C07D317/60 , C07F9/2475 , C07F9/4006

4. 发明公开

EP2322504A4 PROCESS FOR THE PREPARATION OF N-SUBSTITUTED CARBAMIC ACID ESTER AND PROCESS FOR THE PREPARATION OF ISOCYANATE USING THE N-SUBSTITUTED CARBAMIC ACID ESTER 有权
标题翻译：对于生产方法的N-取代氨基甲酸酯及其制造方法的异氰酸酯使用该N-取代氨基甲酸酯
公开(公告)号：EP2322504A4
公开(公告)日：2013-10-09
申请号：EP09845052
申请日：2009-09-29
申请人： ASAHI KASEI CHEMICALS CORP
发明人： MIYAKE NOBUHISA , SHINOHATA MASAAKI , OKUBO ATSUSHI
IPC分类号： C07C263/04 , C07C265/14 , C07C269/04 , C07C271/42
CPC分类号： C07C275/40 , C07C263/04 , C07C269/00 , C07C269/04 , C07C271/54 , C07C271/56 , C07C271/58 , C07C2601/14 , C07C265/14 , C07C271/52

5. 发明公开

EP2341886A1 ANTIMICROBIAL N-CHLORINATED COMPOSITIONS 有权
标题翻译：抗微生物的N-氯化化合物
公开(公告)号：EP2341886A1
公开(公告)日：2011-07-13
申请号：EP09825526.8
申请日：2009-11-06
申请人： NovaBay Pharmaceuticals, Inc.
发明人： JAIN, Rakesh, K. , LOW, Eddy , FRANCAVILLA, Charles , SHIAU, Timothy, P. , NAIR, Satheesh, K.
IPC分类号： A61K8/00
CPC分类号： C07C229/12 , A61K31/14 , C07C229/34 , C07C271/54
摘要： The present application relates to N-chlorinated cationic compounds of Formula I or a salt thereof, and associated compositions and methods of use as antimicrobial agents.

6. 发明公开

EP2306824A1 IONTOPHORETIC DELIVERY OF CURCUMIN AND CURCUMIN ANALOGS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：离子透入输送姜黄素CURCUMINANALOGA阿尔茨海默氏病的治疗
公开(公告)号：EP2306824A1
公开(公告)日：2011-04-13
申请号：EP09770940.6
申请日：2009-06-24
申请人： Codman & Shurtleff, Inc.
发明人： LILIENFELD, Sean , DIMAURO, Thomas, M.
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： A61K31/221 , A61K9/0009 , A61K9/7023 , A61K31/09 , A61K31/12 , A61K31/165 , A61K31/216 , A61K31/22 , A61K31/223 , C07C229/12 , C07C229/34 , C07C271/54
摘要： A method of delivering a curcuminoid to a patient, which includes iontophoretically delivering a charged curcuminoid across the skin of an Alzheimer's Disease patient.

7. 发明公开

EP2292590A2 Prodrugs of 9-aminomethyl tetracycline compounds 审中-公开
标题翻译：前药9-氨基甲基四氮杂环丁酮
公开(公告)号：EP2292590A2
公开(公告)日：2011-03-09
申请号：EP10181641.1
申请日：2004-06-25
申请人： Paratek Pharmaceuticals, Inc.
发明人： Kwasi, Ohemeng , Amoo, Victor , Kim, Oak, K. , Bowser, Todd , Assefa, Haregewein , Bhatia, Beena , Berniac, Joel , Chen, Jackson , Grier, Mark , Honeyman, Laura , Pan, Jingwen , Mechiche, Rachid
IPC分类号： C07C237/26 , C07C271/22 , A61K31/65 , A61P31/04
CPC分类号： C07D211/18 , C07C237/26 , C07C271/22 , C07C271/54 , C07C275/28 , C07C275/30 , C07C2601/14 , C07C2603/46
摘要： A compound of the formula (II):

wherein Q' is a prodrug moiety or a pharmaceutically acceptable salt thereof.
摘要翻译：式（II）的化合物：其中Q'是前药部分或其药学上可接受的盐。

8. 发明公开

EP2197881A1 PROCESS FOR THE MANUFACTURE OF BRIDGED MONOBACTAM INTERMEDIATES 有权
标题翻译：制造桥联中间体的方法
公开(公告)号：EP2197881A1
公开(公告)日：2010-06-23
申请号：EP08804217.1
申请日：2008-09-15
申请人： Basilea Pharmaceutica AG
发明人： MULLER, Marc , WU, Xiaoping , XU, Lin
IPC分类号： C07D487/04 , C07C237/20
CPC分类号： C07C271/54 , C07C271/22 , C07D487/04
摘要： A process for manufacturing a compound of Formula (I) which has cis-conformation and wherein R1 represents a 1-phenyl-C1-C4alkyl or 1-naphthyl-C1-C4alkyl group, wherein the phenyl or naphthyl moiety of R1 is unsubstituted or substituted with one or more C1-C4alkoxy groups and the carbon atoms in 2-, 3-, and/or 4-position of the alkyl part of R1 are, independently of the phenyl or naphthyl moiety of R1 and independently of one another, unsubstituted or substituted with C1-C4alkoxy and/or silyloxy or, preferably, are unsubstituted or substituted with one C1-C4alkoxy group and/or silyloxy group per carbon atom, and R2 represents a C1-C6alkyl group or an unsubstituted or substituted benzyl group, in which process a compound of Formula (II) wherein R3 represents a C1-C6alkyl group or an unsubstituted or substituted benzyl group, and R1 and R2 have the same meaning as in formula (I); is treated with a base at a temperature of 0°C or less in a liquid aprotic solvent for a time period sufficient to obtain the compound of formula (I).
摘要翻译：制备具有顺式构象并且其中R 1代表1-苯基-C 1 -C 4烷基或1-萘基-C 1 -C 4烷基的式（I）化合物的方法，其中R 1的苯基或萘基部分未被取代或被取代与一个或多个C1-C4烷氧基和R1的烷基部分的2-，3-和/或4-位上的碳原子独立地为R1的苯基或萘基部分且彼此独立地为未取代的或被C 1 -C 4烷氧基和/或甲硅烷氧基取代，或者优选未取代或每个碳原子被一个C 1 -C 4烷氧基和/或甲硅烷氧基取代，并且R 2代表C 1 -C 6烷基或未取代或取代的苄基，其中处理其中R3表示C1-C6烷基或未取代或取代的苄基，且R1和R2具有与式（I）中相同的含义的式（II）化合物; 在0℃或更低的温度下，在液体非质子传递溶剂中用碱处理足以获得式（I）化合物的时间。

9. 发明公开

EP2125709A2 COMPOUNDS THAT INHIBIT CHOLINESTERASE 审中-公开
标题翻译： VERBINDUNGEN ZUR HEMMUNG VON CHOLINESTERASE
公开(公告)号：EP2125709A2
公开(公告)日：2009-12-02
申请号：EP08725187.2
申请日：2008-02-04
申请人： Colucid Pharmaceuticals, Inc.
发明人： RUPNIAK, Nadia, M., J. , WHITE, James, F. , SHIOSAKI, Kazumi , LEANDER, J., David , DU, Shoucheng , COUGHLIN, Daniel, J.
IPC分类号： C07C271/44 , C07C271/48 , C07C271/52 , C07C271/56 , C07D211/86 , C07D223/24 , C07D403/14 , C07D413/04 , A61K31/27 , A61K31/496 , A61K31/4402 , A61K31/4422 , A61P25/28
CPC分类号： C07D211/90 , C07C271/44 , C07C271/48 , C07C271/54 , C07C271/56 , C07C2601/02 , C07C2601/14 , C07C2603/32 , C07C2603/74 , C07D213/40 , C07D215/56 , C07D243/38 , C07D267/20 , C07D333/20 , C07D401/04 , C07D405/12 , C07D487/04 , C07D499/68
摘要： Compounds that inhibit cholinesterase activity and, upon hydrolysis release a pharmacologically active agent. The pharmacologically active agent obtained by hydrolysis of the compound can treat, for example, a nervous system condition, a cholinergic deficiency and conditions or diseases associated with a deficiency in a pharmacologically active agent, such as acetylcholine.
摘要翻译：抑制胆碱酯酶活性并在水解时释放药理活性剂的化合物。本发明的化合物用于治疗个体的方法。通过化合物的水解获得的药理活性剂可以治疗例如神经系统状况，胆碱能缺乏以及与药理活性剂如乙酰胆碱缺乏相关的病症或疾病。

10. 发明公开

EP1770085A1 DIAMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME AND FUNGICIDE CONTAINING THE DERIVATIVE AS ACTIVE INGREDIENT 审中-公开
标题翻译： DIAMINDERIVAT，HERSTELLUNGSVERFAHRENDAFÜRUND FUNGIDID MIT DEM DERIVAT ALS WIRKSTOFF
公开(公告)号：EP1770085A1
公开(公告)日：2007-04-04
申请号：EP05766156.3
申请日：2005-07-19
申请人： Mitsui Chemicals, Inc.
发明人： KAKIMOTO, Takeshi, c/o Mitsui Chemicals, Inc. , KAMEKAWA, Hisato, c/o Mitsui Chemicals, Inc. , CHIBA, Yutaka, c/o Mitsui Chemicals, Inc. , KOHNO, Toshiyuki, c/o Mitsui Chemicals, Inc. , KOBAYASHI, Yumi, c/o Mitsui Chemicals, Inc. , TOMURA, Naofumi, c/o Mitsui Chemicals, Inc. , ARAKI, Natsuko, c/o Mitsui Chemicals, Inc. , YOSHIDA, Masako, c/o Mitsui Chemicals, Inc. , AOKI, Yoji, c/o Mitsui Chemicals, Inc. , BANBA, SHINICHI, c/o Mitsui Chemicals, Inc.
IPC分类号： C07C269/04 , C07C269/06 , C07C271/22 , C07C271/34 , C07C271/54 , C07C311/16 , C07C317/44 , C07C323/42 , C07C333/04 , C07D207/08 , C07D207/34 , C07C209/42 , C07D213/68 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D217/26 , C07D231/38 , C07D233/88 , C07D235/24
CPC分类号： C07D405/12 , C07C209/42 , C07C269/04 , C07C269/06 , C07C271/22 , C07C271/34 , C07C271/54 , C07C311/16 , C07C317/44 , C07C323/41 , C07C333/04 , C07C2601/08 , C07C2601/14
摘要： It is an object of the invention to provide a novel fungicide which exhibits a wide controlling spectrum against pathogens of various crops, and solves the toleration problem.
The diamine derivative represented by the formula (1) and a process for preparation of the same, fungicides comprising the same as an active ingredient are disclosed:

[wherein
R1 is substituents such as an alkyl group having 1 to 6 carbon atoms and the like, R2 and R5 are each independently substituents such as hydrogen atom, an alkyl group having 1 to 6 carbon atoms and the like, R3 and R4 are each independently substituents such as hydrogen atom, an alkyl group having 1 to 6 carbon atoms and the like, or R3 and R4 may be bonded to each other to form a hydrocarbon ring having 3 to 6 carbon atoms, R6, R7, R8 and R9 are each independently substituents such as hydrogen atom, an alkyl group having 1 to 6 carbon atoms and the like, R10 is a substituent such as hydrogen atom, an alkyl group having 1 to 6 carbon atoms and the like, A is an oxygen atom or a sulfur atom, and Q is an aryl group or a heterocycle].
摘要翻译：本发明的一个目的是提供一种对各种作物的病原体具有广泛控制谱的新型杀真菌剂，并解决了耐受性问题。公开了式（1）表示的二胺衍生物及其制备方法：其中R1为具有1-6个碳原子的烷基等取代基， R 2和R 5各自独立地为氢原子，碳原子数为1〜6的烷基等取代基，R 3和R 4各自独立地为氢原子，碳原子数1〜6的烷基等取代基，或者R 3和R 4可以彼此键合形成具有3至6个碳原子的烃环，R 6，R 7，R 8和R 9各自独立地为氢原子，具有1至6个碳原子的烷基等取代基中，R 10为氢原子，碳原子数为1〜6的烷基等取代基，A为氧原子或硫原子，Q为芳基或杂环。

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