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1. 发明授权

EP2792673B1 Carbamic acid ester derivatives for the production of isocyanate and aromatic hydroxy compounds 有权
公开(公告)号：EP2792673B1
公开(公告)日：2018-07-25
申请号：EP14168407.6
申请日：2008-11-14
申请人： Asahi Kasei Kabushiki Kaisha
发明人： Shinohata, Masaaki , Miyake, Nobuhisa
IPC分类号： C07C271/42 , C07C271/58
CPC分类号： C07C271/58 , C07C37/055 , C07C263/04 , C08G64/12 , C08G64/42 , C08G69/44 , C07C39/16 , C07C265/14
摘要： An object of the present invention is to provide a process for producing isocyanates, which are industrially useful compounds, without using phosgene, and to provide a process for chemically recycling waste polycarbonate resin. The present invention discloses a process enabling isocyanate compounds to be produced without using phosgene as a raw material by subjecting a carbamic acid ester compound obtained by a reaction between an aromatic polycarbonate resin and an amine compound to a thermal decomposition reaction, while at the same time disclosing a process enabling chemical recycling of aromatic polycarbonate resin by recovering a divalent aromatic hydroxy compound forming aromatic polycarbonates.

2. 发明授权

EP2880015B1 MULTITARGET FAAH AND COX INHIBITORS AND THERAPEUTICAL USES THEREOF 有权
标题翻译： MULTITARGET FAAH和COX抑制剂及其治疗用途
公开(公告)号：EP2880015B1
公开(公告)日：2017-09-27
申请号：EP13755978.7
申请日：2013-08-01
申请人： Fondazione Istituto Italiano Di Tecnologia , The Regents of the University of California , Alma Mater Studiorum -Università di Bologna
发明人： DE VIVO, Marco , SCARPELLI, Rita , CAVALLI, Andrea , MIGLIORE, Marco , PIOMELLI, Daniele , HABRANT, Damien , FAVIA, Angelo
IPC分类号： C07C271/28 , C07C271/42 , C07C271/44 , C07C271/56 , C07C271/58 , A61K31/325 , A61P35/00
CPC分类号： C07C271/56 , C07C271/28 , C07C271/44 , C07C271/58 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14

3. 发明授权

EP2439191B1 METHOD FOR PRODUCING N-SUBSTITUTED CARBAMIC ACID ESTER, METHOD FOR PRODUCING ISOCYANATE USING N-SUBSTITUTED CARBAMIC ACID ESTER, AND COMPOSITION FOR TRANSFERRING AND STORING N-SUBSTITUTED CARBAMIC ACID ESTER CONTAINING N-SUBSTITUTED CARBAMIC ACID ESTER AND AROMATIC HYDROXY COMPOUND 有权
标题翻译：用于制备N-取代氨基，PROCESS FOR PRODUCING异氰酸酯与N-取代输送用和储藏的氨基和组合物的N-取代氨基与N-取代氨基和芳族羟基
公开(公告)号：EP2439191B1
公开(公告)日：2017-01-25
申请号：EP09833912.0
申请日：2009-09-29
申请人： Asahi Kasei Kabushiki Kaisha
发明人： SHINOHATA, Maasaki , MIYAKE, Nobuhisa
IPC分类号： C07C263/04 , C07C265/14 , C07C269/04 , C07C271/42 , C07C269/00 , C07C271/54 , C07C271/56 , C07C271/58 , C07C275/40
CPC分类号： C07C275/40 , C07C263/04 , C07C269/00 , C07C269/04 , C07C271/54 , C07C271/56 , C07C271/58 , C07C2601/14 , C07C265/14 , C07C271/52

4. 发明公开

EP2322504A4 PROCESS FOR THE PREPARATION OF N-SUBSTITUTED CARBAMIC ACID ESTER AND PROCESS FOR THE PREPARATION OF ISOCYANATE USING THE N-SUBSTITUTED CARBAMIC ACID ESTER 有权
标题翻译：对于生产方法的N-取代氨基甲酸酯及其制造方法的异氰酸酯使用该N-取代氨基甲酸酯
公开(公告)号：EP2322504A4
公开(公告)日：2013-10-09
申请号：EP09845052
申请日：2009-09-29
申请人： ASAHI KASEI CHEMICALS CORP
发明人： MIYAKE NOBUHISA , SHINOHATA MASAAKI , OKUBO ATSUSHI
IPC分类号： C07C263/04 , C07C265/14 , C07C269/04 , C07C271/42
CPC分类号： C07C275/40 , C07C263/04 , C07C269/00 , C07C269/04 , C07C271/54 , C07C271/56 , C07C271/58 , C07C2601/14 , C07C265/14 , C07C271/52

5. 发明授权

EP0966435B1 AMINOINDAN DERIVATIVES 失效
标题翻译：氨基酸衍生物
公开(公告)号：EP0966435B1
公开(公告)日：2005-04-06
申请号：EP97953541.6
申请日：1997-12-18
申请人： TEVA PHARMACEUTICAL INDUSTRIES, LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , Technion Research & Development Foundation Limited
发明人： CHOREV, Michael , GOREN, Tamar , HERZIG, Yacov , STERLING, Jeffrey , WEINSTOCK-ROSIN, Marta , YOUDIM, Moussa, B., H.
IPC分类号： C07C271/42 , A61K31/27 , C07C271/58 , C07C271/56 , C07C271/44 , C07C333/04
CPC分类号： C07C271/56 , C07C271/24 , C07C271/44 , C07C271/58 , C07C333/04 , C07C2601/14 , C07C2602/08 , C07C2602/10
摘要： This invention is directed to compounds of formula (I) wherein when a is 0, b is 1 or 2; when a is 1, b is 1, m is from 0-3, X is O or S, Y is halogeno, R1 is hydrogen or C1-4 alkyl, R2 is hydrogen, C1-4 alkyl, or optionally substituted propargyl and R3 and R4 are each independently hydrogen, C1-8 alkyl, C6-12 aryl, C6-12 aralkyl each optionally substituted. This invention is also directed to the use of these compounds for treating depression, Attention Deficit Disorder (ADD), Attention Deficit and Hyperactivity Disorder (ADHD), Tourette's Syndrome, Alzheimer's Disease and other dementias such as senile dementia, dementia of the Parkinson's type, vascular dementia and Lewy body dementia. This invention is further directed to a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及式（I）的化合物，其中当a为0时，b为1或2; 当a为1时，b为1，m为0-3，X为O或S，Y为卤素，R1为氢或C1-4烷基，R2为氢，C1-4烷基或任选取代的炔丙基，R3 和R4各自独立地为氢，C1-8烷基，C6-12芳基，各自任选被取代的C6-12芳烷基。本发明还涉及这些化合物用于治疗抑郁症，注意缺陷障碍（ADD），注意力缺乏和多动症（ADHD），图雷特综合征，阿尔茨海默氏病和其他痴呆如老年性痴呆，帕金森氏型痴呆，血管性痴呆和路易体痴呆。本发明还涉及包含治疗有效量的上述定义的化合物和药学上可接受的载体的药物组合物。

6. 发明公开

EP0236618A2 Insecticidal N'-substituted-N,N'-diacylhydrazines 失效
标题翻译： Insektizide N'-Substierte N，N'-二酰肼。
公开(公告)号：EP0236618A2
公开(公告)日：1987-09-16
申请号：EP86308068.5
申请日：1986-10-17
申请人： ROHM AND HAAS COMPANY
发明人： Hsu, Adam Chi-Tung , Aller, Harold Ernest
IPC分类号： A01N33/26 , C07C243/38 , C07C255/49 , C07C255/32 , C07C271/42 , C07C281/00 , C07C305/02 , C07C317/14 , C07C323/62 , C07C327/00 , C07C331/00
CPC分类号： C07D207/327 , A01N37/28 , A01N37/30 , A01N37/34 , A01N37/36 , A01N37/38 , A01N37/40 , A01N37/42 , A01N37/44 , A01N37/48 , A01N39/00 , A01N39/04 , A01N43/20 , A01N43/28 , A01N43/36 , A01N43/76 , A01N47/20 , A01N47/22 , A01N47/34 , A01N47/46 , A01N47/48 , C07C243/38 , C07C255/00 , C07D263/16 , C07D303/46 , C07D317/68
摘要： This invention is concerned with insecticidal compositions containing N'-substituted-N,N'-diacylhydrazines, methods of using such compositions and with certain of the insecticidal N'-substituted-N,N'-diacylhydrazines which are novel compounds.
摘要翻译：本发明涉及含有N'-取代-N，N'-二酰基肼的杀虫组合物，使用这些组合物的方法以及某些作为新化合物的杀虫N'取代-N，N'-二酰肼的杀虫剂组合物。

7. 发明授权

EP2679575B1 PROCESS FOR PRODUCING CARBONYL COMPOUNDS 有权
公开(公告)号：EP2679575B1
公开(公告)日：2019-04-10
申请号：EP12749951.5
申请日：2012-02-21
申请人： Asahi Kasei Kabushiki Kaisha
发明人： SHINOHATA, Masaaki , MIYAKE, Nobuhisa
IPC分类号： C07C269/04 , C07C263/04 , C07C265/14 , C07C271/58 , C07C269/06 , C07C271/42 , C07C271/56 , C07C271/28

8. 发明公开

EP3153499A1 METHOD FOR PRODUCING N-SUBSTITUTED CARBAMIC ACID ESTER 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG VON N-SUBSTITUIERTEMCARBAMINSÄUREESTER
公开(公告)号：EP3153499A1
公开(公告)日：2017-04-12
申请号：EP16198429.9
申请日：2009-09-29
申请人： ASAHI KASEI KABUSHIKI KAISHA
发明人： SHINOHATA, Maasaki , MIYAKE, Nobuhisa
IPC分类号： C07C263/04 , C07C265/14 , C07C269/04 , C07C271/42 , C07C269/00
CPC分类号： C07C275/40 , C07C263/04 , C07C269/00 , C07C269/04 , C07C271/54 , C07C271/56 , C07C271/58 , C07C2601/14 , C07C265/14 , C07C271/52
摘要： The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (-C(=O)-) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.
摘要翻译：本发明是由有机胺，碳酸衍生物和含有一种或多种羟基化合物的羟基组合物生产由有机胺衍生的N-取代氨基甲酸酯的方法，其中有机胺，碳酸衍生物和羟基组合物使用具有冷凝器，含有羟基组合物的气体，具有衍生自碳酸衍生物的羰基的化合物和在反应中作为副产物形成的氨的氨酯生产反应容器进行反应被引入聚氨酯生产反应容器中的冷凝器中，羟基组合物和衍生自碳酸衍生物的具有羰基的化合物被缩合，其中在缩合羟基组合物中包含的羟基化合物的化学计量比与具有衍生自碳酸衍生物的羰基的缩合化合物为1以上，作为气体从作为气体回收的氨中含有的来自碳酸衍生物的羰基的化合物中所含的羰基数（-C（= O） - ）的比例为冷凝器为1或更小。

10. 发明授权

EP1161416B1 ALPHA-AMINOACETIC ACID DERIVATIVES USEFUL AS ALPHA 4 BETA 7 - RECEPTOR ANTAGONISTS 有权
标题翻译： ALPHA-氨基衍生物作为α+β4 7-受体拮抗剂
公开(公告)号：EP1161416B1
公开(公告)日：2004-04-14
申请号：EP00910364.9
申请日：2000-02-28
申请人： Elan Pharmaceuticals, Inc.
发明人： KONRADI, Andrei , PLEISS, Michael, A. , THORSETT, Eugene, D.
IPC分类号： C07C271/42 , C07D213/56 , C07D295/205 , C07D279/12 , C07D263/24 , A61K31/27 , A61K31/33
CPC分类号： C07D295/205 , C07C271/44 , C07C2601/14 , C07D213/56 , C07D263/24
摘要： Disclosed are compounds which bind α4β7 integrin. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by α4β7 integrin. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

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