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1. 发明公开

EP3342599A1 HEAT-SENSITIVE RECORDING MATERIAL 审中-公开
公开(公告)号：EP3342599A1
公开(公告)日：2018-07-04
申请号：EP16846443.6
申请日：2016-09-13
申请人： Sanko Co., Ltd.
发明人： ISHIBASHI Yoshimi , KINISHI Ryoichi , NAKAGAWA Yoshito
IPC分类号： B41M5/333 , C07C275/28 , C07C311/42 , C07C311/58 , C07C335/16 , C07C323/59 , C07K5/062 , C07K5/083
CPC分类号： B41M5/3333 , B41M5/327 , B41M5/3275 , B41M5/3335 , B41M5/3375 , C07C237/40 , C07C275/28 , C07C275/42 , C07C311/19 , C07C311/42 , C07C311/51 , C07C311/58 , C07C323/59 , C07C335/16
摘要： A heat-sensitive recording material includes a heat-sensitive recording layer containing a basic dye and a developer and provided on a supporting body, in which the developer is at least one type of an N-substituted amino acid derivative represented by the following General Formula: (R-X) m -Y-(Z) m ... (1) (In Formula (1), R represents an alkyl group or an aryl group which may have a substituent. X is a group bonded to the N-terminus of Y, and represents -OCO-, -SO 2 NHCO-, -NHCO-, -NHCS-, or -SO 2 -. Y represents an amino acid residue or a peptide residue. Z represents a group bonded to the C-terminus of Y and represents an OH group or an OR" group. When Y is an amino acid residue other than a cystine residue or when Y is a peptide residue not having a cystine residue, m = 1, and when Y is a peptide residue having n cystine residues, m = n + 1 and n is 1 or 2.)

2. 发明公开

EP3277672A1 INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER 审中-公开
公开(公告)号：EP3277672A1
公开(公告)日：2018-02-07
申请号：EP16715779.1
申请日：2016-04-01
申请人： Bristol-Myers Squibb Company
发明人： BALOG, James, Aaron , GUO, Weiwei , HUANG, Audris , MARKWALDER, Jay, A. , SHAN, Weifang , WILLIAMS, David, K. , NARA, Susheel, Jethanand , ROY, Saumya
IPC分类号： C07D309/14 , C07C275/42 , C07D317/66 , C07D401/12 , C07D405/12 , C07D239/42 , C07D261/14 , C07D487/04 , A61K31/17 , A61P35/00
CPC分类号： C07C275/40 , A61K31/17 , A61K31/196 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/428 , A61K31/437 , A61K31/445 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07C229/42 , C07C233/81 , C07C235/38 , C07C235/56 , C07C255/57 , C07C255/58 , C07C275/30 , C07C275/42 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/08 , C07D211/14 , C07D239/34 , C07D239/47 , C07D265/30 , C07D265/36 , C07D277/64 , C07D295/155 , C07D307/22 , C07D309/04 , C07D309/14 , C07D317/46 , C07D335/02 , C07D401/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08
摘要： There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

3. 发明公开

EP3080077A4 TRIPODAL NITRATE RECEPTOR 审中-公开
标题翻译：三聚体硝酸酯
公开(公告)号：EP3080077A4
公开(公告)日：2017-05-17
申请号：EP14868790
申请日：2014-12-11
申请人： UNIV OF OREGON
发明人： WATT MICHELLE , JOHNSON DARREN W , HALEY MICHAEL M
IPC分类号： G01N31/22 , C07C275/30 , C07C275/42 , C07C335/18 , C07C335/20
CPC分类号： G01N31/227 , C07C275/30 , C07C275/34 , C07C275/42 , C07C335/16 , C07C335/18 , C07C335/20 , C07D251/24 , G01N31/22
摘要： A compound, or a protonate or salt thereof, having a formula I of: wherein Y represents an optionally substituted aromatic group; n is 1 or 2; a is 0 to 4; R1 and R2 are each independently H; optionally substituted alkyl; optionally substituted aralkyl; acyl; phosphonyl; —S02R12; —C(0)R13; —C(0)OR14; —C(0)NR15R16; —C(0)CH2R17; or —C(S)—NR18R19; —S(0)R20; or —S02NR21R22, wherein R12-R22 are each independently H, optionally substituted alkyl, optionally substituted aralkyl, optionally substituted aryl, or —C(0)R23, wherein R23 is H, optionally substituted alkyl, optionally substituted aralkyl, or optionally substituted aryl; and each R3 is independently optionally substituted alkyl, halogen, optionally substituted alkoxy, optionally substituted carboxyl, amide; amino; or nitro.
摘要翻译：具有式I的化合物或其质子化合物或其盐，其中Y表示任选取代的芳族基团; n为1或2; a是0到4; R1和R2各自独立地为H; 任选取代的烷基; 任选取代的芳烷基; 酰基; 膦; -S02R12; -C（O）R13; -C（O）OR 14; -C（O）NR 15 R 16; -C（O）CH2R17; 或-C（S）-NR 18 R 19; -S（O）R 20; 或-SO 2 NR 21 R 22，其中R 12 -R 22各自独立地为H，任选取代的烷基，任选取代的芳烷基，任选取代的芳基或-C（O）R 23，其中R 23为H，任选取代的烷基，任选取代的芳烷基或任选取代的芳基 ; 并且每个R 3独立地是任选取代的烷基，卤素，任选取代的烷氧基，任选取代的羧基，酰胺; 氨基; 或硝基。

4. 发明公开

EP3046902A4 COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION AND/OR FIBROSIS 审中-公开
标题翻译：治疗血液高压和/或纤维化的组合物
公开(公告)号：EP3046902A4
公开(公告)日：2017-01-25
申请号：EP14845828
申请日：2014-09-17
申请人： VECTUS BIOSYSTEMS LTD
发明人： DUGGAN KAREN ANNETTE
IPC分类号： C07C235/34 , A61K31/165 , A61K31/17 , A61K31/18 , C07C233/07 , C07C233/11 , C07C237/20 , C07C255/00 , C07C271/28 , C07C275/28 , C07C307/10 , C07C311/03 , C07D209/18 , C07D213/74 , C07D215/02 , C07D231/56 , C07D235/04 , C07D249/18 , C07D263/54 , C07D277/62
CPC分类号： C07D263/58 , C07C235/34 , C07C237/20 , C07C255/61 , C07C261/04 , C07C271/28 , C07C275/42 , C07C307/10 , C07C311/03 , C07C311/08 , C07D209/08 , C07D209/18 , C07D209/34 , C07D213/74 , C07D213/89 , C07D215/02 , C07D215/227 , C07D231/56 , C07D235/04 , C07D235/08 , C07D235/10 , C07D235/26 , C07D249/18 , C07D263/54 , C07D277/62 , C07D277/68
摘要： The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.

5. 发明公开

EP3039020A1 IDO INHIBITORS 有权
标题翻译： IDO，缝边
公开(公告)号：EP3039020A1
公开(公告)日：2016-07-06
申请号：EP14766038.5
申请日：2014-08-26
申请人： Bristol-Myers Squibb Company
发明人： MARKWALDER, Jay A. , SEITZ, Steven P. , BALOG, James Aaron , HUANG, Audris , WILLIAMS, David K. , CHEN, Libing , MANDAL, Sunil Kumar , SRIVASTAVA, Shefali
IPC分类号： C07D403/12 , C07D309/14 , C07D215/06 , C07D231/12 , C07D333/10 , C07D401/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D257/04 , C07D277/22 , C07C13/00 , A61K31/416 , A61P37/02
CPC分类号： C07D257/04 , A61K31/17 , A61K31/18 , A61K31/381 , A61K31/41 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/451 , A61K31/4709 , A61K31/497 , A61K31/50 , A61K31/506 , A61K31/5375 , A61K45/06 , C07B59/002 , C07C275/42 , C07C311/05 , C07C311/09 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D211/14 , C07D215/06 , C07D231/12 , C07D237/20 , C07D277/22 , C07D309/14 , C07D333/10 , C07D333/38 , C07D401/10 , C07D401/12 , C07D403/12 , C07D407/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D417/12
摘要： There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention.
摘要翻译：公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病如癌症，病毒感染和/或自身免疫性疾病的方法，其利用发明。

6. 发明公开

EP2970155A1 INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE (IDO) 有权
标题翻译：抑制剂吲哚美辛-2,3-二氧化物（IDO）
公开(公告)号：EP2970155A1
公开(公告)日：2016-01-20
申请号：EP14729491.2
申请日：2014-03-12
申请人： Bristol-Myers Squibb Company
发明人： BALOG, James Aaron , HUANG, Audris , CHEN, Bin , CHEN, Libing , SEITZ, Steven P. , HART, Amy C. , MARKWALDER, Jay A.
IPC分类号： C07D261/02 , C07C233/07 , C07D239/22 , C07D213/60
CPC分类号： A61K31/196 , A61K31/18 , A61K31/216 , A61K31/27 , A61K31/36 , A61K31/41 , A61K31/42 , A61K31/4245 , A61K31/44 , A61K31/498 , A61K31/505 , A61K45/06 , A61N5/10 , C07B2200/07 , C07C69/743 , C07C233/55 , C07C235/38 , C07C255/44 , C07C255/57 , C07C271/28 , C07C275/42 , C07C311/47 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/02 , C07C2602/08 , C07C2602/14 , C07C2602/42 , C07D213/56 , C07D213/75 , C07D213/84 , C07D239/42 , C07D241/42 , C07D257/04 , C07D261/08 , C07D261/14 , C07D271/12 , C07D317/66 , Y02A50/411 , Y02A50/414
摘要： There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
摘要翻译：公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和使用所述化合物治疗增殖性疾病如癌症，病毒感染和/或炎症性疾病的方法发明。

7. 发明公开

EP2968330A1 COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS 审中-公开
标题翻译： VERBINDUNGEN UND VERFAHREN ZUR INDUKTION VON CHONDROGENESE
公开(公告)号：EP2968330A1
公开(公告)日：2016-01-20
申请号：EP14770543.8
申请日：2014-03-13
申请人： The California Institute for Biomedical Research , The Scripps Research Institute
发明人： SCHULTZ, Peter, G. , CHATTERJEE, Arnab, K. , ZHU, Shoutian , PAYETTE, Joshua , YOON, Hongchul , YANG, Baiyuan
IPC分类号： A61K31/505 , A61K39/395
CPC分类号： A61K31/54 , A61K31/18 , A61K31/192 , A61K31/194 , A61K31/196 , A61K31/24 , A61K31/255 , A61K31/27 , A61K31/277 , A61K31/357 , A61K31/36 , A61K31/365 , A61K31/402 , A61K31/4035 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/426 , A61K31/433 , A61K31/44 , A61K31/495 , A61K31/5375 , A61K45/06 , C07C233/66 , C07C233/69 , C07C233/73 , C07C233/75 , C07C233/76 , C07C233/80 , C07C233/81 , C07C233/87 , C07C235/52 , C07C235/60 , C07C235/84 , C07C237/22 , C07C251/48 , C07C255/60 , C07C271/20 , C07C275/42 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/17 , C07C311/21 , C07C311/24 , C07C311/46 , C07C317/40 , C07D207/27 , C07D209/46 , C07D209/48 , C07D213/79 , C07D231/40 , C07D233/64 , C07D261/14 , C07D277/46 , C07D285/135 , C07D295/26 , C07D307/88 , C07D317/28 , C07D317/66 , C07D319/08 , C07D319/18 , C12N5/0655 , C12N2506/1353 , A61K2300/00
摘要： Described herein are compounds and compositions for the amelioration of arthritis or joint injuries by inducing mesenchymal stem cells into chondrocytes.
摘要翻译：本文描述了通过将间充质干细胞诱导成软骨细胞来改善关节炎或关节损伤的化合物和组合物。

8. 发明公开

EP2578659A4 WATER-AND-OIL REPELLENT AGENT, AND WATER-AND-OIL REPELLENT AGENT COMPOSITION 审中-公开
标题翻译：拒水拒油及构成水防油剂
公开(公告)号：EP2578659A4
公开(公告)日：2014-07-02
申请号：EP11789900
申请日：2011-06-02
申请人： ASAHI GLASS CO LTD
发明人： HOSHINO TAIKI
IPC分类号： D06M15/576 , D06M15/572
CPC分类号： C09D5/00 , C07C235/84 , C07C275/42 , C08G18/2885 , C08G18/7621 , C08G18/7664 , C08G18/7671 , C08G18/7831 , C08G18/792 , C09D175/04 , D06M15/572 , D06M15/576 , D06M2200/11 , D06M2200/12
摘要： To provide a water/oil repellent agent and a water/oil repellent composition which are capable of imparting sufficient water/oil repellency to the surface of an article and which have low environmental impact. One comprising a reaction product obtained by reacting a fluorinated alcohol or amine having a polyfluoroalkyl moiety having at most 6 carbon atoms with a polyisocyanate compound, which is, when applied to an article, capable of imparting sufficient water/oil repellency, while presenting little environmental impact. When applied to an article, the water/oil repellent composition of the present invention is capable of imparting a high quality water/oil repellency to the article.

9. 发明公开

EP2573069A2 Inhibitors of histone deacetylase and prodrugs thereof 审中-公开
标题翻译： Histondeacetylase - Hemmer und Prodrugs daraus
公开(公告)号：EP2573069A2
公开(公告)日：2013-03-27
申请号：EP12191995.5
申请日：2007-12-19
申请人： MethylGene Inc.
发明人： Deziel, Robert , Ajamian, Alain
IPC分类号： C07C259/06 , C07C279/14 , C07D213/82 , A61K31/215 , A61K31/222 , A61K31/223 , A61K31/4406 , A61P35/00
CPC分类号： C07C311/21 , C07C259/06 , C07C259/10 , C07C275/42 , C07C279/14 , C07C311/13 , C07C311/29 , C07C311/44 , C07C313/06 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07D213/30 , C07D213/70 , C07D215/24 , C07D235/02 , C07D271/08 , C07D285/135 , C07D307/91 , C07D309/06 , C07D317/30 , C07D317/60 , C07D333/34 , C07D333/62 , C07D409/04
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds, prodrugs thereof, and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
摘要翻译：本发明涉及抑制组蛋白脱乙酰酶。本发明提供了化合物，其前体药物和抑制组蛋白脱乙酰酶酶活性的方法。本发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。

10. 发明公开

EP2484661A4 2,3-DIHYDRO-1H-INDENE-2-YLUREA DERIVATIVE AND PHARMACEUTICAL APPLICATION OF SAME 有权
标题翻译： 2,3-二氢-1H-茚-2-基 - 脲衍生物及其医药用途
公开(公告)号：EP2484661A4
公开(公告)日：2013-02-27
申请号：EP10820624
申请日：2010-09-30
申请人： TORAY INDUSTRIES
发明人： KANEKO HIROAKI , KAWAI HIDEKI , IURA YOSUKE , INOUE HIDEKI , KAINO MIE , MEGURO HIROYUKI , UCHIDA TAZURU
IPC分类号： C07C275/34 , A61K31/17 , A61K31/35 , A61P17/00 , A61P29/00 , C07C275/40 , C07D295/12 , C07D309/06
CPC分类号： C07D309/06 , C07C275/34 , C07C275/40 , C07C275/42 , C07C2601/04 , C07C2602/08 , C07D295/135

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