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1. 发明授权

EP1197693B1 Hybrid valve apparatus, system and method for fluid handling 有权
标题翻译：系统具有用于Flussigkeitshandhabung混合阀和方法
公开(公告)号：EP1197693B1
公开(公告)日：2006-11-22
申请号：EP01308303.5
申请日：2001-09-28
申请人： Innovadyne Technologies, Inc. , UT-Battelle, LLC
发明人： Johnson, James E. , Diktycz, Mitchel J. , Picha, Neil R.
IPC分类号： F16K13/00 , G01N1/00 , B01J19/00
CPC分类号： G01N35/1097 , B01J19/0046 , B01J2219/00315 , B01J2219/00394 , B01J2219/00412 , B01J2219/00605 , B01J2219/00659 , C40B60/14 , F16K11/0743 , F16K99/0001 , F16K99/0013 , F16K99/0028 , F16K2099/0084 , G01N1/14 , G01N2035/1041 , Y10T137/86863 , Y10T137/87249 , Y10T436/2575

3. 发明公开

EP2321042A1 AUTOMATED OLIGOSACCHARIDE SYNTHESIZER 审中-公开
标题翻译：自动寡糖合成仪
公开(公告)号：EP2321042A1
公开(公告)日：2011-05-18
申请号：EP09801001.0
申请日：2009-07-23
申请人： Ancora Pharmaceuticals Inc.
发明人： CHRIST, William , KRÖCK, Lenz , PLANTE, Obadiah, J. , CASTAGNER, Bastien , SEEBERGER, Peter, H.
IPC分类号： B01J19/18 , C13K13/00
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00353 , B01J2219/00391 , B01J2219/00394 , B01J2219/00412 , B01J2219/00418 , B01J2219/00423 , B01J2219/00454 , B01J2219/00495 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00698 , B01J2219/00722 , B01J2219/00731
摘要： The technical field of this invention is automated oligosaccharide synthesizers. There is a need in this field for more efficient oligosaccharide synthesizers. For example, the present invention is an apparatus for solid phase oligosaccharide synthesis, which includes a reaction vessel for holding a reaction mixture, such that the reaction vessel is equipped with a temperature control system, a donor vessel for holding a saccharide donor; an activation vessel for holding activator, a pump operably connected to a fluidic valve; an additional fluidic valve connected to the activation vessel, to the first fluidic valve via a first fluid line, and to the reaction vessel via a second fluid line, such that the activator or saccharide donor can be delivered via the second fluidic valve into the first fluid line and then through the second fluid line into the reaction vessel.
摘要翻译：本发明的技术领域是自动寡糖合成仪。该领域需要更有效的寡糖合成仪。例如，本发明是一种用于固相寡糖合成的设备，其包括用于保持反应混合物的反应容器，使得反应容器配备有温度控制系统，用于保持糖类供体的供体容器; 用于容纳活化剂的活化容器，可操作地连接到流体阀的泵; 连接到活化容器的附加流体阀，经由第一流体管线连接到第一流体阀，并且经由第二流体管线连接到反应容器，使得活化剂或糖供体可以经由第二流体阀输送到第一流体阀流体管线，然后通过第二流体管线进入反应容器。

4. 发明公开

EP1177003A4 A HAND-PIECE FOR INJECTION DEVICE WITH A RETRACTABLE AND ROTATING NEEDLE 有权
标题翻译：办理AN注射装置的可伸缩的转针
公开(公告)号：EP1177003A4
公开(公告)日：2004-10-13
申请号：EP00932087
申请日：2000-05-05
申请人： MILESTONE SCIENTIFIC INC
发明人： HOCHMAN MARK N , PETTINATO DAVID , LIVINGSTON TROY W
IPC分类号： A61M5/00 , A61M5/32 , B01J19/00 , C40B60/14
CPC分类号： A61M5/322 , A61M5/00 , A61M5/3232 , A61M2005/3228 , A61M2005/3289 , B01J19/0046 , B01J2219/00313 , B01J2219/00364 , B01J2219/00389 , B01J2219/00394 , B01J2219/00495 , B01J2219/00585 , B01J2219/00698 , B01J2219/00707 , B01J2219/0072 , C40B60/14
摘要： An injection device is arranged, and constructed to simultaneously rotate a needle (22) during its forward translation as a therapeutic agent such as a liquid is ejected therefrom. In one embodiment the injection device is an automatic device including a pump (12) forcing the liquid through a tube (18) to a hand-piece (20), a second position in which the needle (22) extends outwardly of the hand-piece (20) so that it can be used to eject the liquid, with the needle (22) being automatically uni-directionally or bi-directionally rotated as it is advanced between the first, and second positions. In an alternate position a syringe (100) is provided with a barrel (102), a plunger (112) extending into the barrel (102) by the operator. The needle (22), and plunger (112) are arranged so that as the plunger (112) enters the barrel (102) forcing the liquid to be expelled, the needle (22) automatically rotates about its axis at the same time.

5. 发明授权

EP1144106B1 VORRICHTUNG ZUR DURCHFÜHRUNG VON CHEMISCHEN REAKTIONEN 有权
标题翻译：装置用于进行化学反应
公开(公告)号：EP1144106B1
公开(公告)日：2003-07-23
申请号：EP99963564.2
申请日：1999-12-16
申请人： MWG -Biotech AG
发明人： HEIMBERG, Wolfgang , WEICHSELGARTNER, Michael
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00313 , B01J2219/00319 , B01J2219/00326 , B01J2219/00337 , B01J2219/00351 , B01J2219/00389 , B01J2219/00394 , B01J2219/00585 , B01J2219/0059 , B01J2219/00693 , B01J2219/00698 , B01J2219/0072 , B01J2219/00722 , C40B40/06 , C40B60/14

6. 发明公开

EP1144106A2 VORRICHTUNG ZUR DURCHFÜHRUNG VON CHEMISCHEN REAKTIONEN 有权
标题翻译：装置用于进行化学反应
公开(公告)号：EP1144106A2
公开(公告)日：2001-10-17
申请号：EP99963564.2
申请日：1999-12-16
申请人： MWG -Biotech AG
发明人： HEIMBERG, Wolfgang , WEICHSELGARTNER, Michael
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00313 , B01J2219/00319 , B01J2219/00326 , B01J2219/00337 , B01J2219/00351 , B01J2219/00389 , B01J2219/00394 , B01J2219/00585 , B01J2219/0059 , B01J2219/00693 , B01J2219/00698 , B01J2219/0072 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： The invention relates to a device for carrying out chemical reactions. Said device comprises a reaction slider in which a plurality of through openings are configured as reaction chambers and a selection slider which is arranged on the upper surface of the reaction slider and which has at least one traversing control opening. Said selection slider is displaceable relative to the reaction slider in such a manner that the control opening thereof is aligned with one of the reaction chambers of the reaction slider so that a traversing connection for supply of the reaction chamber with a predetermined reagent is formed. The device is further provided with a slider for chemical agents which is arranged below the reaction slider and which is configured with through openings for feeding chemicals to the individual reaction chambers of the reaction slider. The invention provides a means for impinging the sliders with a predetermined force and further provides a valve arrangement with which chemicals can be fed to the chemical slider as a premix.

7. 发明公开

EP0859661A1 APPARATUS AND PROCESS FOR MULTIPLE CHEMICAL REACTIONS 失效
标题翻译： DEVICE AND METHOD FOR多种化学反应的
公开(公告)号：EP0859661A1
公开(公告)日：1998-08-26
申请号：EP96933842.0
申请日：1996-09-23
申请人： BERLEX LABORATORIES, INC.
发明人： MOHAN, Raju , BUCKMAN, Brad, O. , MORRISSEY, Michael, M. , CHITTY, Andrew, I. , MARTIN, John, T.
IPC分类号： B01J19 , C40B50 , C40B60 , C40B70
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00308 , B01J2219/0031 , B01J2219/00335 , B01J2219/00394 , B01J2219/00416 , B01J2219/00423 , B01J2219/00454 , B01J2219/00484 , B01J2219/00495 , B01J2219/005 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00686 , B01J2219/0072 , C40B50/14 , C40B60/14 , C40B70/00 , Y10S436/809 , Y10T436/25 , Y10T436/25375
摘要： Multiple chemical reactions are performed in a plurality of reaction vessels (12) mounted in inlets in a manifold valve block (30). The manifold valve block (30) is connected to a channel block (34) which is utilized in conjunction with a solvent delivery system (21) as part of the reaction cycle. The solvent fluid is drained from the reaction vessels (12) when valves in the manifold valve block (30) are opened while applying a vacuum thereto. Optionally, a thermal block (40) may be utilized in conjunction with the manifold valve block (30) and the channel block (34) to facilitate the reaction. Upon completion of the reactant cycle, the manifold valve block (30) is disconnected from the channel block (34) and connected to a cleavage block assembly (120, 121) which contains vials (128) for collecting reaction products. The cleavage product is drained from the reaction vessels (12) through the manifold valve block (30) into the vials (128) upon opening the valves in the manifold valve block (30) and applying a vacuum to the channel block (34).

8. 发明公开

EP0257797A2 Valve block assemblies 失效
标题翻译： Ventilblockzusammenbau。
公开(公告)号：EP0257797A2
公开(公告)日：1988-03-02
申请号：EP87306518.9
申请日：1987-07-23
申请人： PORTON INSTRUMENTS, INC.
发明人： Farnsworth, Vincent Robert , Cartier, Paul Kelso III
IPC分类号： B01J4/00 , B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00394 , B01J2219/00398 , B01J2219/0059 , B01J2219/00725 , C40B40/10 , C40B60/14 , Y10T137/3124 , Y10T137/314 , Y10T137/86332 , Y10T137/87684
摘要： A valve block assembly having internal delivery channels and a common outlet channel is provided with two delivery valve surfaces with access to the common channel. The common channel comprises easily cleaned linear sections 26, 126 running alternately from one surface to the other, and connecting surface grooves 25, 125 at the valve sites. Diaphragm valves 19, 20, 21 are provided with relief grooves 4a to accommodate deformation of the diaphragm 5. The V-like cross-section of the connecting grooves 25, 125 of the common channel and the conical shape of the nearby outlet 24a of a delivery channel 24 assure that the valve may be opened by only a small actuating force. Reservoirs 10 feeding the delivery channels 24 have an inert atmosphere controlled by pressurizing and venting channels 22, 23 in the valve block 16, 116. Exposure of plastic tubing to oxygen is kept to a minimum. The assembly is particularly adapted for use in a protein sequencer to supply reactants without cross-contamination or oxidative decomposition.
摘要翻译：具有内部输送通道和公共出口通道的阀块组件设置有两个具有进入公共通道的输送阀表面。公共通道包括从一个表面到另一个表面交替运行的容易清洁的线性段26,126以及在阀位处的连接表面槽25,125。隔膜阀19,20,21设置有释放槽4a以适应隔膜5的变形。公共通道的连接槽25,125的V形横截面和附近出口24a的锥形形状输送通道24确保阀只能通过小的致动力打开。供给输送通道24的储存器10具有通过对阀块16,116中的通道22,23进行加压和排气来控制的惰性气体。将塑料管道暴露于氧气中保持最小。该组合物特别适用于蛋白质测序仪，以提供反应物而不会发生交叉污染或氧化分解。

9. 发明公开

EP0225050A2 Automated biopolymer crystal preparation apparatus and process 失效
标题翻译：装置和方法，用于自动地产生二元共聚物的晶体。
公开(公告)号：EP0225050A2
公开(公告)日：1987-06-10
申请号：EP86308404.2
申请日：1986-10-29
申请人： FUJITSU LIMITED
发明人： Fujita, Shozo , Yasuda, Hachiro , Sugama, Akio , Nakane, Naomi , Yagishita, Teruo
IPC分类号： C30B7/00 , C30B29/54
CPC分类号： C30B7/00 , B01J19/0046 , B01J2219/00389 , B01J2219/00394 , B01J2219/00495 , C30B29/58 , C40B60/14 , Y10S117/901 , Y10T117/1008 , Y10T117/1024
摘要： Preparation of biopolymer crystals is made automatic by an apparatus comprising a reactor system (5), a solution liquid supply system (2), temperature control system (4), a control unit (1) controlling the supply system and the temperature control system, and preferably, an image recording system (7).

10. 发明公开

EP3210667A1 MODULAR CONTINUOUS FLOW DEVICE 审中-公开
标题翻译：模块连续流动装置
公开(公告)号：EP3210667A1
公开(公告)日：2017-08-30
申请号：EP16157958.6
申请日：2016-02-29
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人： GILMORE, Kerry , SEEBERGER, Peter H. , PIEBER, Bartholomäus , CHATTERJEE, Sourav
IPC分类号： B01J19/00 , C40B60/00 , C07D321/10 , C07D493/22
CPC分类号： B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00391 , B01J2219/00394 , B01J2219/00409 , B01J2219/00418 , B01J2219/00585 , B01J2219/0059 , B01J2219/0072 , B01J2219/0081 , B01J2219/00813 , B01J2219/00869 , B01J2219/00871 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00936 , B01J2219/00941 , B01J2219/00959 , B01J2219/00963 , C40B60/14
摘要： The invention refers to a modular continuous flow device for automated chemical multistep synthesis under continuous flow conditions. The device comprises a plurality of different types of continuous flow modules and a valve assembly for connecting the continuous flow modules to each other in a parallel or radial manner. This arrangement allows conducting convergent chemical reaction sequences by pre-synthesizing and intermediately storing or simultaneously synthesizing at least one intermediate product which is needed in the main synthetic reaction sequence in order to obtain the final product.
摘要翻译：本发明涉及在连续流动条件下用于自动化学多步合成的模块化连续流动装置。该装置包括多个不同类型的连续流动模块和用于以平行或径向方式将连续流动模块彼此连接的阀组件。这种配置允许通过预合成和中间存储或同时合成至少一种在主合成反应序列中需要的中间产物来进行会聚化学反应序列，以获得最终产物。

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