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1. 发明公开

EP2237885A1 VERFAHREN UND VORRICHTUNG ZUR AUTOMATISIERTEN PROZESSIERUNG EINER PROBE 审中-公开
标题翻译：方法和设备对样品进行自动处理
公开(公告)号：EP2237885A1
公开(公告)日：2010-10-13
申请号：EP09707162.5
申请日：2009-01-13
申请人： Qiagen GmbH
发明人： ROTHMANN, Thomas , HIMMELREICH, Ralf , LAUE, Thomas
IPC分类号： B01L3/00 , C12M1/33 , C12M1/12 , C12N15/10
CPC分类号： B01L3/502715 , B01J2219/00335 , B01J2219/00373 , B01J2219/00423 , B01J2219/00605 , B01J2219/00641 , B01J2219/00722 , B01L7/52 , B01L2200/025 , B01L2200/027 , B01L2200/10 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/1827 , C12M47/06
摘要： The invention relates to a method and a device for processing a biological sample. According to the invention, the processing comprises binding, washing and eluting biomolecules of the biological sample. The aim of the invention is to provide a method and a device for the automatic processing of biological samples which can have a relatively large volume and which can be further process by a microfluidic system. According to the invention, a container (1) is provided with a filter (10) and can be or is closed. A biological sample is introduced into the container. An inlet or outlet (4) for liquids is mounted downstream of the filter. In order to carry out processing, liquids that are present in the container are not only sucked off through the filter and passed on via the inlet or outlet, but liquids required for processing are also pumped into the container through the filter. The container can be connected to a microfluidic system in a relatively easy manner since only one conduit is required for an automated processing.

2. 发明公开

EP2087934A1 Verfahren und Vorrichtung zur automatisierten Prozessierung einer Probe 审中-公开
公开(公告)号：EP2087934A1
公开(公告)日：2009-08-12
申请号：EP08151152.9
申请日：2008-02-07
申请人： Qiagen GmbH
发明人： Rothmann, Thomas c/o QIAGEN GmbH , Himmelreich, Ralf c/o QUIAGEN GmbH , Laue, Thomas c/o QUIAGEN GmbH
IPC分类号： B01L3/00 , C12M1/33 , C12M1/12 , C12N15/10
CPC分类号： B01L3/502715 , B01J2219/00335 , B01J2219/00373 , B01J2219/00423 , B01J2219/00605 , B01J2219/00641 , B01J2219/00722 , B01L7/52 , B01L2200/025 , B01L2200/027 , B01L2200/10 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/1827 , C12M47/06
摘要： Die Erfindung betrifft ein Verfahren und eine Vorrichtung zur Prozessierung einer biologischen Probe. Prozessierung im Sinne der vorliegenden Erfindung umfasst das Binden, das Waschen sowie die Elution van Biomolekülen der biologischen Probe.
Es ist Aufgabe der Erfindung, ein Verfahren und eine Vorrichtung für die automatische Prozessierung biologischer Proben bereitzustellen, die ein relativ großes Volumen haben können und die von einem mikrofluidischen System weiter verarbeitet werden.
Zur Lösung der Aufgabe wird ein verschließbarer oder verschlossener Behälter (1) verwendet, der mit einem Filter (10) versehen ist. Eine biologische Probe wird in den Behälter gebracht. Unterhalb des Filters ist en Zu- bzw. Abfluss (4) für Flüssigkeit vorgesehen. Für de Durchführung der Prozessierung werden im Behälter befindliche Flüssigkeiten nicht nur durch den Filter hindurch abgesaugt und über den Zu- bzw. Abfluss weitergeleitet, sondern hierüber werden für die Prozessierung benötige Flüssigkeiten auch durch den Filter hindurch n den Behälter gepumpt. Da nur eine Leitung für eine automatisierte Prozessierung benötigt wird, kann der Behälter relativ einfach mit einem mikrofluidischen System verbunden werden.
摘要翻译：该方法包括通过入口或出口（3）和/或过滤元件（10）将裂解缓冲液引导到容器（1）和/或室中，其中裂解缓冲液用于分解存在于容器中的生物样品和/或室，并通过微流体系统（2）将裂解缓冲液泵送到通过过滤元件的容器和/或室中，和/或从微流体系统上的容器和/或室吸出裂解缓冲液。用样品泵送乙醇，洗涤缓冲液和洗脱液，以将其分解成容器和/或室。该方法包括通过入口或出口（3）和/或过滤元件（10）将裂解缓冲液引导到容器（1）和/或室中，其中裂解缓冲液用于分解存在于容器中的生物样品和/或室，并通过微流体系统（2）将裂解缓冲液泵送到通过过滤元件的容器和/或室中，和/或从微流体系统上的容器和/或室吸出裂解缓冲液。将样品泵入乙醇，洗涤缓冲液和洗脱液，以通过过滤元件分解成容器和/或室，然后随后从过滤元件上的容器和/或室吸出。通过加热容器和/或室和/或通过从容器中吸出来除去乙醇。微流体系统的通道（4）的直径小于1mm。容器的填充体积为1ml。容器通过中空针与微流体系统连接。存在于容器和/或室中的缓冲液的液面升高和降低数次。包括以下独立权利要求：（1）用于处理集装箱中生物样品的装置; 和（2）用于装置的微流体系统。

3. 发明公开

EP1930724A1 VARIOUS SUBSTANCES SUPPORTER, VARIOUS SUBSTANCES SUPPORTER PROCESSING APPARATUS, AND METHOD OF MENTIONED PROCESSING 有权
标题翻译：支持各种物质，设备加工各种物质用于所述支持及处理方法
公开(公告)号：EP1930724A1
公开(公告)日：2008-06-11
申请号：EP06797279.4
申请日：2006-09-01
申请人： Universal Bio Research Co., Ltd.
发明人： TAJIMA, Hideji
IPC分类号： G01N33/53
CPC分类号： C12Q1/6804 , B01J2219/00292 , B01J2219/00364 , B01J2219/00373 , B01J2219/005 , B01J2219/0052 , B01J2219/00545 , B01J2219/00576 , B01J2219/00596 , B01L3/0275 , B01L3/502 , B01L2200/0647 , B01L2300/0636 , B01L2300/0838 , B01L2300/1827 , G01N30/6047 , G01N30/6052 , G01N30/6073 , G01N33/54313 , G01N35/10 , G01N2035/00564 , G01N2035/00574 , G01N2035/1055 , Y10T436/11
摘要： An object of the present invention is to provide a various-substance holder, a various-substance holder treating apparatus, and a various-substance holder treating method which enable the mutual identification of a plurality of particulate carriers to which various substances are or can be immobilized without the need to arrange the particulate carriers at predetermined positions or in a predetermined order, eliminating the need for time and effort to arrange the various substance at predetermined positions or in a predetermined order to allow treatments to be quickly and easily achieved. The various-substance holder according to the present invention has a plurality of particulate carriers or plural sets of particulate carriers to which plural types of chemical substances are or can be immobilized and a carrier holding portion holding the plurality of particulate carriers or the plural sets of particulate carriers in a substantially stationary state such that the plurality of particulate carriers or the plural sets of particulate carriers can be externally measured. The various-substance holder is configured so that each of the plurality of particulate carriers or at least one of the particulate carriers belonging to the plural sets of the particulate carriers are labeled according to types of the chemical substances or for each of the particulate carriers or each set of the particulate carriers so as to be mutually identifiable before the particulate carriers are introduced and held in the carrier holding portion.
摘要翻译：本发明的一个目的是提供一种各种物质保持器，各种物质保持器处理装置，和一个各种物质保持器处理方法，它使颗粒载体以各种物质是哪个或者可以是多个相互识别固定化，而不需要安排在预定位置或在预定的顺序颗粒载体，从而消除了时间和精力，在规定的位置或按照规定的顺序，使治疗可以快速，方便地实现安排的各种物质的需要。各种物质保持器雅丁到本发明具有颗粒载体或多组颗粒载体，以将多个类型的化学物质，或者可以被固定，并中的多个A载流子保持部分保持的颗粒载体或所述多组的多元性在静止状态下的颗粒载体基本上没有检查颗粒载体或所述多组颗粒载体的的多元性可从外部进行测定。各种物质保持器被配置为每个颗粒载体或属于多组颗粒载体的颗粒载体中的至少一个的多元性标记雅丁到类型的化学物质或用于每个颗粒载体的或没每组颗粒载体的，从而被引入并且在载流子保持部分保持的颗粒载体之前为相互识别。

4. 发明公开

EP1393073A4 METHODS FOR ASSEMBLING PROTEIN MICROARRAYS 审中-公开
标题翻译：施工过程中蛋白质微阵列
公开(公告)号：EP1393073A4
公开(公告)日：2007-03-28
申请号：EP02769307
申请日：2002-05-03
申请人： SIGMA GENOSYS LTD
发明人： GILMORE JAMES , DANIEL STEVEN , HOGAN MIKE , TAM SUNNY , WIESE RICK
IPC分类号： G01N33/53 , C07K1/04 , C40B40/10 , C40B60/14 , G01N33/543 , G01N33/545 , G01N33/566 , G01N37/00 , B01J19/00
CPC分类号： G01N33/545 , B01J19/0046 , B01J2219/00315 , B01J2219/00369 , B01J2219/00373 , B01J2219/00378 , B01J2219/00497 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/00639 , B01J2219/00659 , B01J2219/00662 , B01J2219/00675 , B01J2219/00691 , B01J2219/00704 , B01J2219/00707 , B01J2219/00711 , B01J2219/00725 , B82Y30/00 , C07K1/047 , C40B40/10 , C40B60/14 , G01N33/54353
摘要： The invention provides methods for assembling protein arrays. In one aspect, the methods comprise use of charged or polar array surfaces in the construction of the array. The methods also comprise use of viscous solutions for the deposition of the polypeptides on the array surface in the construction of the array.

5. 发明公开

EP1566216A1 Modular array arrangements 审中-公开
标题翻译： Modulare Mikroarray-Anordnung
公开(公告)号：EP1566216A1
公开(公告)日：2005-08-24
申请号：EP05003288.7
申请日：2005-02-16
申请人： EPPENDORF AG
发明人： Bülow, Sven
IPC分类号： B01L3/00
CPC分类号： B01L3/50855 , B01J19/0046 , B01J2219/00283 , B01J2219/00315 , B01J2219/00335 , B01J2219/00373 , B01J2219/00511 , B01J2219/00527 , B01J2219/00542 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L2300/0609 , B01L2300/0636 , B01L2300/0829
摘要： The present invention pertains to modular array arrangements comprising a carrier and at least one insert (10) for attachment to said carrier, which at least one insert (10) may be positioned in or on said carrier in a predetermined, fixed orientation. In addition, the present invention relates to an insert having first connecting means (16) and at least one section (12) adapted for the application of samples, to a method of preparing a modular array arrangement and to a method for using such modular array arrangements in a screening assay.
摘要翻译：本发明涉及包括载体和用于附接到所述载体的至少一个插入件（10）的模块化阵列布置，所述至少一个插入件（10）可以以预定的固定方向定位在所述载体中或所述载体上。另外，本发明涉及具有第一连接装置（16）和至少一个适用于样品应用的部分（12）的插入件，一种制备模块阵列装置的方法和一种使用这种模块阵列的方法安排筛选试验。

6. 发明公开

EP1425577A4 APPARATUSES AND METHODS FOR CREATING AND TESTING PRE-FORMULATIONS AND SYSTEMS FOR SAME 审中-公开
标题翻译：装置和一种用于生成以及测试预制剂和系统THEREOF
公开(公告)号：EP1425577A4
公开(公告)日：2004-12-29
申请号：EP02731970
申请日：2002-05-24
申请人： SYMYX TECHNOLOGIES INC
发明人： CARLSON ERIC D , CONG PEIJUN , CHANDLER WILLIAM H JR , CHAU HENRY K , DANIELSON EARL , DESROSIERS PETER J , DOOLAN ROBERT D , WU LUPING
IPC分类号： G01N21/64 , B01J19/00 , B01L3/00 , B01L3/06 , B01L7/00 , C07B61/00 , C07D209/20 , C07D293/00 , C40B40/10 , C40B60/08 , C40B60/14 , G01N5/04 , G01N13/00 , G01N21/23 , G01N21/27 , G01N21/33 , G01N21/35 , G01N21/47 , G01N21/65 , G01N21/78 , G01N24/08 , G01N25/04 , G01N30/88 , G01N33/15 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/543 , G01N35/02 , G01N37/00 , G01N33/48
CPC分类号： B01L3/50255 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00315 , B01J2219/00335 , B01J2219/00364 , B01J2219/00373 , B01J2219/00423 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/00689 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/00725 , B01J2219/00756 , B01L3/06 , B01L7/00 , B01L2300/0829 , B01L2300/185 , C40B40/04 , C40B40/10 , C40B60/10 , C40B60/14 , G01N5/045 , G01N21/23 , G01N21/65 , G01N25/04 , G01N33/15 , G01N33/54366 , G01N35/028 , G01N2013/006 , G01N2021/651 , G01N2500/00 , G06F19/703 , G06F19/709 , Y10T117/10
摘要： The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymporphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system.

8. 发明公开

EP1393073A2 METHODS FOR ASSEMBLING PROTEIN MICROARRAYS 审中-公开
标题翻译：施工过程中蛋白质微阵列
公开(公告)号：EP1393073A2
公开(公告)日：2004-03-03
申请号：EP02769307.6
申请日：2002-05-03
申请人： Sigma-Genosys, Ltd.
发明人： GILMORE, James , DANIEL, Steven , HOGAN, Mike , TAM, Sunny , WIESE, Rick
IPC分类号： G01N33/53
CPC分类号： G01N33/545 , B01J19/0046 , B01J2219/00315 , B01J2219/00369 , B01J2219/00373 , B01J2219/00378 , B01J2219/00497 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/00639 , B01J2219/00659 , B01J2219/00662 , B01J2219/00675 , B01J2219/00691 , B01J2219/00704 , B01J2219/00707 , B01J2219/00711 , B01J2219/00725 , B82Y30/00 , C07K1/047 , C40B40/10 , C40B60/14 , G01N33/54353
摘要： The invention provides methods for assembling protein arrays. In one aspect, the methods comprise use of charged or polar array surfaces in the construction of the array. The methods also comprise use of viscous solutions for the deposition of the polypeptides on the array surface in the construction of the array.

9. 发明公开

EP1258285A1 Use of an apparatus for performing multiple catalytic reactions at the same time 审中-公开
标题翻译： Verwendung eines Apparats zur gleichzeitigenDurchführungmehrerer katalytischer Reaktionen
公开(公告)号：EP1258285A1
公开(公告)日：2002-11-20
申请号：EP01201812.3
申请日：2001-05-15
申请人： DSM N.V.
发明人： Schaffrath, Heike , Sielcken, Otto Erik
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00335 , B01J2219/00344 , B01J2219/00373 , B01J2219/00376 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00601 , B01J2219/00716 , B01J2219/00745 , B01J2219/00747 , B01J2219/1923 , C40B30/08 , C40B40/18 , C40B60/14
摘要： Use of an apparatus for performing a multiplicity of catalytic reactions at the same time containing

(1) a pressure-proof vessel,
(2) a cover for opening and closing the apparatus,
(3) a central gas supply,
(4) a pneumatic cylinder,
(5) needle assemblies,
(6) a stirring block,
(7) a heating block,
the heating block (7) contains holes (8) in which multiple single replaceable reaction vessels can be placed and means (9) for heating the reaction vessels, the stirring block (6) contains a number of magnets (10) as much as the number of possible replaceable reaction vessels, the magnets are welded to the block, each magnet is connected to a toothed weel (11) and the toothed weels are connected to a motor (12), the cover (2) contains a number of needle assemblies (13) as much as the number of possible replaceable reaction vessels, each needle assembly contains a needle (14) and a gas inlet port (15), a central gas supply (3) connecting the needle assemblies and providing gas in the reaction vessels via the needles and providing gas in the whole apparatus via a bypass (16) for pressure equalization, and a pneumatic cylinder (4) for opening and closing the cover.
摘要翻译：使用同时进行多重催化反应的装置，包括（1）耐压容器，（2）用于打开和关闭装置的盖，（3）中央气体供应，（4）气动气缸，（5）针组件，（6）搅拌块，（7）加热块，加热块（7）包含孔（8），其中可放置多个单个可更换反应容器和装置（9）反应容器中，搅拌块（6）含有多个可能的可更换反应容器的数量的磁体（10），磁体被焊接到块体上，每个磁体连接到齿状叶片（11），并且齿状皮带连接到马达（12）上，盖（2）包含多个可能的可更换反应容器的数量的针组件（13），每个针组件包含针（14）和气体入口（15），连接针组件并在反应中提供气体的中心气体供应（3）通过针头并通过用于压力平衡的旁路（16）在整个设备中提供气体，以及用于打开和关闭盖子的气缸（4）。

10. 发明公开

EP1184073A3 Reactor control system 无效
标题翻译： Reaktorsteuerungssystem
公开(公告)号：EP1184073A3
公开(公告)日：2002-04-17
申请号：EP01116401.9
申请日：1999-08-12
申请人： SYMYX TECHNOLOGIES
发明人： Turner, Howard , Dales, G. Cameron , Van Erden, Lynn , Van Beek, Johannes A.M. , Hajduk, Damian A. , Nielsen, Ralph B. , Mansky, Paul , Matsiev, Leonid , Wang, Pei , McFarland, Eric
IPC分类号： B01J19/00 , G05D21/00
CPC分类号： B01L3/50851 , B01F15/00207 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00056 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N21/253
摘要： A reactor control system which monitors sensors providing measured values relating to a plurality of reactor vessels of a combinatorial reactor when used in a combinatorial chemical reaction, said system comprising: (a) a receiver for receiving the measured value associated with the contents of each of the plurality of reactor vessels during the course of the combinatorial chemical reaction; and (b) a display for simultaneously displaying during the course of the combinatorial chemical reaction the received measured values, said display comprising a tabular array corresponding to the plurality of reactor vessels.
摘要翻译：一种用于并行处理多个反应混合物并用于监测反应混合物的气相组分的消耗或产生的方法，所述方法包括使反应混合物在多个容器中反应，使得容器中的压力变为消耗或产生反应混合物的气相组分，感测容器内的压力，响应于在容器内感测到的压力将反应混合物的气相组分进入或流出容器，并记录每个容器内的压力变化。

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