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1. 发明公开

EP4325219A3 CHROMATOGRAPHY COLUMN 审中-实审
公开(公告)号：EP4325219A3
公开(公告)日：2024-05-08
申请号：EP24150763.1
申请日：2017-11-10
申请人： Cytiva Sweden AB
发明人： LUNDKVISK, Mats , SALOMONSSON, Daniel
IPC分类号： B01D15/22 , G01N30/60
CPC分类号： B01D15/22 , G01N30/6052 , G01N30/6073
摘要： Disclosed is a chromatography column cylinder 200 formed from a polymer composite comprising an outer layer 220 and inner layer 210 intended to be in direct contact with the intended contents of the cylinder in a volume 202, wherein the outer layer supports the inner layer, for example when there is negative pressure in the volume 202. In one embodiment, one of said layers is molded directly onto a surface of the other layer such that there is no gap between the two layers. Disclosed also is a method for forming a chromatography column cylinder.

2. 发明公开

EP3258260A1 COMPOSITE COLUMN FOR USE IN HIGH PRESSURE LIQUID CHROMATOGRAPHY 有权
标题翻译：用于高压液相色谱的复合柱
公开(公告)号：EP3258260A1
公开(公告)日：2017-12-20
申请号：EP17176505.0
申请日：2017-06-16
申请人： LAKE REGION MANUFACTURING, INC.
发明人： BROADLEY, Mark W. , ECKERT, John K.
IPC分类号： G01N30/60 , B01D15/22
CPC分类号： B01D15/22 , B01D15/10 , B21C1/16 , B21C1/24 , F16L9/14 , G01N30/32 , G01N30/60 , G01N30/6026 , G01N30/6052 , G01N30/6073 , G01N30/6095
摘要： A multi-walled tube (100) comprising an inner tube (112), an intermediate tube (114) and an outer tube (116) that is useful as an analytical column in which chemical mixtures can be separated into their individual components is described. In order to be acceptable as an analytical column, the inner surface (112A) of the multi-walled tube must support effective separation, but not react chemically with or contaminate the solvent or the analyte (sample to be separated). Grade 316 stainless steel is typically preferred for this purpose. Moreover, the inner diameter (ID) surface of the multi-walled column is preferably very smooth (less than 10 micro inch Ra) with no interruptions in the surface such as scratches, pits, or asperities. However, since the column is designed to be attached to chromatographic equipment using standard size connection features, the size of standard fittings define the outer diameter (OD) of the column.
摘要翻译：描述了包括内管（112），中间管（114）和外管（116）的多壁管（100），其可用作分析柱，其中化学混合物可被分离成其各个组分。为了可以用作分析柱，多壁管的内表面（112A）必须支持有效的分离，但不能与溶剂或分析物（待分离的样品）化学反应或污染。通常优选316级不锈钢用于此目的。此外，多壁柱的内径（ID）表面优选非常平滑（小于10微英寸Ra），而不会在表面中断，例如划痕，凹坑或凹凸不平。但是，由于色谱柱设计为使用标准尺寸的连接功能连接到色谱设备，因此标准配件的尺寸确定了色谱柱的外径（OD）。

3. 发明公开

EP3224613A1 METHOD OF ASSESSING THE CLEANNESS OF A BED SUPPORT IN A COLUMN 有权转让
标题翻译：评估柱子清洁度的方法
公开(公告)号：EP3224613A1
公开(公告)日：2017-10-04
申请号：EP15804086.5
申请日：2015-11-25
申请人： GE Healthcare Bio-Sciences AB
发明人： ROSENGREN, Lars , ASPLUND, Magnus , PETTERSSON, Niklas
IPC分类号： G01N30/60 , B01D15/22 , B01J8/02
CPC分类号： B08B9/0321 , B01D15/22 , G01L13/00 , G01N30/603 , G01N30/6052
摘要： The invention discloses a method for individually assessing the cleanness of at least one of an upper (2) and a lower (3) bed support in a process column (1). The method comprises the steps of: a) providing a process column (1) comprising an upper (2) and a lower (3) bed support, a column chamber, a movable adaptor (5), an upper outlet (6) and a lower outlet (7); b) conveying liquid through one of the lower (3) and upper (2) bed supports, e.g. by moving the adaptor (5) downwards at a predetermined rate with one of the upper and lower outlets closed and the other open to force liquid through one of the lower and upper bed supports, and; c) measuring the differential pressure over the bed support through which liquid passes.
摘要翻译：本发明公开了一种用于单独评估处理塔（1）中的上（2）和下（3）床支撑件中的至少一个的清洁度的方法。该方法包括以下步骤：a）提供包括上床（2）和下床（3）床支撑件，柱室，可移动适配器（5），上部出口（6）和一个下部出口（7）; b）将液体输送通过下床（3）和上床（2）中的一个，例如，通过将上部和下部出口中的一个关闭并且另一个打开以迫使液体通过下部和上部床架中的一个，以预定的速率向下移动适配器（5），并且; c）测量液体通过的床架上的压差。

4. 发明授权

EP2748599B1 CHROMATOGRAPHY APPARATUS HAVING DIFFUSION BONDED COUPLER 有权
标题翻译：色谱分析仪
公开(公告)号：EP2748599B1
公开(公告)日：2016-11-23
申请号：EP12826759.8
申请日：2012-08-23
申请人： Waters Technologies Corporation
发明人： MICHIENZI, Joseph D.
IPC分类号： B01D15/22 , G01N30/60 , B01D15/18
CPC分类号： B05B5/16 , B01D15/10 , B01D15/1871 , B01D15/22 , G01N30/60 , G01N30/6004 , G01N30/6026 , G01N30/603 , G01N30/6039 , G01N30/6052 , G01N30/6095 , G01N30/7266 , Y10T29/49908
摘要： An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample. An emitter assembly includes having a deformable end portion, an inlet near the deformable end portion to receive the sample eluent from the microfluidic substrate, and an electrically conductive outlet portion to emit a spray of the sample eluent. A force-applying unit applies a force to the emitter assembly that urges the deformable end portion into contact with the microfluidic substrate. The deformable end portion is more elastic than the microfluidic substrate so that the contact between the microfluidic substrate and the deformable end portion produces a substantially fluid-tight seal between the outlet aperture of the microfluidic substrate and the inlet of the emitter assembly.
摘要翻译：用于化学分离的装置包括具有用于输出样品的洗脱液的出口孔的微流体衬底。发射器组件包括具有可变形的端部部分，在可变形端部附近的入口，以从微流体衬底接收样品洗脱液，以及导电出口部分以发射样品洗脱液的喷雾。力施加单元向发射器组件施加力，其促使可变形端部与微流体衬底接触。可变形端部比微流体衬底更具弹性，使得微流体衬底和可变形端部之间的接触在微流体衬底的出口孔与发射器组件的入口之间产生基本上流体密封的密封。

5. 发明公开

EP1926538A4 HIGH-PRESSURE TUBING 有权转让
标题翻译：高压TUBES
公开(公告)号：EP1926538A4
公开(公告)日：2015-03-11
申请号：EP06814680
申请日：2006-09-14
申请人： WATERS TECHNOLOGIES CORP
发明人： BUCHANAN JOHN , DELLAROVERE DENNIS
IPC分类号： B01D15/08 , B29C63/18 , B29C63/26 , B29C63/34 , B29D23/00 , F16L9/00 , F16L9/147
CPC分类号： G01N30/88 , B01L3/502753 , B01L3/565 , B01L2400/0415 , B01L2400/0487 , B29C63/18 , B29C63/34 , B29L2023/00 , G01N30/32 , G01N30/6052 , G01N30/7233 , G01N2030/324
摘要： A method for making conduits includes inserting an inner tube into an outer tube and melting a portion of the inner tube to form a bond with the outer tube. The inner tube includes a polymeric material and the outer tube includes a material having a greater yield strength than the polymeric material. A conduit includes one or more inner tubes at least one of which is melt-bonded to one or more outer tubes. An analytical instrument includes a separation column, a solvent reservoir and pump, a sample injector, a detector to observe an eluent of the separation column, and tubing to transport fluid between components of the instrument.

6. 发明公开

EP2745104A1 PIPE CONTAINING A METAL CASING WITH A PLASTICS MATERIAL INLAY FOR USE IN LOW AND HIGH PRESSURE APPLICATIONS, IN PARTICULAR AS AN HPLC COLUMN 有权
标题翻译：用塑料材料INLAY可使用低和高压装置的金属护套线，尤其是HPLC色谱柱
公开(公告)号：EP2745104A1
公开(公告)日：2014-06-25
申请号：EP12762041.7
申请日：2012-08-09
申请人： Möller Medical GmbH
发明人： HIRMER, Frank , FRANK, Michael
IPC分类号： G01N30/60 , F16L19/00
CPC分类号： G01N30/60 , F16L9/147 , F16L15/008 , F16L19/00 , G01N30/6004 , G01N30/6026 , G01N30/6039 , G01N30/6052 , G01N30/6073
摘要： Pipe containing a tubular metal casing (29, 29') with an inlay (31) and sealing ring (35), which is characterised in that the inlay (31) is configured as a plastics material tube and is pushed or drawn into the metal casing (29, 29') and a sealing ring (35) consisting of plastics material is connected to the inlay (31) at the end. Because of said structure, a connection to further system parts is possible, which is carry-over- free, inert on the inside, liquid-tight, optionally gas-tight, and pressure-tight. Connection element and connection to connect the pipe to feed and/or discharge lines of a capillary system. Pipes, connection elements and connections of this type are advantageously used in low and high pressure systems, such as, for example, in an HPLC column. The use of such systems is advantageous in in-vitro diagnostics and in liquid handling applications.

7. 发明公开

EP2690435A1 LIQUID CHROMATOGRAPHY COLUMN, AND METHOD FOR ANALYZING HEMOGLOBIN 有权转让
标题翻译： VERFAHREN ZUR ANALYZE VENHÄMOGLOBINSÄULEFÜRFLÜSSIGCHROMATOGRAPHIE
公开(公告)号：EP2690435A1
公开(公告)日：2014-01-29
申请号：EP12760478.3
申请日：2012-03-21
申请人： Sekisui Medical Co., Ltd.
发明人： YOTANI Takuya
IPC分类号： G01N30/60 , G01N30/88
CPC分类号： G01N30/6052 , G01N30/60 , G01N30/6004 , G01N30/88 , G01N2030/8822 , G01N2030/8831
摘要： An object of the present invention is to provide a column for liquid chromatography that can be produced at low cost and allows suppression of non-specific adsorption of components derived from living organisms. Another object of the present invention is to provide a method for analyzing hemoglobin using the column for liquid chromatography.
The present invention provides a column for liquid chromatography having a column pipe and an end fitting, wherein the column pipe and the end fitting comprise polyethylene or polymethylmethacrylate.
摘要翻译：本发明的一个目的是提供一种可以低成本制备的液相色谱柱，并允许抑制来自活生物体的组分的非特异性吸附。本发明的另一个目的是提供使用液相色谱柱分析血红蛋白的方法。本发明提供了一种具有柱管和端部配件的液相色谱柱，其中柱管和端配件包括聚乙烯或聚甲基丙烯酸甲酯。

8. 发明公开

EP1930724A4 VARIOUS SUBSTANCES SUPPORTER, VARIOUS SUBSTANCES SUPPORTER PROCESSING APPARATUS, AND METHOD OF MENTIONED PROCESSING 有权
标题翻译：支持各种物质，设备加工各种物质用于所述支持及处理方法
公开(公告)号：EP1930724A4
公开(公告)日：2012-08-15
申请号：EP06797279
申请日：2006-09-01
申请人： UNIVERSAL BIO RESEARCH CO LTD
发明人： TAJIMA HIDEJI
IPC分类号： G01N33/53 , B01J19/00 , G01N33/543
CPC分类号： C12Q1/6804 , B01J2219/00292 , B01J2219/00364 , B01J2219/00373 , B01J2219/005 , B01J2219/0052 , B01J2219/00545 , B01J2219/00576 , B01J2219/00596 , B01L3/0275 , B01L3/502 , B01L2200/0647 , B01L2300/0636 , B01L2300/0838 , B01L2300/1827 , G01N30/6047 , G01N30/6052 , G01N30/6073 , G01N33/54313 , G01N35/10 , G01N2035/00564 , G01N2035/00574 , G01N2035/1055 , Y10T436/11
摘要： An object of the present invention is to provide a various-substance holder, a various-substance holder treating apparatus, and a various-substance holder treating method which enable the mutual identification of a plurality of particulate carriers to which various substances are or can be immobilized without the need to arrange the particulate carriers at predetermined positions or in a predetermined order, eliminating the need for time and effort to arrange the various substance at predetermined positions or in a predetermined order to allow treatments to be quickly and easily achieved. The various-substance holder according to the present invention has a plurality of particulate carriers or plural sets of particulate carriers to which plural types of chemical substances are or can be immobilized and a carrier holding portion holding the plurality of particulate carriers or the plural sets of particulate carriers in a substantially stationary state such that the plurality of particulate carriers or the plural sets of particulate carriers can be externally measured. The various-substance holder is configured so that each of the plurality of particulate carriers or at least one of the particulate carriers belonging to the plural sets of the particulate carriers are labeled according to types of the chemical substances or for each of the particulate carriers or each set of the particulate carriers so as to be mutually identifiable before the particulate carriers are introduced and held in the carrier holding portion.

9. 发明公开

EP2313192A4 METHOD AND APPARATUS FOR HIGH RESOLUTION FLASH CHROMATOGRAPHY 审中-公开
标题翻译：方法和设备用于高分辨率快速色谱
公开(公告)号：EP2313192A4
公开(公告)日：2012-08-08
申请号：EP09806960
申请日：2009-08-12
申请人： TELEDYNE INSTRUMENTS INC
发明人： DAVISON DALE A , PIPES RUTH , SILVER JACK E
IPC分类号： B01J20/32
CPC分类号： B01D15/325 , B01D15/14 , B01D15/163 , B01D15/20 , B01D15/22 , B01D15/3861 , B01J20/28004 , B01J20/28019 , B01J20/286 , B01J20/287 , G01N30/603 , G01N30/6052 , G01N30/6091 , G01N30/6004

10. 发明授权

EP2035823B1 SEPARATION DEVICE AND CHEMICAL REACTION APPARATUS MADE FROM POLYCRYSTALLINE DIAMOND, APPARATUSES INCLUDING SAME SUCH AS SEPARATION APPARATUSES, AND METHODS OF USE 有权
标题翻译：分离装置和化学反应装置聚晶金刚石设备，如分离装置和使用方法
公开(公告)号：EP2035823B1
公开(公告)日：2012-02-29
申请号：EP07809264.0
申请日：2007-05-31
申请人： U.S. Synthetic Corporation
发明人： VAIL, Michael A.
IPC分类号： G01N30/60 , B01J20/02
CPC分类号： G01N30/6052 , B01J20/282 , B01J2220/82 , G01N2030/525 , G01N2030/528
摘要： A separation device includes a body (50) of sintered diamond particles. The body (50) includes a proximal inlet end (54), a distal outlet end (52), and a plurality of interconnected pores (62) extending therebetween.

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