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1. 发明授权

EP3542839B1 PERSONALIZED BICARBONATE MANAGEMENT SYSTEMS AND METHODS FOR SORBENT-BASED HEMODIALYSIS 有权转让
公开(公告)号：EP3542839B1
公开(公告)日：2024-10-23
申请号：EP19173852.5
申请日：2018-02-07
IPC分类号： A61M1/16
CPC分类号： A61M1/1696 , A61M2205/337920130101 , A61M1/1605 , A61M1/1613 , A61M2205/333420130101

2. 发明授权

EP4129358B1 CLOSED CIRCULATION SYSTEM TEST APPARATUS FOR BLOOD PURIFICATION DEVICE USING WHOLE BLOOD 有权
公开(公告)号：EP4129358B1
公开(公告)日：2024-10-16
申请号：EP21780591.0
申请日：2021-03-31
IPC分类号： A61M1/18 , A61M1/34 , A61M1/16
CPC分类号： B01D65/10 , B01D61/30 , A61M1/3437 , A61M1/3465 , A61M1/3403 , A61M1/1613 , A61M1/1615 , A61M1/341 , A61M2205/7020130101 , A61M1/3623 , A61M2205/1520130101 , A61M2205/70520130101 , A61M2205/70720130101 , A61M2209/0220130101 , B01D63/02

4. 发明授权

EP2701765B1 FLUID VOLUME MONITORING FOR PATIENTS WITH RENAL DISEASE 有权转让
公开(公告)号：EP2701765B1
公开(公告)日：2018-09-05
申请号：EP12850737.3
申请日：2012-04-19
申请人： Medtronic, Inc.
发明人： GERBER, Martin, T. , BURNES, John, E. , LYU, Suping , VENKATESH, Manda, R. , PUDIL, Bryant, J.
IPC分类号： A61B5/145 , A61M1/16 , A61B5/00 , A61B5/026 , A61B5/053 , A61M1/36
CPC分类号： A61M1/1601 , A61B5/0031 , A61B5/026 , A61B5/0295 , A61B5/053 , A61B5/0537 , A61B5/145 , A61B5/14503 , A61B5/14535 , A61B5/14539 , A61B5/14546 , A61B5/4836 , A61B5/4848 , A61B5/4875 , A61B5/6866 , A61B5/7282 , A61B2560/0223 , A61M1/00 , A61M1/14 , A61M1/16 , A61M1/1603 , A61M1/1605 , A61M1/1607 , A61M1/1613 , A61M1/28 , A61M1/34 , A61M1/3403 , A61M1/342 , A61M1/3607 , A61M1/3609 , A61M1/361 , A61M1/3612 , A61M1/3672 , A61M2202/0498 , A61M2205/04 , A61M2205/18 , A61M2205/33 , A61M2205/3303 , A61M2205/3306 , A61M2205/3313 , A61M2205/3331 , A61M2205/3334 , A61M2205/3375 , A61M2205/3523 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/60 , A61M2205/70 , A61M2230/00 , A61M2230/005 , A61M2230/06 , A61M2230/20 , A61M2230/207 , A61M2230/208 , A61M2230/65 , B01D61/00 , B01D61/32 , B01D65/02 , B01D2321/12 , B01D2321/40 , G06F19/00
摘要： Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patent parameters. By comparing the patient's current parameters to past parameters in response to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.

5. 发明公开

EP3290069A3 ADAPTIVE PERITONEAL DIALYSIS INTRA-SESSION ADJUSTMENTS FOR OVERALL SESSION OPTIMIZATION 审中-公开
公开(公告)号：EP3290069A3
公开(公告)日：2018-04-25
申请号：EP17185636.2
申请日：2017-08-09
申请人： Medtronic, Inc.
发明人： GERBER, Martin T. , HOBOT, Christopher M.
IPC分类号： A61M1/28 , A61M1/16
CPC分类号： A61M1/282 , A61M1/1613 , A61M1/1696 , A61M1/28 , A61M1/287 , A61M2205/3303 , A61M2205/3306 , A61M2205/3317 , A61M2205/3344 , A61M2205/3368 , A61M2205/3386 , A61M2205/50 , A61M2205/52 , A61M2230/005 , A61M2230/30 , A61M2230/50 , A61M2230/62
摘要： The invention relates to systems and methods for adjusting one or more dialysis parameters for delivering a peritoneal dialysis cycle to a patient based on patient or system parameters. The systems and methods include various sensors, flow paths, and processors to adjust the dialysis parameters used to deliver peritoneal dialysis therapy, for a specific peritoneal dialysis cycle. For example, a first peritoneal dialysis cycle can provide data on patient or system parameters that can be used to adjust the dialysis parameters used to deliver a subsequent peritoneal dialysis cycle. One or more peritoneal dialysis cycles are contained in a particular peritoneal dialysis therapy session. Patient parameters can include patient blood pressure; volume of fluid removed; patient goal; blood solute level; effluent solute level; effluent temperature; effluent color or clarity; patient posture; tidal volume remaining in patient; and intraperitoneal pressure.

6. 发明公开

EP3290069A2 ADAPTIVE PERITONEAL DIALYSIS INTRA-SESSION ADJUSTMENTS FOR OVERALL SESSION OPTIMIZATION 审中-公开
标题翻译：适应性腹膜透析室内调整总体会议优化
公开(公告)号：EP3290069A2
公开(公告)日：2018-03-07
申请号：EP17185636.2
申请日：2017-08-09
申请人： Medtronic, Inc.
发明人： GERBER, Martin T. , HOBOT, Christopher M.
IPC分类号： A61M1/28 , A61M1/16
CPC分类号： A61M1/282 , A61M1/1613 , A61M1/1696 , A61M1/28 , A61M1/287 , A61M2205/3303 , A61M2205/3306 , A61M2205/3317 , A61M2205/3344 , A61M2205/3368 , A61M2205/3386 , A61M2205/50 , A61M2205/52 , A61M2230/005 , A61M2230/30 , A61M2230/50 , A61M2230/62
摘要： The invention relates to systems and methods for adjusting one or more dialysis parameters for delivering a peritoneal dialysis cycle to a patient based on patient or system parameters. The systems and methods include various sensors, flow paths, and processors to adjust the dialysis parameters used to deliver peritoneal dialysis therapy, for a specific peritoneal dialysis cycle. For example, a first peritoneal dialysis cycle can provide data on patient or system parameters that can be used to adjust the dialysis parameters used to deliver a subsequent peritoneal dialysis cycle. One or more peritoneal dialysis cycles are contained in a particular peritoneal dialysis therapy session. Patient parameters can include patient blood pressure; volume of fluid removed; patient goal; blood solute level; effluent solute level; effluent temperature; effluent color or clarity; patient posture; tidal volume remaining in patient; and intraperitoneal pressure.
摘要翻译：本发明涉及用于基于患者或系统参数调整用于向患者递送腹膜透析循环的一个或多个透析参数的系统和方法。该系统和方法包括各种传感器，流动路径和处理器，以调节用于递送腹膜透析治疗的透析参数，用于特定的腹膜透析循环。例如，第一腹膜透析循环可提供关于患者或系统参数的数据，其可用于调整用于递送随后的腹膜透析循环的透析参数。一个或多个腹膜透析循环包含在特定的腹膜透析疗法环节中。患者参数可以包括患者血压; 流体量被移除; 患者目标; 血液溶质水平; 出水溶质水平; 出水温度; 出水颜色或澄清度; 病人姿势; 患者中剩余的潮气量; 和腹腔压力。

7. 发明公开

EP3148436A4 SYSTEM FOR ANALYZING VASCULAR REFILL DURING SHORT-PULSE ULTRAFILTRATION IN HEMODIALYSIS 有权
公开(公告)号：EP3148436A4
公开(公告)日：2018-02-14
申请号：EP15799738
申请日：2015-05-29
申请人： FRESENIUS MEDICAL CARE HOLDINGS INC
发明人： DE LOS REYES V AURELIO A , FUERTINGER DORIS H , KAPPEL FRANZ , MEYRING-WOSTEN ANNA , THIJSSEN STEPHAN , KOTANKO PETER
IPC分类号： A61B5/145 , A61B5/00 , G16H20/17
CPC分类号： A61M1/1613 , A61B5/02028 , A61B5/026 , A61B5/14535 , A61B5/4836 , A61B5/4875 , A61M1/3609 , A61M2205/18 , A61M2205/3306 , A61M2205/3334 , A61M2205/3344 , A61M2205/3379 , A61M2205/3553 , A61M2205/3584 , A61M2205/50 , A61M2205/502 , A61M2230/005 , A61M2230/20 , A61M2230/207 , A61M2230/30 , G06F17/13 , G06F19/3437 , G16H20/17 , G16H50/50
摘要： A method includes: receiving measurements of a blood-related parameter corresponding to a patient undergoing hemodialysis; estimating a value of one or more hemodialysis treatment-related parameters by applying a vascular refill model based on the received measurements of the blood-related parameter, wherein the one or more hemodialysis treatment-related parameters are indicative of an effect of vascular refill on the patient caused by the hemodialysis; determining, based on the one or more estimated values of the one or more hemodialysis treatment-related parameters, a hemodialysis treatment-related operation; and facilitating performance of the treatment-related operation. The vascular refill model is a two-compartment model based on a first compartment corresponding to blood plasma in the patient's body, a second compartment based on interstitial fluid in the patient's body, and a semi-permeable membrane separating the first compartment and the second compartment.

8. 发明公开

EP3263150A1 BLOOD TREATMENT SYSTEMS AND METHODS 审中-实审
标题翻译：血液处理系统和方法
公开(公告)号：EP3263150A1
公开(公告)日：2018-01-03
申请号：EP17185281.7
申请日：2012-05-24
申请人： DEKA Products Limited Partnership
发明人： Wilt, Michael J. , van der Merwe, Dirk A. , Ballantyne, Todd A. , Grant, Kevin L. , Rosse, Jonathan P. , Flynn, Catharine N. , Yee, Brian K.
IPC分类号： A61M1/10 , A61M1/16 , A61M1/34 , A61M1/36 , G06F1/16 , A61K33/00 , A61M1/14 , A61M1/26 , A61M5/172 , G06F19/00 , A61M1/30
CPC分类号： A61M1/1601 , A61K33/00 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1087 , A61M1/1096 , A61M1/14 , A61M1/16 , A61M1/1605 , A61M1/1613 , A61M1/1619 , A61M1/1654 , A61M1/1656 , A61M1/1658 , A61M1/166 , A61M1/1664 , A61M1/1666 , A61M1/1668 , A61M1/1692 , A61M1/267 , A61M1/301 , A61M1/34 , A61M1/341 , A61M1/3413 , A61M1/3609 , A61M1/3621 , A61M1/3627 , A61M1/3638 , A61M1/3672 , A61M5/172 , A61M2205/12 , A61M2205/15 , A61M2205/18 , A61M2205/3306 , A61M2205/3313 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/3379 , A61M2205/3569 , A61M2205/3584 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2230/65 , G06F19/00 , G06F19/3481 , Y02A50/395 , Y02A90/26
摘要： There is disclosed herein dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. In one set of embodiments, a hemodialysis system may include a blood flow path and a dialysate flow path, where the dialysate flow path includes one or more of a balancing circuit, a mixing circuit, and/or a directing circuit. Preparation of dialysate by the preparation circuit, in some instances, may be decoupled from patient dialysis. In some cases, the circuits are defined, at least partially, within one or more cassettes, optionally interconnected with conduits, pumps, or the like. In one embodiment, the fluid circuit and/or the various fluid flow paths may be at least partially isolated, spatially and/or thermally, from electrical components of the hemodialysis system. In some cases, a gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer that, when activated, is able to urge dialysate to pass through the dialyzer and urge blood in the blood flow path back to the patient. Such a system may be useful, for example, in certain emergency situations (e.g., a power failure) where it is desirable to return as much blood to the patient as possible. The hemodialysis system may also include, in another aspect of the invention, one or more fluid handling devices, such as pumps, valves, mixers, or the like, which can be actuated using a control fluid, such as air. In some cases, the control fluid may be delivered to the fluid handling devices using an external pump or other device, which may be detachable in certain instances. In one embodiment, one or more of the fluid handling devices may be generally rigid (e.g., having a spheroid shape), optionally with a diaphragm contained within the device, dividing it into first and second compartments.
摘要翻译：本文公开了透析系统，其包括使血液透析更有效，更容易和/或更实惠的各种系统和方法。本发明的一个方面通常涉及用于流体流动的新型流体回路。在一组实施例中，血液透析系统可包括血液流动路径和透析液流动路径，其中透析液流动路径包括平衡电路，混合电路和/或引导电路中的一个或多个。在一些情况下，通过制备回路制备透析液可以与患者透析分离。在一些情况下，电路至少部分地限定在一个或多个盒内，可选地与导管，泵等相互连接。在一个实施例中，流体回路和/或各种流体流动路径可以与血液透析系统的电子部件至少部分地，空间地和/或热地隔离。在一些情况下，可以提供与透析液流动路径和/或透析器流体连通的气体供应，所述气体供应在被激活时能够促使透析液穿过透析器并且促使血液流动路径中的血液回到患者。例如，在需要尽可能多地将血液返回给患者的某些紧急情况下（例如电力故障），这样的系统可能是有用的。在本发明的另一方面中，血液透析系统还可以包括一个或多个流体处理装置，例如泵，阀，混合器等，其可以使用控制流体例如空气来启动。在一些情况下，可以使用外部泵或其他装置将控制流体输送到流体处理装置，该外部泵或其他装置在某些情况下可以是可拆卸的。在一个实施例中，一个或多个流体处理装置可以是大致刚性的（例如，具有球体形状），可选地具有容纳在装置内的隔膜，将其分隔成第一隔室和第二隔室。

9. 发明公开

EP3229159A1 THERAPY PREDICTION AND OPTIMIZATION OF SERUM POTASSIUM FOR RENAL FAILURE BLOOD THERAPY, ESPECIALLY HOME HEMODIALYSIS 失效
标题翻译：血钾对肾功能衰竭血液治疗尤其是家庭血液透析治疗的预测和优化
公开(公告)号：EP3229159A1
公开(公告)日：2017-10-11
申请号：EP17173110.2
申请日：2014-08-08
申请人： Baxter International Inc , Baxter Healthcare S.A.
发明人： AKONUR, Alp , LEYPOLDT, John Kenneth , LO, Ying-Cheng , AGAR, Baris Ugar
IPC分类号： G06F19/00
CPC分类号： G06F19/3481 , A61M1/1613 , A61M1/3403 , A61M1/361 , A61M1/3612 , G06F19/00
摘要： A method of predicting serum potassium concentrations in a patient during hemodialysis includes measuring serum potassium concentrations of the patient over a hemodialysis treatment session time and an ultrafiltration rate calculated by a difference between pre- and post-dialytic body weight of the patient during an initial hemodialysis treatment session divided by a total treatment time of the treatment session and estimating a potassium mobilization clearance and a pre-dialysis distribution volume of potassium for the patient. Serum potassium concentrations of the patient can then be predicted at any time during any hemodialysis treatment session with the estimated potassium mobilization clearance and pre-dialysis distribution volume of potassium of the patient.
摘要翻译：在血液透析期间预测患者血清钾浓度的方法包括在血液透析治疗期间测量患者的血清钾浓度和通过在初始血液透析期间患者透析前和透析后体重之间的差异计算超滤率治疗时间除以治疗期的总治疗时间并估计患者的钾移动清除率和钾透析前分布量。然后可以在任何血液透析治疗期间的任何时间预测患者的血清钾浓度，其中估计的钾流动清除率和患者的钾透析前分布容积。

10. 发明授权

EP2714123B1 BLOOD TREATMENT SYSTEMS AND METHODS 有权
标题翻译：血液处理系统和方法
公开(公告)号：EP2714123B1
公开(公告)日：2017-08-09
申请号：EP12743802.6
申请日：2012-05-24
申请人： DEKA Products Limited Partnership
发明人： WILT, Michael, J. , VAN DER MERWE, Dirk, A. , BALLANTYNE, Todd, A. , GRANT, Kevin, L. , ROSSE, Jonathan, P. , FLYNN, Catharine, N. , YEE, Brian, K.
IPC分类号： A61K33/00 , A61M1/26 , A61M1/30 , A61M1/10 , A61M1/14 , A61M1/16 , A61M1/34 , A61M1/36 , A61M5/172 , G06F19/00
CPC分类号： A61M1/1601 , A61K33/00 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1087 , A61M1/1096 , A61M1/14 , A61M1/16 , A61M1/1605 , A61M1/1613 , A61M1/1619 , A61M1/1654 , A61M1/1656 , A61M1/1658 , A61M1/166 , A61M1/1664 , A61M1/1666 , A61M1/1668 , A61M1/1692 , A61M1/267 , A61M1/301 , A61M1/34 , A61M1/341 , A61M1/3413 , A61M1/3609 , A61M1/3621 , A61M1/3627 , A61M1/3638 , A61M1/3672 , A61M5/172 , A61M2205/12 , A61M2205/15 , A61M2205/18 , A61M2205/3306 , A61M2205/3313 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/3379 , A61M2205/3569 , A61M2205/3584 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2230/65 , G06F19/00 , G06F19/3481
摘要： There is disclosed herein dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. In one set of embodiments, a hemodialysis system may include a blood flow path and a dialysate flow path, where the dialysate flow path includes one or more of a balancing circuit, a mixing circuit, and/or a directing circuit. Preparation of dialysate by the preparation circuit, in some instances, may be decoupled from patient dialysis. In some cases, the circuits are defined, at least partially, within one or more cassettes, optionally interconnected with conduits, pumps, or the like. In one embodiment, the fluid circuit and/or the various fluid flow paths may be at least partially isolated, spatially and/or thermally, from electrical components of the hemodialysis system. In some cases, a gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer that, when activated, is able to urge dialysate to pass through the dialyzer and urge blood in the blood flow path back to the patient. Such a system may be useful, for example, in certain emergency situations (e.g., a power failure) where it is desirable to return as much blood to the patient as possible. The hemodialysis system may also include, in another aspect of the invention, one or more fluid handling devices, such as pumps, valves, mixers, or the like, which can be actuated using a control fluid, such as air. In some cases, the control fluid may be delivered to the fluid handling devices using an external pump or other device, which may be detachable in certain instances. In one embodiment, one or more of the fluid handling devices may be generally rigid (e.g., having a spheroid shape), optionally with a diaphragm contained within the device, dividing it into first and second compartments.
摘要翻译：透露系统包括新的流体流动回路。系统可以包括血液和透析液流动路径，其中透析液流动路径包括平衡，混合和/或引导回路。透析液的制备可能与患者透析分离。电路可以被限定在一个或多个盒内。流体回路流体流动路径可以与电气部件隔离。对于某些紧急情况，可以包括与透析液流动路径和/或透析器流体连通的气体供应，该气体供应能够促使透析液通过透析器并将血液推回患者。可以包括流体处理装置，例如可以使用控制流体来启动的泵，阀和混合器。控制流体可以通过可拆卸和/或通常刚性的外部泵或其他装置输送，可选地具有将装置分成第一和第二隔室的隔膜。

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