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1. 发明公开

EP4233987A2 BLOOD TREATMENT SYSTEMS 审中-实审
公开(公告)号：EP4233987A2
公开(公告)日：2023-08-30
申请号：EP23181383.3
申请日：2014-03-14
申请人： DEKA Products Limited Partnership
发明人： Wilt, Michael J. , van der Merwe, Dirk A. , Dale, James D. , Tracey, Brian D. , Grant, Kevin L. , Demers, Jason A. , Flynn, Catharine N.
IPC分类号： A61M60/554
摘要： A system for monitoring fluid flow in an extracorporeal blood circuit comprising: a pumping chamber of a blood pump separated from a control chamber of the blood pump by a flexible diaphragm, the control chamber configured to transmit positive or negative pressure to operate the diaphragm; a pressure sensor configured to measure pressure in the control chamber of the blood pump; a controller configured to receive information from the pressure sensor, and configured to control the delivery of pressure to the control chamber of the blood pump; wherein the controller is configured to cause an application of a time-varying pressure waveform on the blood pump diaphragm during a fill-stroke of the blood pump, and to monitor a pressure variation in the control chamber measured by the pressure sensor, and wherein the controller is configured to determine a blood flow metric based on a variation of a peak-to-peak magnitude and to alert a user based on the blood flow metric.

2. 发明公开

EP3263150A1 BLOOD TREATMENT SYSTEMS AND METHODS 审中-实审
标题翻译：血液处理系统和方法
公开(公告)号：EP3263150A1
公开(公告)日：2018-01-03
申请号：EP17185281.7
申请日：2012-05-24
申请人： DEKA Products Limited Partnership
发明人： Wilt, Michael J. , van der Merwe, Dirk A. , Ballantyne, Todd A. , Grant, Kevin L. , Rosse, Jonathan P. , Flynn, Catharine N. , Yee, Brian K.
IPC分类号： A61M1/10 , A61M1/16 , A61M1/34 , A61M1/36 , G06F1/16 , A61K33/00 , A61M1/14 , A61M1/26 , A61M5/172 , G06F19/00 , A61M1/30
CPC分类号： A61M1/1601 , A61K33/00 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1087 , A61M1/1096 , A61M1/14 , A61M1/16 , A61M1/1605 , A61M1/1613 , A61M1/1619 , A61M1/1654 , A61M1/1656 , A61M1/1658 , A61M1/166 , A61M1/1664 , A61M1/1666 , A61M1/1668 , A61M1/1692 , A61M1/267 , A61M1/301 , A61M1/34 , A61M1/341 , A61M1/3413 , A61M1/3609 , A61M1/3621 , A61M1/3627 , A61M1/3638 , A61M1/3672 , A61M5/172 , A61M2205/12 , A61M2205/15 , A61M2205/18 , A61M2205/3306 , A61M2205/3313 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/3379 , A61M2205/3569 , A61M2205/3584 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2230/65 , G06F19/00 , G06F19/3481 , Y02A50/395 , Y02A90/26
摘要： There is disclosed herein dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. In one set of embodiments, a hemodialysis system may include a blood flow path and a dialysate flow path, where the dialysate flow path includes one or more of a balancing circuit, a mixing circuit, and/or a directing circuit. Preparation of dialysate by the preparation circuit, in some instances, may be decoupled from patient dialysis. In some cases, the circuits are defined, at least partially, within one or more cassettes, optionally interconnected with conduits, pumps, or the like. In one embodiment, the fluid circuit and/or the various fluid flow paths may be at least partially isolated, spatially and/or thermally, from electrical components of the hemodialysis system. In some cases, a gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer that, when activated, is able to urge dialysate to pass through the dialyzer and urge blood in the blood flow path back to the patient. Such a system may be useful, for example, in certain emergency situations (e.g., a power failure) where it is desirable to return as much blood to the patient as possible. The hemodialysis system may also include, in another aspect of the invention, one or more fluid handling devices, such as pumps, valves, mixers, or the like, which can be actuated using a control fluid, such as air. In some cases, the control fluid may be delivered to the fluid handling devices using an external pump or other device, which may be detachable in certain instances. In one embodiment, one or more of the fluid handling devices may be generally rigid (e.g., having a spheroid shape), optionally with a diaphragm contained within the device, dividing it into first and second compartments.
摘要翻译：本文公开了透析系统，其包括使血液透析更有效，更容易和/或更实惠的各种系统和方法。本发明的一个方面通常涉及用于流体流动的新型流体回路。在一组实施例中，血液透析系统可包括血液流动路径和透析液流动路径，其中透析液流动路径包括平衡电路，混合电路和/或引导电路中的一个或多个。在一些情况下，通过制备回路制备透析液可以与患者透析分离。在一些情况下，电路至少部分地限定在一个或多个盒内，可选地与导管，泵等相互连接。在一个实施例中，流体回路和/或各种流体流动路径可以与血液透析系统的电子部件至少部分地，空间地和/或热地隔离。在一些情况下，可以提供与透析液流动路径和/或透析器流体连通的气体供应，所述气体供应在被激活时能够促使透析液穿过透析器并且促使血液流动路径中的血液回到患者。例如，在需要尽可能多地将血液返回给患者的某些紧急情况下（例如电力故障），这样的系统可能是有用的。在本发明的另一方面中，血液透析系统还可以包括一个或多个流体处理装置，例如泵，阀，混合器等，其可以使用控制流体例如空气来启动。在一些情况下，可以使用外部泵或其他装置将控制流体输送到流体处理装置，该外部泵或其他装置在某些情况下可以是可拆卸的。在一个实施例中，一个或多个流体处理装置可以是大致刚性的（例如，具有球体形状），可选地具有容纳在装置内的隔膜，将其分隔成第一隔室和第二隔室。

3. 发明公开

EP4233987A3 BLOOD TREATMENT SYSTEMS 审中-实审
公开(公告)号：EP4233987A3
公开(公告)日：2023-09-20
申请号：EP23181383.3
申请日：2014-03-14
申请人： DEKA Products Limited Partnership
发明人： Wilt, Michael J. , van der Merwe, Dirk A. , Dale, James D. , Tracey, Brian D. , Grant, Kevin L. , Demers, Jason A. , Flynn, Catharine N.
IPC分类号： A61M60/554
摘要： A system for monitoring fluid flow in an extracorporeal blood circuit comprising: a pumping chamber of a blood pump separated from a control chamber of the blood pump by a flexible diaphragm, the control chamber configured to transmit positive or negative pressure to operate the diaphragm; a pressure sensor configured to measure pressure in the control chamber of the blood pump; a controller configured to receive information from the pressure sensor, and configured to control the delivery of pressure to the control chamber of the blood pump; wherein the controller is configured to cause an application of a time-varying pressure waveform on the blood pump diaphragm during a fill-stroke of the blood pump, and to monitor a pressure variation in the control chamber measured by the pressure sensor, and wherein the controller is configured to determine a blood flow metric based on a variation of a peak-to-peak magnitude and to alert a user based on the blood flow metric.

4. 发明公开

EP3524291A1 SYSTEMS AND METHODS FOR DETECTING VASCULAR ACCESS DISCONNECTION 有权
公开(公告)号：EP3524291A1
公开(公告)日：2019-08-14
申请号：EP18214574.8
申请日：2015-05-27
申请人： DEKA Products Limited Partnership
发明人： van der Merwe, Dirk A. , Norris, Michael G. , Baker, Michael A. , Ballantyne, Todd A. , Wilt, Michael J.
IPC分类号： A61M1/36
摘要： A system for detecting whether a vascular access has been interrupted in an arrangement in which two catheters or needles are present in a blood vessel, fistula or graft. A fluid line leading to a pump is connected via a first connector to a first in-dwelling catheter, and a fluid line leading from a pump is connected via a second connector to a second indwelling catheter. Each connector is equipped with an electrode in contact with the lumen of the connector, the electrodes electrically connected to an electronic circuit that measures the impedance or conductivity of fluid between the first connector and second connectors via a fluid path through the blood vessel, fistula or graft. An electronic controller receives the impedance or conductivity data and processes the data to determine whether a vascular access disconnection has occurred. The processing may involve filtering the signal received by the controller, and/or setting provisional flags for a disconnection event that maybe cleared if the signal changes before the expiration of a counter.

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