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1. 发明公开

EP3164115A4 STERILIZATION OF CIPROFLOXACIN COMPOSITION 无效转让
标题翻译：杀菌剂EINER CIPROFLOXACINZUSAMMENSETZUNG
公开(公告)号：EP3164115A4
公开(公告)日：2017-05-17
申请号：EP15814972
申请日：2015-07-01
申请人： OTONOMY INC
发明人： COLEMAN SCOTT H , LIAW WEI-CHENG , WROBLEWSKI JERRY , SAVEL ROBERT
IPC分类号： A61K9/16 , A61K31/497 , C07D215/56
CPC分类号： A61L2/0023 , A61K9/0046 , A61K9/06 , A61K31/496 , A61K47/10 , A61L2/0017 , A61L2/0029
摘要： Disclosed herein are methods of making sterilized ciprofloxacin compositions. In some embodiments, the method includes the steps of: (a) forming an aqueous suspension comprising ciprofloxacin particles; (b) heating the aqueous suspension comprising ciprofloxacin particles at a temperature range of from about 100° C. to about 120° C.; and (c) allowing the aqueous suspension comprising ciprofloxacin particles to cool down. Also described herein are otic formulations containing ciprofloxacin formed by the disclosed methods, and therapeutic use of such otic formulation for providing sustained release of ciprofloxacin into the ear for treating various otic disorders and conditions.
摘要翻译：本文公开了制备灭菌的环丙沙星组合物的方法。在一些实施方案中，该方法包括以下步骤：（a）形成包含环丙沙星颗粒的含水悬浮液; （b）在约100℃至约120℃的温度范围内加热包含环丙沙星颗粒的含水悬浮液; 和（c）使包含环丙沙星颗粒的含水悬浮液冷却。本文还描述了包含通过公开的方法形成的环丙沙星的耳用制剂，以及这种耳用制剂用于向耳中持续释放环丙沙星以治疗各种耳部疾病和病症的治疗用途。

2. 发明公开

EP3141611A2 VALIDATION OF CONTINUOUS VIRAL CLEARANCE 审中-公开
标题翻译： BEWERTUNG DER KONTINUIERLICHEN VIRUSENTFERNUNG
公开(公告)号：EP3141611A2
公开(公告)日：2017-03-15
申请号：EP16194959.9
申请日：2016-10-21
申请人： Bayer Healthcare LLC
发明人： Maiser, Benjamin , Schwan, Peter , Holtman, Laura , Lobedann, Martin
IPC分类号： C12Q1/22 , G01N33/569
CPC分类号： C12Q1/22 , A61L2/0029 , A61L2/0082 , C07K1/14 , C07K1/16 , C07K1/36 , C12N7/00 , C12N2740/13051 , C12N2750/14051 , G01N2333/005
摘要： Disclosed herein is a method for validation of continuous viral clearance comprising the steps of providing a probe to be validated, spiking the probe in a valid manner, performing viral clearance, sampling the spiked probe and analyzing the sample of the spiked probe of step d)..
摘要翻译：本文公开了一种用于验证连续病毒清除的方法，包括以下步骤：提供待验证的探针，以有效方式掺入探针，进行病毒清除，对加标探针进行取样并分析步骤d）的加标探针的样品， ..

3. 发明公开

EP2542305A2 ENHANCED ANTI-MICROBIAL PDT 有权转让
标题翻译：增强抗微生物PDT
公开(公告)号：EP2542305A2
公开(公告)日：2013-01-09
申请号：EP11735020.7
申请日：2011-01-13
申请人： CeramOptec GmbH
发明人： ALBRECHT, Volker , WIELAND, Gerhard , GITTER, Burkhard , NEUBERGER, Wolfgang
IPC分类号： A61N5/00 , A61N5/06 , A61K31/407 , A61P31/04
CPC分类号： A61N5/062 , A61L2/0029 , A61L2/0052 , A61L2202/21 , A61M1/3681 , A61M1/3686 , A61N5/0624 , A61N2005/063 , A61N2005/0652
摘要： Present invention provides enhanced methods and improved devices to eliminate, reduce, destroy and/or inhibit undesired body fluid species, such as pathogen microbes and deteriorated or malignant cells in complex environments like blood, serum and other body fluids. In preferred embodiments, present invention provides an antimicrobial PDT treatment that effectively inactivates, reduces and/or destroys both Gram (−) and Gram (+) bacteria in complex body fluids. Methods to enhance antimicrobial PDT activity includes the steps of administering a photosensitizer to bacteria-contaminated fluid, after a dwell time guiding bacteria-contaminated fluid with photosensitizer through a channel, emitting radiation preferably in an intermittent manner, and restoring treated body fluids to corresponding body regions. Electromagnetic radiation is preferably delivered intermittently with pulse width based on treatment parameters. Preferred device embodiments comprise guiding channels and at least one electromagnetic radiation source, arranged separately or in sequence. Preferably, laser device or LED-panels are used to deliver electromagnetic radiation to activate the photosensitizer. When used with preferred photosensitizer composition based on Safranin O, preferred laser radiation wavelength is in the range of 500-580 nm. Additionally, present invention diminishes adverse host's inflammatory responses by neutralizing the biological activity of pathogenic microorganism fragments and reducing and/or removing pathogenic microorganism fragments responsible for it.
摘要翻译：本发明提供了增强的方法和改进的装置，以消除，减少，破坏和/或抑制诸如血液，血清和其他体液等复杂环境中的病原体微生物和恶化或恶性细胞等不希望的体液物质。在优选实施方案中，本发明提供了一种抗微生物PDT治疗，其有效地灭活，减少和/或破坏复杂体液中的革兰氏阴性细菌和革兰氏阳性细菌。增强抗微生物PDT活性的方法包括以下步骤：在用光敏剂引导细菌污染的流体通过通道，优选以间歇方式发射辐射并将经处理的体液恢复至相应的身体的驻留时间之后，将光敏剂施用于细菌污染的流体区域。电磁辐射优选基于治疗参数以脉冲宽度间歇地传递。优选的设备实施例包括分开或依次布置的引导通道和至少一个电磁辐射源。优选地，使用激光装置或LED面板来传递电磁辐射以激活光敏剂。当与基于番红O的优选光敏剂组合物一起使用时，优选的激光辐射波长在500-580nm的范围内。此外，本发明通过中和致病微生物片段的生物学活性并减少和/或去除对其有害的致病微生物片段来减少不利的宿主炎症反应。

4. 发明公开

EP3386456A1 DISSOLVABLE NASAL SINUS SPONGE 有权
公开(公告)号：EP3386456A1
公开(公告)日：2018-10-17
申请号：EP16813266.0
申请日：2016-11-30
申请人： Medtronic Xomed, Inc.
发明人： SHERMAN, Ethan, G. , CHEN, Wei , GUENTHER, Denise, E.
IPC分类号： A61F13/20 , A61K9/00 , A61L15/22
CPC分类号： A61L24/0042 , A61F13/2005 , A61K9/0043 , A61L2/0029 , A61L15/225 , A61L24/0015 , A61L24/0036 , A61L24/043 , A61L24/08 , A61L31/042 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2202/24 , A61L2300/232 , A61L2300/404 , A61L2400/04 , B65B55/16 , B65B63/08 , C08L5/08
摘要： An implantable article comprising a dissolvable sponge derived from the mixture of chitosan, a first polysaccharide and a second polysaccharides. The polysaccharides have different number average molecular weight characteristics to enable the control of the mechanical features of the sponge.

5. 发明公开

EP3274001A1 STERILISATION OF S-NITROSOTHIOLS 审中-实审转让
标题翻译： S-硝基石油醚的灭菌
公开(公告)号：EP3274001A1
公开(公告)日：2018-01-31
申请号：EP16712414.8
申请日：2016-03-21
申请人： Salupont Consulting Ltd.
发明人： REES, Daryl , ORSI, Antonia
IPC分类号： A61L2/00 , A61K41/00 , A61L2/08 , A61K31/095 , A61K31/195 , A61K31/04
CPC分类号： A61K41/0009 , A61K31/04 , A61K31/095 , A61K31/195 , A61K38/05 , A61K41/0019 , A61L2/0029 , A61L2/0035 , A61L2/007 , A61L2202/18 , A61L2202/21
摘要： This invention provides a method of sterilising an S-nitrosothiol, for example S-nitrosoglutathione, without reduction of purity by more than about 5.0% through degradation. The invention allows sterile S-nitrosothiol or a sterile pharmaceutical pre-composition comprising S-nitrosothiol, wherein the S-nitrosothiol is in dry solid form, to be produced. The sterile pharmaceutical pre-composition is mixed with one or more diluents, excipients, carriers, additional active agents, or any combination thereof, for example sterile saline, to prepare a pharmaceutical composition of S-nitrosothiol for use.

8. 发明公开

EP1112029A4 METHODS FOR USING RESONANT ACOUSTIC AND/OR RESONANT ACOUSTO-EM ENERGY TO DETECT AND/OR EFFECT STRUCTURES 审中-公开
标题翻译：方法和共振声和/或声共振电磁能量用于检测和/或影响结构的
公开(公告)号：EP1112029A4
公开(公告)日：2007-06-06
申请号：EP99951418
申请日：1999-09-10
申请人： GR INTELLECTUAL RESERVE LLC
发明人： BROOKS JULIANA H J , ABEL ALBERT E
IPC分类号： A01G7/04 , A01C1/00 , A01C1/08 , A01M1/00 , A01M29/00 , A61B5/05 , A61B8/00 , A61L2/02 , A61L2/08 , A61M1/36 , A61N5/00 , A61N5/02 , A61N7/00 , C12M1/34 , C12M1/42 , C12Q1/02 , C12Q1/06 , C12Q1/70 , G01N29/032 , G01N29/036 , G01N29/12 , A61B17/22
CPC分类号： A61B5/05 , A61B5/0093 , A61B5/415 , A61B5/417 , A61B8/00 , A61L2/0029 , A61L2/08 , A61N5/00 , A61N7/00 , C12M47/06 , G01N29/032 , G01N29/036 , G01N2291/014 , G01N2291/02466
摘要： The present invention makes use of resonant acoustic and/or acousto-EM energy applied to inorganic or biologic structures for the detection and/or identification, and for augmentation and/or disruption of function within the biologic structure. In particular, the invention provides a method of generating resonant acoustic and/or acousto-EM energy in biologic structures such as virus, bacteria, fungi, worms and tumors for the detection and disruption of these structures. Moreover, the invention provides a method of augmenting functions of biologic structures such as bone through the generation of resonant acoustic and/or acousto-EM energy in the structure. Systems are also provided for the generation and detection of resonant acoustic and/or resonant acousto-EM energy.

9. 发明公开

EP1762251A1 Methods for sterilizing biological materials 审中-公开
标题翻译： Verfahren zum Sterilisieren生物制药材料
公开(公告)号：EP1762251A1
公开(公告)日：2007-03-14
申请号：EP06020540.8
申请日：2001-03-23
申请人： Clearant, Inc.
发明人： Kent, Randall, S. , Horton, Edward, A. , MacPhee, Martin, J. , Beall, Dawson
IPC分类号： A61L2/08 , A61L2/00
CPC分类号： A61L2/0041 , A61L2/0011 , A61L2/0029 , A61L2/0035 , A61L2/0047 , A61L2/0052 , A61L2/0058 , A61L2/007 , A61L2202/22 , A61M1/3681 , A61M1/3683 , A61M1/3686
摘要： Methods are disclosed for sterilizing biological products to reduce the level of active biological contaminants such as viruses, bacteria, yeasts, molds, mycoplasmas and parasites.
摘要翻译：公开了用于灭菌生物制品以降低活性生物污染物（例如病毒，细菌，酵母，霉菌，支原体和寄生虫）的水平的方法。

10. 发明公开

EP1392666A1 BIOLOGICALLY ACTIVE METHYLENE BLUE DERIVATIVES 有权
标题翻译：甲基蓝生物活性衍生物
公开(公告)号：EP1392666A1
公开(公告)日：2004-03-03
申请号：EP02726300.3
申请日：2002-05-30
申请人： Photopharmica Limited
发明人： BROWN, Stanley, Beames , O'GRADY, Cassandra, Claire , GRIFFITHS, John , MELLISH, Kirste, Joanne , TUNSTALL, Richard, George , ROBERTS, David, John, Howard , VERNON, David, Ian
IPC分类号： C07D279/18 , A61K31/5415 , A61P35/00 , A61P31/04
CPC分类号： A61K49/003 , A61K8/4986 , A61K41/0057 , A61L2/0029 , A61L2/0082 , A61L2/08 , A61L2/232 , A61Q11/00 , C07D279/18
摘要： The present invention relates to a phenothiazinium compound of Formula (I), wherein A and B are each independently (a) or (b) in which Z is CH2, O, S, SO2, NH, NCH3, NC2H5, NCH2CH2OH, or NCOCH3 and R?1 and R2¿ are each independently linear or branched C¿n?H2nY, where n is 1-6, Y is H, F, Cl, Br, I, OH, OCH3, OC2H5, OC3H7, CN or OCOCH3, and where X?P-¿ is a counteranion and P is 1, 2 or 3 but not including a compound where A and B are both either-N(CH¿3?)2 or -N(CH2CH3)2. The invention also relates to use of the compound of the invention as a PDT agent or a photodiagnostic agent.

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