专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP3416497A1 FUNCTIONAL MUNG BEAN-DERIVED COMPOSITIONS 审中-公开
公开(公告)号：EP3416497A1
公开(公告)日：2018-12-26
申请号：EP17710438.7
申请日：2017-02-17
申请人： Just, Inc.
发明人： BANSAL-MUTALIK, Ritu , BHIDE, Siddharth , GIBSON, Brenna , HALL, Camilla , JAKUBASCH, Malgorzata , KLEINER, Jake , LANQUAR, Viviane , MAHADEVAN, Swetha , NIEKOWAL, Trevor , PROULX, Jade , ROCHE, Ben , XU, Meng , FLATT, James , PARK, Nathaniel
IPC分类号： A23J1/14
CPC分类号： A23L15/35 , A21D13/40 , A23C9/1526 , A23C13/12 , A23C15/12 , A23G9/38 , A23J1/14 , A23J3/227 , A23L2/66 , A23L7/109 , A23L13/426 , A23V2002/00 , C07K1/36 , C07K14/415 , A23V2200/122 , A23V2250/548 , A23V2300/14 , A23V2300/18 , A23V2300/40
摘要： Provided herein are methods for producing a mung bean protein isolate having high functionality for a broad range of food applications. In some embodiments, the methods for producing the isolate comprise one or more steps selected from: (a) extracting one or more mung bean proteins from a mung bean protein source in an aqueous solution, for example, at a pH between about 6.5-10.0; (b) purifying protein from the extract using at least one of two methods: (i) precipitating protein from the extract at a pH near the isoelectric point of a globulin-rich fraction, for example a pH between about 5.0-6.0; and/or (ii) fractionating and concentrating protein from the extract using filtration such as microfiltration, ultrafiltration or ion-exchange chromatography; and (c) recovering purified protein isolate.

2. 发明授权

EP3189075B1 PROCÉDÉ DE PURIFICATION D'UN ANTICORPS MONOCLONAL 有权
公开(公告)号：EP3189075B1
公开(公告)日：2018-12-12
申请号：EP15759793.1
申请日：2015-09-04
申请人： Laboratoire Français du Fractionnement et des Biotechnologies
发明人： COUTARD, François
IPC分类号： C07K16/06 , C07K1/36 , C07K1/18 , C07K1/22 , C07K1/34
CPC分类号： B01D15/3809 , C07K1/18 , C07K1/22 , C07K1/34 , C07K1/36 , C07K16/065 , C07K16/08 , C07K16/12 , C07K16/1232 , C07K16/1271 , C07K16/1282 , C07K2317/76 , C07K2319/30 , C12M47/12 , C12N15/8258 , G01N30/02

3. 发明授权

EP2041154B1 REFOLDING OF RECOMBINANT PROTEINS 有权
公开(公告)号：EP2041154B1
公开(公告)日：2018-12-12
申请号：EP07812919.4
申请日：2007-07-13
申请人： Genentech, Inc.
发明人： PIZARRO, Shelly , SANCHEZ, Ailen , SCHMELZER, Charles H.
IPC分类号： C07K1/113 , C07K14/475 , C07K1/36 , C07K1/14 , C07K1/20
CPC分类号： C07K1/36 , C07K1/1133 , C07K1/1136 , C07K1/14 , C07K1/20 , C07K14/00 , C07K14/475
摘要： Processes are provided for recovering and purifying refolded recombinant proteins produced in heterologous host cells, which includes the step of refolding the protein in a high pH buffer.

4. 发明公开

EP3404037A1 METHOD FOR PURIFYING FIBRINOGEN 审中-公开
公开(公告)号：EP3404037A1
公开(公告)日：2018-11-21
申请号：EP17738641.4
申请日：2017-01-12
申请人： Green Cross Holdings Corporation
发明人： KIM, Jun Sic , KIM, Hyo Jin , PARK, Ji Yoon , LEE, Ju Ho , SON, Jae Woon , SHIN, Yong Won
IPC分类号： C07K1/30 , C07K1/34 , C07K1/36 , B01J20/08 , C07K14/75 , A61K38/36
CPC分类号： C07K14/75 , A61K38/36 , B01J20/08 , C07K1/30 , C07K1/34 , C07K1/36
摘要： The present disclosure relates to a method for purifying fibrinogen, and more particularly to a method for purifying fibrinogen, comprising the steps of: (a) precipitating fibrinogen of a fibrinogen-containing solution by adding glycine to the solution for a concentration of glycine to be 1.5 to 2.5M, and then removing a supernatant and recovering a precipitate (1 st glycine precipitation); (b) dissolving the precipitate of 1 st glycine precipitation of step (a) in a dissolution buffer to obtain a solution, precipitating the solution by adding glycine thereto for a concentration of glycine to be 0.2 to 1.2M, and recovering a supernatant (2 nd glycine precipitation); (c) precipitating the supernatant of step (b) by adding glycine thereto for a concentration of glycine to be 1.5 to 2.5M, and recovering a precipitate (3 rd glycine precipitation); and (d) dissolving the precipitate of step (c) in a dissolution buffer to obtain a solution, and subjecting the solution to nanofiltration (NF) using a nanofilter.
The novel method for purifying fibrinogen protein according to the present disclosure is a highly safe method that fundamentally blocks the entry of viruses. Furthermore, it can purify fibrinogen protein with high purity and high recovery rate by a simple process, and thus is very economical and efficient. In addition, fibrinogen purified by the method of the present disclosure has an advantage over fibrinogen purified by a conventional method in that it has higher purity, and thus has increased local activity, indicating that it can be effectively used for the prevention and treatment of blood-related diseases, particularly blood clotting diseases.

5. 发明授权

EP2321337B2 METHODS FOR REMOVING A CONTAMINANT USING PROTEIN DISPLACEMENT ION EXCHANGE MEMBRANE CHROMATOGRAPHY 有权
公开(公告)号：EP2321337B2
公开(公告)日：2018-10-10
申请号：EP08797895.3
申请日：2008-08-14
申请人： Genentech, Inc.
发明人： BROWN, Arick , BILL, Jerome, Jr. , TULLY, Timothy , DOWD, Christopher
IPC分类号： C07K1/18 , C07K1/34 , C07K1/36
CPC分类号： C07K1/18 , C07K1/34 , C07K1/36
摘要： Methods for purifying a polypeptide from a composition comprising the polypeptide and at least one contaminant are described, which methods comprise the sequential steps of: (a) passing the composition through an ion exchange membrane, where the polypeptide and the membrane have opposite charge, at operating conditions comprised of a buffer having a pH sufficiently distinct from the pI of the polypeptide to enhance the charge of the polypeptide and a low ionic strength effective to prevent the shielding of charges by buffer ions, which cause the membrane to bind the polypeptide and the at least one contaminant, and (b) recovering the purified polypeptide from the effluent.

6. 发明公开

EP3374380A1 C-TERMINAL EPITOPES IN AMYLOID BETA AND CONFORMATIONALLY-SELECTIVE ANTIBODIES THERETO 审中-公开
公开(公告)号：EP3374380A1
公开(公告)日：2018-09-19
申请号：EP16863265.1
申请日：2016-11-09
申请人： The University of British Columbia
发明人： CASHMAN, Neil R. , PLOTKIN, Steven S.
IPC分类号： C07K14/47 , A61K39/00 , A61K39/385 , A61K39/395 , A61K47/60 , A61K47/68 , A61K49/00 , A61K51/10 , A61P25/28 , A61P37/04 , C07K16/18 , C07K16/46 , C07K5/00 , C07K5/10 , C07K7/06 , C07K7/64 , C12N15/12 , C12N15/13 , C12N5/10 , G01N33/53 , G01N33/577
CPC分类号： C07K14/4711 , A61K39/00 , A61K39/0007 , A61K39/0008 , A61K39/385 , A61K47/643 , A61K47/646 , A61K51/1018 , A61K2039/55505 , A61K2039/6031 , A61K2039/6081 , A61P25/28 , A61P37/06 , C07K1/36 , C07K5/00 , C07K5/10 , C07K5/1008 , C07K5/101 , C07K7/06 , C07K7/64 , C07K14/47 , C07K16/18 , C07K2317/34 , C07K2317/76 , G01N33/6896 , G01N2333/4709
摘要： The disclosure pertains to C-terminal epitopes identified in A-beta, including conformational epitopes, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.

7. 发明公开

EP3374378A1 CHARGE-REVERSED N-TERMINAL SPIDER SILK PROTEIN DOMAIN AND USES THEREOF 审中-公开
公开(公告)号：EP3374378A1
公开(公告)日：2018-09-19
申请号：EP16797823.8
申请日：2016-11-11
申请人： Spiber Technologies AB
发明人： JOHANSSON, Jan , RISING, Anna , KRONQVIST, Nina , NORDLING, Kerstin
IPC分类号： C07K14/435
CPC分类号： C07K14/43518 , C07K1/36 , C07K2319/00 , C07K2319/35
摘要： A protein comprising a moiety of 100-160 amino acid residues having at least 70% identity with the N-terminal (NT) fragment of a spider silk protein, wherein the amino acid residue corresponding to position 40 in NT is selected from the group consisting of Lys, Arg and His; and wherein the amino acid residue corresponding to position 65 in NT is selected from the group consisting of Asp and Glu, is useful as a moiety in a fusion protein for enhancing the solubility of another moiety in the fusion protein, which is a desired protein or polypeptide.

8. 发明公开

EP3305092A1 PROCEDE DE FRACTIONNEMENT DES SOLUBLES DE POIS 审中-公开
公开(公告)号：EP3305092A1
公开(公告)日：2018-04-11
申请号：EP17203082.7
申请日：2014-01-31
申请人： Roquette Frères
发明人： BARATA, Manuel , DUFLOT, Pierrick , DHALLEINE, Claire , VERRIN, Jean-Marc
IPC分类号： A23J1/14
CPC分类号： C07K1/34 , A23J3/14 , B01D61/025 , B01D61/145 , B01D61/147 , B01D61/16 , B01D61/58 , B01D2311/04 , B01D2315/10 , C07K1/36 , C07K14/415 , B01D2311/2642 , B01D2311/2676
摘要： L'invention concerne un procédé de fractionnement des fractions solubles de pois, comprenant la succession d'une étape de microfiltration ou de centrifugation, suivie d'une étape d'ultrafiltration, et d'une éventuelle étape d'osmose inverse. On parvient ainsi à réduire la fuite de protéines vers les fractions solubles, à améliorer le rendement de l'étape unitaire de concentration par évaporation des fractions solubles, et on réussit à isoler de manière sélective les protéines d'intérêt. Il s'agit en outre d'un procédé simple à mettre en oeuvre, les dispositifs utilisés au niveau de chaque étape unitaire étant classiques et bien connus de l'homme du métier. Qui plus est, le procédé objet de la présente invention est exempt de tout solvant organique autre que l'eau.

9. 发明公开

EP3301115A1 CONTINUOUS MULTISTEP PROCESS FOR PURIFYING ANTIBODIES 审中-公开
标题翻译：连续多步法纯化抗体
公开(公告)号：EP3301115A1
公开(公告)日：2018-04-04
申请号：EP17200909.4
申请日：2014-05-06
申请人： SANOFI
发明人： DUTHE, Didier , HEMET, Céline , LANDRIC-BURTIN, Laure , MOTHES, Benoît
IPC分类号： C07K16/06 , C07K1/18 , C07K1/22
CPC分类号： C07K16/065 , C07K1/16 , C07K1/36 , C07K16/40 , C12M47/12
摘要： The invention provides a three-step chromatography process for small and large-scale purification of proteins, specifically monoclonal antibodies, using only four buffer solutions made from a mother solution.
摘要翻译：本发明提供了用于小规模和大规模纯化蛋白质，特别是单克隆抗体的三步色谱法，仅使用由母溶液制备的四种缓冲溶液。

10. 发明公开

EP3250705A1 PROCEDE D'OBTENTION D'UN ISOLAT PEPTIDIQUE ISSU DE LA BIOMASSE DE MICROALGUES ENRICHIES EN PROTEINES 审中-公开
标题翻译：从富含蛋白质的微生物的生物体获得肽分离物的方法
公开(公告)号：EP3250705A1
公开(公告)日：2017-12-06
申请号：EP16705228.1
申请日：2016-01-25
申请人： Roquette Frères
发明人： GUILLEMANT, Marilyne , PATINIER, Samuel , LOOTEN, Philippe
IPC分类号： C12P21/00 , C12R1/89 , C07K1/36
CPC分类号： A23J1/009 , A23J3/347 , A23L27/235 , A23L27/88 , A23L33/18 , C07K1/36 , C07K14/405 , C12N1/12 , C12P21/00
摘要： The invention relates to a peptide isolate isolated from a biomass of protein-enriched microalgae. The invention is characterized in that it comprises: - soluble peptides with a molecular weight between 1 and 20 k Da, - a protein content expressed in N 6.25 of more than 95%, - essentially arginine and glutamic acid.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式