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1. 发明公开

EP1916964A4 IMPLANTS AND METHODS FOR REPAIR, REPLACEMENT AND TREATMENT OF JOINT DISEASE 无效转让
标题翻译：植入物和方法进行修正，更换和治疗关节疾病
公开(公告)号：EP1916964A4
公开(公告)日：2015-11-04
申请号：EP06813900
申请日：2006-08-28
申请人： ZIMMER INC
发明人： GAGE GARY , ADKISSON H DAVIS IV , BLANCHARD CHERYL R
IPC分类号： A61F2/02
CPC分类号： A61F2/30767 , A61F2/28 , A61F2/30749 , A61F2/30756 , A61F2/34 , A61F2/36 , A61F2/3859 , A61F2002/2839 , A61F2002/30011 , A61F2002/30064 , A61F2002/3021 , A61F2002/30224 , A61F2002/30276 , A61F2002/30405 , A61F2002/30448 , A61F2002/30461 , A61F2002/30472 , A61F2002/30762 , A61F2002/30764 , A61F2002/30797 , A61F2002/30841 , A61F2002/30892 , A61F2002/30929 , A61F2002/30934 , A61F2002/30968 , A61F2002/3611 , A61F2002/365 , A61F2220/0008 , A61F2220/0025 , A61F2220/0041 , A61F2220/005 , A61F2220/0075 , A61F2230/0067 , A61F2230/0069 , A61F2230/0086 , A61F2250/0023 , A61F2310/00011 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00059 , A61F2310/00095 , A61F2310/00131 , A61F2310/00395 , A61F2310/00407 , A61F2310/00796 , A61F2310/00964 , A61F2310/00982 , A61F2310/00988 , A61L27/306 , A61L27/3612 , A61L27/3641 , A61L27/3645 , A61L27/3817 , A61L27/3843 , A61L27/446 , A61L27/56
摘要： Implants comprising cartilage and trabecular metal, and methods of making the implants are disclosed. Further disclosed are therapeutic uses of the implants, which include methods of treatment or repair of an chondral or osteochondral defect, such as a chondral or osteochondral injury, lesion or disease. An implant comprises cartilage or chondrocytes and a subchondral base comprising trabecular metal. An implant can comprise a geometric shape such as a cylinder or an anatomical shape such as a condyle, and can be used in conjunction with a positioning structure.

2. 发明公开

EP2403438A4 STENTS MODIFIED WITH MATERIAL COMPRISING AMNION TISSUE AND CORRESPONDING PROCESSES 有权
标题翻译：与AMNIONGEWEBEHALTIGEM材料修改该支架和相关程序
公开(公告)号：EP2403438A4
公开(公告)日：2014-06-04
申请号：EP10749126
申请日：2010-02-26
申请人： PEYTANT SOLUTIONS INC
发明人： SCHORGL JOHN , THOMPSON PAUL , HEALY STEVEN J , THATCHER ROBERT
IPC分类号： A61L31/00
CPC分类号： A61L31/005 , A61F2/062 , A61F2/07 , A61F2/82 , A61F2/86 , A61F2002/065 , A61F2210/0076 , A61F2220/0025 , A61F2220/0066 , A61F2310/00982 , A61L27/3604 , A61L27/3813 , A61L27/3834 , A61L27/507 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2300/30 , A61L2300/412 , A61L2300/64 , A61L2400/18

3. 发明公开

EP2688499A1 TISSUE REPAIR WITH SPACE-SEEKING SPIRALS OF FILAMENT 失效
标题翻译： GEWEBEREPARATUR MIT RAUMSUCHENDEN FILAMENT-SPIRALEN
公开(公告)号：EP2688499A1
公开(公告)日：2014-01-29
申请号：EP12723539.8
申请日：2012-03-23
申请人： Yeung, Jeffrey E. , Yeung, Teresa, T.
发明人： Yeung, Jeffrey E. , Yeung, Teresa, T.
IPC分类号： A61B17/70 , A61F2/46 , A61F2/44 , A61B17/88 , A61B17/34
CPC分类号： A61F2/442 , A61B17/0483 , A61B17/3468 , A61B17/7061 , A61B17/7094 , A61B17/8852 , A61B2017/00805 , A61B2017/00867 , A61F2/0036 , A61F2/4611 , A61F2002/30289 , A61F2002/30294 , A61F2002/30677 , A61F2002/444 , A61F2002/4495 , A61F2002/4635 , A61F2210/0061 , A61F2230/0091 , A61F2250/0067 , A61F2310/00598 , A61F2310/0061 , A61F2310/0097 , A61F2310/00976 , A61F2310/00982
摘要： A distal portion of a filament is extended beyond the distal end of a needle with a gripper. The needle with the extended filament is inserted into a cannula with snagging points at the distal opening of the cannula in tissue. The snagging points of the cannula hook and retain the distal portion of the filament. During partial withdrawal of the needle, a section of filament is deposited in the lumen of the cannula between the distal ends of the needle and cannula. When the needle is re-advanced, the section of filament is expelled or pushed out of the cannula into tissue. The needle is then rotated; the gripper engages and spirals the expelled filament, burrowing into tissue. The needle can further advanced to push and pack the spiral of filament deep into the tissue. The knot-like filament spiral is individually formed by rotation of the needle and friction between the extended filament and tissue. The process of needle partial withdrawal, re-advancement, rotation and pushing is repeated to pack and fill the tissue with interconnecting spirals of filament to prevent migration from tissue. Spiraling of the filament driven by the rotating needle is space seeking, filling, fitting or conforming to fortify, bulk, fill, cushion or repair the tissue. Bulking with filament spirals can repair degenerated disc, urinary incontinence, fecal incontinence or other defective tissue. The filament spirals can also be used as a suture anchor deep within tissue.
摘要翻译：丝线的远端部分用夹具延伸超过针的远端。将具有延伸细丝的针插入具有在组织中插管的远端开口处的阻塞点的插管中。插管钩的阻塞点并保持丝的远端部分。在针的部分抽出期间，在针和插管的远端之间的一段细丝沉积在套管的内腔中。当针被再推进时，细丝的部分被排出或从套管推出到组织中。然后旋转针头; 夹具接合并螺旋排出的细丝，挖入组织。针可以进一步推进以将丝的螺旋深入到组织中。结状丝状螺旋通过针的旋转和延长的细丝与组织之间的摩擦分别形成。针头部分抽出，再推进，旋转和推动的过程重复，用纤维互连的螺旋填充和填充组织以防止从组织迁移。由旋转针驱动的细丝的螺旋形是空间寻找，填充，配合或符合强化，散装，填充，缓冲或修复组织。用丝线螺旋填充可以修复退化的椎间盘，尿失禁，大便失禁或其他有缺陷的组织。长丝螺旋也可以用作组织内部的缝合锚。

4. 发明公开

EP2457001A4 COAXIAL SCREW GEAR SLEEVE MECHANISM 无效
标题翻译： KOAXIALSCHRAUBEN-GETRIEBEHÜLLENMECHANISMUS
公开(公告)号：EP2457001A4
公开(公告)日：2013-01-30
申请号：EP10802916
申请日：2010-07-22
申请人： SPINEX TEC LLC
发明人： JIMENEZ OMAR F , POWLEY NICHOLAS RANSOM , FISCHER ANDREW G , SAFRIS YEFIM I
IPC分类号： F16H55/22 , F16H55/02
CPC分类号： A61F2/4465 , A61B17/7065 , A61B2017/0256 , A61B2017/681 , A61F2/385 , A61F2/3868 , A61F2/4455 , A61F2/447 , A61F2/4611 , A61F2002/2817 , A61F2002/2835 , A61F2002/30235 , A61F2002/30405 , A61F2002/30434 , A61F2002/30523 , A61F2002/30525 , A61F2002/30556 , A61F2002/30579 , A61F2002/30593 , A61F2002/30601 , A61F2002/30604 , A61F2002/3063 , A61F2002/3064 , A61F2002/30644 , A61F2002/30645 , A61F2002/3082 , A61F2002/30841 , A61F2002/30904 , A61F2002/30925 , A61F2002/3409 , A61F2002/3631 , A61F2002/448 , A61F2002/4628 , A61F2002/4629 , A61F2002/482 , A61F2002/5041 , A61F2002/5069 , A61F2002/507 , A61F2220/0025 , A61F2220/0041 , A61F2230/0069 , A61F2240/001 , A61F2250/0009 , A61F2310/00023 , A61F2310/00029 , A61F2310/00796 , A61F2310/00976 , A61F2310/00982 , A61F2310/00988 , A61F2310/00994 , F16H25/20 , F16H25/2056 , F16H25/2214 , F16H2025/2046 , F16H2025/2084 , F16H2025/209 , Y10T29/49 , Y10T74/18608 , Y10T74/18672 , Y10T74/19702 , Y10T74/19749
摘要： Improved methods and apparatuses for vertebral body distraction and fusion in accordance with various embodiments of the present invention employ one or more coaxial screw gear sleeve mechanisms. In various embodiments, coaxial screw gear sleeve mechanisms include a post with a threaded exterior surface and a corresponding sleeve configured to surround the post, the corresponding sleeve having a threaded interior surface configured to interface with the threaded exterior surface of the post and a geared exterior surface. A drive mechanism can be configured to interface with the geared exterior surface of the sleeve, causing the device to distract.
摘要翻译：根据本发明的各种实施例的医疗装置采用一个或多个同轴螺旋齿轮套筒机构。在各种实施例中，同轴螺旋齿轮套筒机构包括具有螺纹外表面的柱和配置成围绕柱的相应套筒，相应的套筒具有螺纹内表面，该内表面被配置为与柱的螺纹外表面相接合，表面。驱动机构可以被配置成与套筒的齿轮外表面相接触，导致装置膨胀。

5. 发明公开

EP2403438A2 STENTS MODIFIED WITH MATERIAL COMPRISING AMNION TISSUE AND CORRESPONDING PROCESSES 有权
标题翻译：与AMNIONGEWEBEHALTIGEM材料修改该支架和相关程序
公开(公告)号：EP2403438A2
公开(公告)日：2012-01-11
申请号：EP10749126.8
申请日：2010-02-26
申请人： Peytant Solutions, Inc.
发明人： SCHORGL, John , THOMPSON, Paul , HEALY, Steven, J. , THATCHER, Robert
IPC分类号： A61F2/82 , A61L27/38 , A61L27/28 , A61L27/04 , A61L27/14 , A61L27/58 , A61M29/04
CPC分类号： A61L31/005 , A61F2/062 , A61F2/07 , A61F2/82 , A61F2/86 , A61F2002/065 , A61F2210/0076 , A61F2220/0025 , A61F2220/0066 , A61F2310/00982 , A61L27/3604 , A61L27/3813 , A61L27/3834 , A61L27/507 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2300/30 , A61L2300/412 , A61L2300/64 , A61L2400/18
摘要： A stent scaffold combined with amniotic tissue provides for a biocompatible stent that has improved biocompatibility and hemocompatibility. The amnion tissue can be variously modified or unmodified form of amnion tissue such as non-cryo amnion tissue, solubilized amnion tissue, amnion tissue fabric, chemically modified amnion tissue, amnion tissue treated with radiation, amnion tissue treated with heat, or a combination thereof. Materials such as polymer, placental tissue, pericardium tissue, small intestine submucosa can be used in combination with the amnion tissue. The amnion tissue can be attached to the inside, the outside, both inside and outside, or complete encapsulation of the stent scaffold. In some embodiments, at least part of the covering or lining comprises a plurality of layers of amnion tissue. The method of making the biocompatible stent and its delivery and deployment are also discussed.

7. 发明公开

EP1662973A4 ACELLULAR MATRIX IMPLANTED INTO AN ARTICULAR CARTILAGE OR OSTEOCHONDRAL LESION PROTECTED WITH A BIODEGRADABLE POLYMER MODIFIED TO HAVE EXTENDED POLYMERIZATION TIME AND METHODS FOR PREPARATION AND USE THEREOF 审中-公开
标题翻译：脱细胞基质植入一个或关节骨软骨病变，WITH修改后用于扩展与制造聚合和使用它们的方法可生物降解聚合物PROTECTED
公开(公告)号：EP1662973A4
公开(公告)日：2011-07-20
申请号：EP04781614
申请日：2004-08-18
申请人： HISTOGENICS CORP
发明人： KUSANAGI AKIHIKO , TARRANT LAURENCE J B
IPC分类号： A61F2/00 , A61B20060101 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/38 , A61L27/24 , A61L27/34 , A61L27/36 , A61L27/52 , A61L27/58
CPC分类号： A61F2/30756 , A61F2/28 , A61F2/2846 , A61F2/3859 , A61F2002/2817 , A61F2002/2825 , A61F2002/30062 , A61F2002/30064 , A61F2002/30677 , A61F2210/0004 , A61F2310/00365 , A61F2310/00982 , A61L27/24 , A61L27/34 , A61L27/3633 , A61L27/3654 , A61L27/52 , A61L27/58 , A61L2430/06

8. 发明公开

EP2173272A1 DOUBLE-STRUCTURED TISSUE IMPLANT AND A METHOD FOR PREPARATION AND USE THEREOF 有权转让
标题翻译：双层结构的组织植入物及其制备方法和用途
公开(公告)号：EP2173272A1
公开(公告)日：2010-04-14
申请号：EP08768602.8
申请日：2008-06-18
申请人： Histogenics Corporation , Claesson, Hans Peter
发明人： CLAESSON, Hans, Peter , TARRANT, Laurence, J. B. , SMITH, Robert, Lane , SHORTKROFF, Sonya
IPC分类号： A61F2/00
CPC分类号： A61L27/48 , A61F2002/0086 , A61F2210/0076 , A61F2310/00371 , A61F2310/00982 , A61L27/24 , A61L27/3817 , A61L27/54 , A61L27/56 , A61L2400/18 , A61L2430/34 , C08L89/06
摘要： A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment.
摘要翻译：双重构造的组织植入物及其制备方法和用途用于植入到组织中的缺陷。双重结构的组织植入物，其包括初级支架和次级支架由......组成结合有非离子型表面活性剂的可溶性胶原溶液和生成的主支架内定位。一个独立的辅助支架植入物或单元。一种用于制备双重结构的植入物的或独立的次级支架，其包含冻干和脱水热处理工艺。

9. 发明公开

EP1981558A2 SUTURABLE DURAL AND MENINGEAL REPAIR PRODUCT COMPRISING COLLAGEN MATRIX 有权
标题翻译：胶原蛋白基质DURA和脑膜上缝合修补产品
公开(公告)号：EP1981558A2
公开(公告)日：2008-10-22
申请号：EP07717864.8
申请日：2007-01-12
申请人： Integra Lifesciences Corporation
发明人： ARCHIBALD, Simon, J. , SPILKER, Mark , INGRAM, Ronald, T. , BRITTAN, Jeffrey, M.
IPC分类号： A61L27/24 , A61L27/56 , A61F2/28 , A61K35/30
CPC分类号： A61L27/24 , A61B17/06166 , A61F2/0077 , A61F2240/001 , A61F2240/004 , A61F2250/0015 , A61F2250/0023 , A61F2310/00365 , A61F2310/00982 , A61L27/50 , A61L27/56 , A61L2430/32
摘要： A matrix for tissue growth includes: (a) a first layer including a first assembly of collagen fibers; (b) a plurality of projections on a top surface of the first layer; and (c) a second layer bonded to a bottom portion of the first layer and including a second assembly of collagen fibers, wherein the second layer has a lower density than the first layer, and the matrix includes pores effective to support cell growth into the matrix. A method for providing the matrix is also described.

10. 发明公开

EP1662973A2 ACELLULAR MATRIX IMPLANTED INTO AN ARTICULAR CARTILAGE OR OSTEOCHONDRAL LESION PROTECTED WITH A BIODEGRADABLE POLYMER MODIFIED TO HAVE EXTENDED POLYMERIZATION TIME AND METHODS FOR PREPARATION AND USE THEREOF 审中-公开
标题翻译：脱细胞基质植入一个或关节骨软骨病变，WITH修改后用于扩展与制造聚合和使用它们的方法可生物降解聚合物PROTECTED
公开(公告)号：EP1662973A2
公开(公告)日：2006-06-07
申请号：EP04781614.5
申请日：2004-08-18
申请人： Histogenics Corporation
发明人： KUSANAGI, Akihiko , TARRANT, Laurence, J., B.
IPC分类号： A61B1/00
CPC分类号： A61F2/30756 , A61F2/28 , A61F2/2846 , A61F2/3859 , A61F2002/2817 , A61F2002/2825 , A61F2002/30062 , A61F2002/30064 , A61F2002/30677 , A61F2210/0004 , A61F2310/00365 , A61F2310/00982 , A61L27/24 , A61L27/34 , A61L27/3633 , A61L27/3654 , A61L27/52 , A61L27/58 , A61L2430/06
摘要： Acellular matrix implants for implantation into an articular cartilage or osteochondral lesion and a method for fabrication thereof. A protective biodegradable polymer barrier having extended polymerization time and a method for preparation thereof. Bone-inducing compositions. A method for treatment of articular cartilage or osteochondral injuries.

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