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1. 发明授权

EP1416876B1 POROUS DELIVERY SCAFFOLD AND METHOD 有权
标题翻译：多孔排气框架和程序
公开(公告)号：EP1416876B1
公开(公告)日：2011-03-23
申请号：EP02752309.1
申请日：2002-07-15
申请人： DePuy Products, Inc.
发明人： MALAVIYA, Prasanna , SCHWARTZ, Herbert, Eugene , PLOUHAR, Pamela, Lynn , ORBAN, Janine, Marie
IPC分类号： A61L27/56 , A61F2/00 , C12N11/08
CPC分类号： A61B17/064 , A61B17/0642 , A61B2017/0646 , A61F2/0811 , A61F2/3872 , A61F2002/30294 , A61F2230/0091 , A61L27/18 , A61L27/3633 , A61L27/56 , A61L31/005 , C08L67/04
摘要： A method of making an implantable scaffold for repairing damaged or diseased tissue includes the step of suspending pieces of an extracellular matrix material in a liquid. The extracellular matrix material and the liquid are formed into a mass. The liquid is subsequently driven off so as to form interstices in the mass. The scaffold may further comprise biological agents that promote tissue repair and healing. Porous implantable scaffolds fabricated by such a method are also disclosed.

2. 发明公开

EP1416876A4 POROUS DELIVERY SCAFFOLD AND METHOD 有权
标题翻译：多孔排气框架和程序
公开(公告)号：EP1416876A4
公开(公告)日：2007-04-18
申请号：EP02752309
申请日：2002-07-15
申请人： DEPUY PRODUCTS INC
发明人： MALAVIYA PRASANNA , SCHWARTZ HERBERT EUGENE , PLOUHAR PAMELA LYNN , ORBAN JANINE MARIE
IPC分类号： A61L27/00 , A61L27/56 , A61B17/064 , A61F2/00 , A61F2/08 , A61F2/38 , A61L27/18 , A61L27/36 , A61L31/00 , C12N5/06 , C12N5/08 , C12N11/08
CPC分类号： A61B17/064 , A61B17/0642 , A61B2017/0646 , A61F2/0811 , A61F2/3872 , A61F2002/30294 , A61F2230/0091 , A61L27/18 , A61L27/3633 , A61L27/56 , A61L31/005 , C08L67/04
摘要： A method of making an implantable scaffold for repairing damaged or diseased tissue includes the step of suspending pieces of an extracellular matrix material in a liquid. The extracellular matrix material and the liquid are formed into a mass. The liquid is subsequently driven off so as to form interstices in the mass. The scaffold may further comprise biological agents that promote tissue repair and healing. Porous implantable scaffolds fabricated by such a method are also disclosed.

3. 发明公开

EP1416888A2 MENISCUS REGENERATION DEVICE AND METHOD 审中-公开
标题翻译：装置和方法进行再生半月板的
公开(公告)号：EP1416888A2
公开(公告)日：2004-05-12
申请号：EP02752290.3
申请日：2002-07-15
申请人： Depuy Products, Inc.
发明人： MALAVIYA, Prasanna , SCHWARTZ, Herbert, Eugene , WHALEN, Terrence, David , PELO, Mark, Joseph , JENKS, Philip, Joseph , PLOUHAR, Pamela, Lynn , LOWER, Jerry, Lee
IPC分类号： A61F2/08 , A61F2/02
CPC分类号： A61L27/3654 , A61B17/0401 , A61B17/06166 , A61B17/064 , A61B17/0642 , A61B2017/00004 , A61B2017/00526 , A61B2017/0475 , A61B2017/06057 , A61B2017/0646 , A61B2017/0647 , A61F2/0063 , A61F2/0811 , A61F2/28 , A61F2/30749 , A61F2/30756 , A61F2/3094 , A61F2/30965 , A61F2/3872 , A61F2/442 , A61F2002/2817 , A61F2002/2839 , A61F2002/30032 , A61F2002/30062 , A61F2002/30131 , A61F2002/30153 , A61F2002/30199 , A61F2002/3021 , A61F2002/30217 , A61F2002/30224 , A61F2002/30225 , A61F2002/30233 , A61F2002/30261 , A61F2002/30281 , A61F2002/30293 , A61F2002/30294 , A61F2002/30429 , A61F2002/30611 , A61F2002/30677 , A61F2002/30678 , A61F2002/30751 , A61F2002/30764 , A61F2002/30766 , A61F2002/30785 , A61F2002/30841 , A61F2002/30848 , A61F2002/30878 , A61F2002/30891 , A61F2002/30892 , A61F2002/30914 , A61F2002/30957 , A61F2002/3096 , A61F2002/30971 , A61F2002/30975 , A61F2210/0004 , A61F2220/0025 , A61F2230/0013 , A61F2230/0019 , A61F2230/0063 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2230/0086 , A61F2230/0091 , A61F2240/001 , A61F2240/004 , A61F2250/003 , A61F2250/0063 , A61F2250/0067 , A61F2310/00365 , A61L27/18 , A61L27/3629 , A61L27/3633 , A61L27/3683 , A61L27/3691 , A61L27/3852 , A61L27/56 , A61L31/005 , A61L2430/06 , C08L67/04
摘要： Methods and devices are provided for regenerating a meniscus. The devices (20) comprise a layer (22) of toughened naturally occurring extracellular matrix. The devices (20) may, optionally, further comprise a biologic material (60) to provide a framework for meniscus regeneration. The methods comprise the steps of removing a portion of a meniscus to provide a space (16), and inserting a device (20) comprising a layer (22) of toughened naturally occurring extracellular matrix into the space.

4. 发明公开

EP1416874A2 HYBRID BIOLOGIC/SYNTHETIC POROUS EXTRACELLULAR MATRIX SCAFFOLDS 审中-公开
标题翻译：生物/合成多孔细胞外基质混合TOWERS
公开(公告)号：EP1416874A2
公开(公告)日：2004-05-12
申请号：EP02747019.4
申请日：2002-07-15
申请人： Depuy Products, Inc.
发明人： MALAVIYA, Prasanna , MELICAN, Mora, C. , REZANIA, Alireza , CHUN, Iksoo
IPC分类号： A61F2/00 , C12N11/08 , C12N5/06 , C12N5/08
CPC分类号： A61L27/3691 , A61B17/0401 , A61B17/06166 , A61B17/064 , A61B17/0642 , A61B2017/00004 , A61B2017/0475 , A61B2017/06057 , A61B2017/0646 , A61F2/0063 , A61F2/08 , A61F2/0811 , A61F2/28 , A61F2/30749 , A61F2/30756 , A61F2/3094 , A61F2/30965 , A61F2/3872 , A61F2/442 , A61F2002/2817 , A61F2002/2839 , A61F2002/30032 , A61F2002/30062 , A61F2002/30131 , A61F2002/30153 , A61F2002/30199 , A61F2002/3021 , A61F2002/30217 , A61F2002/30224 , A61F2002/30225 , A61F2002/30233 , A61F2002/30261 , A61F2002/30281 , A61F2002/30293 , A61F2002/30294 , A61F2002/30429 , A61F2002/30611 , A61F2002/30677 , A61F2002/30678 , A61F2002/30751 , A61F2002/30764 , A61F2002/30766 , A61F2002/30785 , A61F2002/30841 , A61F2002/30848 , A61F2002/30878 , A61F2002/30891 , A61F2002/30892 , A61F2002/30914 , A61F2002/30957 , A61F2002/3096 , A61F2002/30971 , A61F2002/30975 , A61F2210/0004 , A61F2220/0025 , A61F2230/0013 , A61F2230/0019 , A61F2230/0063 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2230/0086 , A61F2230/0091 , A61F2240/001 , A61F2240/004 , A61F2250/003 , A61F2250/0063 , A61F2250/0067 , A61F2310/00365 , A61L27/18 , A61L27/3629 , A61L27/3633 , A61L27/3683 , A61L27/56 , A61L31/005 , A61L2430/06 , C08L67/04
摘要： Methods of making a hybrid biologic/synthetic scaffold for repairing damaged or diseased tissue are provided. The methods include the step of suspending pieces of an extracellular matrix material in a liquid to form a slurry, and coating a synthetic mat with the slurry, or mixing or layering the slurry with a synthetic polymer solution. The liquid is subsequently driven off so as to form a foam. Porous implantable scaffolds fabricated by such a method are also disclosed.

5. 发明公开

EP1416886A4 CARTILAGE REPAIR AND REGENERATION SCAFFOLD AND METHOD 审中-公开
标题翻译：框架和软骨修复和再生程序
公开(公告)号：EP1416886A4
公开(公告)日：2007-04-18
申请号：EP02747021
申请日：2002-07-15
申请人： DEPUY PRODUCTS INC
发明人： PLOUHAR PAMELA LYNN , MALAVIYA PRASANNA , SCHWARTZ HERBERT EUGENE
IPC分类号： A61L27/00 , A61L27/56 , A61B17/00 , A61B17/04 , A61B17/06 , A61B17/064 , A61F2/00 , A61F2/02 , A61F2/08 , A61F2/28 , A61F2/30 , A61F2/38 , A61F2/44 , A61F2/46 , A61L27/18 , A61L27/36 , A61L31/00 , A61P19/00 , C12N5/06 , C12N5/08 , C12N11/08
CPC分类号： A61L27/3852 , A61B17/0401 , A61B17/06166 , A61B17/064 , A61B17/0642 , A61B2017/00004 , A61B2017/0475 , A61B2017/06057 , A61B2017/0641 , A61B2017/0646 , A61B2017/0647 , A61F2/0063 , A61F2/08 , A61F2/0811 , A61F2/28 , A61F2/30749 , A61F2/30756 , A61F2/3094 , A61F2/30965 , A61F2/3872 , A61F2/442 , A61F2002/2817 , A61F2002/2839 , A61F2002/30032 , A61F2002/30062 , A61F2002/30131 , A61F2002/30153 , A61F2002/30199 , A61F2002/3021 , A61F2002/30217 , A61F2002/30224 , A61F2002/30225 , A61F2002/30233 , A61F2002/30261 , A61F2002/30281 , A61F2002/30293 , A61F2002/30294 , A61F2002/30429 , A61F2002/30611 , A61F2002/30677 , A61F2002/30678 , A61F2002/30751 , A61F2002/30764 , A61F2002/30766 , A61F2002/30785 , A61F2002/30841 , A61F2002/30848 , A61F2002/30878 , A61F2002/30891 , A61F2002/30892 , A61F2002/30914 , A61F2002/30957 , A61F2002/3096 , A61F2002/30971 , A61F2002/30975 , A61F2210/0004 , A61F2220/0025 , A61F2230/0013 , A61F2230/0019 , A61F2230/0063 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2230/0086 , A61F2230/0091 , A61F2240/001 , A61F2240/004 , A61F2250/003 , A61F2250/0063 , A61F2250/0067 , A61F2310/00365 , A61L27/18 , A61L27/3604 , A61L27/3633 , A61L27/3654 , A61L27/3683 , A61L27/56 , A61L31/005 , A61L2430/06 , C08L67/04
摘要： A method for the repair of a cartilaginous tissue defect and a cartilage repair device (20, 210) are disclosed. In the method for the repair of a cartilaginous tissue defect (14), a device (20, 210) comprising a synthetic polymer (230) is implanted into a space (16) subsequent to removal of the defect (14), and a biological lubricant is administered at the site of the defect (14). The device (20, 210) comprises a synthetic polymer (230) and a biological lubricant (234).

6. 发明授权

EP1242008B1 A PROSTHETIC DEVICE 有权
标题翻译：移植设备
公开(公告)号：EP1242008B1
公开(公告)日：2006-03-08
申请号：EP00983081.1
申请日：2000-12-14
申请人： Cartificial A/S
发明人： PEDERSEN, Walther, Batsberg , STEENSTRUP, Frederik, Resen , OLSEN, Ole, Ingemann , JAKOBSEN, Lene, Diness , VRAA, Erik , LAURITZEN, Jes, Bruun , BECHGAARD, Klaus
IPC分类号： A61F2/30
CPC分类号： A61F2/30721 , A61B17/025 , A61B17/282 , A61B17/562 , A61B2017/0275 , A61F2/32 , A61F2/4607 , A61F2002/30004 , A61F2002/30112 , A61F2002/30113 , A61F2002/30118 , A61F2002/30125 , A61F2002/30135 , A61F2002/30136 , A61F2002/30156 , A61F2002/302 , A61F2002/30204 , A61F2002/30217 , A61F2002/30242 , A61F2002/30247 , A61F2002/30289 , A61F2002/30294 , A61F2002/30309 , A61F2002/30324 , A61F2002/30327 , A61F2002/30494 , A61F2002/30594 , A61F2002/30596 , A61F2002/30599 , A61F2002/30754 , A61F2002/30772 , A61F2220/0025 , A61F2230/0004 , A61F2230/0006 , A61F2230/0008 , A61F2230/0023 , A61F2230/0063 , A61F2230/0065 , A61F2230/0067 , A61F2230/0071 , A61F2230/0091 , A61F2250/0014 , A61F2250/0036 , A61F2250/0039 , A61F2250/0063 , A61L27/16 , A61L27/26 , C08L23/12
摘要： The present invention relates to a method and a device for alleviating and/or preventing conditions relating to damaged joints involving articulating surfaces, a prosthetic device for insertion into a joint cavity of a joint of a vertebrate, such as a human, said device consisting of a biocompatible material comprising at least a first polymeric component and a second polymeric component, wherein the chain length of the first polymeric component is longer than the chain length of the second polymeric component, the polymeric components in particular being polyethylene, polypropylene and/or polyvinylpyrrolidone. A further aspect of the invention relates to a method for introducing the prosthetic device into a joint, such as a method comprising locking the device to an intro-articular component, thereby fixing or retaining the device in the joint cavity in a manner which is substantially non-invasive with respect to cartilage and bone natively present in the joint cavity. Also the invention relates to an instrument for inserting a prosthetic device according to the invention, comprising means for deforming the prosthetic device into a reduced volume or a slender shape and means for grasping the intra-articular component to which the device is capable of interlocking.

7. 发明公开

EP1416879A2 UNITARY SURGICAL DEVICE AND METHOD 审中-公开
标题翻译：手术单位和方法
公开(公告)号：EP1416879A2
公开(公告)日：2004-05-12
申请号：EP02752331.5
申请日：2002-07-15
申请人： Depuy Products, Inc.
发明人： SCHWARTZ, Herbert, Eugene , MALAVIYA, Prasanna , SINGLA, Amit, Kumar , PELO, Mark, Joseph , PLOUHAR, Pamela, Lynn
IPC分类号： A61F2/02 , A61F2/08 , A01N63/00 , A61B17/04
CPC分类号： A61B17/064 , A61B17/0401 , A61B17/06166 , A61B17/0642 , A61B2017/00004 , A61B2017/0458 , A61B2017/0464 , A61B2017/06057 , A61B2017/06176 , A61B2017/0646 , A61B2017/0647 , A61F2/0063 , A61F2/28 , A61F2/30749 , A61F2/30756 , A61F2/3094 , A61F2/30965 , A61F2/3872 , A61F2002/2817 , A61F2002/30062 , A61F2002/30131 , A61F2002/30281 , A61F2002/30294 , A61F2002/30306 , A61F2002/30429 , A61F2002/30751 , A61F2002/30764 , A61F2002/30766 , A61F2002/30841 , A61F2210/0004 , A61F2220/0025 , A61F2230/0013 , A61F2230/0086 , A61F2230/0091 , A61F2230/0097 , A61L27/18 , A61L27/3633 , A61L27/3654 , A61L27/3683 , A61L27/3852 , A61L27/56 , A61L31/005 , A61L2430/06 , C08L67/04
摘要： Unitary surgical devices (10) are disclosed. One group of the illustrated devices has a pair of biocompatible, bioresorbable anchors (16, 18) connected to fixed lengths suture. The anchors (16, 18) and fixed length of suture are connected to each other prior to surgery. Another group of unitary surgical devices has a pair of fixating mechanisms (15, 17) connected to a base (21) prior to surgery. The second group of illustrated devices generally includes extracellular matrix material either as part of the base (21) or supported on the base (21). The extracellular matrix material serves as tissue regenerating material. In the second group of unitary surgical devices, the fixating mechanisms illustrated generally comprise suture, anchors or pre-formed holes in the base. All of the illustrated unitary surgical devices are useful in repairing a damaged meniscus. The first group of unitary surgical devices can be used to approximate inner surfaces of a tear in the meniscus. The second group of devices can be used either as an insert to be placed between and approximated to the inner surfaces of the tear or as an insert to replace a void in the meniscus left after a menisectomy.

8. 发明公开

EP1416876A2 POROUS DELIVERY SCAFFOLD AND METHOD 有权
标题翻译：多孔排气框架和程序
公开(公告)号：EP1416876A2
公开(公告)日：2004-05-12
申请号：EP02752309.1
申请日：2002-07-15
申请人： Depuy Products, Inc.
发明人： MALAVIYA, Prasanna , SCHWARTZ, Herbert, Eugene , PLOUHAR, Pamela, Lynn , ORBAN, Janine, Marie
IPC分类号： A61F2/00 , A61K35/12 , C12N11/02 , C12N5/00
CPC分类号： A61B17/064 , A61B17/0642 , A61B2017/0646 , A61F2/0811 , A61F2/3872 , A61F2002/30294 , A61F2230/0091 , A61L27/18 , A61L27/3633 , A61L27/56 , A61L31/005 , C08L67/04
摘要： A method of making an implantable scaffold for repairing damaged or diseased tissue includes the step of suspending pieces of an extracellular matrix material in a liquid. The extracellular matrix material and the liquid are formed into a mass. The liquid is subsequently driven off so as to form interstices in the mass. The scaffold may further comprise biological agents that promote tissue repair and healing. Porous implantable scaffolds fabricated by such a method are also disclosed.

9. 发明公开

EP1242008A2 A PROSTHETIC DEVICE 有权
标题翻译：移植设备
公开(公告)号：EP1242008A2
公开(公告)日：2002-09-25
申请号：EP00983081.1
申请日：2000-12-14
申请人： Cartificial A/S
发明人： PEDERSEN, Walther, Batsberg , STEENSTRUP, Frederik, Resen , OLSEN, Ole, Ingemann , JAKOBSEN, Lene, Diness , VRAA, Erik , LAURITZEN, Jes, Bruun , BECHGAARD, Klaus
IPC分类号： A61F2/30
CPC分类号： A61F2/30721 , A61B17/025 , A61B17/282 , A61B17/562 , A61B2017/0275 , A61F2/32 , A61F2/4607 , A61F2002/30004 , A61F2002/30112 , A61F2002/30113 , A61F2002/30118 , A61F2002/30125 , A61F2002/30135 , A61F2002/30136 , A61F2002/30156 , A61F2002/302 , A61F2002/30204 , A61F2002/30217 , A61F2002/30242 , A61F2002/30247 , A61F2002/30289 , A61F2002/30294 , A61F2002/30309 , A61F2002/30324 , A61F2002/30327 , A61F2002/30494 , A61F2002/30594 , A61F2002/30596 , A61F2002/30599 , A61F2002/30754 , A61F2002/30772 , A61F2220/0025 , A61F2230/0004 , A61F2230/0006 , A61F2230/0008 , A61F2230/0023 , A61F2230/0063 , A61F2230/0065 , A61F2230/0067 , A61F2230/0071 , A61F2230/0091 , A61F2250/0014 , A61F2250/0036 , A61F2250/0039 , A61F2250/0063 , A61L27/16 , A61L27/26 , C08L23/12
摘要： The present invention relates to a method and a device for alleviating and/or preventing conditions relating to damaged joints involving articulating surfaces, a prosthetic device for insertion into a joint cavity of a joint of a vertebrate, such as a human, said device consisting of a biocompatible material comprising at least a first polymeric component and a second polymeric component, wherein the chain length of the first polymeric component is longer than the chain length of the second polymeric component, the polymeric components in particular being polyethylene, polypropylene and/or polyvinylpyrrolidone. A further aspect of the invention relates to a method for introducing the prosthetic device into a joint, such as a method comprising locking the device to an intro-articular component, thereby fixing or retaining the device in the joint cavity in a manner which is substantially non-invasive with respect to cartilage and bone natively present in the joint cavity. Also the invention relates to an instrument for inserting a prosthetic device according to the invention, comprising means for deforming the prosthetic device into a reduced volume or a slender shape and means for grasping the intra-articular component to which the device is capable of interlocking.

10. 发明公开

EP2688499A1 TISSUE REPAIR WITH SPACE-SEEKING SPIRALS OF FILAMENT 失效
标题翻译： GEWEBEREPARATUR MIT RAUMSUCHENDEN FILAMENT-SPIRALEN
公开(公告)号：EP2688499A1
公开(公告)日：2014-01-29
申请号：EP12723539.8
申请日：2012-03-23
申请人： Yeung, Jeffrey E. , Yeung, Teresa, T.
发明人： Yeung, Jeffrey E. , Yeung, Teresa, T.
IPC分类号： A61B17/70 , A61F2/46 , A61F2/44 , A61B17/88 , A61B17/34
CPC分类号： A61F2/442 , A61B17/0483 , A61B17/3468 , A61B17/7061 , A61B17/7094 , A61B17/8852 , A61B2017/00805 , A61B2017/00867 , A61F2/0036 , A61F2/4611 , A61F2002/30289 , A61F2002/30294 , A61F2002/30677 , A61F2002/444 , A61F2002/4495 , A61F2002/4635 , A61F2210/0061 , A61F2230/0091 , A61F2250/0067 , A61F2310/00598 , A61F2310/0061 , A61F2310/0097 , A61F2310/00976 , A61F2310/00982
摘要： A distal portion of a filament is extended beyond the distal end of a needle with a gripper. The needle with the extended filament is inserted into a cannula with snagging points at the distal opening of the cannula in tissue. The snagging points of the cannula hook and retain the distal portion of the filament. During partial withdrawal of the needle, a section of filament is deposited in the lumen of the cannula between the distal ends of the needle and cannula. When the needle is re-advanced, the section of filament is expelled or pushed out of the cannula into tissue. The needle is then rotated; the gripper engages and spirals the expelled filament, burrowing into tissue. The needle can further advanced to push and pack the spiral of filament deep into the tissue. The knot-like filament spiral is individually formed by rotation of the needle and friction between the extended filament and tissue. The process of needle partial withdrawal, re-advancement, rotation and pushing is repeated to pack and fill the tissue with interconnecting spirals of filament to prevent migration from tissue. Spiraling of the filament driven by the rotating needle is space seeking, filling, fitting or conforming to fortify, bulk, fill, cushion or repair the tissue. Bulking with filament spirals can repair degenerated disc, urinary incontinence, fecal incontinence or other defective tissue. The filament spirals can also be used as a suture anchor deep within tissue.
摘要翻译：丝线的远端部分用夹具延伸超过针的远端。将具有延伸细丝的针插入具有在组织中插管的远端开口处的阻塞点的插管中。插管钩的阻塞点并保持丝的远端部分。在针的部分抽出期间，在针和插管的远端之间的一段细丝沉积在套管的内腔中。当针被再推进时，细丝的部分被排出或从套管推出到组织中。然后旋转针头; 夹具接合并螺旋排出的细丝，挖入组织。针可以进一步推进以将丝的螺旋深入到组织中。结状丝状螺旋通过针的旋转和延长的细丝与组织之间的摩擦分别形成。针头部分抽出，再推进，旋转和推动的过程重复，用纤维互连的螺旋填充和填充组织以防止从组织迁移。由旋转针驱动的细丝的螺旋形是空间寻找，填充，配合或符合强化，散装，填充，缓冲或修复组织。用丝线螺旋填充可以修复退化的椎间盘，尿失禁，大便失禁或其他有缺陷的组织。长丝螺旋也可以用作组织内部的缝合锚。

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