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1. 发明公开

EP4362850A1 IMPLANT DEVICES AND FABRICATION METHODS FOR IMPLANT DEVICES 审中-公开
公开(公告)号：EP4362850A1
公开(公告)日：2024-05-08
申请号：EP22748552.1
申请日：2022-06-30
申请人： Miach Orthopaedics, Inc. , Wohlert, Stephen
发明人： WOHLERT, Stephen
IPC分类号： A61F2/08
CPC分类号： A61F2/08 , A61B17/1146 , A61B2017/113220130101 , A61F2002/08720130101 , A61F2230/006920130101 , A61F2240/00420130101 , A61L27/3662 , A61L27/24 , A61B2017/0052620130101 , A61L27/3633

2. 发明授权

EP2787923B1 DECELLULARIZED COMPOSITE TISSUE BIOSCAFFOLDS FOR MUSCULOSKELETAL TISSUE INTERFACE RECONSTRUCTION AND METHODS OF PRODUCTION 有权
公开(公告)号：EP2787923B1
公开(公告)日：2018-10-31
申请号：EP12855670.1
申请日：2012-12-07
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： CHANG, James , WOON, Colin , PHAM, Hung
IPC分类号： A61F2/08 , A61L27/36 , A61K35/32
CPC分类号： A61F2/08 , A61K35/32 , A61L27/3683 , A61L27/3687 , A61L27/3691
摘要： One aspect of the present invention is a method of producing a decellularized composite tissue bioscaffold for musculoskeletal tissue interface reconstruction by physicochemically treating a musculoskeletal tissue interface isolated from allogeneic sources. In certain embodiments, such musculoskeletal tissue interfaces can also be isolated from xenogeneic sources. The method comprises treatment of the interface with detergents, chemical oxidants and ultrasonic energy, and wash steps in between to remove residual detergents as well as oxidants. The resulting bioscaffold may be freeze-dried or lyophilized, sterilized and aseptically packaged for subsequent use.

3. 发明公开

EP3218020A4 TISSUE SCAFFOLD DEVICE AND METHOD FOR FABRICATING THEREOF 有权
公开(公告)号：EP3218020A4
公开(公告)日：2018-07-18
申请号：EP15859055
申请日：2015-11-03
申请人： NAT UNIV SINGAPORE
发明人： THIAN ENG SAN , WANG ZUYONG , WANG EE JEN WILSON , HONG MINGHUI
IPC分类号： A61L27/14 , A61F2/00 , A61F2/02 , A61F2/08 , A61L27/12 , A61L27/18 , A61L27/24 , A61L27/56
CPC分类号： A61F2/08 , A61F2002/0081 , A61F2230/0091 , A61F2250/0023 , A61F2250/0028 , A61L27/12 , A61L27/18 , A61L27/24 , A61L27/56 , C08L67/04
摘要： The invention relates to a tissue scaffold device and a method for fabricating the tissue scaffold device. The tissue scaffold device comprises a porous core including a plurality of fibres and an outer portion at least substantially surrounding the porous core, wherein the outer portion includes a plurality of pores elongated along a longitudinal axis of the tissue scaffold device. The tissue scaffold device is preferably a tendon scaffold, and the fibres preferably comprise collagen and poly(ε-caprolactone) (PCL), with or without incorporation of hydroxyapatite nanoparticles.

4. 发明公开

EP3312327A1 REINFORCED ELECTROSPUN FIBROUS MEMBRANE AND PREPARATION METHOD THEREOF 有权
标题翻译：增强型电纺丝纤维膜及其制备方法
公开(公告)号：EP3312327A1
公开(公告)日：2018-04-25
申请号：EP16811022.9
申请日：2016-06-16
申请人： Medprin Regenerative Medical Technologies Co., Ltd.
发明人： LI, Guangyao , DENG, Kunxue , YANG, Yaya , YUAN, Yuyu
IPC分类号： D04H1/728 , D04H1/42 , D01D5/00
CPC分类号： D01D5/0007 , A61F2/08 , A61L27/58 , D01D5/00 , D04H1/42 , D04H1/728
摘要： The present application discloses a reinforced electrospun fibrous membrane and a preparation method thereof. The reinforced electrospun fibrous membrane comprises: an electrospun fibrous membrane body and a plurality of parallel reinforcing thread sets fixed to the electrospun fibrous membrane body via through holes thereon, wherein each of the reinforcing thread sets comprises a starting end and a terminal end, both being connected to an edge of the electrospun fibrous membrane body; each of the reinforcing thread sets comprises at least one reinforcing fibrous thread comprising a main thread and an auxiliary thread respectively arranged at a front side and a bottom side of the electrospun fibrous membrane body and configured to interlace each other at the through hole. By providing reinforcing thread sets on the electrospun fibrous membrane body to impart the electrospun fibrous membrane with a greater mechanical property, the mechanical strength required for the movement of the tissue is ensured, and the electrospun fibrous membrane is easy to be folded or rolled into other shapes. The electrospun fibrous membrane body may be made of degradable materials, which are gradually degraded and absorbed in the process of inducing new tissue formation, thereby providing space for the formation of new tissues.
摘要翻译：本申请公开了一种增强电纺纤维膜及其制备方法。增强电纺纤维膜包括：电纺纤维膜体和通过其上的通孔固定到电纺纤维膜体上的多根平行的增强线组，每根增强线组包括起始端和终止端，二者均为连接到电纺纤维膜体的边缘; 每根增强丝线组包括至少一根增强纤维丝线，所述增强纤维丝线包括主丝线和辅助丝线，所述主丝线和辅助丝线分别设置在所述电纺纤维薄膜体的前侧和底侧，并被配置为在所述通孔处彼此交织。通过在电纺纤维膜体上设置增强线组以赋予电纺纤维膜更大的机械性能，确保了组织移动所需的机械强度，并且电纺纤维膜易于折叠或卷成其他形状。静电纺纤维膜体可以由可降解材料制成，在诱导新组织形成的过程中逐渐被降解和吸收，从而为新组织形成提供空间。

5. 发明公开

EP3236885A1 DEVICE, SYSTEM AND METHOD FOR ANCHORING TO MUSCLE TISSUE 无效转让
标题翻译：用于锚定肌肉组织的装置，系统和方法
公开(公告)号：EP3236885A1
公开(公告)日：2017-11-01
申请号：EP15817351.8
申请日：2015-12-22
申请人： Synergio AG
发明人： SOLEM, Jan Otto
IPC分类号： A61F2/24 , A61M1/12
CPC分类号： A61F2/0811 , A61F2/08 , A61F2/2478 , A61F2002/0894 , A61F2002/249 , A61M1/1008 , A61M1/1012 , A61M1/1034 , A61M1/1068 , A61M1/1086 , A61M1/12
摘要： An implant for assisting contraction and/or extension of a muscle comprises a stem (10) with an adhesion resistant segment (14) and an anchoring segment (20) wherein at least a portion of each of said adhesion resistant segment and said anchoring segment is configured to be implantable within a muscle and said anchoring segment is positioned on a distal portion of said stem and said adhesion resistant segment is positioned proximally on said stem relative to said anchoring segment.
摘要翻译：一种用于辅助肌肉收缩和/或伸展的植入物，包括具有抗粘连部分（14）和锚定部分（20）的茎部（10），其中所述抗粘附部分和所述锚定部分中的每一个的至少一部分是被配置为可植入肌肉内，并且所述锚定段被定位在所述茎的远侧部分上，并且所述抗粘附段相对于所述锚定段被定位在所述茎的近侧。

6. 发明公开

EP3217920A1 RESORBABLE DEVICE FOR RECONSTRUCTING ROTATOR CUFFS 审中-公开
标题翻译：可重复使用的装置，用于重新构建旋转锉刀
公开(公告)号：EP3217920A1
公开(公告)日：2017-09-20
申请号：EP15808805.4
申请日：2015-11-12
申请人： Sambusseti, Antonio
发明人： Sambusseti, Antonio
IPC分类号： A61F2/00 , A61B17/11 , A61F2/08 , A61B17/00 , A61L27/58 , A61L17/12
CPC分类号： A61F2/0063 , A61B17/1146 , A61B2017/00004 , A61F2/08 , A61F2002/0068 , A61F2210/0004 , A61F2230/0023 , A61L17/06 , A61L31/06 , A61L31/148 , C08L67/04
摘要： A device for the reconstruction of the rotator cuff comprises a flat element (2) having at least two opposite ends (2a, 2b) and adapted to be connected to at least one of the damaged tendons of the rotator cuff of a patient at said ends (2a, 2b); said flat element (2) being entirely made of biodegradable and resorbable material.
摘要翻译：用于重建肩袖的装置包括扁平元件（2），所述扁平元件具有至少两个相对的端部（2a，2b）并且适于在所述端部处连接到患者的肩袖的至少一个受损肌腱（2a，2b）; 所述扁平元件（2）完全由可生物降解和可再吸收的材料制成。

7. 发明授权

EP2739241B1 CONNECTIVE TISSUE REPAIR 有权
标题翻译：连接组织修复
公开(公告)号：EP2739241B1
公开(公告)日：2017-09-06
申请号：EP12741064.5
申请日：2012-07-20
申请人： Xiros Limited
发明人： SEEDHOM, Bahaa Botros
IPC分类号： A61F2/00 , A61F2/08
CPC分类号： A61F2/08 , A61F2/0063 , A61F2002/087 , A61F2240/001 , B29C70/08 , B29L2031/7546

8. 发明授权

EP2271354B1 REINFORCED TISSUE GRAFT 有权
标题翻译：增强的组织移植
公开(公告)号：EP2271354B1
公开(公告)日：2017-07-05
申请号：EP09724439.6
申请日：2009-03-27
申请人： Cleveland Clinic Foundation
发明人： DERWIN, Kathleen , AURORA, Amit , IANNOTTI, Joseph, P. , MCCARRON, Jesse, A.
IPC分类号： A61K35/12 , A61L27/40 , A61L27/54 , A61F2/08
CPC分类号： A61L27/40 , A61F2/08 , A61L27/54
摘要： A biocompatible tissue graft is provided. The tissue graft includes an extracellular matrix patch and a means for reinforcing the patch.
摘要翻译：提供生物相容性组织移植物。组织移植物包括细胞外基质贴片和用于增强贴片的手段。

9. 发明公开

EP3184079A1 GRAFT PREPARATION SYSTEM 审中-实审
标题翻译： GRAFT准备系统
公开(公告)号：EP3184079A1
公开(公告)日：2017-06-28
申请号：EP16205252.6
申请日：2016-12-20
申请人： DePuy Synthes Products, LLC
发明人： GUSTAFSON, Adam C.
IPC分类号： A61F2/08
CPC分类号： A61F2/08 , A61F2240/001 , A61F2240/002
摘要： Systems and methods for preparing a ligament graft for a ligament reconstruction procedure are provided. In general, the described techniques utilize a graft holder construct having a graft preparation holder and a suture assembly removably coupled thereto. The graft preparation holder includes an elongate support rail having a longitudinal axis, and a plurality of leaf segments positioned along the longitudinal axis in a spaced relationship and extending laterally from the support rail. The leaf segments can bend to a graft holding configuration so as to define a graft receiving channel configured to receive a graft therethrough. The holder also has at least one support structure configured to mate with the leaf segments to provide stability and rigidity to the segments. The suture assembly has at least one suture tail that can be pulled to affix the suture assembly to a graft without penetrating the graft.
摘要翻译：提供了用于制备用于韧带重建程序的韧带移植物的系统和方法。通常，所描述的技术利用具有移植物制备保持器和可移除地联接到其上的缝合线组件的移植物保持器构造。移植制备支架包括具有纵向轴线的细长支撑导轨以及多个沿着纵向轴线以间隔关系设置并且从支撑导轨横向延伸的叶片段。叶片段可以弯曲成移植物保持结构，以便限定移植物接收通道，该移植物接收通道被配置为接收穿过其中的移植物。保持器还具有至少一个支撑结构，该支撑结构被构造成与叶片段配合以向该段提供稳定性和刚性。缝合线组件具有至少一个缝合线尾部，缝合线尾部可以被拉动以将缝合线组件固定到移植物而不穿透移植物。

10. 发明公开

EP3183387A1 COMPOSITE COMPRISING FABRIC AND POLYAMPHOLYTE HYDROGEL AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：包含织物和聚甘油水合物的复合材料及其制备方法
公开(公告)号：EP3183387A1
公开(公告)日：2017-06-28
申请号：EP14900111.7
申请日：2014-08-19
申请人： National University Corporation Hokkaido University
发明人： GONG, Jian Ping , KUROKAWA, Takayuki , SUN, Tao Lin , KING, Daniel , CROSBY, Alfred
IPC分类号： D06M14/18 , A61F2/08 , A61F2/10 , A61L27/00
CPC分类号： A61F2/08 , A61L15/60 , A61L27/10 , A61L27/16 , A61L27/446 , A61L27/48 , A61L27/52 , A61L27/60 , A61L2430/10 , C08J5/2231 , C08J2325/18 , C08J2339/08 , D06M15/233 , D06M15/267 , D06M15/285 , D06M15/3562 , D06M15/3566
摘要： A composite comprising a fabric and a polyampholyte hydrogel is provided. In the composite, the polyampholyte hydrogel is a hydrogel of a polymer bearing randomly dispersed cationic and anionic repeat groups and at least a part of the fabric is coated with the polyampholyte hydrogel. A method of preparation of the composite comprises steps (a) to (c): (a) providing a monomer mixture for preparation of a polyampholyte hydrogel; (b) immersing a fabric in the monomer mixture solution; and (c) polymerizing monomers in the monomer mixture solution to obtain a precursor of the composite.
摘要翻译：提供了包含织物和聚两性电解质水凝胶的复合材料。在复合材料中，聚两性电解质水凝胶是具有无规分散的阳离子和阴离子重复基团的聚合物的水凝胶，并且至少一部分织物涂覆有聚两性电解质水凝胶。制备该复合材料的方法包括步骤（a）至（c）：（a）提供用于制备聚两性电解质水凝胶的单体混合物; （b）将织物浸入单体混合物溶液中; 和（c）在单体混合物溶液中聚合单体以获得复合物的前体。

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