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1. 发明授权

EP2610322B1 SEMICONDUCTOR NANOPARTICLE ASSEMBLY 有权
标题翻译：半导体纳米粒子形成
公开(公告)号：EP2610322B1
公开(公告)日：2015-05-27
申请号：EP11819625.2
申请日：2011-03-15
申请人： Konica Minolta Medical & Graphic, Inc. , Tohoku University
发明人： TAKAHASHI, Masaru , TAKANASHI, Kensaku , HOSHINO, Hideki , GONDA, Kohsuke , TAKEDA, Motohiro , OHUCHI, Noriaki
IPC分类号： B82B1/00 , C09K11/88 , C01B19/00 , C01B25/08 , C09K11/02 , H01L33/06 , C01B25/22
CPC分类号： H01L33/06 , C01B25/2212 , C09K11/02 , C09K11/025 , C09K11/88

2. 发明授权

EP2618154B1 METHOD FOR DETERMINING EFFECTIVENESS OF MEDICINE CONTAINING ANTIBODY AS COMPONENT 有权
标题翻译：方法用于确定药物的有效性与抗体作为一个组件
公开(公告)号：EP2618154B1
公开(公告)日：2016-12-14
申请号：EP11824725.3
申请日：2011-08-26
申请人： Tohoku University
发明人： MIYASHITA, Minoru , GONDA, Kohsuke , OHUCHI, Noriaki , TAKEDA, Motohiro
IPC分类号： G01N33/574 , G01N21/64 , G01N21/78 , G01N33/536 , G01N33/58 , G01N33/68
CPC分类号： G01N21/6486 , G01N21/6428 , G01N21/6456 , G01N33/582 , G01N33/6854 , G01N33/94 , G01N2800/52

3. 发明公开

EP2613145A1 TISSUE STAINING METHOD, TISSUE EVALUATION METHOD AND BIOSUBSTANCE DETECTION METHOD 有权
标题翻译： GEWEBEFÄRBEVERFAHREN，GEWEBEAUSWERTUNGSVERFAHREN UND VERFAHREN ZUM NACHWEIS VON BIOSUBSTANZEN
公开(公告)号：EP2613145A1
公开(公告)日：2013-07-10
申请号：EP11821360.2
申请日：2011-03-15
申请人： Konica Minolta Medical & Graphic, Inc. , Tohoku University
发明人： AIMIYA, Takuji , GOUDA, Hideki , OKADA, Hisatake , NAKANO, Yasushi , GONDA, Kohsuke , TAKEDA, Motohiro , OHUCHI, Noriaki
IPC分类号： G01N33/48 , G01N1/28 , G01N1/30 , G01N21/64 , G01N33/53 , G01N33/574
CPC分类号： G01N1/30 , B82Y15/00 , B82Y30/00 , G01N21/6428 , G01N33/582 , G01N33/588 , G01N33/74 , G01N33/743 , G01N2001/302 , G01N2021/6441 , G01N2333/71 , G01N2333/723 , G01N2333/91205
摘要： A tissue staining method which comprises: staining a tissue with a staining reagent wherein a biosubstance recognition site is bonded to particles carrying multiple fluorescent substances accumulated therein; in the stained tissue, counting fluorescent points or measuring fluorescent brightness; and evaluating the expression level of a biosubstance, which matches the biosubstance recognition site, in the aforesaid tissue on the basis of the number of the fluorescent points or fluorescent brightness that was measured.
摘要翻译：一种组织染色方法，包括：用染色试剂染色组织，其中生物素识别位点与携带多种荧光物质的颗粒结合; 在染色的组织中，计数荧光点或测量荧光亮度; 并根据测定的荧光点数或荧光亮度，评价与上述组织中生物素识别位点相符的生物素的表达量。

4. 发明公开

EP2613138A1 BIOLOGICAL SUBSTANCE DETECTION METHOD 有权转让
标题翻译： VERFAHREN ZUM NACHWEIS生物学家STOFFE
公开(公告)号：EP2613138A1
公开(公告)日：2013-07-10
申请号：EP11821768.6
申请日：2011-08-30
申请人： Konica Minolta Medical & Graphic, Inc. , Tohoku University
发明人： TAKANASHI, Kensaku , GOUDA, Hideki , OKADA, Hisatake , NAKANO, Yasushi , GONDA, Kohsuke , TAKEDA, Motohiro , OHUCHI, Noriaki
IPC分类号： G01N21/64 , G01N21/27 , G01N33/48 , G01N33/53
CPC分类号： G01N21/6486 , G01N21/6428 , G01N21/6458 , G01N33/4833 , G01N33/582 , G01N2021/6439 , G01N2021/6441
摘要： A biological substance detection method for detecting a biological substance specifically in a pathological specimen, comprising a step of immunologically staining the pathological specimen using a fluorescent label, a step of staining the pathological specimen with a staining reagent for morphology observation purposes (eosin) to observe the morphology of the pathological specimen, a step of irradiating the stained pathological specimen with excited light to cause the emission of a fluorescent and detecting the biological substance in the pathological specimen. In the step of immunologically staining the pathological specimen, a special fluorescent particle for which the excitation wavelength appears in a region that is different from the excitation wavelength region of eosin is used as the fluorescent label.
摘要翻译：一种用于特异性检测病理标本中生物物质的生物物质检测方法，包括使用荧光标记物对病理标本进行免疫染色的步骤，用形态学观察目的的染色试剂（曙红）染色病理标本的步骤，以观察病理标本的形态，用激发光照射染色的病理标本以引起荧光发射并检测病理标本中的生物物质的步骤。在病理标本免疫染色的步骤中，使用在与曙红的激发波长区域不同的区域中出现激发波长的特殊荧光粒子作为荧光标记。

5. 发明公开

EP2613151A1 METHOD FOR DETERMINING CANCER ONSET OR CANCER ONSET RISK 有权
标题翻译：程序用于确定癌症的爆发，否则风险用于癌症的爆发
公开(公告)号：EP2613151A1
公开(公告)日：2013-07-10
申请号：EP11821292.7
申请日：2011-08-26
申请人： Tohoku University
发明人： GONDA, Kohsuke , MIYASHITA, Minoru , TAKEDA, Motohiro , OHUCHI, Noriaki
IPC分类号： G01N33/574 , G01N21/64 , G01N33/48 , G01N33/53 , G01N33/536
CPC分类号： G01N21/6486 , B82Y15/00 , G01N21/6428 , G01N21/6458 , G01N33/57415 , G01N33/588 , G01N2800/50
摘要： Provided is a method for highly accurately and quantitatively determining cancer onset or cancer onset risk by quantitative tissue-staining which is conducted in a biotissue with the use of an antibody capable of recognizing a cancer proliferation inhibitor or a cancer metastasis inhibitor, for example, PAR1 antibody inhibiting the mobility and infiltrating properties of cancer cells. Cancer onset or cancer onset risk is determined by a tissue staining method, said method comprising: a step for labeling an antibody, which is capable of recognizing a cancer proliferation inhibitor or a cancer metastasis inhibitor, with a fluorescent substance and then contacting the fluorescent-labeled antibody with a tissue sample; a step for irradiating a tissue site, which has been contacted with said antibody, with an excitation light to give a fluorescence image; a step for acquiring an intrinsic fluorescence image in a neighborhood region on a shorter or longer wavelength side, compared with the region wherein the wavelength of the fluorescence emitted by the fluorescent substance is acquired, in the same visual field at the same focus point as said fluorescence image; a step for conducting an image processing for removing the fluorescent brightness of said intrinsic fluorescence image from the fluorescent brightness of said fluorescence image to give a corrected fluorescence image; a step for counting cells at the tissue site which has been contacted with the antibody; a step for measuring the average fluorescent brightness per fluorescent particle; and a step for calculating the fluorescent particle count per cell.
摘要翻译：本发明提供一种方法高度准确地设置，并通过定量组织染色定量的确定性采矿癌症发病或癌症发病风险的所有其在生物组织传导通过使用能够识别癌症增殖抑制剂或癌转移抑制剂，例如，PAR1的抗体的抗体抑制流动性和浸润性肿瘤细胞的性质。癌症发病或癌症发病风险是确定性的开采通过组织染色方法，所述方法包括：用于抗体的标记的步骤，所有这些都能够认识到癌症增殖抑制剂或癌转移抑制剂，用荧光物质，然后接触的荧光基团的标记的抗体与组织样品; 用于照射的组织部位，其在激发光被接触与所述抗体，与得到的荧光图像的步骤; 在相同的聚焦点作为所述附近区域内在荧光图像的获取关于一个更短或更长的波长侧，与worin由荧光物质发出的荧光的波长获取的区域相比，在相同的视野的工序荧光图像; 用于进行用于从所述荧光图像的荧光亮度去除所述固有荧光图像的荧光亮度，得到校正荧光图像的图像处理的步骤; 在其中已经与抗体的组织部位的细胞计数的步骤; 用于测量由荧光体粒子的平均荧光亮度的步骤; 和用于计算所述荧光颗粒中的步骤每细胞计数。

6. 发明公开

EP2610212A1 SEMICONDUCTOR NANOPARTICLE AGGREGATE AND PRODUCTION METHOD FOR SEMICONDUCTOR NANOPARTICLE AGGREGATE 有权
标题翻译：半导体纳米颗粒的单位及方法半导体纳米粒子的PowerPack
公开(公告)号：EP2610212A1
公开(公告)日：2013-07-03
申请号：EP11819626.0
申请日：2011-03-15
申请人： Konica Minolta Medical & Graphic, Inc. , Tohoku University
发明人： HOSHINO, Hideki , TAKAHASHI, Masaru , GONDA, Kohsuke , TAKEDA, Motohiro , OHUCHI, Noriaki
IPC分类号： B82B1/00 , B82B3/00 , C09K11/08 , C09K11/54 , C09K11/56 , C09K11/88
CPC分类号： C09K11/00 , A61K49/0067 , B01J13/04 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B33/18 , C09K11/02 , C09K11/025 , C09K11/565 , C09K11/592 , C09K11/62 , C09K11/70 , C09K11/883 , G01N33/588 , H01B1/02
摘要： A semiconductor nanoparticle aggregate containing semiconductor nanoparticles with a core/shell structure is formed by controlling with physical energy the aggregation state of an agglomerate from agglomerated semiconductor nanoparticles.
摘要翻译：含半导体纳米粒子具有核/壳结构的半导体纳米颗粒聚集体是通过用物理能量控制来自半导体纳米颗粒凝聚的凝聚体的聚集状态形成。

7. 发明公开

EP2267125A1 CANCER CELL MOTILITY AND CANCER CELL INFILTRATION INHIBITOR 有权
标题翻译： KREBSZELLENMOTILITÄTS-联合吉非他明
公开(公告)号：EP2267125A1
公开(公告)日：2010-12-29
申请号：EP09726307.3
申请日：2009-03-19
申请人： Tohoku University
发明人： GONDA, Kohsuke , HIGUCHI, Hideo , OHUCHI, Noriaki , TAKEDA, Motohiro
IPC分类号： C12N15/09 , A61K39/395 , A61P35/00 , C07K1/22 , C07K7/06 , C07K14/705 , C07K16/46 , C07K19/00 , G01N33/574 , G01N33/577 , C12P21/08
CPC分类号： C07K16/28 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K2317/34 , C07K2317/76 , G01N33/5029 , G01N33/574 , G01N2500/02 , G01N2500/10 , G01N2800/00
摘要： Provided are an antibody which binds specifically to PAR1 (protease activated receptor 1) or a fragment of the antibody which retains similar characteristics thereto; a composition containing the same for inhibiting the migration activity and invasion activity of cancer cells; and a medicinal composition for treating cancer and the like.
摘要翻译：提供了与PAR1（蛋白酶活化受体1）或与其保持相似特征的抗体片段特异性结合的抗体; 含有该组合物的组合物，用于抑制癌细胞的迁移活性和侵袭活性; 以及用于治疗癌症等的药物组合物。

8. 发明授权

EP2613151B1 METHOD FOR DETERMINING CANCER ONSET OR CANCER ONSET RISK 有权
标题翻译：程序用于确定癌症的爆发，否则风险用于癌症的爆发
公开(公告)号：EP2613151B1
公开(公告)日：2016-06-29
申请号：EP11821292.7
申请日：2011-08-26
申请人： Tohoku University
发明人： GONDA, Kohsuke , MIYASHITA, Minoru , TAKEDA, Motohiro , OHUCHI, Noriaki
IPC分类号： G01N33/574 , G01N21/64 , G01N33/48 , G01N33/53 , G01N33/536 , G01N33/58
CPC分类号： G01N21/6486 , B82Y15/00 , G01N21/6428 , G01N21/6458 , G01N33/57415 , G01N33/588 , G01N2800/50

9. 发明授权

EP2267125B1 CANCER CELL MIGRATION AND CANCER CELL INVASION INHIBITOR 有权
标题翻译： KREBSZELLENMOTILITÄTS-和癌细胞浸润抑制剂
公开(公告)号：EP2267125B1
公开(公告)日：2015-09-02
申请号：EP09726307.3
申请日：2009-03-19
申请人： Tohoku University
发明人： GONDA, Kohsuke , HIGUCHI, Hideo , OHUCHI, Noriaki , TAKEDA, Motohiro
IPC分类号： C12N15/09 , A61K39/395 , A61P35/00 , C07K1/22 , C07K7/06 , C07K14/705 , C07K16/46 , C07K19/00 , G01N33/574 , G01N33/577 , C12P21/08
CPC分类号： C07K16/28 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K2317/34 , C07K2317/76 , G01N33/5029 , G01N33/574 , G01N2500/02 , G01N2500/10 , G01N2800/00

10. 发明公开

EP2610322A1 SEMICONDUCTOR NANOPARTICLE ASSEMBLY 有权
标题翻译： HALBLEITER-NANOPARTIKEL-ANORDNUNG
公开(公告)号：EP2610322A1
公开(公告)日：2013-07-03
申请号：EP11819625.2
申请日：2011-03-15
申请人： Konica Minolta Medical & Graphic, Inc. , Tohoku University
发明人： TAKAHASHI, Masaru , TAKANASHI, Kensaku , HOSHINO, Hideki , GONDA, Kohsuke , TAKEDA, Motohiro , OHUCHI, Noriaki
IPC分类号： C09K11/08 , B82B1/00 , C09K11/70 , C09K11/88 , C01B19/00 , C01B25/08
CPC分类号： H01L33/06 , C01B25/2212 , C09K11/02 , C09K11/025 , C09K11/88
摘要： A semiconductor nanoparticle assembly including semiconductor nanoparticles having a core/shell structure, and wherein the semiconductor nanoparticles are bonded by means of amide bonds.
摘要翻译：一种包含具有核/壳结构的半导体纳米颗粒的半导体纳米颗粒组件，并且其中半导体纳米颗粒通过酰胺键键合。

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