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1. 发明公开

EP2610322A1 SEMICONDUCTOR NANOPARTICLE ASSEMBLY 有权
标题翻译： HALBLEITER-NANOPARTIKEL-ANORDNUNG
公开(公告)号：EP2610322A1
公开(公告)日：2013-07-03
申请号：EP11819625.2
申请日：2011-03-15
申请人： Konica Minolta Medical & Graphic, Inc. , Tohoku University
发明人： TAKAHASHI, Masaru , TAKANASHI, Kensaku , HOSHINO, Hideki , GONDA, Kohsuke , TAKEDA, Motohiro , OHUCHI, Noriaki
IPC分类号： C09K11/08 , B82B1/00 , C09K11/70 , C09K11/88 , C01B19/00 , C01B25/08
CPC分类号： H01L33/06 , C01B25/2212 , C09K11/02 , C09K11/025 , C09K11/88
摘要： A semiconductor nanoparticle assembly including semiconductor nanoparticles having a core/shell structure, and wherein the semiconductor nanoparticles are bonded by means of amide bonds.
摘要翻译：一种包含具有核/壳结构的半导体纳米颗粒的半导体纳米颗粒组件，并且其中半导体纳米颗粒通过酰胺键键合。

2. 发明授权

EP2610322B1 SEMICONDUCTOR NANOPARTICLE ASSEMBLY 有权
标题翻译：半导体纳米粒子形成
公开(公告)号：EP2610322B1
公开(公告)日：2015-05-27
申请号：EP11819625.2
申请日：2011-03-15
申请人： Konica Minolta Medical & Graphic, Inc. , Tohoku University
发明人： TAKAHASHI, Masaru , TAKANASHI, Kensaku , HOSHINO, Hideki , GONDA, Kohsuke , TAKEDA, Motohiro , OHUCHI, Noriaki
IPC分类号： B82B1/00 , C09K11/88 , C01B19/00 , C01B25/08 , C09K11/02 , H01L33/06 , C01B25/22
CPC分类号： H01L33/06 , C01B25/2212 , C09K11/02 , C09K11/025 , C09K11/88

3. 发明公开

EP2610212A1 SEMICONDUCTOR NANOPARTICLE AGGREGATE AND PRODUCTION METHOD FOR SEMICONDUCTOR NANOPARTICLE AGGREGATE 有权
标题翻译：半导体纳米颗粒的单位及方法半导体纳米粒子的PowerPack
公开(公告)号：EP2610212A1
公开(公告)日：2013-07-03
申请号：EP11819626.0
申请日：2011-03-15
申请人： Konica Minolta Medical & Graphic, Inc. , Tohoku University
发明人： HOSHINO, Hideki , TAKAHASHI, Masaru , GONDA, Kohsuke , TAKEDA, Motohiro , OHUCHI, Noriaki
IPC分类号： B82B1/00 , B82B3/00 , C09K11/08 , C09K11/54 , C09K11/56 , C09K11/88
CPC分类号： C09K11/00 , A61K49/0067 , B01J13/04 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B33/18 , C09K11/02 , C09K11/025 , C09K11/565 , C09K11/592 , C09K11/62 , C09K11/70 , C09K11/883 , G01N33/588 , H01B1/02
摘要： A semiconductor nanoparticle aggregate containing semiconductor nanoparticles with a core/shell structure is formed by controlling with physical energy the aggregation state of an agglomerate from agglomerated semiconductor nanoparticles.
摘要翻译：含半导体纳米粒子具有核/壳结构的半导体纳米颗粒聚集体是通过用物理能量控制来自半导体纳米颗粒凝聚的凝聚体的聚集状态形成。

4. 发明公开

EP2613145A1 TISSUE STAINING METHOD, TISSUE EVALUATION METHOD AND BIOSUBSTANCE DETECTION METHOD 有权
标题翻译： GEWEBEFÄRBEVERFAHREN，GEWEBEAUSWERTUNGSVERFAHREN UND VERFAHREN ZUM NACHWEIS VON BIOSUBSTANZEN
公开(公告)号：EP2613145A1
公开(公告)日：2013-07-10
申请号：EP11821360.2
申请日：2011-03-15
申请人： Konica Minolta Medical & Graphic, Inc. , Tohoku University
发明人： AIMIYA, Takuji , GOUDA, Hideki , OKADA, Hisatake , NAKANO, Yasushi , GONDA, Kohsuke , TAKEDA, Motohiro , OHUCHI, Noriaki
IPC分类号： G01N33/48 , G01N1/28 , G01N1/30 , G01N21/64 , G01N33/53 , G01N33/574
CPC分类号： G01N1/30 , B82Y15/00 , B82Y30/00 , G01N21/6428 , G01N33/582 , G01N33/588 , G01N33/74 , G01N33/743 , G01N2001/302 , G01N2021/6441 , G01N2333/71 , G01N2333/723 , G01N2333/91205
摘要： A tissue staining method which comprises: staining a tissue with a staining reagent wherein a biosubstance recognition site is bonded to particles carrying multiple fluorescent substances accumulated therein; in the stained tissue, counting fluorescent points or measuring fluorescent brightness; and evaluating the expression level of a biosubstance, which matches the biosubstance recognition site, in the aforesaid tissue on the basis of the number of the fluorescent points or fluorescent brightness that was measured.
摘要翻译：一种组织染色方法，包括：用染色试剂染色组织，其中生物素识别位点与携带多种荧光物质的颗粒结合; 在染色的组织中，计数荧光点或测量荧光亮度; 并根据测定的荧光点数或荧光亮度，评价与上述组织中生物素识别位点相符的生物素的表达量。

5. 发明公开

EP2613138A1 BIOLOGICAL SUBSTANCE DETECTION METHOD 有权转让
标题翻译： VERFAHREN ZUM NACHWEIS生物学家STOFFE
公开(公告)号：EP2613138A1
公开(公告)日：2013-07-10
申请号：EP11821768.6
申请日：2011-08-30
申请人： Konica Minolta Medical & Graphic, Inc. , Tohoku University
发明人： TAKANASHI, Kensaku , GOUDA, Hideki , OKADA, Hisatake , NAKANO, Yasushi , GONDA, Kohsuke , TAKEDA, Motohiro , OHUCHI, Noriaki
IPC分类号： G01N21/64 , G01N21/27 , G01N33/48 , G01N33/53
CPC分类号： G01N21/6486 , G01N21/6428 , G01N21/6458 , G01N33/4833 , G01N33/582 , G01N2021/6439 , G01N2021/6441
摘要： A biological substance detection method for detecting a biological substance specifically in a pathological specimen, comprising a step of immunologically staining the pathological specimen using a fluorescent label, a step of staining the pathological specimen with a staining reagent for morphology observation purposes (eosin) to observe the morphology of the pathological specimen, a step of irradiating the stained pathological specimen with excited light to cause the emission of a fluorescent and detecting the biological substance in the pathological specimen. In the step of immunologically staining the pathological specimen, a special fluorescent particle for which the excitation wavelength appears in a region that is different from the excitation wavelength region of eosin is used as the fluorescent label.
摘要翻译：一种用于特异性检测病理标本中生物物质的生物物质检测方法，包括使用荧光标记物对病理标本进行免疫染色的步骤，用形态学观察目的的染色试剂（曙红）染色病理标本的步骤，以观察病理标本的形态，用激发光照射染色的病理标本以引起荧光发射并检测病理标本中的生物物质的步骤。在病理标本免疫染色的步骤中，使用在与曙红的激发波长区域不同的区域中出现激发波长的特殊荧光粒子作为荧光标记。

6. 发明授权

EP2613151B1 METHOD FOR DETERMINING CANCER ONSET OR CANCER ONSET RISK 有权
标题翻译：程序用于确定癌症的爆发，否则风险用于癌症的爆发
公开(公告)号：EP2613151B1
公开(公告)日：2016-06-29
申请号：EP11821292.7
申请日：2011-08-26
申请人： Tohoku University
发明人： GONDA, Kohsuke , MIYASHITA, Minoru , TAKEDA, Motohiro , OHUCHI, Noriaki
IPC分类号： G01N33/574 , G01N21/64 , G01N33/48 , G01N33/53 , G01N33/536 , G01N33/58
CPC分类号： G01N21/6486 , B82Y15/00 , G01N21/6428 , G01N21/6458 , G01N33/57415 , G01N33/588 , G01N2800/50

7. 发明授权

EP2267125B1 CANCER CELL MIGRATION AND CANCER CELL INVASION INHIBITOR 有权
标题翻译： KREBSZELLENMOTILITÄTS-和癌细胞浸润抑制剂
公开(公告)号：EP2267125B1
公开(公告)日：2015-09-02
申请号：EP09726307.3
申请日：2009-03-19
申请人： Tohoku University
发明人： GONDA, Kohsuke , HIGUCHI, Hideo , OHUCHI, Noriaki , TAKEDA, Motohiro
IPC分类号： C12N15/09 , A61K39/395 , A61P35/00 , C07K1/22 , C07K7/06 , C07K14/705 , C07K16/46 , C07K19/00 , G01N33/574 , G01N33/577 , C12P21/08
CPC分类号： C07K16/28 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K2317/34 , C07K2317/76 , G01N33/5029 , G01N33/574 , G01N2500/02 , G01N2500/10 , G01N2800/00

8. 发明公开

EP2755026A1 METHOD FOR STAINING TISSUE 有权转让
标题翻译： VERFAHREN ZUMFÄRBENVON GEWEBEN
公开(公告)号：EP2755026A1
公开(公告)日：2014-07-16
申请号：EP12829474.1
申请日：2012-09-04
申请人： Konica Minolta, Inc. , Tohoku University
发明人： GOUDA, Hideki , OKADA, Hisatake , NAKANO, Yasushi , GONDA, Kohsuke , OHUCHI, Noriaki , WATANABE, Mika
IPC分类号： G01N33/48 , G01N1/30 , G01N21/78 , G01N33/53 , G01N33/536
CPC分类号： G01N33/569 , G01N1/30
摘要： It is an object of the present invention to provide a tissue staining method that makes it possible to observe both information on the morphology of a tissue and information on a biological substance such as an antigen molecule to be detected on a single section and in a single view field. The present invention provides a tissue staining method, including carrying out (A) a HE (hematoxylin-eosin) staining, and (B) a histochemical staining, serially on a single tissue section, wherein the histochemical staining is defined as a histochemical technique for detecting a biological substance to be detected in a tissue in a visible manner by use of a binding reaction between the biological substance to be detected and a probe biological substance capable of binding specifically to the biological substance to be detected.
摘要翻译：本发明的目的是提供一种组织染色方法，其可以在单个部分和单个部分上观察关于组织形态的信息和关于待检测的抗原分子的生物物质的信息查看字段。本发明提供一种组织染色方法，其包括在单个组织切片上连续进行（A）HE（苏木精 - 伊红）染色和（B）组织化学染色，其中组织化学染色定义为组织化学技术通过使用待检测的生物物质和能够特异性结合待检测的生物物质的探针生物物质之间的结合反应，以可见的方式检测待检测的生物物质。

9. 发明授权

EP2618154B1 METHOD FOR DETERMINING EFFECTIVENESS OF MEDICINE CONTAINING ANTIBODY AS COMPONENT 有权
标题翻译：方法用于确定药物的有效性与抗体作为一个组件
公开(公告)号：EP2618154B1
公开(公告)日：2016-12-14
申请号：EP11824725.3
申请日：2011-08-26
申请人： Tohoku University
发明人： MIYASHITA, Minoru , GONDA, Kohsuke , OHUCHI, Noriaki , TAKEDA, Motohiro
IPC分类号： G01N33/574 , G01N21/64 , G01N21/78 , G01N33/536 , G01N33/58 , G01N33/68
CPC分类号： G01N21/6486 , G01N21/6428 , G01N21/6456 , G01N33/582 , G01N33/6854 , G01N33/94 , G01N2800/52

10. 发明公开

EP2755019A1 BIOLOGICAL SUBSTANCE DETECTION METHOD 有权转让
标题翻译： VERFAHREN ZUM NACHWEIS生物学家STOFFE
公开(公告)号：EP2755019A1
公开(公告)日：2014-07-16
申请号：EP12829813.0
申请日：2012-09-04
申请人： Konica Minolta, Inc. , Tohoku University
发明人： TAKANASHI, Kensaku , OKADA, Hisatake , NAKANO, Yasushi , GONDA, Kohsuke , OHUCHI, Noriaki , WATANABE, Mika
IPC分类号： G01N21/64
CPC分类号： G01N33/582 , G01N21/6428 , G01N33/56966 , G01N33/57492 , G01N2021/6439 , G01N2333/70596
摘要： The present invention provides a biological substance detection method for specifically detecting a biological substance from a pathological specimen, by which method, when immunostaining using a fluorescent label and staining for morphological observation using a staining agent for morphological observation are simultaneously performed, the results of fluorescence observation and immunostaining can be assessed properly even if the fluorescent label and/or the staining agent is/are deteriorated by irradiation with an excitation light. The biological substance detection method according to the present invention is characterized in that the brightness retention rate of an immunostained part is in a range of 80% to 120% in relation to the brightness retention rate of a part stained for morphological observation when the fluorescent label used for the immunostaining is observed.
摘要翻译：本发明提供了一种用于特异性检测来自病理标本的生物物质的生物物质检测方法，通过该方法，当使用荧光标记物进行免疫染色并同时进行用于形态学观察的染色剂的形态观察染色时，荧光检测结果即使通过用激发光照射使荧光标记和/或染色剂劣化，也可以适当地评价观察和免疫染色。根据本发明的生物物质检测方法的特征在于，当荧光标记物的形态学观察时，与染色的部分的亮度保持率相比，免疫染色部分的亮度保持率在80％至120％的范围内用于免疫染色观察。

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