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1. 发明公开

EP1942180A1 NOVEL MICROORGANISM AND METHOD FOR PRODUCING CAROTENOID USING THE SAME 审中-公开
标题翻译：维也纳中华人民共和国新加坡人民解放军
公开(公告)号：EP1942180A1
公开(公告)日：2008-07-09
申请号：EP06810556.8
申请日：2006-09-26
申请人： Tosoh Corporation
发明人： TANAKA, Toru , IDE, Teruhiko , MURAYAMA, Kei-ichi , OE, Seigou , IMAIZUMI, Toru , HANZAWA, Satoshi , TOYOSHIMA, Toshinobu
IPC分类号： C12N1/20 , C12P23/00
CPC分类号： C12R1/01 , C12P23/00
摘要： To provide a microorganism capable of producing a large amount of carotenoids, mainly astaxanthin, and to provide a method of producing carotenoids using the microorganism, a microorganism having improved carotenoid productivity is used, which is obtainable by breeding a carotenoid producing Paracoccus bacteria which is featured by producing 720 mg or more carotenoid per 1 L of culture medium. Also used is a method of producing carotenoids using the bacterium.
摘要翻译：为了提供能够产生大量类胡萝卜素（主要是虾青素）的微生物，并且提供使用该微生物生产类胡萝卜素的方法，使用具有改善的类胡萝卜素生产率的微生物，其可通过育种产生类胡萝卜素的副细菌获得，其具有特征通过每1升培养基产生720mg以上的类胡萝卜素。也是使用细菌生产类胡萝卜素的方法。

2. 发明公开

EP2546341A1 FC BINDING PROTEIN AND METHOD FOR PRODUCING SAME 有权
标题翻译： FC结合蛋白及其生产方法
公开(公告)号：EP2546341A1
公开(公告)日：2013-01-16
申请号：EP11753056.8
申请日：2011-03-10
申请人： Sagami Chemical Research Institute , Tosoh Corporation
发明人： HATAYAMA, Kouta , ASAOKA, Yoshiharu , TANAKA, Toru , IDE, Teruhiko
IPC分类号： C12N15/09 , C07K14/735 , C12N1/21 , C12P21/02
CPC分类号： C07K14/70535 , C07K1/22 , C07K17/08 , C07K2319/21
摘要： Disclosed are: an Fc binding protein having increased stability with respect to heat, acid, and/or alkalinity compared with the wild type; a method for producing same; and a method for specifically isolating protein containing an Fc binding protein binding site using said Fc binding protein as a ligand for affinity chromatography.
An Fc binding protein was obtained having increased stability with respect to heat, acid, and/or alkalinity compared with the wild-type human Fc receptor by means of substituting at least one specific amino acid residue in the extracellular domain of the wild-type human Fc receptor with another amino acid residue. The Fc binding protein is useful as a ligand for affinity chromatography for example by immobilizing in a solid phase. Also, when the Fc binding protein is expressed using a host that has been transformed with an expression vector containing a polynucleotide coding for said protein, the amount of produced protein is increased compared with using a wild-type human Fc receptor.
摘要翻译：公开了：与野生型相比，具有增加的热，酸和/或碱度稳定性的Fc结合蛋白; 其制造方法; 以及使用所述Fc结合蛋白作为亲和层析的配体特异性分离含有Fc结合蛋白结合位点的蛋白的方法。通过取代野生型人类细胞外结构域中的至少一个特定氨基酸残基，获得与野生型人类Fc受体相比具有关于热，酸和/或碱度增加的稳定性的Fc结合蛋白 Fc受体与另一个氨基酸残基。 Fc结合蛋白可用作亲和层析的配体，例如通过固定在固相中。此外，当使用已经用含有编码所述蛋白质的多核苷酸的表达载体转化的宿主表达Fc结合蛋白时，与使用野生型人Fc受体相比，产生的蛋白质的量增加。

4. 发明公开

EP1942185A1 METHOD FOR PRODUCTION OF CAROTENOID-SYNTHESIZING MICROORGANISM AND METHOD FOR PRODUCTION OF CAROTENOID 审中-公开
标题翻译：工艺用于生产类胡萝卜素类胡萝卜素一个合成微生物和方法
公开(公告)号：EP1942185A1
公开(公告)日：2008-07-09
申请号：EP06810472.8
申请日：2006-09-25
申请人： Tosoh Corporation
发明人： IDE, Teruhiko , TANAKA, Toru
IPC分类号： C12N15/09 , A23K1/16 , A23L1/272 , A23L1/303 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P23/00
CPC分类号： C12P23/00 , A23K20/179 , A23L5/44 , C12N15/743
摘要： A microorganism is provided which allows carotenoid production in industrial production scale. A method of preparing a carotenoid includes: culturing a cell transformed with a DNA chain having a DNA sequence selected from the group consisting of the following (a) to (f) or a cell transformed with a vector having a DNA sequence selected from the group consisting of the following (a) to (f) in an appropriate culture condition, and isolating carotenoid from the cell or a culture medium: (a) DNA sequence encoding a polypeptide having such an enzymatic activity of Paracoccus sp. Strain MBIC1143 that converts a methylene group at 4 position in β-ionone ring into a keto group (crtW), described in SEQ ID NO: 2, or a substantially homologous DNA sequence thereof; (b) DNA sequence encoding a polypeptide having such an enzymatic activity of Paracoccus sp. Strain MBIC1143 that adds one hydroxyl group to a carbon at 3-position of 4-keto-β-ionone ring and/or at 3-position of β-ionone ring (crtZ), described in SEQ ID NO: 3, or a substantially homologous DNA sequence thereof; (c) DNA sequence encoding a polypeptide having such an enzymatic activity of Paracoccus sp. Strain MBIC1143 that converts lycopene into β-carotene (crtY), described in SEQ ID NO: 4, or a substantially homologous DNA sequence thereof; (d) DNA sequence encoding a polypeptide having such an enzymatic activity of Paracoccus sp. Strain MBIC1143 that converts phytoene into lycopene (crtI), described in SEQ ID NO: 5, or a substantially homologous DNA sequence thereof; (e) DNA sequence encoding a polypeptide having prephytoene synthase activity of Paracoccus sp. Strain MBIC1143 (crtB), as described in SEQ ID NO: 6, or a substantially homologous DNA sequence thereof; and (f) DNA sequence encoding a polypeptide having geranylgeranyl diphosphate synthase activity of Paracoccus sp. Strain MBIC1143 (crtE), as described in SEQ ID NO: 7, or a substantially homologous DNA sequence thereof.
摘要翻译：提供一种微生物，其允许在工业生产规模的类胡萝卜素生产。制备类胡萝卜素的方法，包括：培养用具有从所述组包括选择的DNA序列的DNA链转化的细胞的以下（a）从所述组中选择的（f）或用具有的DNA序列的载体转化的细胞的由以下（a）至合适的培养条件（f）中，并分离类胡萝卜素从细胞或培养基中：（a）具有上搜索副球菌属的酶活性编码多肽的DNA序列。应变MBIC1143即亚甲基在4位转换中²紫罗兰酮环成酮基（crtW），在SEQ ID NO描述：2，或其基本上同源的DNA序列; 审查了SP（B）编码具有副球菌的酶活性的多肽的DNA序列。应变MBIC1143确实增加了一个羟基基团的碳在SEQ ID NO描述4-酮平方紫罗兰酮环和/或在²紫罗兰酮环（的crtZ）的3位的3位：3，或基本上它们的同源DNA序列; 审查了SP（C）编码具有副球菌的酶活性的多肽的DNA序列。应变MBIC1143其将番茄红素转化成²胡萝卜素（crtY），在SEQ ID NO描述：4，或它们的基本上同源的DNA序列; 审查了SP（D）编码具有副球菌的酶活性的多肽的DNA序列。应变MBIC1143即（CRTI），在SEQ ID NO描述转换成八氢番茄红素番茄红素：5，或其基本上同源的DNA序列; （E）编码副球菌的多肽具有prephytoene合酶活性的DNA序列。应变MBIC1143（基因crtB），如SEQ ID NO描述：6，或其基本上同源的DNA序列; 和（f）编码DNA序列副球菌的多肽具有二磷酸香叶基香叶合酶活性。应变MBIC1143（的crtE），如SEQ ID NO描述：7，或其基本上同源的DNA序列。

5. 发明授权

EP3048112B1 Fc-BINDING PROTEIN, METHOD FOR PRODUCING SAID PROTEIN, AND ANTIBODY ADSORBENT USING SAID PROTEIN, AND METHODS FOR PURIFYING AND IDENTIFYING ANTIBODY USING SAID ADSORBENT 有权
公开(公告)号：EP3048112B1
公开(公告)日：2020-03-11
申请号：EP14846295.5
申请日：2014-09-18
申请人： Tosoh Corporation
发明人： ASAOKA, Yoshiharu , TANAKA, Toru , IDE, Teruhiko
IPC分类号： C07K14/735 , C07K1/22 , C12N1/21 , C12N15/09 , C12P21/02 , C07H1/06

6. 发明授权

EP2546341B1 FC BINDING PROTEIN AND METHOD FOR PRODUCING SAME 有权
标题翻译： FC-结合蛋白和方法及其
公开(公告)号：EP2546341B1
公开(公告)日：2014-12-31
申请号：EP11753056.8
申请日：2011-03-10
申请人： Sagami Chemical Research Institute , Tosoh Corporation
发明人： HATAYAMA, Kouta , ASAOKA, Yoshiharu , TANAKA, Toru , IDE, Teruhiko
IPC分类号： C12N15/09 , C07K14/735 , C12N1/21 , C12P21/02
CPC分类号： C07K14/70535 , C07K1/22 , C07K17/08 , C07K2319/21

7. 发明公开

EP4424830A1 IMMUNOGLOBULIN-BINDING PROTEIN 审中-实审
公开(公告)号：EP4424830A1
公开(公告)日：2024-09-04
申请号：EP22886969.9
申请日：2022-10-24
申请人： TOSOH CORPORATION
发明人： HASEMI, Takatoshi , IWASE, Akihiro , ENDO, Satoshi , TANAKA, Toru
IPC分类号： C12N15/31 , C07K1/22 , C07K14/195 , C07K14/33 , C07K16/00 , C07K17/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N11/02 , C12N15/13 , C12N15/63 , C12N15/70 , C12P21/02 , C12P21/08
CPC分类号： C12N15/80 , C12N11/02 , C12N15/81 , C12N15/70 , C12N15/63 , C12N15/74 , C12N5/10 , C07K14/195 , C07K14/33 , C07K17/00 , C07K16/00 , C07K1/22 , C12P21/02
摘要： The present invention aims to provide an immunoglobulin-binding protein having an improved chemical stability, especially having an improved alkaline stability, or an immunoglobulin-binding protein capable of allowing antibody elution under mild pH conditions, and an adsorbent on which the protein is immobilized. The object is achieved by improving the alkaline stability or the antibody elution property by including an amino acid sequence which is the same as an amino acid sequence of an immunoglobulin-binding domain of protein L derived from a bacterium belonging to the genus Finegoldia except that the amino acid residue(s) at a particular position(s) of the domain in the amino acid sequence is/are substituted with another particular amino acid residues(s).

8. 发明公开

EP3048112A1 Fc-BINDING PROTEIN, METHOD FOR PRODUCING SAID PROTEIN, AND ANTIBODY ADSORBENT USING SAID PROTEIN, AND METHODS FOR PURIFYING AND IDENTIFYING ANTIBODY USING SAID ADSORBENT 有权
标题翻译： FC-结合蛋白，过程以对其及其制备ANTIKÖRPERADSORPTIONSMITTEL与清洁和抗体识别这种蛋白质及其使用方法该吸附剂
公开(公告)号：EP3048112A1
公开(公告)日：2016-07-27
申请号：EP14846295.5
申请日：2014-09-18
申请人： Tosoh Corporation
发明人： ASAOKA, Yoshiharu , TANAKA, Toru , IDE, Teruhiko
IPC分类号： C07K14/735 , C07K1/22 , C12N1/21 , C12N15/09 , C12P21/02
CPC分类号： C07K14/70535 , C07H1/06 , C07K1/22 , C07K16/283 , C07K17/00 , C07K2317/10 , C07K2317/732
摘要： The present invention addresses the first problem of providing an Fc-binding protein having improved stability, especially stability to heat and acid, of the Fc-binding protein, a method for producing this protein, and an antibody adsorbent using this protein. The present invention also addresses the second problem of providing a method that makes it possible to identify the presence or absence of glycosylation of an antibody, and a material to be used in this method. The first problem is solved by an Fc-binding protein having improved stability to heat and acid obtained by substituting amino acid residues at specific positions in the extracellular domain within human FcγRIIIa with other specific amino acids, a method for producing this protein, and an antibody adsorbent using this protein. The second problem is solved by using an adsorbent capable of specifically adsorbing an antibody having a sugar chain, the adsorbent being obtained by immobilizing human FcγRIIIa on an insoluble carrier.
摘要翻译：本发明解决了具有改进的稳定性，尤其是爱对热的稳定性和酸，所述Fc结合蛋白，用于产生该蛋白的方法，以及使用该蛋白质与抗体吸附剂的第一个问题，提供的与Fc结合蛋白。因此，本发明针对的是第二提供一种方法问题的做使得有可能识别存在或不存在的抗体的糖基化的，并且材料在该方法中使用。第一个问题，是通过求解以Fc结合蛋白具有改善的稳定性，对热和酸通过与其他特定的氨基酸，用于制造这种蛋白的方法人类Fc³RIIIa内的细胞外结构域替换在特定位置的氨基酸残基得到的，到抗体吸附剂使用这种蛋白质。第二个问题，是通过使用能够特异性吸附到抗体，其具有糖链吸附剂的解决，所述吸附剂是由上到不溶性载体固定化人Fc³RIIIa得到。

9. 发明公开

EP1956077A1 NOVEL MICROORGANISM AND METHOD FOR PRODUCING CAROTENOID USING THE SAME 审中-公开
标题翻译：维也纳中华人民共和国新加坡人民解放军
公开(公告)号：EP1956077A1
公开(公告)日：2008-08-13
申请号：EP06821955.9
申请日：2006-10-19
申请人： Tosoh Corporation
发明人： TANAKA, Toru , IDE, Teruhiko
IPC分类号： C12N1/20 , C12N1/21 , C12P23/00 , C12R1/01
CPC分类号： C12R1/01 , C12P23/00
摘要： [Object] To provide a canthaxanthin selective producing bacterium being able to easily extract and purify canthaxanthin, which is one of carotenoids, and a method for producing canthaxanthin by a culture method.
[Solving Means] A carotenoid producing bacterium belonging to the genus Paracoccus is provided which selectively produces canthaxanthin so that the amount thereof is not less than 90 percent by weight of the total amount of produced carotenoids including β-carotene, β-cryptoxanthin, echinenone, canthaxanthin, 3-hydroxyechinenone, 3'-hydroxyechinenone, zeaxanthin, phoenicoxanthin, adonixanthin, and astaxanthin. In addition, a method for producing canthaxanthin is provided which has the steps of culturing the above bacterium, and then collecting carotenoids from bacterial cells or a culture solution after the culturing.
摘要翻译：本发明提供一种能够容易地提取和纯化作为类胡萝卜素之一的角黄素的角黄素选择性生产菌和通过培养方法生产角黄素的方法。 [解决方案]提供属于副球菌属的类胡萝卜素生产细菌，其选择性地生产角黄素，其量不小于包含β-胡萝卜素，β-隐黄质，敌敌畏的类胡萝卜素总量的90重量％角黄素，3-羟基喹喔啉酮，3'-羟基喹喔啉酮，玉米黄质，磷酸黄嘌呤，adonixanthin和虾青素。此外，提供了一种制备角黄素的方法，其具有培养上述细菌的步骤，然后在培养后从细菌细胞或培养液中收集类胡萝卜素。

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