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1. 发明公开

EP3228709A4 TIM PROTEIN-BOUND CARRIER, METHODS FOR OBTAINING, REMOVING AND DETECTING EXTRACELLULAR MEMBRANE VESICLES AND VIRUSES USING SAID CARRIER, AND KIT INCLUDING SAID CARRIER 有权转让
公开(公告)号：EP3228709A4
公开(公告)日：2018-06-20
申请号：EP15865944
申请日：2015-11-27
申请人： WAKO PURE CHEM IND LTD , UNIV OSAKA
发明人： NISHIBU TAKAHIRO , IMAWAKA NAOKO , NARUSE KEN , HANAYAMA RIKINARI
IPC分类号： C12N15/09 , C07K1/14 , C07K14/705 , C07K17/00 , C12N7/02 , G01N33/53
CPC分类号： G01N33/5076 , C07K1/14 , C07K14/70503 , C07K17/00 , C07K17/02 , C07K2319/40 , C12N7/02 , C12N15/09 , G01N33/53 , G01N33/5432 , G01N33/6842 , G01N2015/008 , G01N2015/1006 , G01N2015/149
摘要： An object of the present invention is to provide a carrier and a method for obtaining or removing extracellular membrane vesicle or virus present in a sample in good purity and in an intact state simply and conveniently, as well as and efficiently, or detecting them in high sensitivity. The present invention relates to: "1. a carrier (a Tim carrier) on which a protein (a Tim protein), selected from a T-cell immunoglobulin and mucin domain-containing molecule-4 (a Tim-4) protein, a Tim-3 protein, and a Tim-1 protein, is bound; 2. a method for obtaining the extracellular membrane vesicle or the virus in the sample; 3. a method for removing the extracellular membrane vesicle or the virus in the sample; 4. a method for detecting the extracellular membrane vesicle or the virus in the sample; 5. a kit for capturing the extracellular membrane vesicle or the virus, comprising the Tim carrier; and 6. a kit for capturing the extracellular membrane vesicle or the virus, comprising a reagent containing the Tim protein and a reagent containing the carrier".

2. 发明公开

EP3327029A1 ANTIBODY-BINDING PROTEIN HAVING REDUCED ANTIBODY-BINDING CAPACITY IN ACIDIC pH REGIONS 审中-公开
公开(公告)号：EP3327029A1
公开(公告)日：2018-05-30
申请号：EP16827817.4
申请日：2016-07-21
申请人： Kaneka Corporation
发明人： NISHIHACHIJYO, Masakatsu , NAKANO, Yoshiyuki , KONOIKE, Fuminori , TAKANO, Masayuki , YOSHIDA, Shinichi , MINAKUCHI, Kazunobu
IPC分类号： C07K14/195 , C07K1/22 , C07K17/00 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08
CPC分类号： C07K14/31 , C07K1/22 , C07K14/195 , C07K17/00 , C07K19/00 , C07K2319/30 , C12N5/10 , C12N15/09
摘要： The present invention provides a Protein A ligand that has a reduced antibody-binding capacity in an acidic pH range when the ligand is immobilized on a carrier to prepare an affinity separation matrix. The present invention provides a protein containing an amino acid sequence derived from any of the E, D, A, B, and C domains of Protein A of SEQ ID NOs: 1 to 5 in which a hydrophobic amino acid residue in the Fc binding site is substituted by a different hydrophobic amino acid residue or polar uncharged amino acid residue, wherein the protein has a reduced antibody-binding capacity in an acidic pH range as compared to before the substitution.

3. 发明公开

EP3204411A4 ANTI-TAU ANTIBODY AND USES THEREOF 审中-公开
公开(公告)号：EP3204411A4
公开(公告)日：2018-03-28
申请号：EP15849424
申请日：2015-10-06
申请人： NAT RES COUNCIL CANADA , SUTHERLAND GARNETTE ROY , LAMA SANJU
发明人： SUTHERLAND GARNETTE R , LAMA SANJU , ARBABI GHAHROUDI MEHDI
IPC分类号： A61K49/18 , C07K16/18 , C07K17/00 , C07K17/14 , C12N15/13 , G01N33/53 , G01N33/567
CPC分类号： A61K49/1875 , A61K51/12 , A61K2039/505 , C07K16/18 , C07K17/00 , C07K17/14 , C07K2317/22 , C07K2317/24 , C07K2317/35 , C07K2317/52 , C07K2317/53 , C07K2317/569 , C07K2317/64 , C07K2317/92 , C07K2317/94 , C07K2319/00 , G01N33/00 , G01N33/53 , G01N33/567 , G01N33/6896
摘要： The present invention relates to Tau-specific antibodies, fragments thereof, and uses thereof. More specifically, the present invention relates to Tau-specific antibodies, fragments thereof, and conjugates thereof with conjugated to a superparamagnetic nanoparticle. The molecules of the present invention may be used in visualizing damage from traumatic brain injury.

4. 发明授权

EP2749646B1 IgG-BINDING PEPTIDE AND METHOD FOR DETECTING AND PURIFYING IgG USING SAME 有权转让
标题翻译：用于检测和纯化IgG的IgG结合肽和方法
公开(公告)号：EP2749646B1
公开(公告)日：2018-03-21
申请号：EP12825488.5
申请日：2012-08-23
申请人： Kagoshima University
发明人： ITO, Yuji
IPC分类号： C12N15/09 , C07K1/16 , C07K7/08 , C07K17/00 , C07K19/00 , G01N30/88 , G01N33/53
CPC分类号： C07K7/08 , C07K1/22 , C07K17/00 , C07K17/06 , C07K2319/00 , G01N33/6854 , G01N2030/8831
摘要： Provided is a peptide that specifically or selectively binds to human IgG. This peptide comprises an amino acid sequence consisting of 13 to 17 amino acid residues and is capable of binding to human IgG, wherein the amino acid sequence is represented by formula I: (X 1-3 )-C-(X 2 )-H-R-G-(Xaal)-L-V-W-C-(X 1-3 ), wherein, X each independently represents any amino acid residue except cysteine, C represents a cysteine residue, H represents a histidine residue, R represents an arginine residue, G represents a glycine residue, Xaa1 represents a glutamic acid residue or an asparagine residue, L represents a leucine residue, V represents a valine residue, and W represents a tryptophan residue.

5. 发明公开

EP3274716A1 A METHOD AND PEPTIDES FOR THE DETECTION OF CHLAMYDIA SUIS 审中-公开
标题翻译：一种检测CHLAMYDIA SUIS的方法和肽
公开(公告)号：EP3274716A1
公开(公告)日：2018-01-31
申请号：EP16714304.9
申请日：2016-03-22
申请人： Universiteit Gent
发明人： VANROMPAY, Daisy
IPC分类号： G01N33/569
CPC分类号： G01N33/56927 , C07K7/06 , C07K7/08 , C07K14/295 , C07K17/00 , G01N2333/295 , G01N2469/20
摘要： The present invention relates to a method and kit for detecting and diagnosing Chlamydia suis infections in a subject using peptides comprising the amino acid sequence of GTKDASID and/or SQQSSIAS as antigenic determinants.

6. 发明公开

EP3202774A4 ANTIBODY-BINDING POLYPEPTIDE, ANTIBODY-BINDING FUSION POLYPEPTIDE, AND ADSORBENT MATERIAL 审中-公开
标题翻译： ANTIKÖRPERBINDENDESPOLYPEPTID，ANTIKÖRPERBINDENDESFUSIONSPOLYPEPTID UND ADSORPTIONSMATERIAL
公开(公告)号：EP3202774A4
公开(公告)日：2017-08-16
申请号：EP15847891
申请日：2015-09-04
申请人： FUJIFILM CORP
发明人： MINAMI KOICHI
IPC分类号： C07K4/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K17/00
CPC分类号： C07K1/22 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/001 , C07K17/00 , C07K2319/00
摘要： Provided are an antibody-binding polypeptide as set forth in any one of SEQ ID NOs: 1 to 18 and an adsorption material of an antibody or antibody derivative in which the antibody-binding polypeptide is immobilized on a water-insoluble carrier. These antibody-binding polypeptide and adsorption material have excellent antibody binding properties and selectivity, and also excellent alkali resistance and temporal stability.
摘要翻译：本发明提供了如SEQ ID NO：1至18中任一项所述的抗体结合多肽和其中抗体结合多肽固定在水不溶性载体上的抗体或抗体衍生物的吸附材料。这些抗体结合多肽和吸附材料具有优异的抗体结合性和选择性，并且耐碱性和经时稳定性也优异。

7. 发明公开

EP3052090A4 METHODS AND COMPOSITIONS FOR SELF-ASSEMBLY SYSTEM OF NANOPARTICLES AND MICROPARTICLES FOR MULTI-TARGETING SPECIFICITY 审中-公开
标题翻译： VERFAHREN UND ZUSAMMENSETZUNGENFÜREIN SELBSTANORDENNENDES VON NANOPARTIKELN UND MIKROPARTIKELNFÜRSPEZIFITÄTMEHRERER ZIELE
公开(公告)号：EP3052090A4
公开(公告)日：2017-08-09
申请号：EP14847325
申请日：2014-09-30
申请人： UNIV NORTH CAROLINA CHAPEL HILL
发明人： LIU RIHE
IPC分类号： A61K9/50 , A61K9/51 , A61K49/18 , A61P35/00 , B82Y5/00 , B82Y40/00 , C07K17/00 , G01N33/50
CPC分类号： A61K49/0004 , A61K47/48853 , A61K47/6921 , A61K47/6923 , B82Y5/00 , C07K17/00 , C07K17/10 , G01N33/54346 , G01N2333/4727 , G01N2800/7028

8. 发明公开

EP3048112A4 Fc-BINDING PROTEIN, METHOD FOR PRODUCING SAID PROTEIN, AND ANTIBODY ADSORBENT USING SAID PROTEIN, AND METHODS FOR PURIFYING AND IDENTIFYING ANTIBODY USING SAID ADSORBENT 有权
标题翻译： FC-BINDENDES PROTEIN，VERFAHREN ZUR HERSTELLUNG DAVON UNDANTIKÖRPERADSORPTIONSMITTEL麻省理工学院DIESEM蛋白质研究中心ZUR REINIGUNG UND IDENTIFIZIERUNG DES抗菌剂UNTER VERWENDUNG DIESES ADSORPTIONSMITTELS
公开(公告)号：EP3048112A4
公开(公告)日：2017-07-26
申请号：EP14846295
申请日：2014-09-18
申请人： TOSOH CORP
发明人： ASAOKA YOSHIHARU , TANAKA TORU , IDE TERUHIKO
IPC分类号： C07K14/735 , C07H1/06 , C07K1/22 , C12N1/21 , C12N15/09 , C12P21/02
CPC分类号： C07K14/70535 , C07H1/06 , C07K1/22 , C07K16/283 , C07K17/00 , C07K2317/10 , C07K2317/732
摘要： The present invention addresses the first problem of providing an Fc-binding protein having improved stability, especially stability to heat and acid, of the Fc-binding protein, a method for producing this protein, and an antibody adsorbent using this protein. The present invention also addresses the second problem of providing a method that makes it possible to identify the presence or absence of glycosylation of an antibody, and a material to be used in this method. The first problem is solved by an Fc-binding protein having improved stability to heat and acid obtained by substituting amino acid residues at specific positions in the extracellular domain within human Fc³RIIIa with other specific amino acids, a method for producing this protein, and an antibody adsorbent using this protein. The second problem is solved by using an adsorbent capable of specifically adsorbing an antibody having a sugar chain, the adsorbent being obtained by immobilizing human Fc³RIIIa on an insoluble carrier.
摘要翻译：本发明解决了提供具有提高的Fc结合蛋白的稳定性，特别是热和酸的稳定性的Fc结合蛋白的第一个问题，产生该蛋白的方法和使用该蛋白的抗体吸附剂。本发明还解决了提供一种方法的第二个问题，该方法可以鉴定抗体的糖基化的存在或不存在，以及该方法中使用的材料。第一个问题可以通过一种Fc结合蛋白来解决，该Fc结合蛋白具有改善的对热和酸的稳定性，通过用其他特定氨基酸取代人FcrRIIIa胞外结构域的特定位置处的氨基酸残基而获得，其制备方法和抗体使用这种蛋白质的吸附剂。通过使用能够特异性地吸附具有糖链的抗体的吸附剂解决了第二个问题，所述吸附剂通过将人FcRIIIa固定在不溶性载体上而获得。

9. 发明公开

EP3167935A1 METHOD AND CARRIER COMPLEXES FOR DELIVERING MOLECULES TO CELLS 有权
标题翻译：用于向细胞递送分子的方法和载体复合物
公开(公告)号：EP3167935A1
公开(公告)日：2017-05-17
申请号：EP16188609.8
申请日：2004-05-03
申请人： Cornell Research Foundation, Inc.
发明人： SZETO, Hazel , ZHAO, Kesheng , BIRK, Alex V. , ROBERTSON, Hugh D.
IPC分类号： A61P31/00 , A61P39/06 , A61P35/00 , C07K5/10 , C07K5/11 , C07K5/107 , C12N15/87 , A61K47/64 , A61K47/66
CPC分类号： A61K47/48246 , A61K31/713 , A61K38/47 , A61K47/64 , C07K5/1016 , C07K5/1019 , C07K17/00 , C12N9/2471 , C12N9/96 , C12N15/113 , C12N15/87 , C12N2310/3513 , C12N2320/32 , C12Y302/01023
摘要： The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a molecule and an aromatic cationic peptide.
摘要翻译：本发明涉及载体复合物和将分子递送至细胞的方法。载体复合物包含根据本发明的分子和芳族阳离子肽。在一个实施方案中，将分子递送至细胞的方法包括使细胞与载体复合物接触。在另一个实施方案中，用于将分子递送至细胞的方法包括使细胞与分子和芳香族阳离子肽接触。

10. 发明公开

EP2935337A4 MIXED PAYLOAD CONTAINING POLYMERS AND USE THEROF 审中-公开
标题翻译：与聚合物的和使用它们的混合PAYLOAD
公开(公告)号：EP2935337A4
公开(公告)日：2016-10-05
申请号：EP13866215
申请日：2013-12-19
申请人： AKRIVIS TECHNOLOGIES LLC
发明人： BERNIAC JOEL , PANWAR RAJIV
IPC分类号： C07K17/00 , A61K39/00
CPC分类号： G01N33/581 , A61K47/48215 , A61K47/48315 , A61K47/48723 , A61K47/60 , A61K47/645 , A61K47/6891 , C07K17/00 , C12N9/0065 , C12Q1/6841 , C12Y111/01007 , G01N33/58 , G01N33/582
摘要： The invention provides methods for delivery of payloads to targets in samples using mixed payload polymers. The invention further provides reagents and kits for practicing the methods of the invention. The invention also provides methods for preparation of reagents for use in the methods of the invention.

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