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1. 发明公开

EP3800192A1 PROCESSES FOR PREPARING PHARMACEUTICALLY RELEVANT PEPTIDES 审中-实审转让
公开(公告)号：EP3800192A1
公开(公告)日：2021-04-07
申请号：EP20196964.9
申请日：2016-03-07
申请人： Stealth Biotherapeutics Corp
发明人： DUNCAN, Scott , WILSON, D. Travis
IPC分类号： C07K1/04 , C07K1/02 , C07K5/11
摘要： The present technology provides methods of generating the peptides, and pharmaceutically acceptable salts of the peptides and intermediates thereof. In some embodiments, the peptide is D-Arg-2'6'-Dmt-Lys-Phe-NH 2 .

2. 发明公开

EP3501532A2 THERAPEUTIC COMPOSITIONS INCLUDING FRATAXIN, LACTOFERRIN, AND MITOCHONDRIAL ENERGY GENERATING ENZYMES, AND USES THEREOF 审中-公开
公开(公告)号：EP3501532A2
公开(公告)日：2019-06-26
申请号：EP18210159.2
申请日：2015-05-27
申请人： Stealth BioTherapeutics Corp
发明人： WILSON, D. Travis
IPC分类号： A61K38/07 , A61K31/353
CPC分类号： A61K38/10 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/13 , A61K38/1709 , A61K38/40 , A61K38/44 , A61K38/443 , A61K38/45 , A61K38/46 , A61K38/51 , A61K38/53 , A61K47/645 , C07K5/06078 , C07K5/06095 , C07K5/06156 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/0821 , C07K5/1016 , C07K5/1021 , C12Y101/01037 , C12Y101/01042 , C12Y102/04002 , C12Y103/05001 , C12Y106/05003 , C12Y109/03001 , C12Y110/02002 , C12Y203/03001 , C12Y306/03014 , C12Y402/01002 , C12Y402/01003 , C12Y602/01004 , C12Y604/01001
摘要： Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of a therapeutic biological molecule, and/or naturally or artificially occurring derivatives, analogues, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents ( e.g., an aromatic-cationic peptide). The present technology provides compositions related to aromatic-cationic peptides linked to a therapeutic biological molecule and uses of the same. In some embodiments, the aromatic-cationic peptide comprises 2',6'-dimethyl-Tyr-D-Arg-Phe-Lys-NH 2 , Phe-D-Arg-Phe-Lys-NH 2 , or D-Arg-2',6'-Dmt-Lys-Phe-NH 2 .

3. 发明授权

EP2961420B1 METHODS AND COMPOSITIONS FOR THE PREVENTION OR TREATMENT OF BARTH SYNDROME 有权转让
公开(公告)号：EP2961420B1
公开(公告)日：2019-09-11
申请号：EP14756991.7
申请日：2014-02-28
申请人： Stealth Biotherapeutics Corp
发明人： WILSON, D. Travis , BAMBERGER, Mark
IPC分类号： A61K38/06 , A61P11/00 , A61P9/04

4. 发明公开

EP3501532A3 THERAPEUTIC COMPOSITIONS INCLUDING FRATAXIN, LACTOFERRIN, AND MITOCHONDRIAL ENERGY GENERATING ENZYMES, AND USES THEREOF 审中-公开
公开(公告)号：EP3501532A3
公开(公告)日：2019-07-17
申请号：EP18210159.2
申请日：2015-05-27
申请人： Stealth BioTherapeutics Corp
发明人： WILSON, D. Travis
IPC分类号： A61K38/07 , A61K31/353
摘要： Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of a therapeutic biological molecule, and/or naturally or artificially occurring derivatives, analogues, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents ( e.g., an aromatic-cationic peptide). The present technology provides compositions related to aromatic-cationic peptides linked to a therapeutic biological molecule and uses of the same. In some embodiments, the aromatic-cationic peptide comprises 2',6'-dimethyl-Tyr-D-Arg-Phe-Lys-NH 2 , Phe-D-Arg-Phe-Lys-NH 2 , or D-Arg-2',6'-Dmt-Lys-Phe-NH 2 .

5. 发明公开

EP3458159A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF MITOCHONDRIAL MYOPATHIES 审中-公开
公开(公告)号：EP3458159A1
公开(公告)日：2019-03-27
申请号：EP17800258.0
申请日：2017-05-19
申请人： Stealth BioTherapeutics Corp
发明人： WILSON, D. Travis
IPC分类号： A61P27/12 , A61P27/02 , A61K38/07 , A61K47/54 , A61K47/64 , A61K45/06 , C07K5/10

6. 发明公开

EP2996707A1 METHODS FOR THE PREVENTION OR TREATMENT OF LEFT VENTRICLE REMODELING 有权转让
标题翻译：用于预防或治疗左室重构
公开(公告)号：EP2996707A1
公开(公告)日：2016-03-23
申请号：EP13884895.7
申请日：2013-10-22
申请人： Stealth Biotherapeutics Corp , Heart Institute Good Samaritan Hospital
发明人： WILSON, D. Travis , KLONER, Robert, A.
IPC分类号： A61K38/06
CPC分类号： A61K38/06 , A61K9/0004 , A61K9/0024 , A61K31/401 , A61K36/80 , A61K45/06 , C07K5/0817 , A61K2300/00
摘要： The disclosure provides methods of preventing, treating, or ameliorating LV remodeling in a mammalian subject. The methods comprise administering to the subject a therapeutic amount of an aromatic-cationic peptide such as D-Arg-2,6-Dmt- Lys-Phe-NH2.

7. 发明授权

EP3265109B1 PROCESSES FOR PREPARING PHARMACEUTICALLY RELEVANT PEPTIDES 有权转让
公开(公告)号：EP3265109B1
公开(公告)日：2020-10-21
申请号：EP16762314.9
申请日：2016-03-07
申请人： Stealth BioTherapeutics Corp
发明人： DUNCAN, Scott , WILSON, D. Travis
IPC分类号： C07K1/04 , C07K1/02 , C07K5/11

8. 发明公开

EP3626252A1 METHODS AND COMPOSITIONS FOR THE PREVENTION OR TREATMENT OF BARTH SYNDROME 审中-公开
公开(公告)号：EP3626252A1
公开(公告)日：2020-03-25
申请号：EP19190165.1
申请日：2014-02-28
申请人： Stealth Biotherapeutics Corp
发明人： WILSON, D. Travis , BAMBERGER, Mark
IPC分类号： A61K38/06 , A61P11/00 , A61P9/04
摘要： The disclosure provides methods of preventing or treating Barth Syndrome in a mammalian subject, reducing risk factors associated with Barth Syndrome, and/or reducing the likelihood or severity of Barth Syndrome. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to increase expression of TAZ1 in subjects in need thereof.

9. 发明授权

EP2996707B1 METHODS FOR THE PREVENTION OR TREATMENT OF LEFT VENTRICLE REMODELING 有权转让
公开(公告)号：EP2996707B1
公开(公告)日：2019-09-11
申请号：EP13884895.7
申请日：2013-10-22
申请人： Stealth Biotherapeutics Corp , Heart Institute Good Samaritan Hospital
发明人： WILSON, D. Travis , KLONER, Robert, A.
IPC分类号： A61K38/07 , A61P9/10

10. 发明公开

EP3077049A1 COMPOSITIONS AND METHODS FOR TREATING VITILIGO 有权转让
标题翻译： ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON VITILIGO
公开(公告)号：EP3077049A1
公开(公告)日：2016-10-12
申请号：EP14866993.0
申请日：2014-12-02
申请人： Stealth BioTherapeutics Corp
发明人： WILSON, D. Travis
IPC分类号： A61P17/00
CPC分类号： A61K38/07 , G01N33/5044 , G01N33/5091 , G01N33/6893 , G01N2800/207 , G01N2800/52
摘要： The present technology provides methods of preventing or treating vitiligo. The methods provide administering aromatic-cationic peptides in effective amounts to treat or ameliorate melanocyte degeneration such as that found in a subject suffering from, or predisposed to vitiligo. In some embodiments, the methods comprise administering to a subject suffering from, or at risk for vitiligo, an effective amount of an aromatic-cationic peptide to subjects in need thereof. The present technology relates to the treatment, amelioration or prevention of vitiligo in mammals or mammalian cells, through administration of therapeutically effective amounts of aromatic-cationic peptides, such as D-Arg-2′,6′-Dmt-Lys-Phe-NH2.
摘要翻译：本技术提供了预防或治疗白癜风的方法。所述方法提供有效量的治疗或改善黑素细胞变性的有效量的芳香族 - 阳离子肽，例如患有或易患白癜风的受试者中发现的。在一些实施方案中，所述方法包括向患有或具有白癜风风险的受试者向有需要的受试者施用有效量的芳族阳离子肽。本技术涉及治疗，改善或预防哺乳动物或哺乳动物细胞中的白癜风，通过施用治疗有效量的芳族阳离子肽，例如D-Arg-2'，6'-Dmt-Lys-Phe-NH 2 。

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