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    • 1. 发明公开
    • MEANS AND METHODS FOR TREATING OR DIAGNOSING IDH1 R132H MUTANT-POSITIVE CANCERS
    • PEPTIDEFÜRDIE BEHANDLUNG UND DIORNOS VON IDH1 R132H POSITIVEN KREBSARTEN
    • EP2800580A1
    • 2014-11-12
    • EP13700266.3
    • 2013-01-03
    • Deutsches KrebsforschungszentrumRuprecht-Karls-Universität Heidelberg
    • PLATTEN, MichaelSCHUMACHER, TheresaWICK, Wolfgang
    • A61K38/43G01N33/00A61P35/00
    • G01N33/57496A61K38/43A61K39/0011C12N9/0006C12Y101/01042G01N33/57407G01N33/57426G01N2333/904
    • The present invention concerns the field of tumor therapeutics and diagnostics. Specifically, it relates to a peptide comprising at least 8 amino acids in length which are present as contiguous amino acid sequence in the human Isocitratdehydrogenase Type 1 (IDH1), wherein said peptide has at least one amino acid exchange from R to H at a position corresponding to position 132, for use in preventing and/or treating cancer. Further contemplated is a medicament comprising the said peptide. Furthermore, the invention relates to a method for diagnosing cancer characterized by having a mutation in the genome of at least some cancer cells which results in the expression of a mutant IDH1 having the R132H mutation comprising the steps of contacting a blood sample of a subject suspected to suffer from such a cancer with a peptide comprising at least 10 amino acids in length which are present as contiguous amino acid sequence in the IDH1,wherein said peptide has at least one amino acid exchange from R to H at a position corresponding to position 132 for a time and under conditions which allow for specific binding of a component of the immune system to the peptide, and determining whether, or not, binding of the said component of the immune system to the peptide occurred, wherein the cancer is diagnosed if the occurrence of binding has been determined. Provided by the invention is also a kit and a device for carrying out said method.
    • 本发明涉及肿瘤治疗和诊断领域。 具体地说,本发明涉及包含长度为至少8个氨基酸的肽,其在人类异柠檬酸脱氢酶1型(IDH1)中作为连续氨基酸序列存在,其中所述肽在位置上具有至少一个R至H的氨基酸交换 对应于位置132,用于预防和/或治疗癌症。 进一步考虑的是包含所述肽的药物。 此外,本发明涉及一种用于诊断癌症的方法,其特征在于在至少一些癌细胞的基因组中具有突变,其导致具有R132H突变的突变体IDH1的表达,包括以下步骤:使被怀疑的受试者的血液样品 患有长度为至少10个氨基酸的肽的这种癌症,其在IDH1中作为连续氨基酸序列存在,其中所述肽在对应于位置132的位置具有至少一个从R至H的氨基酸交换 在一段时间和在允许免疫系统的组分与肽的特异性结合的条件下,以及确定是否发生免疫系统的所述组分与肽的结合,其中如果 确定了结合的发生。 本发明还提供一种用于执行所述方法的套件和装置。