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1. 发明公开

EP3149035A4 THERAPEUTIC COMPOSITIONS INCLUDING THERAPEUTIC SMALL MOLECULES AND USES THEREOF 审中-公开
公开(公告)号：EP3149035A4
公开(公告)日：2018-05-16
申请号：EP15798937
申请日：2015-05-27
申请人： STEALTH BIOTHERAPEUTICS CORP
发明人： WILSON D TRAVIS , BAMBERGER MARK , OATES PETER
IPC分类号： C07K16/00 , A01N1/02 , A61K38/06 , A61K38/07 , A61K38/08 , A61K45/06 , C12P21/08
CPC分类号： A61K38/10 , A01N1/0226 , A61K31/122 , A61K31/194 , A61K31/198 , A61K31/205 , A61K31/355 , A61K31/375 , A61K31/385 , A61K31/4415 , A61K31/455 , A61K31/51 , A61K31/519 , A61K31/525 , A61K31/675 , A61K31/714 , A61K38/04 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/13 , A61K45/06 , A61K47/48315 , A61K47/645 , C07K5/06078 , C07K5/06086 , C07K5/06095 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/1008 , C07K5/1016 , C07K5/1019 , C07K5/1024 , A61K2300/00
摘要： Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of TSM, and/or naturally or artificially occurring derivatives, analogues, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide). The present technology provides compositions related to aromatic-cationic peptides linked to TSM and uses of the same. In some embodiments, the aromatic-cationic peptide comprises 2′,6′-dimethyl-Tyr-D-Arg-Phe-Lys-NH2, Phe-D-Arg-Phe-Lys-NH2, or D-Arg-2′,6′-Dmt-Lys-Phe-NH2.

2. 发明公开

EP2996707A4 METHODS FOR THE PREVENTION OR TREATMENT OF LEFT VENTRICLE REMODELING 有权转让
标题翻译：预防或治疗左侧虚拟重塑的方法
公开(公告)号：EP2996707A4
公开(公告)日：2016-12-07
申请号：EP13884895
申请日：2013-10-22
申请人： STEALTH BIOTHERAPEUTICS CORP , HEART INST GOOD SAMARITAN HOSPITAL
发明人： WILSON D TRAVIS , KLONER ROBERT A
IPC分类号： A61K38/06 , A61K9/00 , A61K31/401 , A61K36/80 , A61K45/06 , A61P9/00 , C07K5/09
CPC分类号： A61K38/06 , A61K9/0004 , A61K9/0024 , A61K31/401 , A61K36/80 , A61K45/06 , C07K5/0817 , A61K2300/00
摘要： The disclosure provides methods of preventing, treating, or ameliorating LV remodeling in a mammalian subject. The methods comprise administering to the subject a therapeutic amount of an aromatic-cationic peptide such as D-Arg-2,6-Dmt-Lys-Phe-NH2.

3. 发明公开

EP3182989A4 METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF DISEASE 有权转让
公开(公告)号：EP3182989A4
公开(公告)日：2018-04-11
申请号：EP15833335
申请日：2015-08-20
申请人： STEALTH BIOTHERAPEUTICS CORP
发明人： WILSON D TRAVIS
IPC分类号： A61K38/07
CPC分类号： A61K38/1875 , A61K31/165 , A61K31/192 , A61K31/727 , A61K31/737 , A61K38/06 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： The present technology is directed to compositions and methods for preventing, ameliorating, or reducing the severity of one or more signs, or symptoms associated with a reduction of function, decreased expression level of, and/or deficiency in one or more of COL4A3, COL4A4 and COL4A5 genes. Also disclosed herein are methods of preventing or treating Alport Syndrome in a mammalian subject, reducing risk factors associated with Alport Syndrome, and/or reducing the likelihood or severity of Alport Syndrome. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide.

4. 发明公开

EP3114136A4 PHARMACEUTICALLY RELEVANT AROMATIC-CATIONIC PEPTIDES 无效
公开(公告)号：EP3114136A4
公开(公告)日：2017-11-01
申请号：EP14884543
申请日：2014-12-23
申请人： STEALTH BIOTHERAPEUTICS CORP
发明人： WILSON D TRAVIS
IPC分类号： C07K14/605 , A61K38/26 , A61K45/06 , C07K5/09 , C07K5/107
CPC分类号： C07K5/1021 , A61K38/00 , C07K1/107 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/1016

5. 发明公开

EP3077049A4 COMPOSITIONS AND METHODS FOR TREATING VITILIGO 有权转让
标题翻译： ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON VITILIGO
公开(公告)号：EP3077049A4
公开(公告)日：2017-07-19
申请号：EP14866993
申请日：2014-12-02
申请人： STEALTH BIOTHERAPEUTICS CORP
发明人： WILSON D TRAVIS
IPC分类号： A61K38/07 , A61P17/00
CPC分类号： A61K38/07 , G01N33/5044 , G01N33/5091 , G01N33/6893 , G01N2800/207 , G01N2800/52
摘要： The present technology provides methods of preventing or treating vitiligo. The methods provide administering aromatic-cationic peptides in effective amounts to treat or ameliorate melanocyte degeneration such as that found in a subject suffering from, or predisposed to vitiligo. In some embodiments, the methods comprise administering to a subject suffering from, or at risk for vitiligo, an effective amount of an aromatic-cationic peptide to subjects in need thereof. The present technology relates to the treatment, amelioration or prevention of vitiligo in mammals or mammalian cells, through administration of therapeutically effective amounts of aromatic-cationic peptides, such as D-Arg-2′,6′-Dmt-Lys-Phe-NH2.
摘要翻译：本技术提供了预防或治疗白癜风的方法。该方法提供有效量的芳香族阳离子肽以治疗或改善黑素细胞变性，例如在遭受白癜风或易患白癜风的受试者中发现的黑素细胞变性。在一些实施方案中，所述方法包括对患有或有风险患有白癜风的受试者施用有效量的芳香族阳离子肽给有需要的受试者。本技术涉及通过施用治疗有效量的芳香族阳离子肽，例如D-Arg-2'，6'-Dmt-Lys-Phe-NH 2，在哺乳动物或哺乳动物细胞中治疗，改善或预防白癜风。

6. 发明公开

EP2961378A4 METHODS FOR THE TREATMENT OF MITOCHONDRIAL DISEASE 有权转让
标题翻译：用于治疗线粒体疾病的化合物
公开(公告)号：EP2961378A4
公开(公告)日：2016-08-17
申请号：EP14757000
申请日：2014-02-28
申请人： STEALTH BIOTHERAPEUTICS CORP
发明人： WILSON D TRAVIS
IPC分类号： A61K38/06 , A61P9/04 , A61P11/00
CPC分类号： C07K5/1019 , A61K38/00 , A61K38/07 , C07K5/1016
摘要： The disclosure provides methods of preventing, ameliorating or treating disruption of mitochondrial function and symptoms thereof. The methods provide administering aromatic-cationic peptides in effective amounts to prevent, treat or ameliorate the disruption of mitochondrial oxidative phosphorylation in a cell such as that found in a subject suffering from, or predisposed to a mitochondrial disease or disorder. In some embodiments, the methods comprise administering to a subject suffering from, or at risk for a mitochondrial disease or disorder, an effective amount of an aromatic-cationic peptide to subjects in need thereof.

7. 发明公开

EP3148565A4 THERAPEUTIC COMPOSITIONS INCLUDING FRATAXIN, LACTOFERRIN, AND MITOCHONDRIAL ENERGY GENERATING ENZYMES, AND USES THEREOF 审中-公开
公开(公告)号：EP3148565A4
公开(公告)日：2018-06-06
申请号：EP15799189
申请日：2015-05-27
申请人： STEALTH BIOTHERAPEUTICS CORP
发明人： WILSON D TRAVIS
IPC分类号： A61K38/07 , A61K31/353
CPC分类号： A61K38/10 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/13 , A61K38/1709 , A61K38/40 , A61K38/44 , A61K38/443 , A61K38/45 , A61K38/46 , A61K38/51 , A61K38/53 , A61K47/48315 , A61K47/645 , C07K5/06078 , C07K5/06095 , C07K5/06156 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/0821 , C07K5/1016 , C07K5/1021 , C12Y101/01037 , C12Y101/01042 , C12Y102/04002 , C12Y103/05001 , C12Y106/05003 , C12Y109/03001 , C12Y110/02002 , C12Y203/03001 , C12Y306/03014 , C12Y402/01002 , C12Y402/01003 , C12Y602/01004 , C12Y604/01001
摘要： Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of a therapeutic biological molecule, and/or naturally or artificially occurring derivatives, analogues, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide). The present technology provides compositions related to aromatic-cationic peptides linked to a therapeutic biological molecule and uses of the same. In some embodiments, the aromatic-cationic peptide comprises 2′,6′-dimethyl-Tyr-D-Arg-Phe-Lys-NH2, Phe-D-Arg-Phe-Lys-NH2, or D-Arg-2′,6′-Dmt-Lys-Phe-NH2.

8. 发明公开

EP3087093A4 PHARMACEUTICALLY RELEVANT AROMATIC-CATIONIC PEPTIDES 有权转让
标题翻译： PHARMAZEUTISCH RELEVANTEOMATISCH-KATIONISCHE PEPTIDE
公开(公告)号：EP3087093A4
公开(公告)日：2017-09-27
申请号：EP14874049
申请日：2014-12-23
申请人： STEALTH BIOTHERAPEUTICS CORP
发明人： WILSON D TRAVIS
IPC分类号： C07K14/605 , A61K38/26 , A61K45/06 , C07K1/02
CPC分类号： C07K5/1019 , C07K1/02

9. 发明公开

EP2961420A4 METHODS AND COMPOSITIONS FOR THE PREVENTION OR TREATMENT OF BARTH SYNDROME 有权转让
标题翻译：预防或治疗巴氏综合症的方法和组合物
公开(公告)号：EP2961420A4
公开(公告)日：2016-08-17
申请号：EP14756991
申请日：2014-02-28
申请人： STEALTH BIOTHERAPEUTICS CORP
发明人： WILSON D TRAVIS , BAMBERGER MARK
IPC分类号： A61K38/06 , A61P9/04 , A61P11/00
CPC分类号： A61K38/06 , A61K38/07 , A61K45/06
摘要： The disclosure provides methods of preventing or treating Barth Syndrome in a mammalian subject, reducing risk factors associated with Barth Syndrome, and/or reducing the likelihood or severity of Barth Syndrome. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to increase expression of TAZ1 in subjects in need thereof.

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