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1. 发明公开

EP2745761A1 FLUORESCENCE OBSERVATION APPARATUS, FLUORESCENCE OBSERVATION SYSTEM, AND METHOD FOR PROCESSING FLUORESCENCE IMAGE 审中-公开
标题翻译： FLUORESZENZBEOBACHTUNGSVORRICHTUNG，FLUORESZENZBEOBACHTUNGSSYSTEM UND VERFAHREN ZUR VERARBEITUNG EINES FLUORESZENZBILDES
公开(公告)号：EP2745761A1
公开(公告)日：2014-06-25
申请号：EP12823651.0
申请日：2012-08-08
申请人： Olympus Corporation
发明人： ISHIHARA, Yasushige
IPC分类号： A61B1/00 , G02B23/24
CPC分类号： G01N21/64 , A61B1/00009 , A61B1/043 , A61B1/0638 , A61B1/0646 , G02B23/2461 , G06T5/009
摘要： Provided is a fluoroscopy apparatus that allows examination with a highly quantitative fluorescence image by sufficiently removing the residual dependence on factors such as distance from a divided image.
Employed is a fluoroscopy apparatus (100) including a preprocessing section (46) that multiplies at least one of a fluorescence image and a reference-light image by a coefficient by which distance characteristics of fluorescence intensity and distance characteristics of return-light intensity acquired from a standard sample in advance are made directly proportional to each other to generate a correction fluorescence image and a correction reference-light image; a divided-image generating section (43) that divides the correction fluorescence image by the correction reference-light image to generate a divided image; a threshold-setting section (45) that sets a threshold based on a mean grayscale level of pixels in the divided image; an image-adjusting section (51) that enhances contrast between a region with grayscale levels above the set threshold set by the threshold-setting section and a region with grayscale levels below the threshold in the divided image; and a monitor (50) that displays the divided image with the enhanced contrast.
摘要翻译：提供一种荧光透视装置，其能够通过充分去除对分割图像的距离等因素的残留依赖性，通过高度定量的荧光图像进行检查。使用的荧光透视装置（100）包括：预处理部（46），其将荧光图像和参考光图像中的至少一个乘以荧光强度的距离特性和从其获得的返回光强度的距离特性的系数预先将标准样品直接成比例地生成校正荧光图像和校正基准光图像; 分割图像生成部（43），其通过所述校正基准光图像分割所述校正荧光图像，生成分割图像; 阈值设定部（45），其基于分割图像中的像素的平均灰度等级来设定阈值; 增强了阈值设定部设定的设定阈值以上的灰度等级的区域与分割图像中的灰度级低于阈值的区域之间的对比度的图像调整部（51）以及显示具有增强的对比度的分割图像的监视器（50）。

2. 发明公开

EP2412292A1 CAPSULE MEDICAL DEVICE AND CAPSULE MEDICAL SYSTEM 审中-公开
标题翻译：医学KAPSELGERÄTUND MEDISISES KAPSELSYSTEM
公开(公告)号：EP2412292A1
公开(公告)日：2012-02-01
申请号：EP10755891.8
申请日：2010-03-12
申请人： Olympus Corporation
发明人： ISHIHARA, Yasushige
IPC分类号： A61B1/00 , A61B5/07
CPC分类号： A61B5/0071 , A61B1/00016 , A61B1/00055 , A61B1/041 , A61B1/043 , A61B5/0084 , A61B5/061 , A61B5/073 , A61B5/14539 , A61B2562/0209
摘要： The burden on a patient is reduced, and acquired measurement information is readily and reliably collected. A capsule-type medical device (10) is provided, including a capsule-type casing (12) that is introduced into a body cavity of a patient, a measurement-information acquisition unit (20) that is disposed inside the casing and that acquires measurement information about a site to be examined in the body cavity; an IC chip (32) that stores the measurement information acquired by the measurement-information acquisition unit (20); a capsule antenna (34) that receives from outside the body cavity a measurement-information-reading signal and that transmits outside the body cavity the measurement information stored in the IC chip (32); a pH sensor unit (40) that determines a passing position by acquiring positional information in the body cavity; and a buzzer (50) that issues a notification sound outside the body cavity when the passing position determined by the pH sensor unit (40) satisfies a predetermined positional condition.
摘要翻译：减轻患者的负担，并且容易且可靠地收集获取的测量信息。提供一种胶囊型医疗装置（10），包括被引入到患者的体腔内的胶囊型壳体（12），设置在所述壳体内并且获取的测定信息取得部（20）关于在体腔内检查的部位的测量信息; 存储由测量信息获取单元（20）获取的测量信息的IC芯片（32）; 从所述体腔外部接收测量信息读取信号并将体内外的所述测量信息传送到所述IC芯片（32）中的胶囊型天线（34）; pH传感器单元（40），其通过获取所述体腔中的位置信息来确定通过位置; 以及当由pH传感器单元（40）确定的通过位置满足预定的位置条件时，在体腔外发出通知声音的蜂鸣器（50）。

3. 发明授权

EP2754380B1 FLUORESCENCE OBSERVATION DEVICE 失效转让
标题翻译：荧光观察装置
公开(公告)号：EP2754380B1
公开(公告)日：2017-08-30
申请号：EP12830529.9
申请日：2012-07-23
申请人： Olympus Corporation
发明人： ISHIHARA, Yasushige
IPC分类号： A61B1/00 , A61B1/04 , G02B23/24
CPC分类号： G01N21/64 , A61B1/00009 , A61B1/00039 , A61B1/043 , G06T5/00

4. 发明授权

EP2149328B1 CAPSULE MEDICAL DEVICE AND CAPSULE MEDICAL SYSTEM 有权
标题翻译：封装的医疗设备和封装的医疗系统
公开(公告)号：EP2149328B1
公开(公告)日：2016-07-20
申请号：EP08764371.4
申请日：2008-05-20
申请人： Olympus Corporation
发明人： ISHIHARA, Yasushige
IPC分类号： A61B1/00 , A61B5/07
CPC分类号： A61B1/041 , A61B1/00004 , A61B1/00036 , A61B1/043 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/065 , A61B5/073 , H04N5/347 , H04N2005/2255

5. 发明公开

EP3037030A1 FLUORESCENCE OBSERVATION APPARATUS 审中-公开
标题翻译： FLUORESZENZBEOBACHTUNGSVORRICHTUNG
公开(公告)号：EP3037030A1
公开(公告)日：2016-06-29
申请号：EP14838502.4
申请日：2014-07-14
申请人： Olympus Corporation
发明人： KUBO, Kei , ISHIHARA, Yasushige
IPC分类号： A61B1/00 , A61B1/04
CPC分类号： A61B5/0071 , A61B1/00009 , A61B1/0005 , A61B1/043 , A61B1/045 , A61B1/0638 , A61B1/0646 , G06T5/008 , G06T5/50 , G06T19/006 , G06T19/20 , G06T2207/10064 , G06T2207/10068 , G06T2207/20212
摘要： Provided is a fluorescence observation apparatus (100) including a light source (3) that radiates illumination light and excitation light onto a subject; a return-light-image generating portion (61) and a fluorescence-image generating portion (62) that generate a return-light image (G1) and a fluorescence image (G2) of the subject, respectively; a fluorescence detecting portion (63) that detects a fluorescence region in the fluorescence image (G2); a return-light-image adjusting portion (65) that adjusts gradation values of the return-light image (G1); a superimposed-image generating portion (66) that generates a superimposed image (G3) by using the return-light image (G1'), in which the gradation values have been adjusted, and the fluorescence image (G2); and a coefficient setting portion (64) that sets, in the case in which the fluorescence region is detected by the fluorescence detecting portion (63), a degree-of-adjustment, by which the gradation values of the return-light image (G1) are adjusted by the return-light-image adjusting portion (65), so that the gradation values of the return-light image (G1) are decreased as compared with the case in which the fluorescence region is not detected by the fluorescence detecting portion (63).
摘要翻译：本发明提供一种荧光观察装置（100），其包括将照明光和激发光照射到被检体上的光源（3）分别产生被摄体的返回光图像（G1）和荧光图像（G2）的返回光图像生成部（61）和荧光图像生成部（62）检测荧光图像（G2）中的荧光区域的荧光检测部（63）。调整返回光图像（G1）的灰度值的返回光图像调整部（65）。通过使用调整了灰度值的返回光图像（G1'）和荧光图像（G2）来生成叠加图像（G3）的叠加图像生成部（66）。以及系数设定部（64），其在通过荧光检测部（63）检测出荧光区域的情况下设定调整度，通过该调节度，返回光图像（G1 ）通过返回光图像调整部（65）进行调整，使得与未被荧光检测部检测出荧光区域的情况相比，返回光图像（G1）的灰度值降低（63）。

6. 发明授权

EP2412295B1 FLUOROSCOPY APPARATUS, FLUOROSCOPY SYSTEM, AND FLUORESCENCE IMAGE PROCESSING METHOD 有权
标题翻译： FLUOROSKOPIEAPPARAT，透视和荧光观测方法
公开(公告)号：EP2412295B1
公开(公告)日：2015-12-02
申请号：EP10755918.9
申请日：2010-03-16
申请人： Olympus Corporation
发明人： ISHIHARA, Yasushige
IPC分类号： A61B1/04
CPC分类号： A61B1/00057 , A61B1/00009 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B5/0071 , A61B5/0084 , A61B2560/0233 , G06T5/009

7. 发明公开

EP2926713A1 OBSERVATION DEVICE 无效转让
标题翻译： BEOBACHTUNGSVORRICHTUNG
公开(公告)号：EP2926713A1
公开(公告)日：2015-10-07
申请号：EP13859294.4
申请日：2013-11-22
申请人： Olympus Corporation
发明人： KUBO, Kei , ISHIHARA, Yasushige , SHIDA, Hiromi
IPC分类号： A61B1/00 , A61B1/04 , G01N21/64 , G02B23/24 , G02B23/26
CPC分类号： A61B1/0638 , A61B1/00009 , A61B1/00186 , A61B1/043 , G02B23/2484 , G02B23/26 , H04N2005/2255
摘要： Provided is an observation apparatus (100) comprising a light source (3) that irradiates a subject (X) with illumination light and special light that acts on a specific region of the subject (X); a return-light-image generating portion (61) that generates a return-light image (G1) by capturing return light coming from the subject (X) due to irradiation with the illumination light; a special-light-image generating portion (62) that generates a special-light image (G2) by capturing signal light coming from the subject (X) due to irradiation with the special light; an extraction portion (63) that extracts the specific region from the special-light image (G2); and an enhancement processing portion (64) that performs enhancement processing, which is based on return-light image information, on the return-light image (G1), in a region corresponding to the extracted specific region.
摘要翻译：本发明提供一种观察装置（100），其具备照射被检体（X）的光源（3），该照明光和作用于被检体（X）的特定区域的特殊光; 返回光图像生成部（61），其通过从照明光照射而捕获来自被摄体（X）的返回光，生成返回光图像（G1）特殊光图像生成部（62），其特征在于：通过利用所述特殊光照射来捕捉来自所述被摄体（X）的信号光，生成特殊光图像（G2）提取部（63），从所述特殊光图像（G2）提取所述特定区域; 以及增强处理部分，在对应于所提取的特定区域的区域中，对返回光图像（G1）执行基于返回光图像信息的增强处理。

8. 发明公开

EP2835092A1 FLUORESCENT OBSERVATION DEVICE AND METHOD FOR OPERATING FLUORESCENT OBSERVATION DEVICE 审中-公开
标题翻译：荧光观测装置及其操作方法荧光观察装置
公开(公告)号：EP2835092A1
公开(公告)日：2015-02-11
申请号：EP13772945.5
申请日：2013-03-28
申请人： Olympus Corporation , Olympus Medical Systems Corp.
发明人： KUBO, Kei , ISHIHARA, Yasushige , SHIDA, Hiromi , TAKEKOSHI, Satoshi
IPC分类号： A61B1/00 , A61B1/04
CPC分类号： G01N21/6456 , A61B1/00009 , A61B1/0005 , A61B1/00055 , A61B1/043 , A61B1/045 , F04C2270/041 , G01N2201/124 , G06K9/4604 , G06T7/0012 , G06T2207/30004
摘要： The invention provides a fluoroscopy apparatus including an image-capturing device (19) that acquires a fluorescence image of a subject (A); a sensitivity adjusting portion (23) that sets a sensitivity of the image-capturing device (19) to fluorescence on the basis of a gradation value of the fluorescence image; a notifying portion (25) that extracts a lesion part from the fluorescence image acquired by the image-capturing device (19) with the sensitivity set by the sensitivity adjusting portion (23) and presents it to an operator; and a display switching portion (24) that displays the fluorescence image on a display unit (7) when the sensitivity in the image-capturing device (19) is equal to or less than a predetermined threshold and that presents information showing the existence of the lesion part on the notifying portion (25) when the sensitivity is greater than the predetermined threshold.
摘要翻译：本发明提供了包含（19）做了一个图像拍摄装置取得被检体（A）的荧光图像的荧光观察装置; 灵敏度调整部（23）做了将图像拍摄装置（19）的荧光的荧光图像的灰度值的基础上的灵敏度; 通知部（25）做了提取病变部从与由灵敏度调节部（23）中设定的灵敏度的摄像装置（19）取得的荧光图像，并且将其呈现给操作者处; 以及显示切换部（24）做了显示器的显示单元（7）当在图像捕获装置（19）的灵敏度是大于预定阈值等于或小于上的荧光图像和没有给出了显示的该存在信息病变的部分通知部（25）当灵敏度大于所述预定阈值。

9. 发明公开

EP2754380A1 FLUORESCENCE OBSERVATION DEVICE 失效转让
标题翻译： FLUORESZENZBEOBACHTUNGSGERÄT
公开(公告)号：EP2754380A1
公开(公告)日：2014-07-16
申请号：EP12830529.9
申请日：2012-07-23
申请人： Olympus Corporation
发明人： ISHIHARA, Yasushige
IPC分类号： A61B1/00 , A61B1/04 , G02B23/24
CPC分类号： G01N21/64 , A61B1/00009 , A61B1/00039 , A61B1/043 , G06T5/00
摘要： The purpose is to reduce correction errors and acquire quantitative information of an object. Provided is a fluorescence observation device (100) including: a light source (10); a fluorescence-image generation part (41) that acquires a fluorescence image (G1) of an object F irradiated with excitation light; a white-light-image generation part (42) that acquires a white-light image (G2) of the object F irradiated with illumination light; an image correction part (43) that generates a corrected fluorescence image (G3) from these images (G1 and G2); a threshold setting part (45) that sets a threshold based on the average of gradation values of the entire image (G3), a first coefficient therefor, the standard deviation of the gradation values of the image (G3), and a second coefficient therefor; an extraction part (47) that determines and extracts a region in the image (G3) that has a gradation value exceeding the threshold, as a region of interest; a monitor (50) that displays the region of interest and the image (G2) in association with each other; and an input section (53) through which an observer inputs a result as to whether the determination made by the extraction part (47) is right or wrong, in which the threshold setting part (45) sets at least one of the first coefficient and the second coefficient so as to reflect the input result input through the input section (53).
摘要翻译：目的是减少校正误差并获取对象的定量信息。提供了一种荧光观察装置（100），包括：光源（10）; 获取被激发光照射的被摄体F的荧光图像（G1）的荧光图像生成部（41）获取用照明光照射的被摄体F的白光图像（G2）的白光图像生成部（42）从所述图像（G1和G2）生成校正后的荧光图像（G3）的图像校正部（43）。基于整个图像（G3）的灰度值的平均值，其第一系数，图像（G3）的灰度值的标准偏差和其第二系数的阈值设定部分（45） ; 提取部分（47），其确定并提取具有超过阈值的灰度值的图像（G3）中的区域作为关注区域; 监视器（50），其相关联地显示感兴趣的区域和图像（G2）; 以及输入部（53），观察者通过该输入部输入关于由提取部（47）作出的判定是否为对的结果，阈值设定部（45）设定第一系数和第二系数，以便反映通过输入部分（53）输入的输入结果。

10. 发明公开

EP2556787A1 FLUORESCENCE OBSERVATION DEVICE 审中-公开
标题翻译：荧光观察装置
公开(公告)号：EP2556787A1
公开(公告)日：2013-02-13
申请号：EP11765965.6
申请日：2011-04-07
申请人： OLYMPUS CORPORATION
发明人： ISHIHARA, Yasushige
IPC分类号： A61B1/00 , A61B1/04
CPC分类号： A61B6/504 , A61B1/00009 , A61B1/0005 , A61B1/00186 , A61B1/043 , A61B1/05 , A61B1/0638 , A61B1/0646 , A61B1/0669 , G06T5/009 , G06T5/50
摘要： Provided is a fluoroscopy device that can correct a variation in fluorescence intensity, which is dependent on the observation distance, the observation angle, etc., in a fluorescence image in accordance with the observation conditions. A fluoroscopy device 1 includes a light source 3 that irradiates an observation site X with excitation light and white light; a fluorescence-image generating section 21 that acquires a fluorescence image by capturing fluorescence generated in the observation site X irradiated with the excitation light; a reference-image generating section 20 that acquires a reference image by capturing return light returning from the observation site X irradiated with the white light; an observation-condition determining section 22 that determines the observation conditions of the observation site X on the basis of the reference image acquired by the reference-image generating section 20; a preprocessing section 24 that corrects gradation values of the reference image on the basis of the observation conditions of the observation site X; and a fluorescence-image correcting section 25 that generates a corrected fluorescence image by dividing the fluorescence image acquired by the fluorescence-image generating section 21 by the reference image whose gradation values have been corrected by the preprocessing section 24.
摘要翻译：本发明提供一种荧光观察装置，其能够根据观察条件来校正荧光图像中的与观察距离，观察角度等相关的荧光强度的变化。荧光观察装置1具有：向观察对象部位X照射激励光和白色光的光源3; 荧光图像生成部21，其拍摄通过激励光照射的观察对象部位X所产生的荧光，从而取得荧光图像; 参照图像生成部20，其拍摄从照射了白色光的观察对象部位X返回的返回光，取得参照图像; 观察条件判定部22，其基于参照图像生成部20所获取的参照图像来判定观察对象X的观察条件; 预处理部分24，其基于观察部位X的观察条件来校正参考图像的灰度值; 以及荧光图像校正部25，其通过将由荧光图像生成部21获取的荧光图像除以由预处理部24校正了灰度值的基准图像来生成校正后的荧光图像。

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