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1. 发明公开

EP2594639A4 HOLDER THAT HOLDS IDENTIFYING INFORMATION FOR IDENTIFYING AN IDENTIFICATION SUBJECT, AND USE THEREFOR 审中-公开
标题翻译：具有识别信息持有者用于识别标识的实体，它们的用途
公开(公告)号：EP2594639A4
公开(公告)日：2014-02-05
申请号：EP11806911
申请日：2011-07-15
申请人： NGK INSULATORS LTD
发明人： HIROTA TOSHIKAZU , NIWA KOUSUKE
IPC分类号： C12N15/09 , B42D15/10 , C12Q1/68 , G06K19/06
CPC分类号： B42D25/29 , B42D25/00 , B42D25/21 , B42D25/23 , B42D2033/20 , C12Q2563/179 , C12Q2563/185 , G07D7/14

2. 发明公开

EP2824180A4 METHOD FOR DETECTING TARGET NUCLEIC ACID 审中-公开
标题翻译：一种用于检测靶核酸
公开(公告)号：EP2824180A4
公开(公告)日：2016-03-02
申请号：EP12870538
申请日：2012-11-15
申请人： NGK INSULATORS LTD
发明人： NIWA KOUSUKE , HIROTA TOSHIKAZU
IPC分类号： C12N15/09 , C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/689 , C12Q2600/16 , C12Q2525/161 , C12Q2537/162 , C12Q2565/518
摘要： The disclosure of this Description includes: a step of preparing a solid-phase body provided with a detection probe having a predetermined nucleotide sequence; a step of preparing a signaling target nucleic acid having a signal generating part for detecting the target nucleic acid; a step of bringing the signaling target nucleic acid, the detection probe, and an oligonucleotide being a mediator having a first site that hybridizes specifically with the target nucleic acid and a second site (preferably 20 to 50 nucleotides or more preferably 20 to 25 nucleotides in length) that hybridizes specifically with a part having the predetermined nucleotide sequence of the detection probe into contact with one another so that a hybridization product of these components can be formed; and a step of obtaining data based on the signal generating part of the signaling target nucleic acid on the solid-phase body.

3. 发明公开

EP1385000A4 METHOD FOR MAKING BIOCHIP 有权
标题翻译：用于生产生物芯片
公开(公告)号：EP1385000A4
公开(公告)日：2006-04-19
申请号：EP02722893
申请日：2002-04-30
申请人： NGK INSULATORS LTD
发明人： HIROTA TOSHIKAZU , OHNISHI TAKAO , TSUJI HIROYUKI
IPC分类号： B01J19/00 , B01L3/02 , C40B40/06 , C40B60/14 , G01N33/53 , G01N35/10 , G01N37/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00693 , B01J2219/00695 , B01J2219/00702 , B01J2219/00722 , B01L3/0241 , C40B40/06 , C40B60/14 , G01N35/109 , Y10T436/2575
摘要： A method for making a biochip by arranging spots of a plurality of kinds of sample, at a high density, at specified positions on a substrate (2) by using an ejection head (3) provided with one or more ejection modules each comprising one or more ejection unit, and a first moving table (5) on which at least one tray (4) fixed with one or more substrate (2) is detachable mounted. According to the method, the work for arranging and fixing liquid drops of microvolume on a specified substrate at a high density (work for forming microspots) can be carried out with high precision while shortening the time for forming microspots.

4. 发明公开

EP1365249A4 BIOCHIP AND METHOD OF MANUFACTURING THE BIOCHIP 有权
标题翻译： BIOCHIP UND VERFAHREN ZU SEINER HERSTELLUNG
公开(公告)号：EP1365249A4
公开(公告)日：2006-04-19
申请号：EP02711366
申请日：2002-02-07
申请人： NGK INSULATORS LTD
发明人： HIROTA TOSHIKAZU , OHNISHI TAKAO , YAMADA SAICHI , YAMADA KAZUNARI , TAKEUCHI YUKIHISA
IPC分类号： B01J19/00 , B01L3/00 , B41J2/16 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N37/00
CPC分类号： G01N33/54366 , B01J19/0046 , B01J2219/00351 , B01J2219/00378 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00722 , B01L3/5088 , B82Y5/00 , C12Q1/6837 , G01N33/54353
摘要： A method of manufacturing a biochip, comprising the steps of feeding immobilization reinforcing liquid (16) onto a substrate (10) (first feed step) and feeding a specimen (14) obtained in a specimen conditioning step onto the immobilization reinforcing liquid (16) fed onto the substrate (10), whereby a biochip having a plurality of capture spots arranged on the substrate (10) can be manufactured by feeding, onto the substrate (10), a plurality types of captures reacting specifically to a subject and used for obtaining the information on the structure or function of the subject.
摘要翻译：在基于捕获产生包括大量点的生物芯片的制造方法中，通过向基板（10）上提供多种类型的捕获来将斑点布置在基板（10）上，用于特异性地与样品反应以获得关于样品的结构或功能的信息，将固定补强溶液（16）供应到基板（10）上（第一供应步骤）。随后，将在样品制备步骤中获得的样品（14）供给到已经供给到基板（10）上的固定补强溶液（16），从而生成生物芯片（第二供给步骤）。

5. 发明公开

EP2495334A4 METHOD FOR DETECTION OF TARGET NUCLEIC ACID 有权
标题翻译：检测方法的靶核酸的
公开(公告)号：EP2495334A4
公开(公告)日：2013-08-21
申请号：EP10826718
申请日：2010-10-26
申请人： NGK INSULATORS LTD
发明人： NIWA KOUSUKE , HIROTA TOSHIKAZU , KAWASE MITSUO
IPC分类号： C12Q1/68 , C12M1/00 , C12N15/09 , G01N33/53 , G01N33/543 , G01N37/00
CPC分类号： C12Q1/689 , C12Q1/6858 , C12Q2600/158 , C12Q2531/107 , C12Q2537/143 , C12Q2563/107 , C12Q2565/514
摘要： An object of the disclosure of the present specification is to provide a method for detection of a target nucleic acid which allows construction of an effective detection system of a target nucleic acid. For this purpose, in the disclosure of the present specification, a first primer 30 comprising an identification sequence 32 complementary to a target sequence 12 in a target nucleic acid and a tag addition sequence 36, and a second primer 40 having a label 42 are prepared. The first primer 30 and the second primer 40 are used for the target nucleic acid 10 in a sample to amplify a chimeric DNA 60 having a tag sequence 66 and the label 42. The chimeric DNA 60 is hybridized with a detection probe 104 on a solid phase 100 to obtain signal intensity information based on the label 42, and the target nucleic acid 10 is detected based on the signal intensity information.

6. 发明公开

EP1655604A4 ANALYTICAL TEST PIECE AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：分析试件和方法及其生产
公开(公告)号：EP1655604A4
公开(公告)日：2007-10-24
申请号：EP04746355
申请日：2004-06-24
申请人： NGK INSULATORS LTD
发明人： OHNISHI TAKAO , HIROTA TOSHIKAZU
IPC分类号： G01N33/543 , B01F13/00 , B01L3/00 , G01N33/52 , G01N33/544 , G01N33/58
CPC分类号： G01N33/54386 , B01F13/0059 , B01F13/0071 , B01L3/508 , B01L2200/16 , B01L2300/0822
摘要： Analytical test piece (10) comprising support (1) and, disposed on the surface (11) and/or in the interior of the support (1), reagent spots (2), the analytical test piece (10) adapted to, when analyte-containing sample (3) is introduced in the surface (11) of support (1), cause the analyte-containing sample (3) to be brought into contact with and react with the reagent spots (2) disposed on the surface (11) and/or in the interior of the support (1) so as to induce formation of a detectable substance (signal substance) or exhibition of detectable property (or signal property), wherein the reagent spots (2) are composed of multiple types of reagent spots (21, 22) constituted of any of multiple types of solutions which upon mixing with each other exert given function, so that the sample (3) introduced in the surface (11) of the support (1) is brought into contact with the multiple types of reagent spots (21, 22) so as to effect not only mutual mixing of the multiple types of reagent spots (21, 22) but also reaction with the multiple types of reagent spots (21, 22) having been mixed together, thereby realizing formation of a signal substance or exhibition of signal property. This analytical test piece excels in analytical reliability, analytical sensitivity (analytical precision) and storage stability.

7. 发明公开

EP2762562A4 METHOD FOR DETECTING TARGET NUCLEIC ACID 有权
标题翻译：检测目标核酸的方法
公开(公告)号：EP2762562A4
公开(公告)日：2015-05-06
申请号：EP12832061
申请日：2012-09-14
申请人： NGK INSULATORS LTD
发明人： NIWA KOUSUKE , HIROTA TOSHIKAZU , KAWASE MITSUO
IPC分类号： C12N15/09 , C12Q1/68 , G01N33/543
CPC分类号： C12Q1/6837 , C12Q1/6844 , C12Q2525/161 , C12Q2565/519
摘要： The disclosure of the present description provides a method for detecting a target nucleic acid, whereby probe hybridization can be accomplished efficiently. To that end, a target nucleic acid is amplified using a first primer having a tag sequence complementary to a detection probe pre-associated with the target nucleic acid and a first recognition sequence that recognizes a first base sequence in the target nucleic acid and also having a linking site capable of inhibiting or arresting a DNA polymerase reaction disposed between the tag sequence and the first recognition sequence, and a second primer having a second recognition sequence that recognizes a second base sequence in the target nucleic acid, the amplified fragment is brought into contact with a detection probe so as to allow hybridization, and the hybridization product is detected.
摘要翻译：本说明书的公开内容提供了用于检测靶核酸的方法，由此可以有效地实现探针杂交。为此目的，使用具有与靶核酸预先相关联的检测探针互补的标签序列的第一引物和识别靶核酸中的第一碱基序列的第一识别序列扩增靶核酸，并且还具有能够抑制或阻止设置在标记序列和第一识别序列之间的DNA聚合酶反应的连接位点和具有识别靶核酸中的第二碱基序列的第二识别序列的第二引物，将扩增的片段置于与检测探针接触以允许杂交，并检测杂交产物。

8. 发明公开

EP1589340A4 REACTIVE CHIP AND METHOD FOR DETECTING BOND OF TARGET SUBSTANCE USING THAT CHIP 有权
标题翻译： REACTIVE CHIP AND METHOD FOR鉴别该物质粘结的目的地使用本CHIPS
公开(公告)号：EP1589340A4
公开(公告)日：2007-06-13
申请号：EP04700535
申请日：2004-01-07
申请人： NGK INSULATORS LTD
发明人： YOSHIDA YASUKO , HIROTA TOSHIKAZU , TAKEUCHI YUKIHISA
IPC分类号： G01N33/53 , G01G3/13 , G01N5/02 , G01N33/543 , G01N33/566 , G01N37/00
CPC分类号： G01N33/54373 , B01J2219/00605 , B01J2219/00637 , B01J2219/00704 , G01N33/5438
摘要： A novel reactive chip for detecting a wide range of target substances with highly accuracy while shortening the reaction time and preventing mismatch bond effectively. The reactive chip has capture probes (60) bonding to the target substance secured, respectively, to three or more oscillation faces (50) arranged on a substrate (30). Each oscillation face is provided with an oscillation generating part (40) where a piezoelectric/electrostrictive element (20) is sandwitched by a first electrode (11) and a second electrode (12).

9. 发明公开

EP1482028A4 REACTION CELL AND METHOD OF USING THE CELL 有权
标题翻译：反应池和利用细胞方法
公开(公告)号：EP1482028A4
公开(公告)日：2007-05-02
申请号：EP03743540
申请日：2003-02-28
申请人： NGK INSULATORS LTD
发明人： TAKEUCHI YUKIHISA , YOSHIDA YASUKO , HIROTA TOSHIKAZU
IPC分类号： B01F11/02 , G01N35/02 , B01L3/00 , C12M1/00 , G01N11/16 , G01N33/543 , H01L41/09
CPC分类号： B01L3/5085 , B01F11/0266 , B01L2300/0627 , B01L2300/0803 , B01L2400/0439 , G01N11/16 , G01N33/54393
摘要： A reaction cell (1), comprising a container-like cell body (2) and a circular piezoelectric vibrator (3) fixed to the outside lower surface of the cell body (2), the cell body (2) further comprising a circular bottom plate part (2A) and a peripheral wall part (2B) rising from the peripheral edge of the bottom plate part (2A) and surrounding the bottom plate part (2A), wherein the bottom plate part (2A) and the peripheral wall part (2B) are formed of ceramics integrally with each other, a space surrounded by the peripheral wall part (2B) on the bottom plate part (2A) is formed in a solution storage space (4), and the piezoelectric vibrator (3) is stuck on the outside lower surface of the bottom plate part (2A) concentrically with each other.

10. 发明公开

EP1143252A4 BIOCHIP 有权
标题翻译：生物芯片
公开(公告)号：EP1143252A4
公开(公告)日：2007-01-24
申请号：EP00969959
申请日：2000-10-20
申请人： NGK INSULATORS LTD
发明人： HIROTA TOSHIKAZU , OHNISHI TAKAO
IPC分类号： B01J19/00 , B01L3/00 , B01L3/02 , B01L7/00 , B01L9/00 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N35/00 , G01N35/10 , G01N33/566
CPC分类号： G01N35/00029 , B01J19/0046 , B01J2219/00317 , B01J2219/00351 , B01J2219/00369 , B01J2219/00378 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01L3/0241 , B01L3/0268 , B01L3/5085 , B01L3/5088 , B01L9/54 , B01L2200/021 , B01L2200/027 , B01L2300/0816 , B01L2300/0819 , B01L2400/027 , B01L2400/0439 , C12Q1/6837 , C40B40/06 , C40B60/14 , G01N2035/00158 , G01N2035/1039 , Y10T436/25 , Y10T436/2575 , C12Q2565/507
摘要： The inspection accuracy of gene analysis conducted using a DNA microarray is improved. A DNA microarray (20) is prepared by supplying a sample solution onto a substrate (10) to form an array of spots (80) of the sample solution on the substrate (10). The shape of the spots (80) when viewed from above is generally circular, and the sizes thereof are different.

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