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1. 发明公开

EP2760585A2 SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS 审中-公开
标题翻译： SYSTEME UND VERFAHRENFÜRBIOLOGISCHE ANALYSEN
公开(公告)号：EP2760585A2
公开(公告)日：2014-08-06
申请号：EP12784373.8
申请日：2012-09-28
申请人： Life Technologies Corporation
发明人： FREUDENTHAL, Jacob K. , DAHLHOFF, Geoffrey , MAHER, Kevin , CHEN, Mingsong , LIM, Gary , DANEHY, Ronald , FORTESCUE, David , SHEN, Ming , SOH, Woon Liang Terence , CHENG, Francis , WU, Ruoyun , LEE, Thiam Chye , CHAPPELL, Gary , LIM, Chee Kiong , DERE, Jeff , STRAUB, Ted , FONSECA, Jorge , BOO, Kuan Moon , LAU, Soo Yong
IPC分类号： B01L7/00 , B01L3/00 , C12Q1/68
CPC分类号： C12Q1/686 , B01L3/50855 , B01L3/50857 , B01L7/52 , B01L2200/023 , B01L2200/025 , B01L2200/028 , B01L2200/143 , B01L2300/021 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/1827 , B01L2300/1844
摘要： A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
摘要翻译：提供生物分析系统。该系统包括被配置为容纳多个样本保持器中的任何一个的可互换组件，每个样本保持器被配置为接收多个样本。该系统还包括配置成使多个样品循环通过一系列温度的控制系统。该系统还包括被配置为检测从多个样本发射的荧光信号的光学系统。特别地，光学系统可以包括单个场透镜，激发源，光学传感器和多个滤光器组件。激发源可以是一个或多个发光二极管。场透镜可以是双凸透镜。

2. 发明公开

EP2761277A1 OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS 有权转让
标题翻译： OPTISCHE SYSTEME UND VERFAHREN ZUR BIOLOGISCHEN ANALYZE
公开(公告)号：EP2761277A1
公开(公告)日：2014-08-06
申请号：EP12783710.2
申请日：2012-09-28
申请人： Life Technologies Corporation
发明人： MAHER, Kevin , CHEN, Mingsong , FREUDENTHAL, Jacob , BOO, Kuan, Moon , LAU, Soo, Yong , FORTESCUE, David , SHEN, Ming , SOH, Woon Liang, Terence
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , G01N21/6428 , G01N21/6452 , G01N2021/6471 , G01N2021/6478 , G01N2201/062
摘要： An instrument for processing and/or measuring a biological process contains an excitation source, a sample holder, an optical sensor, an excitation optical system, and an emission optical system. The sample holder is configured to receive a plurality of biological samples. The optical sensor is configured to receive an emission from the biological samples. The excitation optical system is disposed along an excitation optical path and is configured to direct the electromagnetic radiation from the excitation source to the biological samples. The emission optical system is disposed along an emission optical path and is configured to direct electromagnetic emissions from the biological samples to the optical sensor. The instrument further contains a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.
摘要翻译：用于处理和/或测量生物过程的仪器包含激发源，样品架，光学传感器，激发光学系统和发射光学系统。样品架配置成接收多个生物样品。光学传感器被配置为接收来自生物样品的发射。激发光学系统沿着激发光学路径设置并且被配置为将来自激发源的电磁辐射引导到生物样品。发射光学系统沿着发射光路设置并且被配置为将来自生物样品的电磁辐射引导到光学传感器。仪器还包括多个过滤器组件，其被配置为沿着至少一个光路可互换地定位。多个滤波器部件包括第一滤波器组件，其特征在于第一光功率和具有第一滤波器功能的第一滤波器，第一滤波器功能的特征在于第一低通波长或第一高通波长中的至少一个。第二滤波器组件的特征在于具有第二滤波器功能的第二光功率和第二滤波器，第二滤波器功能包括与第一低通波长不同的第二低通波长或第二高通波长中的至少一个通过波长不同于第一高通波长。

3. 发明公开

EP3253492A2 SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS 有权
标题翻译：用于生物分析的系统和方法
公开(公告)号：EP3253492A2
公开(公告)日：2017-12-13
申请号：EP16708007.6
申请日：2016-02-05
申请人： Life Technologies Corporation
发明人： CHU, Yong , MARKS, Jeffrey , FREUDENTHAL, Jacob , CHEN, Mingsong , TOH, Tiong Han , AGUANNO, Mauro , LAU, Lik Seng , LOH, Lian Seng , TEO, Kok Siong , CHU, Zeng Wei , MATHERS, Xin , UY, Michael , YEO, Huei Steven , BOO, Kuan Moon , LEE, Way Xuang , KOO, Chin Yong , TEO, Wei Fuh , LAU, Soo Yong , SHIN, Hon Siu , TAN, Zeqi , WESSEL, Thomas , WOO, David
IPC分类号： B01L7/00 , G01N21/64 , G01N35/02 , G01N35/00
CPC分类号： B01L7/52 , B01L2200/145 , B01L2300/18 , B01L2300/1822 , C12Q1/6806 , G01N21/274 , G01N21/6452 , G01N21/6486 , G01N35/026 , G01N2021/6439 , G01N2035/00316 , G01N2035/00366 , G01N2201/061 , G01N2201/12
摘要： A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.

4. 发明公开

EP4379392A2 SYSTEMS FOR BIOLOGICAL ANALYSIS 审中-公开
公开(公告)号：EP4379392A2
公开(公告)日：2024-06-05
申请号：EP24157142.1
申请日：2016-02-05
申请人： Life Technologies Corporation
发明人： CHU, Yong , MARKS, Jeffrey , FREUDENTHAL, Jacob , CHEN, Mingsong , TOH, Tiong Han , AGUANNO, Mauro , LAU, Lik Seng , LOH, Lian Seng , TEO, Kok Siong , CHU, Zeng Wei , MATHERS, Xin , UY, Michael , YEO, Huei Steven , BOO, Kuan Moon , LEE, Way Xuang , KOO, Chin Yong , TEO, Wei Fuh , LAU, Soo Yong , SHIN, Hon Siu , TAN, Zeqi , WESSEL, Thomas , WOO, David
IPC分类号： G01N35/00
CPC分类号： G01N35/026 , G01N2035/0031620130101 , G01N2035/0036620130101 , G01N21/274 , G01N21/6452 , G01N2021/643920130101 , B01L2200/14520130101 , B01L2300/182220130101 , B01L7/52
摘要： A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.

5. 发明公开

EP3254085A1 SYSTEMS AND METHODS FOR ASSESSING BIOLOGICAL SAMPLES 有权
标题翻译：用于评估生物样本的系统和方法
公开(公告)号：EP3254085A1
公开(公告)日：2017-12-13
申请号：EP16705683.7
申请日：2016-02-05
申请人： Life Technologies Corporation
发明人： CHEN, Mingsong , BOO, Kuan Moon , TOH, Tiong Han , AGUANNO, Mauro , LAU, Soo Yong , YEO, Huei Steven , TEO, Wei Fuh
IPC分类号： G01N21/64 , G02B21/24
CPC分类号： C12Q1/686 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0829 , B01L2300/168 , B01L2300/18 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6458 , G01N2021/6463 , G02B21/244
摘要： An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The may instrument further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.

6. 发明公开

EP2959284A2 OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS 审中-公开
标题翻译：光学系统和生物分析方法
公开(公告)号：EP2959284A2
公开(公告)日：2015-12-30
申请号：EP14709128.4
申请日：2014-02-24
申请人： Life Technologies Corporation
发明人： CHEN, Mingsong , AGUANNO, Mauro , BOO, Kuan Moon , SOH, Woon Liang Terence , FREUDENTHAL, Jacob , MARKS, Jeffrey
IPC分类号： G01N21/27
CPC分类号： G01N21/6486 , G01N21/0332 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2201/061 , G01N2201/0624 , G01N2201/0627 , G01N2201/121
摘要： An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.

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