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1. 发明公开

EP2760585A2 SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS 审中-公开
标题翻译： SYSTEME UND VERFAHRENFÜRBIOLOGISCHE ANALYSEN
公开(公告)号：EP2760585A2
公开(公告)日：2014-08-06
申请号：EP12784373.8
申请日：2012-09-28
申请人： Life Technologies Corporation
发明人： FREUDENTHAL, Jacob K. , DAHLHOFF, Geoffrey , MAHER, Kevin , CHEN, Mingsong , LIM, Gary , DANEHY, Ronald , FORTESCUE, David , SHEN, Ming , SOH, Woon Liang Terence , CHENG, Francis , WU, Ruoyun , LEE, Thiam Chye , CHAPPELL, Gary , LIM, Chee Kiong , DERE, Jeff , STRAUB, Ted , FONSECA, Jorge , BOO, Kuan Moon , LAU, Soo Yong
IPC分类号： B01L7/00 , B01L3/00 , C12Q1/68
CPC分类号： C12Q1/686 , B01L3/50855 , B01L3/50857 , B01L7/52 , B01L2200/023 , B01L2200/025 , B01L2200/028 , B01L2200/143 , B01L2300/021 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/1827 , B01L2300/1844
摘要： A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
摘要翻译：提供生物分析系统。该系统包括被配置为容纳多个样本保持器中的任何一个的可互换组件，每个样本保持器被配置为接收多个样本。该系统还包括配置成使多个样品循环通过一系列温度的控制系统。该系统还包括被配置为检测从多个样本发射的荧光信号的光学系统。特别地，光学系统可以包括单个场透镜，激发源，光学传感器和多个滤光器组件。激发源可以是一个或多个发光二极管。场透镜可以是双凸透镜。

2. 发明授权

EP2761027B1 METHODS AND SYSTEMS FOR VISUALIZING AND EVALUATING DATA 有权转让
标题翻译：用于可视化和评估数据的方法和系统
公开(公告)号：EP2761027B1
公开(公告)日：2017-10-25
申请号：EP12784368.8
申请日：2012-09-28
申请人： Life Technologies Corporation
发明人： JANAWAY, Gordon , ALIMINATI, Manjula , WU, Ruoyun , FORTESCUE, David , SHEN, Ming
IPC分类号： C12Q1/68
CPC分类号： G06F19/24 , C12Q1/6851 , C12Q2537/165 , C12Q2563/159

3. 发明公开

EP2761027A1 METHODS AND SYSTEMS FOR VISUALIZING AND EVALUATING DATA 有权转让
标题翻译： VERFAHREN UND SYSTEME ZUR VISUALISIERUNG UND AUSWERTUNG VON DATEN
公开(公告)号：EP2761027A1
公开(公告)日：2014-08-06
申请号：EP12784368.8
申请日：2012-09-28
申请人： Life Technologies Corporation
发明人： JANAWAY, Gordon , ALIMINATI, Manjula , WU, Ruoyun , FORTESCUE, David , SHEN, Ming
IPC分类号： C12Q1/68
CPC分类号： G06F19/24 , C12Q1/6851 , C12Q2537/165 , C12Q2563/159
摘要： A computer-implemented method of generating a digital polymerase chain reaction (dPCR) result is provided. The method includes detecting a first set of emission data from a plurality of samples, each included in a sample region of a plurality of sample regions, at a first time during an amplification period. The method further includes determining a positive or negative amplification determination for each sample of the plurality of samples based in part on the first set of emission data. A dPCR result is generated based on the positive or negative amplification determinations for the plurality of samples.
摘要翻译：提供了一种计算机实现的产生数字聚合酶链反应（dPCR）结果的方法。该方法包括在放大期间的第一时间，从多个样本中检测出第一组发射数据，每个样本包括多个采样区域的采样区域。该方法还包括部分地基于第一组发射数据来确定多个样本中的每个样本的正或负放大确定。基于多个样本的正或负放大确定产生dPCR结果。

4. 发明公开

EP2671179A1 SYSTEMS AND METHODS FOR THE ANALYSIS OF PROTEIN MELT CURVE DATA 有权转让
标题翻译：系统分析仪VERFAHREN ZUR ANALYZE VON PROTEINSCHMELZKURVENDATEN
公开(公告)号：EP2671179A1
公开(公告)日：2013-12-11
申请号：EP12707407.8
申请日：2012-02-01
申请人： Life Technologies Corporation
发明人： MAJUMDAR, Nivedita , LEONG, Harrison , WU, Ruoyun
IPC分类号： G06F19/26
CPC分类号： G06F19/26 , G06F3/0482 , G06F3/04847 , G06F19/24 , G06T11/206 , G06T2200/24
摘要： The present teachings relate to embodiments of systems and methods for the analysis of melt curve data for a plurality of samples. According to various embodiments, a melting temperature (Tm) may be determined across a range of different types of protein melt curve data, having variability over a plurality of analytical attributes in order to accommodate the complexity of protein melt curve data. The combination of a plurality of samples, coupled with the complexity of the data gives rise for a need to process the data in a manner that readily facilitates end-user to analysis of the data. Various embodiments of an interactive graphical user interface (GUI) according to the present teachings provide for rapid and sequential changes that may be made by an end user to displayed protein melt curve data to allow such analysis.
摘要翻译：本教导涉及用于分析多个样品的熔体曲线数据的系统和方法的实施例。根据各种实施方案，可以在不同类型的蛋白质熔融曲线数据的范围内确定熔解温度（Tm），其具有多个分析属性的变异性，以便适应蛋白质熔融曲线数据的复杂性。多个样本的组合以及数据的复杂性导致需要以容易促进最终用户分析数据的方式处理数据。根据本教导的交互式图形用户界面（GUI）的各种实施例提供了终端用户可以进行快速和顺序的改变以显示蛋白质熔解曲线数据以允许这种分析。

5. 发明授权

EP2671179B1 SYSTEMS AND METHODS FOR THE ANALYSIS OF PROTEIN MELT CURVE DATA 有权转让
公开(公告)号：EP2671179B1
公开(公告)日：2019-05-01
申请号：EP12707407.8
申请日：2012-02-01
申请人： Life Technologies Corporation
发明人： MAJUMDAR, Nivedita , LEONG, Harrison , WU, Ruoyun
IPC分类号： G06F19/26 , G06F19/24

6. 发明公开

EP2591434A2 SYSTEMS AND METHODS FOR ASSIGNING ATTRIBUTES TO A PLURALITY OF SAMPLES 审中-公开
标题翻译：系统和方法的属性，而一些样品分配
公开(公告)号：EP2591434A2
公开(公告)日：2013-05-15
申请号：EP11804433.8
申请日：2011-07-08
申请人： Life Technologies Corporation
发明人： LEONG, Harrison , WU, Ruoyun , LEE, Thiam Chye
IPC分类号： G06F19/10 , G06F3/048 , G06F3/14
CPC分类号： B01L7/52 , B01L3/5085 , B01L3/50851 , B01L99/00 , B01L2300/023 , B01L2300/024 , B01L2300/025 , B01L2300/027 , B01L2300/046 , B01L2300/0654 , B01L2300/0822 , B01L2300/0829 , G01N2035/00891
摘要： Systems and methods for assigning attributes to a plurality of samples are provided. An exemplary system includes an instrument configured to perform an experiment on a plurality of samples in a multi- sample support device and to produce a plurality of measured values. The system further includes a computer system in communication with the instrument. The computer system is configured to receive the plurality of measured values from the instrument, store the plurality of measured values in a memory configured as a grid of cells representing the grid of the multi- sample support device, display the grid of cells in a graphical user interface, receive a selected cell from the graphical user interface, receive two or more attribute values for the selected cell from the graphical user interface, and store the two or more assigned attribute values along with a measured value of the selected cell in the memory configured as a grid of cells.

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