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1. 发明公开

EP3107658A1 APPARATUSES, SYSTEMS AND METHODS FOR PROVIDING SCALABLE THERMAL CYCLERS AND ISOLATING THERMOELECTRIC DEVICES 有权
标题翻译：设备，系统和提供可扩展的热循环器和隔离热电装置的方法
公开(公告)号：EP3107658A1
公开(公告)日：2016-12-28
申请号：EP15704906.5
申请日：2015-02-04
申请人： Life Technologies Corporation
发明人： LIM, Chee Kiong , LEE, Way Xuang , LOH, Wuh Ken , CHING, Chee Wee , KOO, Chin Yong , KOH, Siew Ying , TOH, Tiong Han , BOO, Kuan Moon , LAU, Soo Yong
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , B01L2200/147 , B01L2300/0829 , B01L2300/1805 , B01L2300/1822 , B01L2300/1883 , C12Q1/6806
摘要： In one aspect, a thermal cycler system including a sample block and a thermoelectric device is disclosed. In various embodiments, the sample block has a first surface configured to receive a plurality of reaction vessels and an opposing second surface. In various embodiments the thermoelectric device is operably coupled to the second surface of the sample block. In various embodiments a thermal control unit is provided. In various embodiments the thermal control unit includes a computer processing unit. In various embodiments the thermal control unit includes an electrical current source. In various embodiments the thermal control unit also includes an electrical interface portion configured to connect the thermoelectric device with the electrical current source by way of an electrical cable. In various embodiments the thermal control unit is oriented in a different plane than the sample block and thermoelectric cooler.

2. 发明授权

EP1628771B2 THERMAL CYCLING APPARATUS FOR PROVIDING THERMAL UNIFORMITY 有权转让
公开(公告)号：EP1628771B2
公开(公告)日：2018-10-31
申请号：EP04753774.1
申请日：2004-05-28
申请人： Life Technologies Corporation
发明人： SHIN, Hon Siu, No. 23 Tampines Street, 34 , NGUI, Jew Kwee , LIM, Chee Kiong , LAU, Ching Ong , TAN, Lim Hi , KEE, Yang Hooi
IPC分类号： B01L7/00 , C12Q1/68
CPC分类号： B01L7/52 , B01L2300/0829 , B01L2300/1822
摘要： An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.

3. 发明授权

EP3107658B1 APPARATUSES, SYSTEMS AND METHODS FOR PROVIDING SCALABLE THERMAL CYCLERS AND ISOLATING THERMOELECTRIC DEVICES 有权
公开(公告)号：EP3107658B1
公开(公告)日：2018-07-04
申请号：EP15704906.5
申请日：2015-02-04
申请人： Life Technologies Corporation
发明人： LIM, Chee Kiong , LEE, Way Xuang , LOH, Wuh Ken , CHING, Chee Wee , KOO, Chin Yong , KOH, Siew Ying , TOH, Tiong Han , BOO, Kuan Moon , LAU, Soo Yong
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , B01L2200/147 , B01L2300/0829 , B01L2300/1805 , B01L2300/1822 , B01L2300/1883 , C12Q1/6806
摘要： In one aspect, a thermal cycler system including a sample block and a thermoelectric device is disclosed. In various embodiments, the sample block has a first surface configured to receive a plurality of reaction vessels and an opposing second surface. In various embodiments the thermoelectric device is operably coupled to the second surface of the sample block. In various embodiments a thermal control unit is provided. In various embodiments the thermal control unit includes a computer processing unit. In various embodiments the thermal control unit includes an electrical current source. In various embodiments the thermal control unit also includes an electrical interface portion configured to connect the thermoelectric device with the electrical current source by way of an electrical cable. In various embodiments the thermal control unit is oriented in a different plane than the sample block and thermoelectric cooler.

4. 发明公开

EP2556173A2 IMPROVED THERMAL UNIFORMITY FOR THERMAL CYCLER INSTRUMENTATION USING DYNAMIC CONTROL 有权转让
标题翻译：利用动态控制改善热循环器仪表的热一致性
公开(公告)号：EP2556173A2
公开(公告)日：2013-02-13
申请号：EP11766806.1
申请日：2011-04-08
申请人： Life Technologies Corporation
发明人： CONNER, Thomas A. , LIM, Chee Kiong , PALLAS, Michael C. , CHING, Chee Wee
IPC分类号： C12Q1/68 , C12M1/38 , G01N33/50
CPC分类号： B01L7/52 , B01L2200/147 , B01L2300/1822 , B01L2300/1894
摘要： A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.
摘要翻译：提供了用于进行聚合酶链式反应（PCR）以改善热不均匀性的方法。该方法包括：通过第一传感器测量样本块的第一样本块扇区的第一温度，并且通过第二传感器测量样本块的与第一样本块相邻的第二样本块扇区的第二温度样本块部门。该方法进一步包括通过热电控制器计算第一温度和第二温度之间的温度差并且通过热电控制器基于温度差通过使用一个或多个温度计来调整第一样本块扇区的第一温度更多的热电冷却器。一个或多个热电冷却器被配置为通过调整来自热电控制器的功率输出来加热或冷却第一样本块扇区。

5. 发明公开

EP3046671A1 APPARATUSES, SYSTEMS AND METHODS FOR PROVIDING THERMOCYCLER THERMAL UNIFORMITY 有权转让
标题翻译：设备，系统和产生均匀温度课程，为一个热循环方法
公开(公告)号：EP3046671A1
公开(公告)日：2016-07-27
申请号：EP14777985.4
申请日：2014-09-15
申请人： Life Technologies Corporation
发明人： SHIN, Hon Siu , KOO, Chin Yong , LEE, Way Xuang , LIM, Chee Kiong , CHING, Chee Wee , RAMACHANDRAN, Niroshan
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , B01L2200/147 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/12 , B01L2300/1822
摘要： A thermal block assembly including a sample block and two or more thermoelectric devices, is disclosed. The sample block has a top surface configured to receive a plurality of reaction vessels and an opposing bottom surface. The thermoelectric devices are operably coupled to the sample block, wherein each thermoelectric device includes a housing for a thermal sensor and a thermal control interface with a controller. Each thermoelectric device is further configured to operate independently from each other to provide a substantially uniform temperature profile throughout the sample block.

6. 发明公开

EP2760585A2 SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS 审中-公开
标题翻译： SYSTEME UND VERFAHRENFÜRBIOLOGISCHE ANALYSEN
公开(公告)号：EP2760585A2
公开(公告)日：2014-08-06
申请号：EP12784373.8
申请日：2012-09-28
申请人： Life Technologies Corporation
发明人： FREUDENTHAL, Jacob K. , DAHLHOFF, Geoffrey , MAHER, Kevin , CHEN, Mingsong , LIM, Gary , DANEHY, Ronald , FORTESCUE, David , SHEN, Ming , SOH, Woon Liang Terence , CHENG, Francis , WU, Ruoyun , LEE, Thiam Chye , CHAPPELL, Gary , LIM, Chee Kiong , DERE, Jeff , STRAUB, Ted , FONSECA, Jorge , BOO, Kuan Moon , LAU, Soo Yong
IPC分类号： B01L7/00 , B01L3/00 , C12Q1/68
CPC分类号： C12Q1/686 , B01L3/50855 , B01L3/50857 , B01L7/52 , B01L2200/023 , B01L2200/025 , B01L2200/028 , B01L2200/143 , B01L2300/021 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/1827 , B01L2300/1844
摘要： A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
摘要翻译：提供生物分析系统。该系统包括被配置为容纳多个样本保持器中的任何一个的可互换组件，每个样本保持器被配置为接收多个样本。该系统还包括配置成使多个样品循环通过一系列温度的控制系统。该系统还包括被配置为检测从多个样本发射的荧光信号的光学系统。特别地，光学系统可以包括单个场透镜，激发源，光学传感器和多个滤光器组件。激发源可以是一个或多个发光二极管。场透镜可以是双凸透镜。

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