专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP0972760A1 PROCESS FOR THE PURIFICATION OR ISOLATION OF (2S, 3R)-1-HALO-2-HYDROXY-3-(PROTECTED AMINO)-4-PHENYLTHIOBUTANES OR OPTICAL ANTIPODES THEREOF 失效
标题翻译：用于清洁或提取方法的（2S，3R）-1- HALO 2-羟基-3-（保护的氨基）-4- PHENYLTHIOBUTANEN或其旋光对映体
公开(公告)号：EP0972760A1
公开(公告)日：2000-01-19
申请号：EP98935265.3
申请日：1998-07-29
申请人： KANEKA CORPORATION
发明人： UEDA, Yasuyoshi , MAEHARA, Katsuji , SUGAWA, Tadashi , MURAO, Hiroshi , NISHIYAMA, Akira , MANABE, Hajime
IPC分类号： C07C323/25 , C07C319/28
CPC分类号： C07C319/28 , Y02P20/55 , C07C323/25
摘要： The present invention has for its object to provide a commercially useful, expedient and efficient method for purification and isolation of an N-protected (2S,3R)-1-halo-2-hydroxy-3-amino-4-phenylthiobutane (1) or its enantiomer, which is capable of removing the various contaminants, particularly said byproducts, whereby the problem of instability of the compound (1) or its enantiomer can be overcome and a high product yield can be insured.
The present invention relates to a method of purifying and isolating an N-protected (2S,3R)-1-halo-2-hydroxy-3-amino-4-phenylthiobutane (1):
(wherein X represents a halogen atom; one of P 1 and P 2 represents a hydrogen atom and the other represents an amino-protecting group, or P 1 and P 2 taken together represents an amino-protecting group) or its enantiomer, which comprises using an aromatic hydrocarbon solvent to remove impurities occurring in said compound (1) or impurities occurring in said enantiomer from said compound (1) containing impurities or its enantiomer containing impurities and isolate said compound (1) or said enantiomer as crystals.
摘要翻译：本发明的目的是提供一种用于N-保护的纯化和分离商业上有用的，有利的，高效的方法（2S，3R）-1-卤代-2-羟基-3-氨基-4- phenylthiobutane（1）或它的对映异构体，所有这一切是能够除去各种污染物，特别是所述副产品，由此将化合物（1）或对映体的不稳定的麻烦可以被克服和高的产物收率可以投保的。本发明涉及一种纯化和分离的N-保护的方法（2S，3R）-1-卤代-2-羟基-3-氨基-4- phenylthiobutane（1）：（worin X darstellt卤素原子 ; P的<1>和P <2> darstellt氢原子和氨基保护基的其它darstellt，或P <1>和P <2>一起darstellt氨基保护基的）或它的对映体，其中包括使用以芳香族烃溶剂，以除去杂质在所述化合物存在的（1）或杂质在从所述化合物（1）含有杂质或其对映体含有杂质的对映体和所述分离所述化合物（1）或所述对映体的结晶发生的。

2. 发明授权

EP0827943B1 PROCESSES FOR THE REDUCTION OF CARBONYL COMPOUNDS 失效
标题翻译：一种用于减少羰基
公开(公告)号：EP0827943B1
公开(公告)日：2003-05-21
申请号：EP97901761.3
申请日：1997-01-29
申请人： KANEKA CORPORATION
发明人： SUGAWA, Tadashi , MOROSHIMA, Tadashi , INOUE, Kenji , KAN, Kazunori
IPC分类号： C07B41/02 , C07C29/143 , C07C33/22 , C07C213/00 , C07C215/28 , C07C271/10 , C07C323/43
CPC分类号： C07B53/00 , C07B41/02 , C07C29/143 , C07C213/00 , C07C269/06 , C07C319/20 , C07C323/43 , C07C271/16 , C07C271/22 , C07C33/22 , C07C33/46

3. 发明公开

EP0930292A1 PROCESS FOR PREPARING $g(b)-AMINO-$g(a)-HYDROXY ACID DERIVATIVES 失效
标题翻译： VERFAHREN ZUR HERSTELLUNG VON BETA-AMINO-ALPHA-HYDROXYCARBONSAEURE-DERIVATEN
公开(公告)号：EP0930292A1
公开(公告)日：1999-07-21
申请号：EP97935797.7
申请日：1997-08-18
申请人： KANEKA CORPORATION
发明人： MATSUMOTO, Shingo , MATSUO, Kazuhiko , SUGAWA, Tadashi , MOROSHIMA, Tadashi , INOUE, Kenji
IPC分类号： C07C229/22 , C07C229/34 , C07C227/02 , C07D209/48
CPC分类号： C07C303/44 , C07C227/02 , C07C227/42 , C07C269/08 , C07C271/18 , C07C303/40 , C07D209/26 , Y02P20/55 , C07C311/19 , C07C229/22 , C07C229/34
摘要： An object of the present invention is to provide a process for producing a β-amino-α-hydroxy acid derivative via efficient and industrially utilizable steps.
The present invention provides a process for producing a β-amino-α-hydroxy acid derivative represented by the general formula (2) given below which comprises hydrolyzing an α-amino-α',α'-dihaloketone derivative of the general formula (1) given below in the presence of a base, followed by protecting the amino group or without protecting the same.
摘要翻译：本发明的目的是提供一种通过有效和可工业利用的步骤生产β-氨基-α-羟基酸衍生物的方法。本发明提供一种制备由下述通式（2）表示的β-氨基-α-羟基酸衍生物的方法，其包括水解通式（1）的α-氨基-α'，α'-二卤代酮衍生物），然后保护氨基或不保护氨基。

4. 发明公开

EP0827943A1 PROCESSES FOR THE REDUCTION OF CARBONYL COMPOUNDS 失效
标题翻译： VERFAHREN ZUR REDUKTION VON CARBONYLVERBINDUNGEN
公开(公告)号：EP0827943A1
公开(公告)日：1998-03-11
申请号：EP97901761.3
申请日：1997-01-29
申请人： KANEKA CORPORATION
发明人： SUGAWA, Tadashi , MOROSHIMA, Tadashi , INOUE, Kenji , KAN, Kazunori
IPC分类号： C07B41/02 , C07C29/143 , C07C33/22 , C07C213/00 , C07C215/28 , C07C271/10 , C07C323/43
CPC分类号： C07B53/00 , C07B41/02 , C07C29/143 , C07C213/00 , C07C269/06 , C07C319/20 , C07C323/43 , C07C271/16 , C07C271/22 , C07C33/22 , C07C33/46
摘要： The present invention provides a process for reducing carbonyl compounds to hydroxy compounds, in particular stereoselectively reducing α-aminohaloketone derivatives, under mild conditions in an easy and simple manner, which comprises reacting a carbonyl compound of the general formula (1) with an organoaluminum compound of the general formual (4) to provide the corresponding alcohol compound of the general formula (5).
摘要翻译：本发明提供了一种在温和条件下以容易和简单的方式将羰基化合物还原成羟基化合物，特别是立体选择性还原α-氨基卤代酮衍生物的方法，其包括使通式（1）的羰基化合物与有机铝化合物的通式（4）提供相应的通式（5）的醇化合物。

5. 发明授权

EP0930292B1 PROCESS FOR PREPARING BETA-AMINO-ALPHA-HYDROXY ACID DERIVATIVES 失效
标题翻译： PROCESS FORβ-氨基α-羟基衍生物的制备
公开(公告)号：EP0930292B1
公开(公告)日：2002-10-16
申请号：EP97935797.7
申请日：1997-08-18
申请人： KANEKA CORPORATION
发明人： MATSUMOTO, Shingo , MATSUO, Kazuhiko , SUGAWA, Tadashi , MOROSHIMA, Tadashi , INOUE, Kenji
IPC分类号： C07C229/22 , C07C229/34 , C07C227/02 , C07D209/48 , C07C311/19 , C07D209/26
CPC分类号： C07C303/44 , C07C227/02 , C07C227/42 , C07C269/08 , C07C271/18 , C07C303/40 , C07D209/26 , Y02P20/55 , C07C311/19 , C07C229/22 , C07C229/34
摘要： A process for preparing β-amino-α-hydroxy acid derivatives in an efficient and commercially useable manner. The process is characterized by hydrolyzing an α-amino-α',α'-dihaloketone derivative represented by general formula (1) in the presence of a base, optionally followed by the protection of the amino group, to prepare a β-amino-α-hydroxy acid derivative represented by general formula (2).

6. 发明授权

EP0779366B1 PROCESS FOR PRODUCING OPTICALLY ACTIVE 1-HALO-3-AMINO-4-PHENYL-2-BUTANOL DERIVATIVES 失效
标题翻译： PROCESS FOR PRODUCTION光学活性的1-卤代-3-氨基-4-苯基-2-丁醇衍生物的
公开(公告)号：EP0779366B1
公开(公告)日：2002-04-03
申请号：EP96918833.3
申请日：1996-06-19
申请人： KANEKA CORPORATION
发明人： SUGAWA, Tadashi , INOUE, Kenji
IPC分类号： C12P41/00 , C12P13/02 , C12P13/00
CPC分类号： C12P13/001 , Y10S435/822 , Y10S435/911
摘要： A process for producing optically active 1-halo-3-amino-4-phenyl-2-butanol derivatives from optically active 1-halo-3-amino-4-phenyl-2-butanone derivatives stereoselectively in a high yield by bringing the butanone derivatives into contact with microorganisms.

7. 发明授权

EP0754669B1 PROCESSES FOR PRODUCING ALPHA-HALO KETONES, ALPHA-HALOHYDRINS AND EPOXIDES 失效
标题翻译：用于生产ALPHA卤代酮，α-卤代醇和环氧化物
公开(公告)号：EP0754669B1
公开(公告)日：2001-10-31
申请号：EP96901520.5
申请日：1996-02-02
申请人： KANEKA CORPORATION
发明人： NISHIYAMA, Akira , SUGAWA, Tadashi , MANABE, Hajime , INOUE, Kenji , YOSHIDA, Noritaka
IPC分类号： C07C45/48 , C07C49/80 , C07C29/143 , C07C33/46 , C07C221/00 , C07C225/16 , C07C213/00 , C07C215/28 , C07D301/26 , C07D303/04 , C07C269/06
CPC分类号： C07D303/36 , C07C29/143 , C07C45/48 , C07C269/06 , C07C319/20 , C07C323/43 , C07C31/34 , C07C33/46

8. 发明授权

EP0972760B1 PROCESS FOR THE PURIFICATION OR ISOLATION OF (2S, 3R)-1-HALO-2-HYDROXY-3-(PROTECTED AMINO)-4-PHENYLTHIOBUTANES OR OPTICAL ANTIPODES THEREOF 失效
标题翻译：用于清洁或提取方法的（2S，3R）-1- HALO 2-羟基-3-（保护的氨基）-4- PHENYLTHIOBUTANEN或其旋光对映体
公开(公告)号：EP0972760B1
公开(公告)日：2004-09-22
申请号：EP98935265.3
申请日：1998-07-29
申请人： KANEKA CORPORATION
发明人： UEDA, Yasuyoshi , MAEHARA, Katsuji , SUGAWA, Tadashi , MURAO, Hiroshi , NISHIYAMA, Akira , MANABE, Hajime
IPC分类号： C07C323/25 , C07C319/28
CPC分类号： C07C319/28 , Y02P20/55 , C07C323/25
摘要： A process for the purification or isolation of (2S, 3R)-1-halo-2-hydroxy-3-(protected amino)-4-phenylthiobutanes of general formula (1) or optical antipodes thereof, which comprises ridding a compound of general formula (1) contaminated with impurities or an optical antipode thereof contaminated similarly by the use of an aromatic hydrocarbon solvent to thereby obtain the compound or the antipode as a crystal. In said formula, X is halogeno; and P?1 and P2¿ are each independently hydrogen or an amino-protecting group, or alternatively P?1 and P2¿ may be united to form an amino-protecting group.

9. 发明授权

EP0863120B1 PROCESS FOR PREPARING OPTICALLY ACTIVE ALCOHOLIC COMPOUNDS 失效
标题翻译：方法制备旋光醇化合物
公开(公告)号：EP0863120B1
公开(公告)日：2002-08-07
申请号：EP97924268.2
申请日：1997-05-30
申请人： KANEKA CORPORATION
发明人： SUGAWA, Tadashi , INOUE, Kenji , KAN, Kazunori
IPC分类号： C07C33/46 , C07C31/02 , C07C33/20 , C07C29/143
CPC分类号： C07C29/143 , C07B2200/07 , C07C33/20

10. 发明公开

EP0863120A1 PROCESS FOR PREPARING OPTICALLY ACTIVE ALCOHOLIC COMPOUNDS 失效
标题翻译： VERFAHREN ZUM BEREITEN VON OPTISCH AKTIVEM ALKOHOLVERBINDUNGEN
公开(公告)号：EP0863120A1
公开(公告)日：1998-09-09
申请号：EP97924268.2
申请日：1997-05-30
申请人： KANEKA CORPORATION
发明人： SUGAWA, Tadashi , INOUE, Kenji , KAN, Kazunori
IPC分类号： C07C33/46 , C07C31/02 , C07C33/20 , C07C29/143
CPC分类号： C07C29/143 , C07B2200/07 , C07C33/20
摘要： A process for preparing optically active alcoholic compounds wherein a carbonyl compound is assymmetrically reduced in an economical and practical manner.
The process comprises treating a prochiral carbonyl compound represented by the general formula (1) with an optically active organoaluminum compound represented by the general formula (2) to conduct asymmetric reduction, thereby preparing an optically active alcoholic compound represented by the general formula (3).
摘要翻译：制备光学活性醇化合物的方法，其中羰基化合物以经济和实用的方式不对称地还原。该方法包括用通式（2）表示的光学活性有机铝化合物处理由通式（1）表示的前手性羰基化合物，进行不对称还原，由此制备由通式（3）表示的光学活性醇化合物，。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式