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    • 9. 发明公开
    • PROCESSES FOR THE PRODUCTION OF OPTICALLY ACTIVE COMPOUNDS HAVING SUBSTITUENTS AT THE 2-POSITION
    • PROCESS FOR在2-位来制备光学活性化合物的取代基
    • EP1600438A1
    • 2005-11-30
    • EP04714501.6
    • 2004-02-25
    • KANEKA CORPORATION
    • YAMAMOTO, ShogoTAKEDA, ToshihiroFUSE, YoshihideUEDA, Yasuyoshi
    • C07C319/14C07C51/43C07C57/58C07C319/28C07C323/56
    • C07B53/00C07B2200/07C07C51/363C07C319/14C07C57/58C07C323/56
    • The present invention provides a process for producing an optically active compound having a thio group at the 2-position important for manufacturing medicines. An optically active compound having a hydroxyl group at the 2-position is chlorinated with inversion of the configuration at the 2-position, and the resultant optically active compound having a chlorine atom at the 2-position is reacted with a metal thiolate to introduce a thio group with inversion of the configuration at the 2-position. This process is capable of minimizing racemization and producing an optically active compound having a thio group at the 2-position at low cost in high yield. When the optically active compound having a chlorine atom at the 2-position is reacted with the metal thiolate in coexistence with water in the reaction system, the optically active compound having a thio group at the 2-position with higher optical purity can be produced in higher yield. An optically active carboxylic acid having a thio group at the 2-position is crystallized in the presence of an aliphatic hydrocarbon solvent and/or a sulfur-containing solvent to effectively remove coexistent impurities such as an optical isomer and the like, thereby producing crystals of an optically active carboxylic acid having a thio group at the 2-position with higher purity.
    • 本发明提供了用于以2位用于制造药物重要具有硫基光学活性化合物的制造方法。 在2-位上的羟基基团的光学活性化合物是氯化与在2-位的构型的反转,将所得具有在2-位上的氯原子的光学活性化合物与金属硫醇盐引入 硫基与在2位上的构型反转。 这个过程能够最小化的外消旋化,并在光学活性的化合物在生产以高收率低成本在具有2位上含有硫基的。 当具有在2-位上的氯原子的光学活性化合物与金属硫醇盐在反应体系中反应。在共存水,可以在产生在具有较高光学纯度的2-位上具有一个硫基的光学活性化合物 更高的产量。 的诸如旋光异构体和类似物,从而产生结晶:具有在2-位上含有硫基的光学活性羧酸在脂族烃溶剂和/或溶剂来有效地去除共存的杂质的含硫的存在下结晶化 的光学具有硫基活性羧酸在具有更高纯度的2-位。
    • 10. 发明公开
    • METHOD OF PRODUCING REDUCED COENZYME Q10 AS OILY PRODUCT
    • VERFAHREN ZUR HERSTELLUNG VON REDUZIERTEM COENZYM Q10 ALSÖLIGESPRODUKT
    • EP1415971A1
    • 2004-05-06
    • EP02746038.5
    • 2002-07-15
    • KANEKA CORPORATION
    • UEDA, TakahiroKITAMURA, ShiroUEDA, Yasuyoshi
    • C07C43/23
    • C07C41/26C07C41/34C07C43/23
    • The present invention provides a method for obtaining reduced coenzyme Q 10 which is useful as an ingredient in foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. suited for a commercial scale production in high quality and efficiently.
      The high-quality oily reduced coenzyme Q 10 which has low viscosity and thereby easily handled may be produced by separating an aqueous phase from the reaction mixture obtainable by oily reacting oxidized coenzyme Q 10 with a reducing agent in water, or by distilling off an coexisting organic solvent at or above the melting temperature of reduced coenzyme Q 10 in concentrating the organic phase containing reduced coenzyme Q 10 . Moreover, a solution or slurry of reduced coenzyme Q 10 may be obtained by adding a desired solvent to the obtained oily product, or a solid of reduced coenzyme Q 10 may be produced by contacting the oily product with a seed crystal.
    • 还原型辅酶Q 10的制备在水中还原氧化型辅酶Q 100份产物,然后除去水相。 还包括一种独立的权利要求,用于制备还原型辅酶Q 10是一种油,其包括在还原型辅酶Q 10或更高的熔点下蒸出有机溶剂,然后除去水相。