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1. 发明授权

EP0399414B1 Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same 失效
标题翻译：的哌啶衍生物，处理其制备以及含有该药物组合物。
公开(公告)号：EP0399414B1
公开(公告)日：1994-09-21
申请号：EP90109534.9
申请日：1990-05-19
申请人： HOKURIKU PHARMACEUTICAL CO., LTD.
发明人： Itoh, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Ogawa, Nobuo , Nishino, Hiroyuki , Sakaguchi, Jun
IPC分类号： C07D211/46 , C07D211/54 , A61K31/445
CPC分类号： C07D211/54 , C07D211/46

2. 发明公开

EP0180810A1 Novel alpha-aminoalkyl-alpha-alkylphenylacetonitriles 失效
标题翻译：新的α-氨基烷基-α-烷基苯基乙腈
公开(公告)号：EP0180810A1
公开(公告)日：1986-05-14
申请号：EP85112977.5
申请日：1985-10-12
申请人： Hokuriku Pharmaceutical Co.,Ltd
发明人： Itoh, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Ogawa, Nobuo , Kurata, Sakae , Nishino, Hiroyuki , Yoshida, Toshihiko
IPC分类号： C07C121/75 , C07C121/66 , C07D295/08 , A61K31/275 , A61K31/445
CPC分类号： C07C255/00
摘要： Novel alpha-aminoalkyl-alpha-alkylphenylacetonitrile derivatives useful for treatment of cardio vaso diseases, a peripheral circulatory insufficiency and cerebral circulation failure are disclosed.
摘要翻译：公开了用于治疗心血管疾病，外周循环不全和脑循环衰竭的新的α-氨基烷基-α-烷基苯基乙腈衍生物。

3. 发明公开

EP0556813A1 Amphoteric tricyclic compounds as antihistaminic and antiallergic agents 失效
标题翻译： Amphotere tricyclische Verbindungen als antihistaminische und antiallergische Mittel。
公开(公告)号：EP0556813A1
公开(公告)日：1993-08-25
申请号：EP93102518.3
申请日：1993-02-18
申请人： HOKURIKU PHARMACEUTICAL CO., LTD.
发明人： Ito, Yasuo , Kato, Hideo , Yasuda, Shingo , Kado, Noriyuki , Iwasaki, Nobuhiko , Nishino, Hiroyuki , Takeshita, Makoto
IPC分类号： C07D491/044 , C07D491/052 , A61K31/445
CPC分类号： C07D491/04
摘要： Novel amphoteric tricyclic compound represented by the following formula:

wherein R¹ represents a hydrogen atom or a halogen atom; X represents -O-, -CH₂O-, or -OCH₂-; and Y represents a C₂-C₅ alkylene group which may optionally be substituted with a lower alkyl group, and a pharmacologically acceptable salt thereof are disclosed. Also disclosed are a method for preparing the same, a pharmaceutical composition comprising the same useful as an antiallergic agent and an agent for bronchial asthma, and a method for treatment of an allergic disease or bronchial asthma comprising the step of administering the same.
摘要翻译：由下式表示的新型两性三环化合物：其中R 1表示氢原子或卤素原子的 X表示-O-，-CH 2 O-或-OCH 2 - ; 并且Y表示可以任选被低级烷基取代的C 2 -C 5亚烷基及其药理学上可接受的盐。还公开了其制备方法，包含与抗过敏剂和支气管哮喘药有关的药物组合物的药物组合物，以及治疗过敏性疾病或支气管哮喘的方法，其包括施用该过敏性疾病或支气管哮喘的步骤。

4. 发明公开

EP0451772A1 Piperidine compounds, method for preparation thereof, and a pharamceutical composition comprising the same 失效
标题翻译：哌啶类化合物，它们的制备方法和药物组合物。
公开(公告)号：EP0451772A1
公开(公告)日：1991-10-16
申请号：EP91105567.1
申请日：1991-04-09
申请人： HOKURIKU PHARMACEUTICAL CO., LTD.
发明人： Ito, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Ogawa, Nobuo , Nishino, Hiroyuki , Sakaguchi, Jun
IPC分类号： C07D409/04 , A61K31/445
CPC分类号： C07D409/04
摘要： Novel piperidine compounds represented by the following formula (I):

wherein Y represents an alkylene group having 1 to 7 carbon atoms; A is a group represented by formula I-a or formula I-b:

wherein X represents -CH₂-S- or -S-; and R represents a hydrogen atom or a lower alkyl group with a proviso that A is a group represented by formula I-a, or R represents a hydrogen atom with a proviso that A is a group represented by formula I-b and pharmacologically acceptable salts thereof are disclosed. Also disclosed are a method for preparing the same; a pharmaceutical composition comprising the same; an antiallergic agent and an agent for bronchial asthma comprising the same; and a method for treatment of an allergic disease or bronchial asthma comprising the step of administering the same.
摘要翻译：由下式（I）代表的新的哌啶化合物：具有1至7个碳原子的亚烷基团的worinÿdarstellt; A是由式I-a或式表示的基团I-B： worin X darstellt -CH 2 -S-或-S-; 和R darstellt氢原子或附带条件的低级烷基做A是由式表示的基团I-A，或R darstellt氢原子附带条件没有A是由式I-b和药理学上可接受的其盐盘游离缺失表示的基团。所以游离缺失盘是其制备方法; 一种药物组合物是相同的; 抗过敏剂和用于支气管哮喘，其包括相同的试剂; 以及用于治疗过敏性疾病的或支气管哮喘的方法，包括给予相同的步骤。

5. 发明公开

EP0399414A1 Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same 失效
标题翻译：的哌啶衍生物，处理其制备以及含有该药物组合物。
公开(公告)号：EP0399414A1
公开(公告)日：1990-11-28
申请号：EP90109534.9
申请日：1990-05-19
申请人： HOKURIKU PHARMACEUTICAL CO., LTD.
发明人： Itoh, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Ogawa, Nobuo , Nishino, Hiroyuki , Sakaguchi, Jun
IPC分类号： C07D211/46 , C07D211/54 , A61K31/445
CPC分类号： C07D211/54 , C07D211/46
摘要： A piperidine derivative represented by the following general formula (I):
wherein R₁ and R₂ are the same or different and each independently represents a hydrogen atom, a halogen atom, a lower alkyl group, or a lower alkoxy group; R₃ represents a hydrogen atom or a lower alkyl group; X represents an oxygen atom or a sulfur atom; Y represents an alkylene group having 1 to 7 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an -A-O-B- group wherein A and B are the same or different and each independently represents an alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), a pharmaceutical composition comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).
摘要翻译：由下述通式（I）表示的哌啶衍生物： worin R1和R2是相同或不同，并且各自unabhängigdarstellt氢原子，卤原子，低级烷基，或低级烷氧基; R 3表示氢原子或低级烷基; X darstellt到氧原子或硫原子; 具有可任选被低级烷基，或Y darstellt substituiertem到-AOB-组worin A和B是相同的或不同的，并且具有1至3的亚烷基基团的每个unabhängigdarstellt 1至7个碳原子的亚烷基基团Y的darstellt 这可能与低级烷基，任选地substituiertem碳原子是游离缺失盘。所以游离缺失盘是式（I）中，在抗组胺和抗过敏剂，其包含式（I）的化合物的化合物，的药理学上可接受的盐的药物组合物包含式（I）的化合物，和用于的治疗的方法通过施用式（I）的化合物的过敏性疾病。

6. 发明授权

EP0150235B1 Derivatives of 3-pyrrolidinopropiophenone and a process for preparation thereof 失效
标题翻译： 3-吡咯烷酮普罗宁酮的衍生物及其制备方法
公开(公告)号：EP0150235B1
公开(公告)日：1987-10-07
申请号：EP84100827.9
申请日：1984-01-26
申请人： Hokuriku Pharmaceutical Co.,Ltd
发明人： Itho, Yasuo , Kato, Hideo , Ogawa, Nobuo , Koshinaka, Eiichi , Nishino, Hiroyuki
IPC分类号： C07D295/10
CPC分类号： C07D295/108

7. 发明授权

EP0556813B1 Amphoteric tricyclic compounds as antihistaminic and antiallergic agents 失效
标题翻译：两性三环化合物作为抗组胺和抗过敏剂
公开(公告)号：EP0556813B1
公开(公告)日：1997-11-26
申请号：EP93102518.3
申请日：1993-02-18
申请人： HOKURIKU PHARMACEUTICAL CO., LTD.
发明人： Ito, Yasuo , Kato, Hideo , Yasuda, Shingo , Kado, Noriyuki , Iwasaki, Nobuhiko , Nishino, Hiroyuki , Takeshita, Makoto
IPC分类号： C07D491/044 , C07D491/052 , A61K31/445
CPC分类号： C07D491/04

8. 发明授权

EP0180810B1 Novel alpha-aminoalkyl-alpha-alkylphenylacetonitriles 失效
标题翻译：新型ALPHA-氨基亚氨基-L-阿氨基苯乙烯胺
公开(公告)号：EP0180810B1
公开(公告)日：1988-08-03
申请号：EP85112977.5
申请日：1985-10-12
申请人： Hokuriku Pharmaceutical Co.,Ltd
发明人： Itoh, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Ogawa, Nobuo , Kurata, Sakae , Nishino, Hiroyuki , Yoshida, Toshihiko
IPC分类号： C07C121/75 , C07C121/66 , C07D295/08 , A61K31/275 , A61K31/445
CPC分类号： C07C255/00

9. 发明公开

EP0150235A1 Derivatives of 3-pyrrolidinopropiophenone and a process for preparation thereof 失效
标题翻译：引发冯·3-吡咯烷基苯丙酮和Verfahren zu ihrer Herstellung。
公开(公告)号：EP0150235A1
公开(公告)日：1985-08-07
申请号：EP84100827.9
申请日：1984-01-26
申请人： Hokuriku Pharmaceutical Co.,Ltd
发明人： Itho, Yasuo , Kato, Hideo , Ogawa, Nobuo , Koshinaka, Eiichi , Nishino, Hiroyuki
IPC分类号： C07D295/10
CPC分类号： C07D295/108
摘要： Derivatives of 3-pyrrolidinopropiophenone of the formula (I)
wherein R is an ethyl-, propyl-, isopropyl-, butyl-, isobutylgroup or a cycloalkyl-group having 5 to 7 carbon atoms, and the pharmaceutically acceptable acid addition salts thereof, exhibit a potent activity on muscle relaxation. Furtheron a process for the preparation of these compounds is disclosed.
摘要翻译：式（I）... 的3-吡咯烷基苯丙酮酮的衍生物，其中R是具有5-7个碳原子的乙基，丙基，异丙基，丁基，异丁基或环烷基，其可接受的酸加成盐显示出对肌肉松弛的有效活性。公开了制备这些化合物的方法。

10. 发明公开

EP0406739A3 Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same 失效
标题翻译：哌啶衍生物，其制备方法和包含其的药物组合物
公开(公告)号：EP0406739A3
公开(公告)日：1992-02-26
申请号：EP90112533.6
申请日：1990-06-30
申请人： HOKURIKU PHARMACEUTICAL CO., LTD.
发明人： Itoh, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Nishino, Hiroyuki , Sakaguchi, Jun
IPC分类号： C07D211/70 , C07D405/04 , A61K31/445
CPC分类号： C07D405/04 , C07D211/70
摘要： A piperidine derivative represented by the following general formula (I):

wherein R represents a hydrogen atom or a lower alkyl group; X represent -CH=CH-, -CH₂CH₂-, or -CH₂O-; Y represent an alkylene group having 1 to 5 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an -A-O-B- group wherein A and B are the same or different and each independently represents and alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), a method for preparation of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).

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