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4. 发明公开

EP3386987A1 ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME 有权
公开(公告)号：EP3386987A1
公开(公告)日：2018-10-17
申请号：EP16873226.1
申请日：2016-11-01
申请人： Rohm And Haas Electronic Materials Korea Ltd.
发明人： MOON, Doo-Hyeon , JUN, Ji-Song
IPC分类号： C07D491/044 , C07D495/04 , C09K11/06 , H01L27/32 , H01L51/54 , H05B33/14
CPC分类号： H01L51/0067 , C07D491/06 , C07D495/06 , C09K11/06 , C09K2211/1007 , C09K2211/1018 , C09K2211/1029 , C09K2211/185 , H01L51/0052 , H01L51/0071 , H01L51/0072 , H01L51/5008 , H01L51/5016 , H01L51/5072 , H01L2251/5384
摘要： The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. By using the organic electroluminescent compound of the present disclosure, it is possible to provide an organic electroluminescent device having low driving voltage and/or excellent power efficiency and/or improved driving lifespan.

5. 发明公开

EP3148972A1 PYRAZOLONE DERIVATIVES AS NITROXYL DONORS 有权转让
标题翻译：吡唑酮衍生物作为氮氧自由基供体
公开(公告)号：EP3148972A1
公开(公告)日：2017-04-05
申请号：EP15726852.5
申请日：2015-05-26
申请人： Cardioxyl Pharmaceuticals Inc. , The Johns Hopkins University
发明人： KALISH, Vincent J. , BROOKFIELD, Frederick A. , COURTNEY, Stephen M. , FROST, Lisa M. , TOSCANO, John P. , GUTHRIE, Daryl A. , NORTH, Carl L.
IPC分类号： C07D231/46 , C07D231/56 , C07D401/04 , C07D401/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D491/044 , C07D491/048 , C07D491/052 , A61K31/4152 , A61P9/00
CPC分类号： C07D231/46 , C07D231/56 , C07D401/04 , C07D401/10 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D491/044 , C07D491/048 , C07D491/052
摘要： The disclosed subject matter provides pyrazolone derivative compounds, pharmaceutical compositions comprising such compounds, kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.
摘要翻译：所公开的主题提供吡唑啉酮衍生物化合物，包含此类化合物的药物组合物，包含此类化合物的试剂盒以及使用此类化合物或药物组合物的方法。具体而言，所公开的主题提供了使用这种化合物或药物组合物治疗心力衰竭的方法。

6. 发明公开

EP2921513A1 EPOXY COMPOUND, PRODUCTION METHOD THEREFOR, AND CURABLE EPOXY RESIN COMPOSITION 审中-公开
标题翻译： EPOXIDVERBINDUNG，HERSTELLUNGSVERFAHRENDAFÜRUNDHÄRTBAREEPOXIDHARZZUSAMMENSETZUNG
公开(公告)号：EP2921513A1
公开(公告)日：2015-09-23
申请号：EP13852931.8
申请日：2013-10-30
申请人： Daicel Corporation
发明人： INOUE, Hiroko
IPC分类号： C08G59/20 , C07D491/044 , C08G59/02
CPC分类号： C08G59/26 , C07D209/48 , C07D491/044 , C08G59/24 , C08G59/4042
摘要： An object of the present invention is to provide a novel epoxy compound capable of forming a highly heat-resistant cured product. The epoxy compound of the present invention is a compound represented by the following formula (1):

wherein X 1 and X 2 are the same or different and represent an alkylene group, an oxygen atom, a sulfur atom, or no bond; R represents a bivalent group having one or more atoms; R 1 to R 8 are the same or different and represent a hydrogen atom, an alkenyl group which may have a substituent, an epoxidized alkenyl group which may have a substituent, or an alkyl group which may have a substituent; and Y 1 and Y 2 are the same or different and are a bivalent group represented by the following formula (a) :

or a bivalent group represented by the following formula (b) :

provided that least one of R 1 to R 12 in formula (1) is an alkenyl group which may have a substituent, an epoxidized alkenyl group which may have a substituent, or an alkyl group which may have a substituent. Besides, when both Y 1 and Y 2 in formula (1) are a bivalent group represented by formula (a), at least one of R 1 to R 10 is an epoxidized alkenyl group which may have a substituent.
摘要翻译：本发明的目的是提供一种能够形成高耐热固化产物的新型环氧化合物。本发明的环氧化合物是由下式（1）表示的化合物：其中X 1和X 2相同或不同，表示亚烷基，氧原子，硫原子或无键; R表示具有一个或多个原子的二价基团; R 1〜R 8相同或不同，表示氢原子，可具有取代基的烯基，可具有取代基的环氧化烯基或可具有取代基的烷基; Y 1和Y 2相同或不同，为由下式（a）表示的二价基团或由下式（b）表示的二价基团：式（1）可以具有取代基的烯基，可以具有取代基的环氧化烯基或可以具有取代基的烷基。此外，当式（1）中的Y 1和Y 2都是由式（a）表示的二价基团时，R 1至R 10中的至少一个是可以具有取代基的环氧化烯基。

7. 发明授权

EP2441767B1 Salinosporamides and methods for use thereof 有权
标题翻译：其Salinosporamide和使用方法
公开(公告)号：EP2441767B1
公开(公告)日：2015-06-10
申请号：EP11163737.7
申请日：2004-06-18
申请人： The Regents of the University of California
发明人： Fenical, William H. , Jensen, Paul R. , Mincer, Tracy J. , Feling, Robert H. R.
IPC分类号： C07D491/044 , A61K31/407
CPC分类号： C07D491/044 , A61K31/407 , C07D491/04 , C12P17/188

8. 发明公开

EP2491022A1 DIAZEPAM DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS 有权
标题翻译：趋化因子受体DIAZEPANDERIVATE AS调节剂
公开(公告)号：EP2491022A1
公开(公告)日：2012-08-29
申请号：EP10765643.1
申请日：2010-10-18
申请人： F.Hoffmann-La Roche AG
发明人： AEBI, Johannes , BINGGELI, Alfred , GREEN, Luke , HARTMANN, Guido , MAERKI, Hans P. , MATTEI, Patrizio
IPC分类号： C07D241/10 , C07D243/08 , C07D401/06 , C07D403/06 , C07D491/044 , C07D498/04 , C07D401/14 , A61K31/551 , A61K31/497 , A61K31/503 , A61P9/10
CPC分类号： C07D401/06 , C07D241/10 , C07D243/08 , C07D401/14 , C07D403/06 , C07D491/044 , C07D498/04
摘要： The invention is concerned with novel bicyclic compounds of Formula (I), wherein n, m, p, A, L, R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , R
7 , R
8 , R
9 and R
10 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR2 receptor, CCR5 receptor and/or CCR3 receptor and can be used as medicaments.

9. 发明公开

EP2441767A1 Salinosporamides and methods for use thereof 有权
标题翻译： Salinosporamide和Verwendungsverfahrendafür
公开(公告)号：EP2441767A1
公开(公告)日：2012-04-18
申请号：EP11163737.7
申请日：2004-06-18
申请人： The Regents Of the University of California
发明人： Fenical, William H. , Jensen, Paul R. , Mincer, Tracy J. , Feling, Robert H. R.
IPC分类号： C07D491/044 , A61K31/407
CPC分类号： C07D491/044 , A61K31/407 , C07D491/04 , C12P17/188
摘要： The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hypoproliferative mammalian cells. The CNB392 and CNB476 strains lie within the family Micromonosporaceae, and the generic epithet Salinospora has been proposed for this obligate marine group. The reaction products produced by this strain are classified as salinosporamides, and are particularly advantageous in treating neoplastic disorders due to their low molecular weight, low IC 50 values, high pharmaceutical potency, and selectivity for cancer cells over fungi.
摘要翻译：本发明基于以下发现：海洋放线菌株CNB392和CNB476的某些发酵产物是低增殖哺乳动物细胞的有效抑制剂。 CNB392和CNB476菌株位于Micromonosporaceae中，并且已经为这个专性海洋组提出了通用的Salinospora。由该菌株产生的反应产物分类为salinosporamide，并且由于其低分子量，低IC 50值，高药物效力和对真菌的癌细胞的选择性而特别有利于治疗肿瘤性疾病。

10. 发明授权

EP2240492B1 PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS 有权转让
标题翻译：过程阿塞那平，在这种方法中使用的中间产品
公开(公告)号：EP2240492B1
公开(公告)日：2011-10-05
申请号：EP08870123.0
申请日：2008-12-22
申请人： N.V. Organon
发明人： KEMPERMAN, Gerardus Johannes
IPC分类号： C07D491/044 , C07D207/08 , A61K31/407 , A61P25/24
CPC分类号： C07D491/044 , C07D207/08
摘要： The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process.

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