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1. 发明授权

EP0556813B1 Amphoteric tricyclic compounds as antihistaminic and antiallergic agents 失效
标题翻译：两性三环化合物作为抗组胺和抗过敏剂
公开(公告)号：EP0556813B1
公开(公告)日：1997-11-26
申请号：EP93102518.3
申请日：1993-02-18
申请人： HOKURIKU PHARMACEUTICAL CO., LTD.
发明人： Ito, Yasuo , Kato, Hideo , Yasuda, Shingo , Kado, Noriyuki , Iwasaki, Nobuhiko , Nishino, Hiroyuki , Takeshita, Makoto
IPC分类号： C07D491/044 , C07D491/052 , A61K31/445
CPC分类号： C07D491/04

2. 发明授权

EP0488139B1 Pharmaceutical composition comprising calcium polycarbophil 失效
标题翻译：聚卡波非含钙药物。
公开(公告)号：EP0488139B1
公开(公告)日：1995-07-26
申请号：EP91120102.8
申请日：1991-11-26
申请人： HOKURIKU PHARMACEUTICAL CO., LTD.
发明人： Ito, Yasuo , Kato, Hideo , Nagata, Osamu , Yamazaki, Masahiro , Ishibashi, Takeo , Kitayama, Masakazu
IPC分类号： A61K31/78 , A61K9/20
CPC分类号： A61K31/78 , A61K9/1652 , A61K9/2054 , Y10S514/867

3. 发明公开

EP0420120A2 Optically active benzyl alcohol compound and pharmaceutical composition 失效
标题翻译： Optisch aktive Benzylalkoholverbindung und pharmazeutische Zusammensetzung。
公开(公告)号：EP0420120A2
公开(公告)日：1991-04-03
申请号：EP90118338.4
申请日：1990-09-25
申请人： HOKURIKU PHARMACEUTICAL CO., LTD.
发明人： Ito, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Kurata, Sakae , Morikawa, Koji
IPC分类号： C07C215/60 , A61K31/135
CPC分类号： C07C215/60
摘要： A levo-rotatory enantiomer of benzyl alcohol compound represented by the following formula (I):
wherein . C represents an asymmetric carbon atom; a pharmacologically acceptable salt of the compound; and a method for preparing the enantiomer is disclosed. Also disclosed are methods for ralaxing uterine smooth muscle and bladder smooth muscle comprising administering the levo-rotatory enantiomer. Further disclosed is a pharmaceutical composition for the treatment of premature labor or incontinence of urine comprising an effective amount of the levo-rotatory enantiomer together with a pharmaceutically acceptable carrier or coating. Lastly disclosed are methods for the treatment of premature labor or incontinence of urine comprising the steps of determining that a mammal has one of these illnesses and administering the levo-rotatory enantiomer to the mammal.
摘要翻译：由下式（I）表示的苄醇化合物的左旋旋光对映异构体：其中C表示不对称碳原子的化合物的药理学上可接受的盐; 并公开了制备对映异构体的方法。还公开了用于将子宫平滑肌和膀胱平滑肌进行排泄的方法，其包括施用左旋对映异构体。还公开了一种用于治疗早产或尿失禁的药物组合物，其包含有效量的左旋对映异构体以及药学上可接受的载体或涂层。最后公开的是用于治疗早产或尿失禁的方法，包括确定哺乳动物具有这些疾病之一并向哺乳动物施用左旋对映异构体的步骤。

4. 发明授权

EP0420120B1 Optically active benzyl alcohol compound and pharmaceutical composition 失效
标题翻译：光学活性的苄醇化合物和药物组合物。
公开(公告)号：EP0420120B1
公开(公告)日：1994-08-31
申请号：EP90118338.4
申请日：1990-09-25
申请人： HOKURIKU PHARMACEUTICAL CO., LTD.
发明人： Ito, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Kurata, Sakae , Morikawa, Koji
IPC分类号： C07C215/60 , A61K31/135
CPC分类号： C07C215/60

5. 发明公开

EP0465716A1 Optically active thiazetoquino-line-3-carboxylic acid compound, method for preparation thereof, and a pharmaceutical composition comprising the same 失效
标题翻译：光学活性Thiazetochinolin -3-羧酸化合物，它们的制备方法和含有药物组合物。
公开(公告)号：EP0465716A1
公开(公告)日：1992-01-15
申请号：EP90119802.8
申请日：1990-10-16
申请人： HOKURIKU PHARMACEUTICAL CO., LTD.
发明人： Ito, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Ogawa, Nobuo , Yagi, Noriyuki , Yoshida, Toshihiko , Suzuki, Tomio
IPC分类号： C07D513/04 , A61K31/435
CPC分类号： C07D513/04
摘要： An optically active thiazetoquinoline-3-carboxylic acid compound represented by the following formula (I):

wherein R¹ is a hydrogen atom or a lower alkyl group; R² is a fluorine atom or a chlorine atom; R³ is a hydrogen atom, a lower alkanoyl group, a halogenated lower alkanoyl, or the residue of carboxylic acid ester; and C * represents an asymmetric carbon atom of S- or R-configuration, a pharmacologically acceptable salt thereof, and a method for preparing the compound are disclosed. Also disclosed are antibacterial agent, antineoplastic agent, and anti-AIDS virus agent comprising the same, a pharmaceutical composition for the treatment of bacterial infectious disease, tumor, and AIDS comprising an effective amount of the same.
摘要翻译：光学活性thiazetoquinoline -3-羧酸的由下式（I）表示的酸化合物： worin - [R <1>是一个氢原子或一个低级烷基; [R <2>为氟原子或氯原子; [R <3>是氢原子，低级链烷酰基，卤代低级烷酰基，或羧酸酯的残基; 和C * darstellt到S-的不对称碳原子或R构型，或其药理学可接受的盐，以及制备该化合物的方法进行游离缺失光盘。所以圆盘游离缺失是抗菌剂，抗肿瘤剂和抗艾滋病病毒剂，其包含相同的，用于细菌感染性疾病，肿瘤的治疗的药物组合物，和有效量的相同的艾滋病，包括

6. 发明公开

EP0430025A2 Xanthine compound, method for preparing thereof, and a pharmaceutical composition comprising the same 失效
标题翻译：黄嘌呤化合物，涉及它们的制备和含有它们的药物制剂的方法。
公开(公告)号：EP0430025A2
公开(公告)日：1991-06-05
申请号：EP90122146.5
申请日：1990-11-20
申请人： HOKURIKU PHARMACEUTICAL CO., LTD.
发明人： Ito, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Yagi, Noriyuki , Iwasaki, Nobuhiko
IPC分类号： C07D473/06 , A61K31/52
CPC分类号： C07D473/04
摘要： A novel xanthine compound having bronchodilating and brain function improving activity represented by the following formula (I) and (II):

wherein R¹ represents a hydrogen atom, 4-methoxybenzyl group, a straight- or branched-chain alkyl group having 1 to 6 carbon atoms, or a cycloalkyl group having 3 to 6 carbon atoms; R² represents a hydrogen atom, a straight- or branched-chain alkyl group having 1 to 6 carbon atoms, or a cycloalkyl group having 3 to 6 carbon atoms; n represents an integer of from 1 to 4; and A represents -COCH₃ or - C(OR³)(OR⁴)CH₃ in which R³ and R⁴ independently represents an alkyl group having 1 to 3 carbon atoms or R³ together with R⁴ represents a polymethylene group having 2 to 4 carbon atoms is disclosed. Also disclosed are a pharmacologically acceptable salt of the same, method for preparing the same, and a pharmaceutical composition for the treatment of respiratory tract disease or brain disfunction comprising the effective amount of same.
摘要翻译： worin - [R <1> darstellt为氢原子，4-甲氧基苄基，直链或支链烷基：具有支气管扩张和脑功能改善用下式（I）表示的活性和（II）的新型黄嘌呤化合物具有1至6个碳原子，或具有3至6个碳原子的环烷基基团; [R <2>代表氢原子，具有1至6个碳原子，或具有3至6个碳原子的环烷基的直链或支链烷基; Ñdarstellt从1至4的整数; 和A darstellt -COCH 3或 - C（OR <3>）（OR <4>）CH 3，其中R <3>和R <4>具有1至3个碳原子或R烷基的unabhängigdarstellt <3>连同 [R <4> darstellt具有聚亚甲基2至4个碳原子被游离缺失盘。所以圆盘游离缺失可用于制备相同的是相同的，方法的药理学上可接受的盐，以及用于呼吸道疾病或脑功能障碍的包含有效量的相同治疗的药物组合物。

7. 发明授权

EP0447857B1 A polycyclic compound, method for preparing the same, and pharmaceutical composition comprising the same 失效
标题翻译：多环化合物，它们的制备方法和含有它们的药物组合物。
公开(公告)号：EP0447857B1
公开(公告)日：1994-12-14
申请号：EP91103059.1
申请日：1991-03-01
申请人： HOKURIKU PHARMACEUTICAL CO., LTD.
发明人： Sawanishi, Hiroyuki , Ito, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Ogawa, Nobuo , Morikawa, Kouji
IPC分类号： C07D267/20 , C07D281/16 , C07D223/20 , C07D487/04 , A61K31/55
CPC分类号： C07D487/04 , C07D223/20 , C07D267/20 , C07D281/16

8. 发明公开

EP0488139A1 Pharmaceutical composition comprising calcium polycarbophil 失效
标题翻译：聚卡泊芬 - 卡尔扎伊（Polycarbophil-Kalzium）参与了Arzneimittel。
公开(公告)号：EP0488139A1
公开(公告)日：1992-06-03
申请号：EP91120102.8
申请日：1991-11-26
申请人： HOKURIKU PHARMACEUTICAL CO., LTD.
发明人： Ito, Yasuo , Kato, Hideo , Nagata, Osamu , Yamazaki, Masahiro , Ishibashi, Takeo , Kitayama, Masakazu
IPC分类号： A61K31/78 , A61K9/20
CPC分类号： A61K31/78 , A61K9/1652 , A61K9/2054 , Y10S514/867
摘要： A pharmceutical composition capable of being disintegrated in an acidic environment, which comprises calcium polycarbophil and 1 to 80 % by weight of a cellulose derivative such as carboxymethylcellulose or low substituted hydroxypropylcellulose based on the calcium polycarbophil. The pharmaceutical composition in a form of a tablet, a capsule, or granules is useful as a bulk-forming laxative or an antidiarrheic agent since it can be disintegrated readily in the stomach and form a complete dispersion of polycarbophil in the digestive tract.
摘要翻译：能够在酸性环境中分解的药物组合物，其包含聚卡波非钙和1至80重量％的纤维素衍生物，例如基于聚卡必普的羧甲基纤维素或低取代的羟丙基纤维素。片剂，胶囊或颗粒形式的药物组合物可用作体积形成泻药或止泻药，因为其可以在胃中容易地分解并形成聚卡泊芬在消化道中的完全分散体。

9. 发明公开

EP0430025A3 Xanthine compound, method for preparing thereof, and a pharmaceutical composition comprising the same 失效
标题翻译： XANTHINE化合物，其制备方法和包含其的药物组合物
公开(公告)号：EP0430025A3
公开(公告)日：1992-05-06
申请号：EP90122146.5
申请日：1990-11-20
申请人： HOKURIKU PHARMACEUTICAL CO., LTD.
发明人： Ito, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Yagi, Noriyuki , Iwasaki, Nobuhiko
IPC分类号： C07D473/06 , A61K31/52
CPC分类号： C07D473/04
摘要： A novel xanthine compound having bronchodilating and brain function improving activity represented by the following formula (I) and (II):

wherein R¹ represents a hydrogen atom, 4-methoxybenzyl group, a straight- or branched-chain alkyl group having 1 to 6 carbon atoms, or a cycloalkyl group having 3 to 6 carbon atoms; R² represents a hydrogen atom, a straight- or branched-chain alkyl group having 1 to 6 carbon atoms, or a cycloalkyl group having 3 to 6 carbon atoms; n represents an integer of from 1 to 4; and A represents -COCH₃ or - C(OR³)(OR⁴)CH₃ in which R³ and R⁴ independently represents an alkyl group having 1 to 3 carbon atoms or R³ together with R⁴ represents a polymethylene group having 2 to 4 carbon atoms is disclosed. Also disclosed are a pharmacologically acceptable salt of the same, method for preparing the same, and a pharmaceutical composition for the treatment of respiratory tract disease or brain disfunction comprising the effective amount of same.
摘要翻译：具有由下式（I）和（II）表示的支气管扩张和脑功能改善活性的新颖的黄嘌呤化合物：其中R 1表示氢原子，4-甲氧基苄基，直链或支链烷基具有1至6个碳原子的基团或具有3至6个碳原子的环烷基; R 2表示氢原子，具有1〜6个碳原子的直链或支链烷基或具有3〜6个碳原子的环烷基; n表示1〜4的整数，和A表示-COCH 3或-C（OR 3）（OR 4））CH 3，其中R 3和R 4独立地表示具有1至3个碳原子的烷基或R 3与 R 4表示碳原子数2〜4的多亚甲基。还公开了其药学上可接受的盐，其制备方法和用于治疗呼吸道疾病或脑功能障碍的药物组合物，其包含其有效量。

10. 发明公开

EP0556813A1 Amphoteric tricyclic compounds as antihistaminic and antiallergic agents 失效
标题翻译： Amphotere tricyclische Verbindungen als antihistaminische und antiallergische Mittel。
公开(公告)号：EP0556813A1
公开(公告)日：1993-08-25
申请号：EP93102518.3
申请日：1993-02-18
申请人： HOKURIKU PHARMACEUTICAL CO., LTD.
发明人： Ito, Yasuo , Kato, Hideo , Yasuda, Shingo , Kado, Noriyuki , Iwasaki, Nobuhiko , Nishino, Hiroyuki , Takeshita, Makoto
IPC分类号： C07D491/044 , C07D491/052 , A61K31/445
CPC分类号： C07D491/04
摘要： Novel amphoteric tricyclic compound represented by the following formula:

wherein R¹ represents a hydrogen atom or a halogen atom; X represents -O-, -CH₂O-, or -OCH₂-; and Y represents a C₂-C₅ alkylene group which may optionally be substituted with a lower alkyl group, and a pharmacologically acceptable salt thereof are disclosed. Also disclosed are a method for preparing the same, a pharmaceutical composition comprising the same useful as an antiallergic agent and an agent for bronchial asthma, and a method for treatment of an allergic disease or bronchial asthma comprising the step of administering the same.
摘要翻译：由下式表示的新型两性三环化合物：其中R 1表示氢原子或卤素原子的 X表示-O-，-CH 2 O-或-OCH 2 - ; 并且Y表示可以任选被低级烷基取代的C 2 -C 5亚烷基及其药理学上可接受的盐。还公开了其制备方法，包含与抗过敏剂和支气管哮喘药有关的药物组合物的药物组合物，以及治疗过敏性疾病或支气管哮喘的方法，其包括施用该过敏性疾病或支气管哮喘的步骤。

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