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1. 发明公开

EP3297657A1 EXTRACELLULAR DNA AS A THERAPEUTIC TARGET IN NEURODEGENERATION 有权
标题翻译：细胞外DNA作为神经降解的治疗靶点
公开(公告)号：EP3297657A1
公开(公告)日：2018-03-28
申请号：EP16800375.4
申请日：2016-05-11
申请人： GENKIN, Dmitry Dmitrievich , Tets, Georgy Viktorovich , Tets, Viktor Veniaminovich
发明人： GENKIN, Dmitry Dmitrievich , Tets, Georgy Viktorovich , Tets, Viktor Veniaminovich
IPC分类号： A61K38/46 , A61P25/16 , A61P25/28
CPC分类号： A61K38/465 , A61K9/0019 , A61K9/0053 , A61K9/0085 , A61K47/61 , A61P25/16 , A61P25/18 , A61P25/28 , C12Y301/02021 , C12Y301/21001
摘要： The invention relates to the use of deoxyribonuclease (DNase) enzyme for inhibiting progression and for prevention and treatment of neurodegeneration.

2. 发明授权

EP3297657B1 EXTRACELLULAR DNA AS A THERAPEUTIC TARGET IN NEURODEGENERATION 有权
公开(公告)号：EP3297657B1
公开(公告)日：2020-03-25
申请号：EP16800375.4
申请日：2016-05-11
申请人： Genkin, Dmitry Dmitrievich , Tets, Georgy Viktorovich , Tets, Viktor Veniaminovich
发明人： Genkin, Dmitry Dmitrievich , Tets, Georgy Viktorovich , Tets, Viktor Veniaminovich
IPC分类号： A61K38/46 , A61P25/16 , A61P25/28 , A61K47/61 , A61K9/00 , A61P25/18

3. 发明授权

EP3075840B1 DEVICE FOR DETERMINING THE SENSITIVITY OF MICROORGANISMS TO ANTIMICROBIAL DRUGS 有权转让
公开(公告)号：EP3075840B1
公开(公告)日：2018-10-17
申请号：EP14866121.8
申请日：2014-10-27
申请人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
发明人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
IPC分类号： C12M1/26 , C12Q1/06 , C12Q1/18
CPC分类号： C12Q1/18 , C12M23/12 , C12M41/34
摘要： The invention relates to the field of microbiology. A device for determining the sensitivity of microorganisms to antimicrobial drugs is configured in the form of a sterile plate made from a plastic material with indentations and is provided with a hermetically sealing element which covers the sterile plate. The indentations are filled with a solid culture medium containing agar. In different indentations, the culture medium contains antimicrobial drugs or combinations thereof or serves as a control. Between the plate and the hermetically sealing element, the device contains a moisture-absorbing material with a rigid mesh situated therebelow. The device is provided with a transparent protective lid made from a rigid durable plastic.

4. 发明公开

EP3384918A1 DRUGS (VARIANTS) AND METHODS FOR RESTORING MICROFLORA 有权
公开(公告)号：EP3384918A1
公开(公告)日：2018-10-10
申请号：EP16871132.3
申请日：2016-12-02
申请人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
发明人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
IPC分类号： A61K35/66 , C12N1/20
CPC分类号： A61K35/66 , C12N1/20
摘要： The invention relates to microbiology and medicine and can be used to prevent and treat diseases and conditions associated with disruption of normal (autochthonous) microflora (microbiota) in humans or animals. In particular, a solution for recovery or creation of the subject's microflora comprising an active component containing microorganisms isolated from the microflora of the subject or the donor, wherein the active component can be enriched with bacteriophages of said microflora and/or additional microorganisms of the microflora cultivated on a nutrient medium, while the additional microorganisms of the microflora include microorganisms of the microflora that are yet nonculturable in the absence of the host organism, is proposed. Also provided are a pharmaceutical dosage form comprising the above solution and methods for prevention or treatment of diseases and/or conditions associated with and/or accompanied by a disorder or lack of the subject's own microflora, comprising administering the solution or pharmaceutical dosage form.

5. 发明公开

EP3315597A1 NUTRIENT MEDIUM FOR CULTIVATING BACTERIA 有权
标题翻译：培养细菌的营养培养基
公开(公告)号：EP3315597A1
公开(公告)日：2018-05-02
申请号：EP16814798.1
申请日：2016-06-23
申请人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
发明人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
IPC分类号： C12N1/20 , C12R1/01
CPC分类号： C12N1/20 , C12R1/01
摘要： The invention relates to microbiology, and more particularly to nutrient media used for cultivating bacteria for the subsequent study thereof. A nutrient medium comprising a pancreatic digest of casein, a peptic digest of meat, a heart pancreatic digest, yeast extract, starch and water is characterized in that it additionally contains violuric acid and beef infusion, wherein the ratio of ingredients is (wt%): 0.3-1.0 pancreatic digest of casein; 0.1-1.5 peptic digest of meat; 0.1-0.9 heart pancreatic digest; 0.1-2.0 yeast extract, 0.3-0.8 starch; 0.001-0.05 violuric acid; 2.0-15 beef infusion; the remainder water. The nutrient medium can additionally contain 0.3-2.5 wt% agar-agar and/or 1-20 wt% whole or hemolyzed sheep red blood cells and/or 1-20 wt% whole or hemolyzed human red blood cells and/or 1-15 wt% horse blood serum. This provides for the simultaneous growth of the maximum possible number of bacteria present in an inoculate.
摘要翻译：本发明涉及微生物学，并且更具体地涉及用于培养细菌的营养培养基以用于随后的研究。包含胰酪氨酸消化液，肉消化液消化液，心脏胰脏消化液，酵母提取物，淀粉和水的营养培养基，其特征在于它还含有紫苏酸和牛肉浸液，其中成分比例为（wt％）：0.3-1.0胰酪氨酸消化物; 0.1-1.5消化肉消化; 0.1-0.9心脏胰腺消化; 0.1-2.0酵母提取物，0.3-0.8淀粉; 0.001-0.05三聚乙酸; 2.0-15牛肉输液; 剩下的水。营养培养基可另外含有0.3-2.5重量％琼脂琼脂和/或1-20重量％全血或溶血羊红细胞和/或1-20重量％全血或溶血的人红细胞和/或1-15 wt％马血清。这提供了接种物中存在的最大可能数量的细菌的同时增长。

6. 发明授权

EP3315597B1 NUTRIENT MEDIUM FOR CULTIVATING BACTERIA 有权
公开(公告)号：EP3315597B1
公开(公告)日：2020-02-12
申请号：EP16814798.1
申请日：2016-06-23
申请人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
发明人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
IPC分类号： C12N1/20 , C12R1/01

7. 发明公开

EP2918672A1 METHOD FOR DETERMINING THE SENSITIVITY OF MICROORGANISMS TO ANTIMICROBIAL SUBSTANCES 有权转让
标题翻译：用于确定免受微生物抗菌物质的敏感性
公开(公告)号：EP2918672A1
公开(公告)日：2015-09-16
申请号：EP13853343.5
申请日：2013-05-13
申请人： TETS, Viktor Veniaminovich , Tets, Georgy Viktorovich
发明人： TETS, Viktor Veniaminovich , Tets, Georgy Viktorovich
IPC分类号： C12N5/02 , C12Q1/18
CPC分类号： C12Q1/18
摘要： The invention relates to medicine and to veterinary medicine, and specifically to means for determining the sensitivity of various microorganisms, including bacteria and fungi, to antimicrobial substances. The method for determining the sensitivity of microorganisms to antimicrobial substances comprises taking biological material, incubating microorganisms contained therein on a nutrient medium, introducing an antimicrobial substance to be investigated into the nutrient medium and subsequently assessing the result. A dense, rich nutrient medium is used for cultivating the microorganisms. The antimicrobial substance being investigated is introduced into the nutrient medium prior to cultivation of the microorganisms in a concentration close to the maximum concentration achievable at the location at which the biological material is taken. The sensitivity of the microorganisms to the antimicrobial substance is assessed after the appearance of visible growth of microorganisms in a control culture. Vitamins and/or amino acids, and/or nutritional supplements can be added to the nutrient medium.
摘要翻译：本发明涉及医学和兽医学，并且具体地涉及用于确定采矿各种微生物，包括细菌和真菌，抗微生物物质的敏感性。确定性采矿的方法，微生物的抗微生物物质的敏感性包括服用的生物材料，孵化的营养培养基上其中所含的微生物，引入抗微生物物质可查到营养培养基中并随后assesing结果。密集，营养丰富培养基用于培养微生物。所述抗微生物物质被调查是对微生物的培养在接近最大浓度在能够使其采取的生物材料中的位置达到的浓度之前引入到营养培养基中。微生物的抗微生物物质的灵敏度微生物可见生长的对照培养物的外观后评估。维生素和/或氨基酸，和/或营养补充剂可以被添加到营养培养基中。

8. 发明公开

EP3332786A1 AGENT AGAINST FUNGAL INFECTIONS 有权
公开(公告)号：EP3332786A1
公开(公告)日：2018-06-13
申请号：EP16833399.5
申请日：2016-08-01
申请人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
发明人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
IPC分类号： A61K31/505 , A61P31/10 , A01P3/00
CPC分类号： A61K31/513 , A61K31/505 , A61P31/10
摘要： The invention relates to fungicides and can be used for treating diseases caused by fungi, and also for preventing fungal damage to various materials and agricultural products. Claimed is an agent against fungal infections which is in the form of salts of 2,4-dioxo-5-(2-hydroxy-3,5-dichlorobenzylidene)amino-6-methyl-1,3-pyrimidine, where R is 4-NO 2 , 2-OH-5-NO 2 , 2-OH-3,5-Cl 2 , 5-Br-4-OH-3-OCH 3 , 2-OH-5-Cl, 2,4-Cl 2 , 3,5-Br 2 -2-OH. The result is an agent against fungal infections which has a broad spectrum of activity and is highly soluble, rendering it more effective for use in the form of solutions.

9. 发明公开

EP3075840A1 DEVICE FOR DETERMINING THE SENSITIVITY OF MICROORGANISMS TO ANTIMICROBIAL DRUGS 有权转让
标题翻译：方法用于确定微生物对抗菌药物的敏感性
公开(公告)号：EP3075840A1
公开(公告)日：2016-10-05
申请号：EP14866121.8
申请日：2014-10-27
申请人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
发明人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
IPC分类号： C12M1/26 , C12Q1/06 , C12Q1/18
CPC分类号： C12Q1/18 , C12M23/12 , C12M41/34
摘要： The invention relates to the field of microbiology. A device for determining the sensitivity of microorganisms to antimicrobial drugs is configured in the form of a sterile plate made from a plastic material with indentations and is provided with a hermetically sealing element which covers the sterile plate. The indentations are filled with a solid culture medium containing agar. In different indentations, the culture medium contains antimicrobial drugs or combinations thereof or serves as a control. Between the plate and the hermetically sealing element, the device contains a moisture-absorbing material with a rigid mesh situated therebelow. The device is provided with a transparent protective lid made from a rigid durable plastic.
摘要翻译：本发明涉及微生物学领域。确定性采矿微生物的抗菌药物的敏感性在由塑料材料制成的压痕的无菌板的形式配置，并设置有覆盖所述无菌板气密密封元件的设备。该缺口被填充固体培养基含有琼脂。在不同的凹口，所述培养基包含抗菌药或其组合或作为对照。板和密封元件之间，该装置包含具有刚性网格位于下方的水分吸收材料。该装置设置有由刚性耐用的塑料制成的透明的保护盖。

10. 发明授权

EP2596794B1 METHOD FOR TREATING LIVER DISEASES OF VARIOUS ORIGINS 有权
公开(公告)号：EP2596794B1
公开(公告)日：2019-08-07
申请号：EP10797363.8
申请日：2010-06-04
申请人： Tets, Georgy Viktorovich , Tets, Viktor Veniaminovich
发明人： Tets, Georgy Viktorovich , Tets, Viktor Veniaminovich
IPC分类号： A61K31/515 , A61P1/16

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