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1. 发明公开

EP3297657A1 EXTRACELLULAR DNA AS A THERAPEUTIC TARGET IN NEURODEGENERATION 有权
标题翻译：细胞外DNA作为神经降解的治疗靶点
公开(公告)号：EP3297657A1
公开(公告)日：2018-03-28
申请号：EP16800375.4
申请日：2016-05-11
申请人： GENKIN, Dmitry Dmitrievich , Tets, Georgy Viktorovich , Tets, Viktor Veniaminovich
发明人： GENKIN, Dmitry Dmitrievich , Tets, Georgy Viktorovich , Tets, Viktor Veniaminovich
IPC分类号： A61K38/46 , A61P25/16 , A61P25/28
CPC分类号： A61K38/465 , A61K9/0019 , A61K9/0053 , A61K9/0085 , A61K47/61 , A61P25/16 , A61P25/18 , A61P25/28 , C12Y301/02021 , C12Y301/21001
摘要： The invention relates to the use of deoxyribonuclease (DNase) enzyme for inhibiting progression and for prevention and treatment of neurodegeneration.

2. 发明公开

EP1655036A1 METHOD FOR TREATING ONCOLOGICAL DISEASES 失效转让
标题翻译： VERFAHREN ZUR BEHANDLUNG VON ONKOLOGISCHEN ERKRANKUNGEN
公开(公告)号：EP1655036A1
公开(公告)日：2006-05-10
申请号：EP04748955.4
申请日：2004-07-01
申请人： GENKIN, Dmitry Dmitrievich , Tets, Viktor Veniaminovich
发明人： GENKIN, Dmitry Dmitrievich , TETS, Viktor Veniaminovich , TETS, Georgy Viktorovich
IPC分类号： A61K38/43 , A61K39/395 , A61P35/00
CPC分类号： A61K39/0011 , A61K38/465 , A61K38/48 , A61K2039/505 , A61K2039/53 , C07K16/44 , C12Y301/21001 , A61K2300/00
摘要： The invention relates to medicine and veterinary science and can be used for treating mainly solid tumors. The inventive method for treating oncological diseases consisting in injecting a blood extracellular DNA destroying agent into a systemic blood circulation. Said blood extracellular DNA destroying agent can be embodied in the form of a DNAse enzyme, in particular a bovine pancreatic DNAse which is parenterally injected in doses ranging from of 50 000 Kunz units to 250 000 000 Kunz units a day every day during 5-360 days or in the form of a recombinant human DNAse. In addition, a blood extracellular DNA binding agent embodied in the form of anti-DNA antibodies can be injected into a systemic blood circulation. In addition a modified agent which modifies the chemical composition and/or conformation and/or polymery and/or an association with proteins and/or lipids and/or ribonucleic acids of the blood extracellular DNA. Said modifying agent can be embodied in the form of a enzyme-ribonuclease. An extracellular ribonuclease of a Serratia Mercenses bacterium can be used in the form of said agents.
摘要翻译：本发明涉及医学和兽医学，可用于主要治疗实体瘤。用于治疗肿瘤疾病的本发明的方法，其包括将血液细胞外DNA破坏剂注入全身血液循环中。所述血液细胞外DNA破坏剂可以以DNA酶，特别是牛胰腺DNAse的形式体现，其中每天在5-360之间每天以5万盎司单位至2.5万盎司单位的肠胃外注射天或重组人DNAse的形式。此外，以抗DNA抗体形式体现的血液细胞外DNA结合剂可以注射到全身血液循环中。另外还可以改变与细胞外DNA的蛋白质和/或脂质和/或核糖核酸的化学组成和/或构象和/或聚合和/或结合的修饰剂。所述改性剂可以以酶 - 核糖核酸酶的形式实施。沙雷氏菌属细菌的细胞外核糖核酸酶可以以所述药剂的形式使用。

3. 发明公开

EP1666055A1 METHOD FOR TREATING ONCOLOGICAL, VIRULENT AND SOMATIC DISEASES, METHOD FOR CONTROLLING TREATMENT EFFICIENCY, PHARMACEUTICAL AGENTS AND COMPOSITION FOR CARRYING OUT SAID TREATMENT 审中-公开
标题翻译：方法用于治疗肿瘤，恶毒，躯体疾病，方法控制处理效率，药剂和组合物进行该处理的处理
公开(公告)号：EP1666055A1
公开(公告)日：2006-06-07
申请号：EP03796243.8
申请日：2003-07-14
申请人： Tets, Viktor Veniaminovich , GENKIN, Dmitry Dmitrievich
发明人： TETS, Viktor Veniaminovich , GENKIN, Dmitry Dmitrievich , TETS, Georgy Viktorovich
IPC分类号： A61K38/43 , A61K31/7088 , A61K39/395 , A61M1/36 , G01N33/68 , A61P35/00 , A61P31/00
CPC分类号： C07K16/44 , A61K38/465 , A61K39/0011 , C12Y301/21001
摘要： The invention relates to medicine and veterinary science and discloses a novel method for treating oncological, virulent and somatic diseases whose main target for therapeutic action is embodied in the form of DNA which freely circulates in blood plasma (and other liquid media) and originates from tumoral and mutant cells or cells infected by bacteria, fungi or protozoan and from different microorganisms which reside in the organism thereof. Said invention also relates to novel pharmaceutical compositions and to the use thereof for treating oncological diseases and infectious states provoked by bacteria, fungi and protozoa and non-infectious somatic diseases and states produced by accumulation of somatic mutations in cells of organism. Medicinal and immunological compositions, sorption and physico-chemical engineering and the method for using them in order to treat malignant tumors and other diseases are also disclosed.
摘要翻译：本发明涉及医学和兽医学和圆盘更小的新颖的方法，用于治疗肿瘤，毒力和躯体疾病其主要目标为治疗作用体现在DNA的形式，其在血浆（和其它液体介质）自由流通，并从肿瘤起源和突变体的细胞或细胞由细菌，真菌或原生动物，以及其中其驻留在生物体不同的微生物感染。所以说本发明涉及新的药物组合物和涉及其用于治疗肿瘤性疾病和由细菌，真菌和原生动物和非感染性疾病和躯体状态通过在生物体细胞的体细胞突变的累积产生引起的感染状态。药用和免疫组合物，吸附和物理化学工程和用于以治疗恶性肿瘤和其他疾病使用它们的方法是如此游离缺失盘。

4. 发明公开

EP1661579A2 METHOD FOR TREATING DISEASES ASSOCIATED WITH CHANGES OF QUALITATIVE AND/ QUANTITATIVE COMPOSITION OF BLOOD EXTRACELLULAR DNA 失效转让
标题翻译： METHOD FOR全身性细菌感染相关的与所述质量和/或血中的细胞外DNA的定量组成变动的处理
公开(公告)号：EP1661579A2
公开(公告)日：2006-05-31
申请号：EP04775224.1
申请日：2004-07-01
申请人： GENKIN, Dmitry Dmitrievich , Tets, Viktor Veniaminovich
发明人： GENKIN, Dmitry Dmitrievich , TETS, Viktor Veniaminovich , TETS, Georgy Viktorovich
IPC分类号： A61K38/43 , A61K38/46 , A61P31/00 , A61P3/10 , A61P9/10
CPC分类号： A61K38/465 , C12Y301/21001
摘要： The invention relates to medicine and veterinary science and can be used for treating diseases associated with changes of the qualitative and/ quantitative composition of blood extracellular DNA, namely generalised infection diseases provoked by bacteria, diseases provoked by fungi and protozoa, atherosclerosis, pancreatic diabetes, allergic diseases associated with delayed response hypersensitivity and diseases due to somatic cell gene mutations. The inventive method for treating diseases associated with modifications of the qualitative and/or quantitative composition of blood extracellular DNA, namely generalised infection diseases provoked by bacteria, diseases provoked by fungi and protozoa, atherosclerosis, pancreatic diabetes, allergic diseases associated with delayed response hypersensitivity and diseases due to somatic cell gene mutations consists in injecting an agent destroying blood extracellular DNA. DNAse enzyme injected into a systemic blood circulation in doses which modify the electrophoretic profile of the blood extracellular DNA definable by pulse-electrophoresis can be used in the form of an agent destroying said blood extracellular DNA. Said DNAse enzyme can be injected in doses and at regimes ensuring the level of a blood plasma DNA-hydrolytic activity which is measured in the blood plasma and is higher than 150 Kunz units per litre of plasma during a total time higher than 12 hours a day. The inventive method makes it possible to develop a high-efficient and low-toxic method for treating diseases associated with modifications of qualitative and/or quantitative composition of blood extracellular DNA individually or in combination thereof.
摘要翻译：本发明涉及医学和兽医学，可用于治疗与血细胞外DNA，由细菌引起即广义感染性疾病，真菌和原生动物引起的疾病，动脉粥样硬化，胰糖尿病的定性和/定量组合物的变化相关的疾病，具有延迟超敏反应和由于体细胞基因突变相关疾病的过敏性疾病。用于治疗与血细胞外DNA，由细菌引起即广义感染性疾病，真菌和原生动物，动脉粥样硬化，胰糖尿病引起的疾病的定性和/或定量的组合物的修改相关的疾病本发明的方法，具有延迟响应超敏反应相关的过敏性疾病和由于体细胞基因突变besteht在注入的试剂破坏血细胞外DNA的疾病。注入到全身血液循环中哪一个修改通过脉冲电泳血液胞外DNA可定义的电泳轮廓剂量DNA酶酶可以在代理破坏血细胞外的DNA。所述的形式使用。所述DNA酶酶可以在剂量和在制度确保其在血浆中时的总时间测量，并且每升血浆的高于150个Kunz的单位血浆DNA水解活性的水平所有每天高于12小时内注入，本发明的方法使得有可能开发用于治疗与血细胞外DNA单独或以其组合的定性和/或定量的组合物的变型相关的疾病的高效率和低毒性的方法。

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