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1. 发明公开

EP4340682A1 IMMUNOMODULATION OF TUMOR MICROENVIRONMENT 审中-实审
公开(公告)号：EP4340682A1
公开(公告)日：2024-03-27
申请号：EP22805535.6
申请日：2022-05-20
申请人： Genkin, Dmitry Dmitrievich , Tets, Georgy, Viktorovich , Tets, Viktor, Veniaminovich
发明人： Genkin, Dmitry Dmitrievich , Tets, Georgy, Viktorovich , Tets, Viktor, Veniaminovich
IPC分类号： A47G19/12

2. 发明授权

EP3297657B1 EXTRACELLULAR DNA AS A THERAPEUTIC TARGET IN NEURODEGENERATION 有权
公开(公告)号：EP3297657B1
公开(公告)日：2020-03-25
申请号：EP16800375.4
申请日：2016-05-11
申请人： Genkin, Dmitry Dmitrievich , Tets, Georgy Viktorovich , Tets, Viktor Veniaminovich
发明人： Genkin, Dmitry Dmitrievich , Tets, Georgy Viktorovich , Tets, Viktor Veniaminovich
IPC分类号： A61K38/46 , A61P25/16 , A61P25/28 , A61K47/61 , A61K9/00 , A61P25/18

3. 发明公开

EP0896819A1 ANTIGLUCOCORTICOID DRUG 失效
标题翻译：使用昆虫Feromonen的病理的糖皮质激素过剩引起的治疗
公开(公告)号：EP0896819A1
公开(公告)日：1999-02-17
申请号：EP96902026.2
申请日：1996-02-01
申请人： Burlakov, Sergei Dmitrievich , Genkin, Dmitry Dmitrievich , Surkov, Kirill Gennadievich , Tets, Viktor Veniaminovich
发明人： Burlakov, Sergei Dmitrievich , Genkin, Dmitry Dmitrievich , Surkov, Kirill Gennadievich , Tets, Viktor Veniaminovich
IPC分类号： A61K31/045 , A61K31/075 , A61K31/11
CPC分类号： A61K31/235 , A61K31/045 , A61K31/22
摘要： The invention is related to medicine and veterinary fields, in particular to nonsteroidal antiglucocorticoids. An aim of the invention is the establishment of a new class of drugs with low toxicity and high activity in regulation of sensitivity of mammalian cells to the glucocorticoid hormones. There is a naval application of an insect pheromone with long-chain aliphatic nonsteroidal structure or its synthetic analog or derivative that is unsaturated aliphatic alcohol, aldehyde or ester, for specific inhibition of glucocorticoid hormone influence on mammalian cells. The aliphatic carbon chain length of these pheromones varies from 10 to 21 carbon atoms. There is also a possibility of combining application of two or more pheromones and/or their synthetic analogs and derivatives for enhancement of therapeutic activity, selection being made on the basis of different hydrophobic properties proportional to the aliphatic carbon chain length. Difference in lengths of these chains must be no loss than five carbon atoms. Example of preparation of the pharmaceutical forms and results of comparative experiments that show their high activity are disclosed.
摘要翻译：本发明涉及医药和兽医领域，特别是对非甾体antiglucocorticoids。本发明的一个目的是建立一个新的一类药物与在哺乳动物细胞中糖皮质激素的激素敏感性调节低毒性和高活性的。存在与长链脂肪族的非甾体结构或其合成类似物或衍生物的昆虫信息素的海军应用确实是不饱和脂醇，醛或酯，用于在哺乳动物细胞上的糖皮质激素激素影响特异性抑制。合成信息素的脂族碳链长度而变化，从10到21个碳原子。因此，存在两个或更多个信息激素和/或合成的类似物的组合应用的可能性和衍生它们的用于增强的治疗活性的，正比于脂肪族碳链长度不同的疏水性能的基础上作出的选择。差在链论文的长度必须不超过5个碳原子的损失。制备的药物形式和对比实验的结果的例子并显示它们的高活性是游离缺失盘。

4. 发明公开

EP0820772A1 IMMUNOMODULATING MEDICINAL AGENT 失效
标题翻译：免疫调节药物剂
公开(公告)号：EP0820772A1
公开(公告)日：1998-01-28
申请号：EP95923615.9
申请日：1995-04-27
申请人： Travkin, Oleg Viktorovich , Genkin, Dmitry Dmitrievich
发明人： Travkin, Oleg Viktorovich , Genkin, Dmitry Dmitrievich
IPC分类号： A61K38/21 , A61K31/435 , A61K47/44 , A61K9/127 , A61K9/50
CPC分类号： A61K31/473 , A61K9/127 , A61K31/435
摘要： The invention relates to medicine and veterinary science, specifically to immunomodulating medicinal preparations based on hydrophobic interferon inducers used in anti-viral therapy. The problem addressed by the invention is to broaden the range of effective uses, improve potency, reduce toxicity and simplify production of the agent in question. A novelty is the use of complex ethers of 10-methylene carboxy-9-acridone as a low molecular weight interferon inducer in conjunction with a pharmaceutically acceptable carrier, and the selection of substances used to ensure solubility in water and for microencapsulation in the case of a lipid carrier.
摘要翻译：本发明涉及医学和兽医学，具体涉及基于用于抗病毒疗法的疏水性干扰素诱导剂的免疫调节药物制剂。本发明解决的问题是扩大有效用途的范围，提高效力，减少毒性并简化所述试剂的生产。新颖之处在于将10-亚甲基羧基-9-吖啶酮的复合醚作为低分子量干扰素诱导剂与药学上可接受的载体一起使用，以及选择用于确保在水中的溶解度和用于微胶囊化的物质一种脂质载体。

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