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1. 发明公开

EP1557565A2 Microfabricated elastomeric valve and pump systems 有权
标题翻译：微型弹性阀和泵系统
公开(公告)号：EP1557565A2
公开(公告)日：2005-07-27
申请号：EP05075473.8
申请日：2000-06-27
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： Unger, Marc A. , Scherer, Axel , Quake, Stephen R. , Chou, Hou-Pu , Thorsen, Todd A.
IPC分类号： F04B43/04 , F15C5/00
CPC分类号： F04B43/043 , F15C5/00 , F16K99/0001 , F16K99/0015 , F16K99/0046 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0094
摘要： A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer, bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.
摘要翻译：一种制造弹性体结构的方法，包括：在第一微机械模具的顶部上形成第一弹性体层，所述第一微机械模具具有第一凸起突起，所述第一凸起形成沿所述第一弹性体层的底表面延伸的第一凹陷; 在第二微机械模具的顶部上形成第二弹性体层，所述第二微机械模具具有第二凸起突起，所述第二凸起形成沿所述第二弹性体层的底表面延伸的第二凹陷，将所述第二弹性体层的底表面结合到顶部所述第一弹性体层的表面使得在所述第一和第二弹性体层之间的所述第二凹陷中形成控制通道; 以及将第一弹性体层定位在平面基底的顶部上，使得在第一弹性体层和平面基底之间的第一凹陷中形成流动通道。

2. 发明公开

EP1065378A3 Microfabricated elastomeric valve and pump systems 有权
标题翻译：微型弹性阀和泵系统
公开(公告)号：EP1065378A3
公开(公告)日：2001-05-02
申请号：EP00305389.9
申请日：2000-06-27
申请人： California Institute of Technology
发明人： Unger, Marc A. , Chou, Hou-Pu , Thorsen, Todd A. , Scherer, Axel , Quake, Stephen R.
IPC分类号： F04B43/04 , F15C5/00
CPC分类号： B29C51/00 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2400/046 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , B81B5/00 , B81B2201/036 , B81B2201/054 , B81C1/00119 , B81C2201/019 , B81C2201/034 , C12Q1/6874 , F04B43/043 , F15C1/06 , F15C5/00 , F16K11/20 , F16K13/00 , F16K31/126 , F16K99/0001 , F16K99/0015 , F16K99/0046 , F16K99/0048 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0094 , Y10T137/0491 , Y10T137/0497 , Y10T137/2224 , Y10T137/87249 , Y10T156/10 , Y10T428/24479 , Y10T428/24744 , C12Q2535/125
摘要： A method of fabricating an elastomeric structure for a micropump or valve comprising: forming a first elastomeric layer on top of a first micromachined mold (10), the first micromachined mold (10) having a first raised protrusion (11) which forms a first recess (21) extending along a bottom surface of the first elastomeric layer (20); forming a second elastomeric layer (22) on top of a second micromachined mold, the second micromachined mold having a second raised protrusion (13) which forms a second recess (23) extending along a bottom surface of the second elastomeric layer, bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel (30) forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.
摘要翻译：一种制造用于微型泵或阀门的弹性体结构的方法，包括：在第一微机械加工模具（10）的顶部形成第一弹性体层，所述第一微机械加工模具（10）具有第一凸起突起（11）（21），其沿着所述第一弹性体层（20）的底表面延伸; 在第二微机械加工模具的顶部上形成第二弹性体层（22），所述第二微机械加工模具具有形成沿所述第二弹性体层的底表面延伸的第二凹部（23）的第二凸起突起（13），将所述底部所述第二弹性体层的表面延伸到所述第一弹性体层的顶表面上，使得在所述第一弹性体层和所述第二弹性体层之间的所述第二凹陷中形成控制通道（30）以及将第一弹性体层定位在平面基底的顶部上，使得在第一弹性体层和平面基底之间的第一凹陷中形成流动通道。

3. 发明公开

EP2309130A3 Microfabricated elastomeric valve and pump systems 有权
标题翻译：微制造的弹性体阀门和泵系统
公开(公告)号：EP2309130A3
公开(公告)日：2013-03-06
申请号：EP10180441.7
申请日：2000-06-27
申请人： California Institute of Technology
发明人： Unger, Marc A. , Scherer, Axel , Quake, Stephen R. , Chou, Hou-Pu , Thorsen, Todd A.
IPC分类号： F04B43/04 , F15C5/00 , F16K99/00
CPC分类号： B29C51/00 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2400/046 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , B81B5/00 , B81B2201/036 , B81B2201/054 , B81C1/00119 , B81C2201/019 , B81C2201/034 , C12Q1/6874 , F04B43/043 , F15C1/06 , F15C5/00 , F16K11/20 , F16K13/00 , F16K31/126 , F16K99/0001 , F16K99/0015 , F16K99/0046 , F16K99/0048 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0094 , Y10T137/0491 , Y10T137/0497 , Y10T137/2224 , Y10T137/87249 , Y10T156/10 , Y10T428/24479 , Y10T428/24744 , C12Q2535/125
摘要： A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer, bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

4. 发明授权

EP1557565B1 Microfabricated elastomeric valve and pump systems 有权
标题翻译：弹性微型泵或微型阀系统
公开(公告)号：EP1557565B1
公开(公告)日：2016-08-10
申请号：EP05075473.8
申请日：2000-06-27
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： Unger, Marc A. , Scherer, Axel , Quake, Stephen R. , Chou, Hou-Pu , Thorsen, Todd A.
IPC分类号： F04B43/04 , F15C5/00 , F16K99/00
CPC分类号： F04B43/043 , F15C5/00 , F16K99/0001 , F16K99/0015 , F16K99/0046 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0094

5. 发明公开

EP1557565A3 Microfabricated elastomeric valve and pump systems 有权
标题翻译：弹性微型泵或微型阀系统
公开(公告)号：EP1557565A3
公开(公告)日：2013-02-27
申请号：EP05075473.8
申请日：2000-06-27
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： Unger, Marc A. , Scherer, Axel , Quake, Stephen R. , Chou, Hou-Pu , Thorsen, Todd A.
IPC分类号： F04B43/04 , F15C5/00 , F16K99/00
CPC分类号： F04B43/043 , F15C5/00 , F16K99/0001 , F16K99/0015 , F16K99/0046 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0094
摘要： A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer, bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

6. 发明公开

EP2299256A3 Microfabricated crossflow devices and methods 审中-公开
标题翻译：小型化的交叉流的装置和方法
公开(公告)号：EP2299256A3
公开(公告)日：2012-10-10
申请号：EP10178333.0
申请日：2001-09-14
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： Quake, Stephen R. , Thorsen, Todd
IPC分类号： G01N15/14
CPC分类号： C12Q1/68 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2200/12 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/12 , B01L2300/123 , B01L2400/0418 , B01L2400/0421 , B01L2400/0454 , B01L2400/0481 , B01L2400/0484 , B01L2400/0487 , B01L2400/0638 , C12M1/34 , G01N15/1404 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N33/54366 , G01N35/08 , G01N2015/0065 , G01N2015/0088 , G01N2015/1006 , G01N2015/1081 , G01N2015/1411 , G01N2015/1481 , G01N2015/149 , Y10T436/118339 , Y10T436/143333
摘要： A microfluidic device for analyzing and/or sorting biological material (e.g., molecules such as polynucleotides and polypeptides, including proteins and enzymes; viruses and cells) and methods for its use are provided. The device and methods of the invention are useful for sorting particles, e.g. virions. The invention is also useful for high throughput screening, e.g. combinatorial screening. The microfluidic device comprises a main channel and an inlet region in communication with the main channel at a droplet extrusion region. Droplets of solution containing the biological material are deposited into the main channel through the droplet extrusion region. A fluid different from and incompatible with the solution containing the biological material flows through the main channel so that the droplets containing the biological material do not diffuse or mix. Biological material within the droplets can be analyzed and/or sorted by detecting a predetermined characteristic of the biological sample in each droplet and sorting the droplet accordingly.

7. 发明公开

EP2299256A2 Microfabricated crossflow devices and methods 审中-公开
标题翻译： Miniaturisierte Querstromvorrichtungen und -Verfahren
公开(公告)号：EP2299256A2
公开(公告)日：2011-03-23
申请号：EP10178333.0
申请日：2001-09-14
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： Quake, Stephen R. , Thorsen, Todd
IPC分类号： G01N15/14
CPC分类号： C12Q1/68 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2200/12 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/12 , B01L2300/123 , B01L2400/0418 , B01L2400/0421 , B01L2400/0454 , B01L2400/0481 , B01L2400/0484 , B01L2400/0487 , B01L2400/0638 , C12M1/34 , G01N15/1404 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N33/54366 , G01N35/08 , G01N2015/0065 , G01N2015/0088 , G01N2015/1006 , G01N2015/1081 , G01N2015/1411 , G01N2015/1481 , G01N2015/149 , Y10T436/118339 , Y10T436/143333
摘要： A microfluidic device for analyzing and/or sorting biological material (e.g., molecules such as polynucleotides and polypeptides, including proteins and enzymes; viruses and cells) and methods for its use are provided. The device and methods of the invention are useful for sorting particles, e.g. virions. The invention is also useful for high throughput screening, e.g. combinatorial screening. The microfluidic device comprises a main channel and an inlet region in communication with the main channel at a droplet extrusion region. Droplets of solution containing the biological material are deposited into the main channel through the droplet extrusion region. A fluid different from and incompatible with the solution containing the biological material flows through the main channel so that the droplets containing the biological material do not diffuse or mix. Biological material within the droplets can be analyzed and/or sorted by detecting a predetermined characteristic of the biological sample in each droplet and sorting the droplet accordingly.
摘要翻译：提供了用于分析和/或分选生物材料的微流体装置（例如分子，例如多核苷酸和多肽，包括蛋白质和酶;病毒和细胞）及其使用方法。本发明的装置和方法可用于分选颗粒，例如病毒颗粒。本发明也可用于高通量筛选，例如组合筛选。微流体装置包括在液滴挤出区域处与主通道连通的主通道和入口区域。含有生物材料的溶液的液滴通过液滴挤出区沉积到主通道中。与包含生物材料的溶液不同且不相容的流体流过主通道，使得含有生物材料的液滴不会扩散或混合。可以通过检测每个液滴中生物样品的预定特征并相应地分选液滴来分析和/或分选液滴内的生物材料。

9. 发明公开

EP1195523A2 Microfabricated elastomeric valve and pump systems 有权
标题翻译：弹药Mikropumpen- oder Mikroventilsystem
公开(公告)号：EP1195523A2
公开(公告)日：2002-04-10
申请号：EP01128819.8
申请日：2000-06-27
申请人： California Institute of Technology
发明人： Unger, Marc A. , Scherer, Axel , Quake, Stephen R. , Chou, Hou-Pu , Thorsen, Todd A.
IPC分类号： F04B43/04
CPC分类号： F04B43/043 , F15C5/00
摘要： A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.
摘要翻译：一种制造弹性体结构的方法，包括：在第一微加工模具的顶部上形成第一弹性体层，所述第一微加工模具具有形成沿所述第一弹性体层的底表面延伸的第一凹槽的第一凸起突起; 在第二微加工模具的顶部上形成第二弹性体层，所述第二微加工模具具有形成沿所述第二弹性体层的底表面延伸的第二凹槽的第二凸起突起; 将第二弹性体层的底表面粘合到第一弹性体层的顶表面上，使得控制通道形成在第一和第二弹性体层之间的第二凹部中; 以及将所述第一弹性体层定位在平面基底的顶部上，使得在所述第一弹性体层和所述平面基底之间的所述第一凹部中形成流动通道。

10. 发明公开

EP1065378A2 Microfabricated elastomeric valve and pump systems 有权
标题翻译：弹性微型泵或微型阀系统
公开(公告)号：EP1065378A2
公开(公告)日：2001-01-03
申请号：EP00305389.9
申请日：2000-06-27
申请人： California Institute of Technology
发明人： Unger, Marc A. , Chou, Hou-Pu , Thorsen, Todd A. , Scherer, Axel , Quake, Stephen R.
IPC分类号： F04B43/04 , F15C5/00
CPC分类号： B29C51/00 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2400/046 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , B81B5/00 , B81B2201/036 , B81B2201/054 , B81C1/00119 , B81C2201/019 , B81C2201/034 , C12Q1/6874 , F04B43/043 , F15C1/06 , F15C5/00 , F16K11/20 , F16K13/00 , F16K31/126 , F16K99/0001 , F16K99/0015 , F16K99/0046 , F16K99/0048 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0094 , Y10T137/0491 , Y10T137/0497 , Y10T137/2224 , Y10T137/87249 , Y10T156/10 , Y10T428/24479 , Y10T428/24744 , C12Q2535/125
摘要： A method of fabricating an elastomeric structure for a micropump or valve comprising: forming a first elastomeric layer on top of a first micromachined mold (10), the first micromachined mold (10) having a first raised protrusion (11) which forms a first recess (21) extending along a bottom surface of the first elastomeric layer (20); forming a second elastomeric layer (22) on top of a second micromachined mold, the second micromachined mold having a second raised protrusion (13) which forms a second recess (23) extending along a bottom surface of the second elastomeric layer, bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel (30) forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

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