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1. 发明公开

EP2872635A4 GENOME SURGERY WITH PAIRED, PERMEANT ENDONUCLEASE EXCISION 审中-公开
标题翻译：有一对采取紧急ENDONUKLEASEEXZISION基因组手术
公开(公告)号：EP2872635A4
公开(公告)日：2016-04-06
申请号：EP13816139
申请日：2013-07-10
申请人： UNIV NEVADA , SCHILLER MARTIN , STRONG CHRISTY
发明人： SCHILLER MARTIN , STRONG CHRISTY
IPC分类号： C12N15/85 , C12N15/10
CPC分类号： C12N15/63 , C07K2319/10 , C07K2319/81 , C12N9/22 , C12N15/102 , C12N15/52 , C12N15/85 , C12N15/907

2. 发明公开

EP2018173A4 MAGNETORHEOLOGICAL FLUIDS AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译：磁流变液及其治疗应用
公开(公告)号：EP2018173A4
公开(公告)日：2009-09-23
申请号：EP07783892
申请日：2007-05-17
申请人： UNIV NEVADA
发明人： MURPHY WILLIAM J , WELNIAK LISBETH A , EVRENSEL CAHIT , FUCHS ALAN , GORDANINEJAD FARARMARZ
IPC分类号： A61K33/26 , A61K41/00 , A61K51/00 , A61P35/00
CPC分类号： A61K33/26 , A61K38/2013 , A61K41/0052 , A61K45/06

3. 发明公开

EP2968273A4 METHODS OF TREATING MUSCULAR DYSTROPHY 审中-公开
标题翻译： VERFAHREN ZUR BEHANDLUNG VON MUSKELDYSTROPENEN
公开(公告)号：EP2968273A4
公开(公告)日：2016-08-31
申请号：EP14764428
申请日：2014-03-14
申请人： UNIV NEVADA
发明人： BURKIN DEAN , WUEBBLES RYAN
IPC分类号： A61K31/404 , A61K45/06 , A61P21/00 , A61P21/04
CPC分类号： A61K31/404 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are α7β1 integrin modulatory agents and methods of using such to treat conditions associated with decreased α7β1 integrin expression or activity, including muscular dystrophy. In one example, methods for treating a subject with muscular dystrophy are disclosed. The methods include administering an effective amount of an α7β1 integrin modulatory agent to the subject with muscular dystrophy, wherein the α7β1 integrin modulatory agent increases α7β1 integrin expression or activity as compared to α7β1 integrin expression or activity prior to treatment, thereby treating the subject with muscular dystrophy. Also disclosed are methods of enhancing muscle regeneration, repair, or maintenance in a subject and methods of enhancing α7β1 integrin expression by use of the disclosed α7β1 integrin modulatory agents. Methods of prospectively preventing or reducing muscle injury or damage in a subject are also disclosed.
摘要翻译：本文公开了α7＆bgr; 1整合素调节剂和使用其来治疗与降低的α7和bgr1整合素表达或活性（包括肌营养不良）相关的病症的方法。在一个实例中，公开了用于治疗具有肌营养不良症的受试者的方法。所述方法包括向具有肌营养不良症的受试者施用有效量的α7＆bgr1整联蛋白调节剂，其中α7和bgr1整联蛋白调节剂与α7和bgr1整合素的表达或活性相比，α7和bgr1整合素表达或活性与治疗，从而治疗患有肌营养不良症的受试者。还公开了增强受试者肌肉再生，修复或维持的方法以及通过使用公开的α7＆bgr1整联蛋白调节剂来增强α7和bgr1整合素表达的方法。还公开了前瞻性预防或减少受试者的肌肉损伤或损伤的方法。

4. 发明公开

EP0912596A4 PLANT PLASTID DIVISION GENES 失效
标题翻译：植物基因用于调节PLASTIDTEILUNG
公开(公告)号：EP0912596A4
公开(公告)日：2002-04-10
申请号：EP97933198
申请日：1997-06-27
申请人： UNIV NEVADA
发明人： OSTERYOUNG KATHERINE W
IPC分类号： A01H5/00 , C07K14/415 , C12N15/09 , C12N15/29 , C12N15/82 , C07H21/04
CPC分类号： C12N15/8269 , C07K14/415
摘要： Disclosed are DNA sequences that play a critical role in regulating plastid division in plants. Also disclosed is a method for obtaining transgenic plants with novel phenotypes, characterized by alterations in plastid number and size.

5. 发明公开

EP1931812A4 TARGETS AND PROCESSES FOR FABRICATING SAME 审中-公开
标题翻译：目标在HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP1931812A4
公开(公告)日：2014-07-30
申请号：EP06803322
申请日：2006-09-12
申请人： UNIV NEVADA
发明人： COWAN THOMAS E , MALEKOS STEVEN , KORGAN GRANT , ADAMS JESSE , SENTOKU YASUHIKO , LE GALLOUDEC NATHALIE , FUCHS JULIEN
IPC分类号： C23C14/34 , H05G2/00
CPC分类号： H05H1/24 , G21B1/19 , H01J35/08 , H05G2/00 , H05G2/001 , H05G2/008 , H05H1/02 , Y02E30/16 , Y10T428/12 , Y10T428/12299 , Y10T428/1241 , Y10T428/12493 , Y10T428/12806 , Y10T428/12868 , Y10T428/12889 , Y10T428/13
摘要： In particular embodiments, the present disclosure provides targets including a metal layer and defining a hollow inner surface. The hollow inner surface has an internal apex. The distance between at least two opposing points of the internal apex is less than about 15 μm. In particular examples, the distance is less than about 1 μm. Particular implementations of the targets are free standing. The targets have a number of disclosed shaped, including cones, pyramids, hemispheres, and capped structures. The present disclosure also provides arrays of such targets. Also provided are methods of forming targets, such as the disclosed targets, using lithographic techniques, such as photolithographic techniques. In particular examples, a target mold is formed from a silicon wafer and then one or more sides of the mold are coated with a target material, such as one or more metals.
摘要翻译：在具体实施例中，本公开提供了包括金属层并限定中空内表面的目标。中空的内表面具有内部顶点。内部顶点的至少两个相对点之间的距离小于约15μm。在具体示例中，该距离小于约1μm。目标的具体实现是独立的。目标具有许多公开的形状，包括锥体，金字塔，半球和封盖结构。本公开还提供了这样的目标的阵列。还提供了使用光刻技术（诸如光刻技术）形成靶的方法，例如所公开的靶。在具体实例中，目标模具由硅晶片形成，然后模具的一个或多个侧面涂覆有目标材料，例如一种或多种金属。

6. 发明公开

EP1692266A4 IMPROVED METHODS FOR DETECTING AND MEASURING SPECIFIC NUCLEIC ACID SEQUENCES 审中-公开
标题翻译：改进方法检测和测量的特定核酸序列
公开(公告)号：EP1692266A4
公开(公告)日：2009-11-18
申请号：EP04810459
申请日：2004-11-08
申请人： UNIV NEVADA RENO
发明人： TAM-CHANG SUK-WAH , HUNTER KENNETH W , PUBLICOVER NELSON G
IPC分类号： C12M3/00 , C12N20060101 , C12Q1/68 , G01N33/00
CPC分类号： C12Q1/6876 , C12Q1/6816 , C12Q1/6818 , C12Q1/6837 , C12Q2525/185 , C12Q2525/301 , C12Q2565/107 , C12Q2565/101 , C12Q2525/101

7. 发明公开

EP1107662A4 MANIPULATION OF TOCOPHEROL LEVELS IN TRANSGENIC PLANTS 审中-公开
标题翻译： - 影响生育酚在转基因植物
公开(公告)号：EP1107662A4
公开(公告)日：2003-07-02
申请号：EP99945207
申请日：1999-08-25
申请人： UNIV NEVADA
发明人： DELLAPENNA DEAN , SHINTANI DAVID K
IPC分类号： A01H5/00 , C12N5/10 , C12N9/10 , C12N15/09 , C12N15/82 , C12P17/06 , C12R1/91 , A01H5/10 , C12N5/14 , C12N15/29 , C12N15/52
CPC分类号： C12N9/1007 , C12N15/8243
摘要： Disclosed is a gene sequence which as been identified as encoding 2-methyl-6-phytylplastoquinol/2-methyl-6-solanylplastoquinol-9 methyltransferase from photosynthetic organisms. The enzyme 2-methyl-6-phytylplastoquinol/2-methyl-6-solanylplastoquinol-9 methyltransferase is a fundamental enzyme in the production of tocopherols and plastoquinols in higher plants. 2-Methyl-6-phytylplastoquinol/2-methyl-6-solanylplastoquinol-9 methyltransferase is believed to be involved in regulating the relative amounts of the various tocopherols present in photosynthetic organisms. By introducing a genetic construct having a 2-methyl-6-phytylplastoquinol/2-methyl-6-solanylplastoquinol-9 methyltransferase coding sequence placed under the control of a plant promoter in a plant, transgenic plants can be made having altered 2-methyl-6-phytylplastoquinol/2-methyl-6-solanylplastoquinol-9 methyltransferase expression, to effect changes in the tocopherol profile of the plant. Transgenic plants can be made that have altered tocopherol levels in their tissues.

8. 发明公开

EP2954098A4 ROOM TEMPERATURE ELECTRODEPOSITION OF ACTINIDES FROM IONIC SOLUTIONS 审中-公开
标题翻译：镀锌来自离子溶液的锕系元素在室温下
公开(公告)号：EP2954098A4
公开(公告)日：2016-09-07
申请号：EP14749320
申请日：2014-02-11
申请人： UNIV NEVADA
发明人： HATCHETT DAVID , CZERWINSKI KENNETH , DROESSLER JANELLE
IPC分类号： C25D3/54 , C25C1/22 , C25C3/34 , C25C5/04 , C25D3/66
CPC分类号： C25D3/665 , C25C3/34 , C25C5/04 , C25D3/54

9. 发明公开

EP2892525A4 METHODS OF TREATING MUSCULAR DYSTROPHY 有权
标题翻译：治疗肌肉营养不良的方法
公开(公告)号：EP2892525A4
公开(公告)日：2016-08-03
申请号：EP13835809
申请日：2013-09-10
申请人： UNIV NEVADA
发明人： BURKIN DEAN , WUEBBLES RYAN
IPC分类号： A61K31/33 , A61K31/16 , A61K31/19 , A61K31/20 , A61K31/277 , A61K31/335 , A61K31/341 , A61K31/343 , A61K31/36 , A61K31/37 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/4025 , A61K31/4035 , A61K31/41 , A61K31/415 , A61K31/56 , A61P21/00 , A61P21/04
CPC分类号： A61K38/05 , A61K31/16 , A61K31/19 , A61K31/20 , A61K31/277 , A61K31/341 , A61K31/343 , A61K31/36 , A61K31/37 , A61K31/381 , A61K31/4025 , A61K31/4035 , A61K31/41 , A61K31/415 , A61K31/4178 , A61K31/4196 , A61K31/421 , A61K31/426 , A61K31/4365 , A61K31/4402 , A61K31/4418 , A61K31/444 , A61K31/47 , A61K31/4709 , A61K31/473 , A61K31/496 , A61K31/498 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/53 , A61K31/5365 , A61K31/5375 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/551 , A61K31/57 , A61K31/575 , A61K31/661 , A61K38/39 , A61K45/06
摘要： Disclosed herein are α7β1 integrin modulatory agents and methods of using such to treat conditions associated with decreased α7β1 integrin expression or activity, including muscular dystrophy. In one example, methods for treating a subject with muscular dystrophy are disclosed. The methods include administering an effective amount of an α7β1 integrin modulatory agent to the subject with muscular dystrophy, wherein the α7β1 integrin modulatory agent increases α7β1 integrin expression or activity as compared to α7β1 integrin expression or activity prior to treatment, thereby treating the subject with muscular dystrophy. Also disclosed are methods of enhancing muscle regeneration, repair, or maintenance in a subject and methods of enhancing α7β1 integrin expression by use of the disclosed α7β1 integrin modulatory agents. Methods of prospectively preventing or reducing muscle injury or damage in a subject are also disclosed.

10. 发明公开

EP2882447A4 METHODS FOR DIAGNOSING, PROGNOSING AND TREATING MUSCULAR DYSTROPHY 审中-公开
标题翻译：方法的诊断，预后和肌肉治疗
公开(公告)号：EP2882447A4
公开(公告)日：2016-04-06
申请号：EP13827774
申请日：2013-08-09
申请人： UNIV NEVADA
发明人： BURKIN DEAN , WUEBBLES RYAN , VAN RY PAM
IPC分类号： A61K38/17 , A61P19/08 , A61P21/00
CPC分类号： A61K38/1709 , A61K38/1732 , C07K1/22 , C12N15/09 , C12N15/70 , C12Q1/6883 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/15 , G01N33/6896 , G01N2333/42 , G01N2333/4724 , G01N2500/00 , G01N2800/2878 , G01N2800/2885 , G01N2800/52
摘要： Disclosed herein are methods for diagnosing, prognosing and treating muscular dystrophy. The disclosed methods can be used to diagnosis, prognosis or treat a subject with merosin-deficient congenital muscular dystrophy Type 1A (MDC1A), limb-girdle muscular dystrophy (LGMD), facioscapulohumeral (FHMD), Beckers muscular dystrophy (BMD) or Duchenne muscular dystrophy (DMD). Also disclosed are methods of determining the effectiveness of an agent for the treatment of muscular dystrophy. In an example, a method of diagnosing or prognosing a subject with muscular dystrophy includes detecting expression of Galectin-1 or Galectin-3 in a sample obtained from the subject at risk of having or having one or more signs or symptoms associated with muscular dystrophy, thereby diagnosing or prognosing the subject with muscular dystrophy. Also provided are methods of enhancing muscle regeneration, repair, or maintenance in a subject by administering galectin, such as Galectin-1 and/or Galectin-3 to a subject in need thereof.

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