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1. 发明公开

EP4372080A1 PERICYTE-LIKE CELL EXPRESSING VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AT HIGH LEVEL 审中-实审
公开(公告)号：EP4372080A1
公开(公告)日：2024-05-22
申请号：EP22842176.4
申请日：2022-07-14
申请人： Astellas Pharma Inc. , OSAKA UNIVERSITY , National Center for Child Health and Development
发明人： SHIMATANI, Kenichiro , SATO, Hiromu , SASAI, Masao , SAWA, Yoshiki , SAITO, Atsuhiro , MIYAGAWA, Shigeru
IPC分类号： C12N5/071 , A61K35/44 , A61K35/545 , A61P9/00 , A61P9/10 , A61P43/00
CPC分类号： A61K35/545 , A61K35/44 , A61P9/00 , A61P9/10 , A61P43/00 , C12N5/06
摘要： An object of the present invention is to provide a pericyte-like cell having high angiogenic potential with a higher cell proliferation ability than a primary pericyte available in the past and high VEGF expression, and a method for producing the same. Provided are a method for producing a VEGF-highly expressing pericyte-like cell, the method including selecting a CD56(-) pericyte-like cell from a population including a pericyte-like cell obtained by inducing differentiation of a pluripotent stem cell; and a VEGF-highly expressing pericyte-like cell produced by the production method.

2. 发明公开

EP4029938A1 NUCLEIC ACID DETECTION METHOD BY REAL-TIME PCR 审中-实审
公开(公告)号：EP4029938A1
公开(公告)日：2022-07-20
申请号：EP20862595.4
申请日：2020-09-11
申请人： Sekisui Medical Co., Ltd. , National Center for Child Health and Development
发明人： EBINUMA, Hiroyuki , INOUE, Hiroaki , UCHIYAMA, Toru
IPC分类号： C12N15/09 , C12Q1/6851 , C12Q1/686 , C12Q1/6876 , G01N33/50
摘要： An object of the invention is to provide an optical detection method and a quantification method of a product obtained by amplifying a target nucleic acid contained in a paper piece of a blood spot in a filter paper obtained by blotting blood on a filter paper and then drying the blood using nucleic acid amplification reaction by real-time PCR and to further provide a kit used for the methods. The invention provides a method and a kit which can optically detect and quantify a target nucleic acid from a dried blood spot in a filter paper by real-time PCR without any complicated pretreatment, by adjusting the size of the punched piece of the dried blood spot in a filter paper or the whole blood amount contained in the punched piece, the amount of the PCR reaction reagent, or performing the PCR reaction in a PCR reaction tube closed with a cap.

3. 发明公开

EP4029509A1 COMPOSITION FOR ENHANCING EFFECT OF ANTIBODY DRUG 审中-实审
公开(公告)号：EP4029509A1
公开(公告)日：2022-07-20
申请号：EP20862447.8
申请日：2020-09-10
申请人： Aureo Co., Ltd. , National Center for Child Health and Development
发明人： RII Ko , FUJINO Masayuki , MORIYA Yukiko
IPC分类号： A61K31/716 , A23L33/10 , A61K36/06 , A61K39/395 , A61P35/00 , A61P43/00
摘要： Provided is a composition capable of enhancing the effect of an antibody drug such as an immune checkpoint inhibitor, etc. A β-glucan is used as an active ingredient of a composition for enhancing the effect of an antibody drug. This composition is used suitably for antibody drugs that have an effect of suppressing growth of cancer via immune checkpoint inhibition; e.g., antibody drugs including a monoclonal antibody to PD-L1.

5. 发明公开

EP3150067A1 ORGAN PRESERVATION SOLUTION 无效
标题翻译： ORGANKONSERVIERUNGSLÖSUNG
公开(公告)号：EP3150067A1
公开(公告)日：2017-04-05
申请号：EP15799853.5
申请日：2015-02-24
申请人： SBI Pharmaceuticals Co., Ltd. , National Center For Child Health And Development
发明人： TANAKA, Tohru , NAKAJIMA, Motowo , OTA, Urara , ITO, Hidenori , RII, Ko
IPC分类号： A01N1/02
CPC分类号： A01N1/0226 , A01N1/02
摘要： Provided is an organ preservation solution for use in transplantation, which is capable of effectively preventing the occurrence of ischemia-reperfusion injury. Prepared is an organ preservation solution comprising a mixture of the following components: (a) potassium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, L-ascorbic acid, L-ascorbic acid phosphate ester, and D-glucose; (b) potassium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, L-ascorbic acid, L-ascorbic acid phosphate ester, glycine, and D-glucose; (c) potassium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, L-ascorbic acid, L-ascorbic acid phosphate ester, L-cysteine, glycine, and D-glucose; or (d) potassium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, L-ascorbic acid, L-ascorbic acid phosphate ester, L-cysteine, glycine, an iron compound, and D-glucose.
摘要翻译：提供用于移植的器官保存溶液，其能够有效地防止缺血再灌注损伤的发生。制备的是包含以下组分的混合物的器官保存溶液：（a）氯化钾，磷酸氢二钠，磷酸二氢钠，L-抗坏血酸，L-抗坏血酸磷酸酯和D-葡萄糖; （b）氯化钾，磷酸氢二钠，磷酸二氢钠，L-抗坏血酸，L-抗坏血酸磷酸酯，甘氨酸和D-葡萄糖; （c）氯化钾，磷酸氢二钠，磷酸二氢钠，L-抗坏血酸，L-抗坏血酸磷酸酯，L-半胱氨酸，甘氨酸和D-葡萄糖; 或（d）氯化钾，磷酸氢二钠，磷酸二氢钠，L-抗坏血酸，L-抗坏血酸磷酸酯，L-半胱氨酸，甘氨酸，铁化合物和D-葡萄糖。

6. 发明公开

EP3072964A1 NOVEL CHIMERA GENE ATF7IP-PDGFRB FOR ACUTE LYMPHOBLASTIC LEUKEMIA 审中-公开
标题翻译： NEUARTIGESCHIMÄRESGEN ATF7IP-PDGFRBFÜRAKUTE LYMPHOBLASTISCHELEUKÄMIE
公开(公告)号：EP3072964A1
公开(公告)日：2016-09-28
申请号：EP14863814.1
申请日：2014-11-17
申请人： National Center For Child Health And Development , National Cancer Center , LSIP, LLC
发明人： KIYOKAWA, Nobutaka , MATSUMOTO, Kenji , KOBAYASHI, Kenichiro , ICHIKAWA, Hitoshi
IPC分类号： C12N15/09 , A61K39/395 , A61K45/00 , C07K14/705 , C07K19/00 , C12N9/12 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/574
CPC分类号： C12N9/96 , A61K31/404 , A61K31/5025 , A61K31/506 , A61K45/06 , C07K14/4702 , C07K14/71 , C07K2319/00 , C12N9/12 , C12Y207/10001 , G01N33/502 , G01N33/57484 , G01N2500/00 , G01N2500/10 , A61K2300/00
摘要： To identify a mutation that can serve as an indicator for predicting the effectiveness of drug treatment in cancers such as leukemia; to provide a means for detecting said mutation; and to provide a means for identifying, based on said mutation, patients with cancer or subjects with a risk of cancer, in whom a drug targeting a gene having said mutation or a protein encoded by said gene shows a therapeutic effect.
A method for detecting a gene fusion serving as a responsible mutation (driver mutation) for cancer, the method comprising the step of detecting an ATF7IP-PDGFRB fusion polynucleotide or a polypeptide encoded thereby, in an isolated sample from a subject.
摘要翻译：确定可作为预测癌症如白血病药物治疗有效性的指标的突变; 以提供检测所述突变的方法; 并且提供一种用于基于所述突变识别患有癌症的患者或具有癌症风险的受试者的方法，其中靶向具有所述突变的基因的药物或由所述基因编码的蛋白质表现出治疗效果。一种用于检测癌症的负责突变（驱动突变）的基因融合的方法，所述方法包括在受试者的分离样品中检测ATF7IP-PDGFRB融合多核苷酸或由其编码的多肽的步骤。

7. 发明公开

EP4082615A1 INHIBITOR OF FERTILIZED EGG FRAGMENTATION 审中-实审
公开(公告)号：EP4082615A1
公开(公告)日：2022-11-02
申请号：EP20905606.8
申请日：2020-12-25
申请人： National Center for Child Health and Development
发明人： MIYADO, Kenji , MIYAMOTO, Yoshitaka
IPC分类号： A61P15/08 , A61P43/00 , C12N5/073 , C12N5/075 , C12N5/076 , C12N1/00 , C12N1/04 , A61K31/4172
摘要： Provided is a novel means of inhibiting fertilized egg fragmentation. The present invention provides an inhibitor of fertilized egg fragmentation, said inhibitor comprising selenoneine or ergothioneine, a tautomer or dimer thereof, or a pharmaceutically acceptable salt of the same as an active agent.

8. 发明公开

EP1486562A1 METHOD OF EXAMINING ALLERGIC DISEASE 审中-公开
标题翻译： VERFAHREN ZUR UNTERSUCHUNG EINER ALLERGISCHEN ERKRANKUNG
公开(公告)号：EP1486562A1
公开(公告)日：2004-12-15
申请号：EP03703034.3
申请日：2003-01-23
申请人： Genox Research, Inc. , Japan as represented by General Director of Agency of National Center for Child Health and Development
发明人： NAGATA, Naoko, c/o Teikyo Univ. Biotech Center , OSHIDA, Tadahiro, c/o Teikyo Univ. Biotech Center , SUGITA, Yuji, c/o Teikyo Univ. Biotech Center , KUBO, Masato, c/o Science Univ. of Tokyo , SAITO, Hirohisa, c/o National Research Institute
IPC分类号： C12N15/09 , C12Q1/68 , G01N33/15 , G01N33/50
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/158 , G01N33/505 , G01N33/6863 , G01N2500/00 , G01N2800/24
摘要： SOCS3 gene is identified as a gene whose expression level in T cells of patients with an atopic disorder is significantly higher than that of normal healthy subjects. The present inventors found that this gene can be used in testing for allergic diseases and in screening for therapeutic agents. The present invention enables screening for compounds useful in the treatment of allergic diseases.
摘要翻译： SOCS3基因被鉴定为一种特异性疾病患者T细胞的表达水平显着高于正常健康受试者的基因。本发明人发现，该基因可用于过敏性疾病的检测和治疗剂的筛选。本发明能够筛选用于治疗过敏性疾病的化合物。

9. 发明公开

EP1498493A1 METHOD OF EXAMINING ALLERGIC DISEASE 审中-公开
标题翻译： VERFAHREN ZUR UNTERSUCHUNG EINER ALLERGISCHEN ERKRANKUNG
公开(公告)号：EP1498493A1
公开(公告)日：2005-01-19
申请号：EP03703371.9
申请日：2003-02-25
申请人： Genox Research, Inc. , Japan as represented by General Director of Agency of National Center for Child Health and Development
发明人： MATSUMOTO, Yoshiko, Genox Research, Inc. , IMAI, Yukiho, Genox Research, Inc. , YOSHIDA, Nei, Genox Research, Inc. , OSHIDA, Tadahiro, Genox Research, Inc. , SUGITA, Yuji, Genox Research, Inc. , SAITO, Hirohisa
IPC分类号： C12Q1/68 , C12N15/00 , G01N33/68 , G01N33/53 , A61K31/711 , A61K39/395 , A61P37/08
CPC分类号： G01N33/6893 , A01K2217/05 , A61K31/711 , C07K14/4706 , C07K14/4713 , C12Q1/6883 , C12Q2600/158 , G01N33/505 , G01N2800/24
摘要： B1799 gene, whose expression level increases significantly in the patient group, was successfully identified by screening for a gene which shows difference in expression in blood collected from multiple healthy subjects and patients of allergic diseases employing the differential display method. The gene expression level is specifically high in T cells and increased due to T cell activation. This gene can be used in testing for allergic diseases and also in screening for therapeutic agents for allergic diseases.
摘要翻译：通过筛选从多个健康受试者和使用差异显示方法的过敏性疾病患者中收集的血液中的表达差异的基因，成功鉴定了患者组中其表达水平显着升高的B1799基因。基因表达水平在T细胞中特异性高，并且由于T细胞活化而增加。该基因可用于过敏性疾病的检测，也可用于筛选过敏性疾病的治疗剂。

10. 发明授权

EP2873417B1 IMMUNE TOLERANCE INDUCER 有权
公开(公告)号：EP2873417B1
公开(公告)日：2019-03-06
申请号：EP13816500.6
申请日：2013-07-03
申请人： SBI Pharmaceuticals Co., Ltd. , National Center For Child Health And Development
发明人： TANAKA, Tohru , NAKAJIMA, Motowo , ABE, Fuminori , HAGA, Naomi , TAKAHASHI, Kiwamu , ITO, Hidenori , RII, Ko
IPC分类号： A61K31/197 , A61K33/26 , A61K38/19 , A61K31/194 , A61P37/08 , A61P37/06 , A61P17/00

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