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1. 发明公开

EP4202041A1 METHOD FOR MAINTAINING AND AMPLIFYING HUMAN PRIMORDIAL GERM CELLS / HUMAN PRIMORDIAL GERM CELL-LIKE CELLS 审中-公开
公开(公告)号：EP4202041A1
公开(公告)日：2023-06-28
申请号：EP21858422.5
申请日：2021-08-17
申请人： Kyoto University
发明人： SAITOU, Mitinori , MURASE, Yusuke
IPC分类号： C12N5/075 , C12N5/0735
摘要： The present invention provides a method for maintaining and expanding a human primordial germ cell-like cell (hPGCLC) derived from a human primordial germ cell (hPGC) or a human pluripotent stem cell, including culturing hPGCLC in the presence of (i) a forskolin or phosphodiesterase 4 (PDE4) inhibitor, and (ii) one or more cytokines selected from the group consisting of a basic fibroblast growth factor (bFGF), a leukemia inhibitory factor (LIF), and an epidermal growth factor (EGF).

2. 发明授权

EP3168296B1 AGENT FOR IMPROVING NORMAL DEVELOPMENT RATE OF FERTILIZED EGGS 有权
公开(公告)号：EP3168296B1
公开(公告)日：2020-09-09
申请号：EP15818957.1
申请日：2015-07-10
申请人： SBI Pharmaceuticals Co., Ltd. , Yamagata University
发明人： TANAKA, Tohru , NAKAJIMA, Motowo , TAKAHASHI, Kiwamu , NAKAJIMA, Osamu
IPC分类号： A61K31/197 , A61K33/26 , A61K45/06 , A61P15/08 , A01K67/02 , C12N5/073 , C12N5/075

3. 发明授权

EP2787073B1 COMPOSITIONS AND METHODS FOR AUTOLOGOUS GERMLINE MITOCHONDRIAL ENERGY TRANSFER 有权
公开(公告)号：EP2787073B1
公开(公告)日：2019-03-20
申请号：EP14164380.9
申请日：2012-04-13
申请人： The General Hospital Corporation
发明人： Tilly, Jonathan, Lee , Woods, Dori C.
IPC分类号： C12N5/075

4. 发明公开

EP3358005A1 CULTURE METHOD FOR DIFFERENTIATING PRIMORDIAL GERM CELLS INTO FUNCTIONALLY MATURE OOCYTES 审中-公开
公开(公告)号：EP3358005A1
公开(公告)日：2018-08-08
申请号：EP16846670.4
申请日：2016-09-16
申请人： Tokyo University of Agriculture Educational Corporated , National Agriculture and Food Research Organization , Kyushu University, National University Corporation
发明人： OBATA, Yayoi , HIRAO, Yuji , HAYASHI, Katsuhiko
IPC分类号： C12N5/075 , C12N5/0735 , C12N15/09
CPC分类号： C12N5/0609 , C12N5/0604 , C12N15/09 , C12N2500/90 , C12N2501/30 , C12N2506/02
摘要： The present invention addresses the problem of providing a method for differentiating primordial germ cells into functionally mature GV stage oocytes by in vitro culture. The present invention pertains to a method for differentiating primordial germ cells into functional GV stage oocytes in vitro including (a) a step for forming secondary follicles by culturing primordial germ cells and feeder cells adjacent to the primordial germ cells under conditions that eliminate the effects of estrogen or factors having a similar function to estrogen, (b) a step for partially cleaving the bonds between the granulosa cell layer and the thecal cell layer among the oocyte, granulosa cell layer, and thecal cell layer that constitute the formed secondary follicles, and (c) a step for differentiating the oocytes into functional GV stage oocytes by culturing the oocytes and granulosa cell layer that constitute the secondary follicles and the thecal cell layer in medium including a polymer compound.

5. 发明公开

EP3260535A1 METHOD FOR MASS PRODUCTION OF MOUSE OVUM BASED ON NOVEL SUPEROVULATION-INDUCTION TREATMENT 审中-公开
标题翻译：一种基于新的超调节诱导处理的大量生产小鼠卵的方法
公开(公告)号：EP3260535A1
公开(公告)日：2017-12-27
申请号：EP16752581.5
申请日：2016-02-19
申请人： National University Corporation Kumamoto University
发明人： NAKAGATA, Naomi , TAKEO, Toru
IPC分类号： C12N5/075 , A01K67/02 , C12N5/0735
CPC分类号： A61K39/3955 , A01K67/02 , A01K67/0275 , A01K2227/105 , A61K9/0019 , A61K38/22
摘要： The purpose of the present invention is to provide a novel method that achieves excellent superovulation-induction efficiency. Specifically, the purpose of the invention is to provide a method that achieves superior superovulation-induction efficiency compared with conventional methods using equine chorionic gonadotropin (eCG) and human chorionic gonadotropin (hCG). The present invention provides a superovulation-induction method characterized in that an anti-inhibin antibody and equine chorionic gonadotropin (eCG) are simultaneously administered to a female mouse, followed by administration of human chorionic gonadotropin (hCG) thereto.
摘要翻译：本发明的目的是提供一种实现优异的超排卵诱导效率的新方法。具体而言，本发明的目的是提供一种与使用马绒毛膜促性腺激素（eCG）和人绒毛膜促性腺激素（hCG）的常规方法相比实现超级排卵诱导效率的方法。本发明提供了一种超排卵诱导方法，其特征在于将抗抑制素抗体和马绒毛膜促性腺激素（eCG）同时给予雌性小鼠，然后给予人绒毛膜促性腺激素（hCG）。

6. 发明公开

EP3144378A1 BLADE-MOUNTED MICROPIPETTE HOLDING DEVICE AND METHOD FOR INJECTING SPERM INTO OVULAR CYTOPLASM 审中-公开
标题翻译：吉隆坡密克罗尼西亚州
公开(公告)号：EP3144378A1
公开(公告)日：2017-03-22
申请号：EP15792375.6
申请日：2015-04-28
申请人： Kitazato Science Co., Ltd.
发明人： JINNO Masao , INOUE Futoshi
IPC分类号： C12M1/00 , C12N5/075 , C12N5/076 , G02B21/32
CPC分类号： C12M23/48 , C12M21/06 , C12M35/00 , G02B21/32
摘要： A blade tip-provided micropipette holding apparatus (1) of the present invention has a tubular micropipette holder (5) so constructed that a blade tip-provided micropipette (15) to be inserted into a living cell can be mounted on a front-end portion thereof and a holder-holding device (2) for holding the micropipette holder (5). The holder-holding device (2) has a base member (20) and a tubular rotating member (3) which is rotatably held by the base member (20) and into which the tubular micropipette holder (5) can be penetrated. The tubular rotating member (3) has holder position adjusting mechanisms (6, 7) each composed of a plurality of side holes (35) formed on a side surface of the tubular rotating member (3) at different positions of the side surface thereof in a circumferential direction thereof and holder position adjusting members (62, 72) each capable of entering into the tubular rotating member (3) from the side holes (35) and contacting an outer surface of the micropipette holder (5) penetrating through the tubular rotating member (3).
摘要翻译：本发明的刀片提供的微量吸移管保持装置（1）具有管状微量吸管支架（5），其构造成可将插入活细胞的叶片提供的微量吸管（15）安装在前端的一部分和用于保持微量移液管保持器（5）的保持器保持装置（2）。保持器保持装置（2）具有基部构件（20）和由基部构件（20）可旋转地保持的管状旋转构件（3），并且可以穿过管状微量捕捉器保持器（5）。管状旋转构件（3）具有保持器位置调节机构（6,7），每个由在其侧表面的不同位置处形成在管状旋转构件（3）的侧表面上的多个侧孔（35）组成其周向方向和保持器位置调节构件（62,72）各自能够从侧孔（35）进入管状旋转构件（3），并接触穿过管状旋转的微量移液管保持器（5）的外表面会员（3）。

7. 发明公开

EP2854514A4 SELECTION OF SYMBIOTA BY SCREENING MULTIPLE HOST-SYMBIONT ASSOCIATIONS 审中-公开
标题翻译： symbiots通过放映多HOST共生关系SELECTION
公开(公告)号：EP2854514A4
公开(公告)日：2016-01-20
申请号：EP13796907
申请日：2013-05-29
申请人： AGRICULTURE VICTORIA SERV PTY
发明人： SPANGENBERG GERMAN CARLOS , FORSTER JOHN WHITE , COGAN NOEL , RAN YIDONG , MASON JOHN GREGORY , SAWBRIDGE TIMOTHY IVOR , HAYES BEN , HAYDEN MATTHEW JAMES , GUTHRIDGE KATHRYN MICHAELA , ROCHFORT SIMONE JANE , COCKS BEN , DAETWYLER HANS DIETER
IPC分类号： A01H17/00 , C12N5/04 , C12N5/074 , C12N5/075 , C12Q1/68
CPC分类号： A01H17/00 , A01H5/10 , C12N15/1058
摘要： The present invention relates to new methods of selecting and breeding organisms, in particular organisms which exhibit symbiotic behaviour with symbionts, and to new organisms and symbiota developed thereby, such as plant or grass and endophyte symbiota. Multiple symbionts are deployed in multiple organisms and selected for improved symbiotic compatibility and performance early in the breeding process. Methods include producing improved organisms from germplasm, by inoculating host organism germplasm libraries with symbionts selected from symbiont libraries and selecting improved host organisms exhibiting desired symbiota characteristics, and selection of organism-symbiont associations with a desired genetic and metabolic profile by metagenomic analysis of nucleic acid libraries from an organism or organism-symbiont association.

8. 发明公开

EP2960328A1 DERIVATION OF EMBRYONIC STEM CELLS 审中-公开
标题翻译： ABLEITUNG VON EMBRYONALEN STAMMZELLEN
公开(公告)号：EP2960328A1
公开(公告)日：2015-12-30
申请号：EP15164137.0
申请日：2005-11-04
申请人： Ocata Therapeutics, Inc.
发明人： Chung, Young , Lanza, Robert
IPC分类号： C12N5/00 , C12N5/02 , C12N15/82 , C12N5/075 , C12N15/873 , C12N5/0735 , C12N5/073
CPC分类号： C12N5/0606 , A61K35/545 , C12N5/0604 , C12N15/873 , C12N2501/119 , C12N2501/603 , C12N2501/91 , C12N2502/02 , C12N2506/02
摘要： This present invention provides novel methods for deriving embryonic stem cells, those cells and cell lines, and the use of the cells for therapeutic and research purposes without the destruction of the embryo. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF.
摘要翻译：本发明提供用于衍生胚胎干细胞，那些细胞和细胞系的新颖方法，以及用于治疗和研究目的而不破坏胚胎的细胞的用途。它还涉及在植入胚胎之前建立和储存自体干细胞系的新方法，例如与生殖疗法如IVF结合。

9. 发明公开

EP2787810A4 INORGANIC PYROPHOSPHATE AND USES THEREOF 审中-公开
标题翻译：无机及其用途PYROPHOSPHATE
公开(公告)号：EP2787810A4
公开(公告)日：2015-05-27
申请号：EP12855337
申请日：2012-12-07
申请人： UNIV MISSOURI
发明人： SUTOVSKY PETER , YI YOUNG-JOO
IPC分类号： A01N1/02 , A61D19/02 , A61D19/04 , C12N5/071 , C12N5/075 , C12N5/076
CPC分类号： A61B17/43 , A01N1/0226 , A61D19/02 , C12N5/0604 , C12N5/0609 , C12N5/061 , C12N5/0612 , C12N2500/05 , C12N2517/10 , G01N33/5005
摘要： The present invention provides a new and improved sperm stimulating additive comprising a certain amount of inorganic pyrophosphate (PPi). Addition of PPi in the media for human/animal in vitro fertilization (IVF) improves fertilization rate; addition of PPi in the semen extender for farm animal artificial insemination (AI) may improve pregnancy rates; furthermore, mammalian oocytes matured in vitro in a medium including PPi attain improved fertilization and developmental potential, while embryos cultured in medium supplemented with PPi have improved development to blastocyst.

10. 发明公开

EP2854514A1 SELECTION OF SYMBIOTA BY SCREENING MULTIPLE HOST-SYMBIONT ASSOCIATIONS 审中-公开
标题翻译： symbiots通过放映多HOST共生关系SELECTION
公开(公告)号：EP2854514A1
公开(公告)日：2015-04-08
申请号：EP13796907.7
申请日：2013-05-29
申请人： Agriculture Victoria Services Pty Ltd
发明人： SPANGENBERG, German, Carlos , FORSTER, John, White , COGAN, Noel , RAN, Yidong , MASON, John, Gregory , SAWBRIDGE, Timothy, Ivor , HAYES, Ben , HAYDEN, Matthew, James , GUTHRIDGE, Kathryn, Michaela , ROCHFORT, Simone, Jane , COCKS, Ben , DAETWYLER, Hans, Dieter
IPC分类号： A01H17/00 , C12N5/04 , C12N5/074 , C12N5/075 , C12Q1/68
CPC分类号： A01H17/00 , A01H5/10 , C12N15/1058 , C12Q1/68
摘要： The present invention relates to new methods of selecting and breeding organisms, in particular organisms which exhibit symbiotic behaviour with symbionts, and to new organisms and symbiota developed thereby, such as plant or grass and endophyte symbiota. Multiple symbionts are deployed in multiple organisms and selected for improved symbiotic compatibility and performance early in the breeding process. Methods include producing improved organisms from germplasm, by inoculating host organism germplasm libraries with symbionts selected from symbiont libraries and selecting improved host organisms exhibiting desired symbiota characteristics, and selection of organism-symbiont associations with a desired genetic and metabolic profile by metagenomic analysis of nucleic acid libraries from an organism or organism-symbiont association.

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