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1. 发明授权

EP1260508B1 REAGENTS FOR THE QUANTITATION OF ACTIVE OXYGEN 有权
标题翻译：化试剂测定活性氧
公开(公告)号：EP1260508B1
公开(公告)日：2010-04-14
申请号：EP01908143.9
申请日：2001-02-28
申请人： Sekisui Medical Co., Ltd. , Nagano, Tetsuo
发明人： NAGANO, Tetsuo , URANO, Yasuteru , SETSUKINAI, Ken-ichi
IPC分类号： C07D311/16 , C07D311/82 , G01N31/00
CPC分类号： C07D311/16 , G01N31/225

2. 发明公开

EP1731898A1 FLUORESCENT PROBES 审中-公开
标题翻译： FLUORESZENZSONDEN
公开(公告)号：EP1731898A1
公开(公告)日：2006-12-13
申请号：EP05719873.1
申请日：2005-03-03
申请人： Nagano, Tetsuo , DAIICHI PURE CHEMICALS CO., LTD.
发明人： NAGANO, Tetsuo , WADA, Yoko, 42, Tokyo University Shirokane dorm. , URANO, Yasuteru
IPC分类号： G01N21/78 , C07D311/82 , C09B11/28
CPC分类号： C07D311/82 , C07D311/90 , C09B11/24
摘要： A fluorescent probe which is represented by the following formula (wherein R 1 and R 2 represent hydrogen atom, or a substituent for trapping proton, a metal ion, or an active oxygen species; R 3 represents a monovalent substituent other than hydrogen atom, carboxy group, or sulfo group; R 4 and R 5 represent hydrogen atom, a halogen atom, or an alkyl group; R 6 to R 9 represent an alkyl group; R 10 and R 11 represent hydrogen atom, a halogen atom, or an alkyl group; M - represents a counter ion; and the combination of R 1 , R 2 , and R 3 (1) imparts a substantially high electron density to the benzene ring to which they bond so that the compound can be substantially non-fluorescent before trapping proton, a metal ion, or an active oxygen species, and (2) substantially reduces electron density of the benzene ring to which they bond so that the compound after trapping proton, a metal ion, or an active oxygen species can be highly fluorescent after the trapping.
摘要翻译：由下式（其中R 1和R 2表示氢原子或用于捕获质子的取代基，金属离子或活性氧类）表示的荧光探针; R 3表示除氢原子以外的一价取代基，羧基基团或磺基; R 4和R 5表示氢原子，卤素原子或烷基; R 6至R 9表示烷基; R 10和R 11表示氢原子，卤素原子或烷基基团; M - 表示抗衡离子;并且R 1，R 2和R 3（1）的组合对它们所键合的苯环赋予了基本上高的电子密度，使得化合物可以基本上不发生荧光捕获质子，金属离子或活性氧，以及（2）大大降低了它们键合的苯环的电子密度，使得捕获质子，金属离子或活性氧的化合物可以是高度荧光的陷后。

3. 发明公开

EP1674579A1 FLUORESCENT PROBE 审中-公开
标题翻译： FLUORESZENZSONDE
公开(公告)号：EP1674579A1
公开(公告)日：2006-06-28
申请号：EP04772924.9
申请日：2004-09-03
申请人： DAIICHI PURE CHEMICALS CO., LTD. , Nagano, Tetsuo
发明人： NAGANO, Tetsuo , KAMIYA, Mako , URANO, Yasuteru
IPC分类号： C12Q1/34 , G01N21/64 , G01N21/78
CPC分类号： C09B11/08 , C12Q1/34
摘要： A fluorescent probe which is represented by the following formula (I):

(wherein, R 1 represents a monovalent substituent other than hydrogen atom, carboxy group, or sulfo group; R 2 represents hydrogen atom, or a monovalent substituent; R 3 and R 4 each independently represents hydrogen atom or a halogen atom; and R 5 represents a monovalent group which is cleaved by contact with a measuring object, provided that a combination of R 1 and R 2 is selected so that the oxidation potential of the benzene ring to which they bind makes (1) the compound represented by the formula (I) substantially no fluorescent before the cleavage, and (2) a compound after the cleavage, which is derived from the compound represented by the formula (I), substantially highly fluorescent after the cleavage).
摘要翻译：由下式（I）表示的荧光探针：（其中，R 1表示除氢原子以外的一价取代基，羧基或磺基; R 2表示氢原子或一价取代基; R 3和R 4各自独立地表示氢原子或卤素原子; R 5表示通过与测量对象接触而被切割的一价基团，条件是选择R 1和R 2的组合，使得苯环的氧化势为它们结合使得（1）由式（I）表示的化合物在切割前基本上不发荧光，和（2）衍生自由式（I）表示的化合物的裂解后的化合物，基本上高度荧光分裂后）。

4. 发明公开

EP1553408A4 FLUORESCENT PROBE 审中-公开
标题翻译： FLUORESZENZSONDE
公开(公告)号：EP1553408A4
公开(公告)日：2005-08-17
申请号：EP03741232
申请日：2003-07-07
申请人： NAGANO TETSUO , DAIICHI PURE CHEMICALS CO LTD
发明人： NAGANO TETSUO , URANO YASUTERU , KENMOKU SUGURU , KANDA KOHJIRO
IPC分类号： C07D311/82 , C07D407/04 , C09B11/06 , C09B11/24 , G01N27/447 , G01N31/22 , G01N31/00 , G01N21/78
CPC分类号： G01N27/44726 , C07D311/82 , C09B11/06 , C09B11/245 , G01N31/22
摘要： A fluorescent probe represented by the following formula (I): (I) wherein R1 and R2 each represents hydrogen, a substituent for trapping a proton, metal ion, or active oxygen species, etc.; R3 represents a monovalent substituent; R4 and R5 each represents hydrogen or halogeno; and R6 represents hydrogen, alkylcarbonyl, or alkylcarbonyloxymethyl; provided that R1, R2, and R3 are selected in such a combination that (1) before the trapping of, e.g., a proton, R1, R2, and R3 give a substantially high electron density to the benzene ring to which they are bonded, in order that the compound represented by the formula (I) be substantially nonfluorescent and that (2) after the trapping of, e.g., a proton, R1, R2, and R3 substantially reduce the electron density of the benzene ring to which they are bonded, in order that the compound resulting from the trapping and derived from the compound represented by the formula (I) be substantially highly fluorescent. The fluorescent probe has excellent fluorescent properties.
摘要翻译：由下式（I）表示的荧光探针：（I）其中R 1和R 2各自表示氢，用于俘获质子的取代基，金属离子或活性氧等; R3代表一价取代基; R4和R5各自代表氢或卤代; 和R6代表氢，烷基羰基或烷基羰氧基甲基; 条件是R1，R2和R3以如下组合选择：（1）在俘获例如质子之前，R1，R2和R3给与它们键合的苯环提供相当高的电子密度，为了使式（I）表示的化合物基本上无荧光，并且（2）在捕获例如质子之后，R 1，R 2和R 3实质上降低它们键合的苯环的电子密度以便由捕获得到的和由式（I）代表的化合物衍生的化合物基本上是高度荧光的。荧光探针具有优异的荧光特性。

5. 发明授权

EP1271133B1 Method of measurement based on fluorescence energy transfer using a long-lived fluorescence donor 有权
标题翻译：基于荧光能量转移长与供体荧光寿命测量方法
公开(公告)号：EP1271133B1
公开(公告)日：2008-05-28
申请号：EP01908141.3
申请日：2001-02-28
申请人： DAIICHI PURE CHEMICALS CO., LTD. , Nagano, Tetsuo
发明人： NAGANO, Tetsuo , KIKUCHI, Kazuya , KORESAWA, Mitsunori , KOJIMA, Hirotatsu
IPC分类号： G01N21/78 , G01N33/50 , C09K11/07
CPC分类号： G01N33/542 , G01N21/6428 , G01N2021/6441
摘要： A method for measuring a substance to be measured by means of a fluorescence, which comprises carrying out a measurement in the presence of (1) a specific fluorescent probe emitting a fluorescence by a specific reaction with the substance to be measured and (2) a donor having a long life fluorescence by itself and being capable of combining with the specific fluorescent probe as an acceptor and of allowing the acceptor to undergo a fluorescence resonance energy transfer (provided that the donor forms no chemical bonding with the specific fluorescent probe), wherein a fluorescence emitted by the reaction of the acceptor with the substance to be measured is converted to a long life fluorescence of excitation type by the fluorescence resonance energy transfer induced in the acceptor.

6. 发明授权

EP1314730B1 REAGENT FOR DETERMINING SINGLET OXYGEN 有权
标题翻译：原子氧试剂
公开(公告)号：EP1314730B1
公开(公告)日：2007-01-10
申请号：EP01961247.2
申请日：2001-08-31
申请人： DAIICHI PURE CHEMICALS CO., LTD. , Nagano, Tetsuo
发明人： NAGANO, Tetsuo , URANO, Yasuteru , TANAKA, Kumi
IPC分类号： C07D311/82 , C07D493/08 , C07D493/10 , A61B10/00 , G01N21/76 , G01N21/78 , G01N33/483
CPC分类号： C07D493/08 , C07D311/82 , C07D493/10 , Y10T436/20
摘要： A compound represented by general formula (I) or a salt thereof, wherein R?1, R2, R3, R4, R5, and R6¿ each independently represents hydrogen, halogeno, C¿1-4? alkyl, or C1-6 alkoxyl; R?7 and R8¿ each independently represents C¿1-4? alkyl; and R?9¿ represents hydrogen, C¿1-12? alkanoyl, or acetoxy methyl. They are useful as a reagent for the determination of singlet oxygen.

7. 发明公开

EP1271133A4 MEASURING METHOD USING LONG LIFE FLUORESCENCE OF EXCITATION TYPE 有权
标题翻译：测量方法的刺激long类型的实时荧光
公开(公告)号：EP1271133A4
公开(公告)日：2006-02-08
申请号：EP01908141
申请日：2001-02-28
申请人： DAIICHI PURE CHEMICALS CO LTD , NAGANO TETSUO
发明人： NAGANO TETSUO , KIKUCHI KAZUYA , KORESAWA MITSUNORI , KOJIMA HIROTATSU
IPC分类号： G01N21/78 , C09K11/07 , G01N21/64 , G01N33/50 , G01N33/542
CPC分类号： G01N33/542 , G01N21/6428 , G01N2021/6441
摘要： A method for measuring a substance to be measured by means of a fluorescence, which comprises carrying out a measurement in the presence of (1) a specific fluorescent probe emitting a fluorescence by a specific reaction with the substance to be measured and (2) a donor having a long life fluorescence by itself and being capable of combining with the specific fluorescent probe as an acceptor and of allowing the acceptor to undergo a fluorescence resonance energy transfer (provided that the donor forms no chemical bonding with the specific fluorescent probe), wherein a fluorescence emitted by the reaction of the acceptor with the substance to be measured is converted to a long life fluorescence of excitation type by the fluorescence resonance energy transfer induced in the acceptor.

8. 发明公开

EP1271133A1 MEASURING METHOD USING LONG LIFE FLUORESCENCE OF EXCITATION TYPE 有权
标题翻译： Messverfahren basierend auf Fluoreszenz- Energie-Transfer mit einem Donor langer Fluoreszenzlebenszeit
公开(公告)号：EP1271133A1
公开(公告)日：2003-01-02
申请号：EP01908141.3
申请日：2001-02-28
申请人： DAIICHI PURE CHEMICALS CO. LTD. , Nagano, Tetsuo
发明人： NAGANO, Tetsuo , KIKUCHI, Kazuya , KORESAWA, Mitsunori , KOJIMA, Hirotatsu
IPC分类号： G01N21/78
CPC分类号： G01N33/542 , G01N21/6428 , G01N2021/6441
摘要： A method for measurement of a target substance in a sample by means of fluorescence, which comprises the step of carrying out the measurement in the presence of (1) a specific fluorescent probe which specifically reacts with the target substance to generate fluorescence, and (2) a donor which, per se, has long-lived fluorescence and is capable of inducing fluorescence resonance energy transfer to the specific fluorescent probe that acts as an acceptor, provided that the donor forms no binding to the specific fluorescent probe by means of a chemical bond; and the step of converting fluorescence, wherein said fluorescence is resulted from a reaction between the acceptor and the target substance, into long-lived excitation fluorescence by the fluorescence resonance energy transfer which is induced on the acceptor.
摘要翻译：一种通过荧光测定样品中的目标物质的方法，其包括在（1）特异性荧光探针存在下进行测定的步骤的步骤，所述荧光探针与目标物质特异性反应以产生荧光，和（2 ）供体本身具有长寿命的荧光并且能够诱导荧光共振能量转移到用作受体的特异性荧光探针，条件是供体通过化学物质不与特定荧光探针结合键; 以及通过在受体上诱导的荧光共振能量转移，将受体和目标物质之间的反应所产生的荧光发生长期激发荧光的荧光转化步骤。

9. 发明公开

EP1260510A1 FLUORESCENT PROBES FOR THE QUANTITATION OF ZINC 有权
标题翻译： FLUORESZIERENDE PROBEN ZUR数量BESTIMMUNG VON ZINK
公开(公告)号：EP1260510A1
公开(公告)日：2002-11-27
申请号：EP01908142.1
申请日：2001-02-28
申请人： DAIICHI PURE CHEMICALS CO. LTD. , Nagano, Tetsuo
发明人： NAGANO, Tetsuo , KIKUCHI, Kazuya , HIRANO, Tomoya
IPC分类号： C07D311/82 , C07D493/10 , C07D405/14 , C09B11/28 , G01N21/77
CPC分类号： C07D493/10 , C07D311/82 , C09B11/24 , C09B11/245 , C09B11/28 , Y02P20/55
摘要： A compound represented by general formula (IA) or a salt thereof useful as a fluorescent probe for zinc: wherein R 1 and R 2 represent a hydrogen atom or a group represented by formula (A), wherein X 1 , X 2 , X 3 , and X 4 represent a hydrogen atom, an alkyl group, a 2-pyridylmethyl group, or a protective group for an amino group, and m and n represent 0 or 1, provided that R 1 and R 2 do not simultaneously represent hydrogen atoms; R 3 and R 4 represent a hydrogen atom or a halogen atom; and R 5 and R 6 represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group, and R 7 represents a hydrogen atom or an alkyl group.
摘要翻译：用作锌荧光探针的通式（IA）表示的化合物或其盐：其中R 1和R 2表示氢原子或由式（A）表示的基团，其中X 1， X 2，X 3和X 4表示氢原子，烷基，2-吡啶基甲基或氨基的保护基，m和n表示0或1，提供 R 1和R 2不同时表示氢原子; R 3和R 4表示氢原子或卤素原子; R 5和R 6表示氢原子，烷基羰基或烷基羰氧基甲基，R 7表示氢原子或烷基。

10. 发明授权

EP1260510B1 FLUORESCENT PROBES FOR THE QUANTITATION OF ZINC 有权
标题翻译：荧光样品锌的定量测定
公开(公告)号：EP1260510B1
公开(公告)日：2006-10-18
申请号：EP01908142.1
申请日：2001-02-28
申请人： DAIICHI PURE CHEMICALS CO., LTD. , Nagano, Tetsuo
发明人： NAGANO, Tetsuo , KIKUCHI, Kazuya , HIRANO, Tomoya
IPC分类号： C07D311/82 , C07D493/10 , C07D405/14 , C09B11/28 , G01N21/77 , C07D311/00 , C07D307/00
CPC分类号： C07D493/10 , C07D311/82 , C09B11/24 , C09B11/245 , C09B11/28 , Y02P20/55
摘要： Compounds of the general formula (IA) or salts thereof, useful as fluorescent probes for the quantitation of zinc: (IA) wherein R?1 and R2¿ are each hydrogen or a group of the general formula (A) (wherein X?1, X2, X3 and X4¿ are each hydrogen, alkyl, 2-pyridylmethyl, or an amino-protective group; and m and n are each 0 or 1), with the proviso that both R?1 and R2¿ must not be hydrogen; R?3 and R4¿ are each hydrogen or halogeno; R?5 and R6¿ are each hydrogen, alkylcarbonyl, or alkylcarbonyloxymethyl; and R7 is hydrogen or alkyl.

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