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1. 发明公开

EP1314730A4 REAGENT FOR DETERMINING SINGLET OXYGEN 有权
标题翻译：原子氧试剂
公开(公告)号：EP1314730A4
公开(公告)日：2004-07-14
申请号：EP01961247
申请日：2001-08-31
申请人： DAIICHI PURE CHEMICALS CO LTD , NAGANO TETSUO
发明人： NAGANO TETSUO , URANO YASUTERU , TANAKA KUMI
IPC分类号： C07D311/82 , C07D493/08 , C07D493/10 , C07D493/22 , A61B10/00 , G01N21/76 , G01N21/78 , G01N33/483
CPC分类号： C07D493/08 , C07D311/82 , C07D493/10 , Y10T436/20
摘要： A compound represented by general formula (I) or a salt thereof, wherein R?1, R2, R3, R4, R5, and R6¿ each independently represents hydrogen, halogeno, C¿1-4? alkyl, or C1-6 alkoxyl; R?7 and R8¿ each independently represents C¿1-4? alkyl; and R?9¿ represents hydrogen, C¿1-12? alkanoyl, or acetoxy methyl. They are useful as a reagent for the determination of singlet oxygen.

2. 发明公开

EP1553408A4 FLUORESCENT PROBE 审中-公开
标题翻译： FLUORESZENZSONDE
公开(公告)号：EP1553408A4
公开(公告)日：2005-08-17
申请号：EP03741232
申请日：2003-07-07
申请人： NAGANO TETSUO , DAIICHI PURE CHEMICALS CO LTD
发明人： NAGANO TETSUO , URANO YASUTERU , KENMOKU SUGURU , KANDA KOHJIRO
IPC分类号： C07D311/82 , C07D407/04 , C09B11/06 , C09B11/24 , G01N27/447 , G01N31/22 , G01N31/00 , G01N21/78
CPC分类号： G01N27/44726 , C07D311/82 , C09B11/06 , C09B11/245 , G01N31/22
摘要： A fluorescent probe represented by the following formula (I): (I) wherein R1 and R2 each represents hydrogen, a substituent for trapping a proton, metal ion, or active oxygen species, etc.; R3 represents a monovalent substituent; R4 and R5 each represents hydrogen or halogeno; and R6 represents hydrogen, alkylcarbonyl, or alkylcarbonyloxymethyl; provided that R1, R2, and R3 are selected in such a combination that (1) before the trapping of, e.g., a proton, R1, R2, and R3 give a substantially high electron density to the benzene ring to which they are bonded, in order that the compound represented by the formula (I) be substantially nonfluorescent and that (2) after the trapping of, e.g., a proton, R1, R2, and R3 substantially reduce the electron density of the benzene ring to which they are bonded, in order that the compound resulting from the trapping and derived from the compound represented by the formula (I) be substantially highly fluorescent. The fluorescent probe has excellent fluorescent properties.
摘要翻译：由下式（I）表示的荧光探针：（I）其中R 1和R 2各自表示氢，用于俘获质子的取代基，金属离子或活性氧等; R3代表一价取代基; R4和R5各自代表氢或卤代; 和R6代表氢，烷基羰基或烷基羰氧基甲基; 条件是R1，R2和R3以如下组合选择：（1）在俘获例如质子之前，R1，R2和R3给与它们键合的苯环提供相当高的电子密度，为了使式（I）表示的化合物基本上无荧光，并且（2）在捕获例如质子之后，R 1，R 2和R 3实质上降低它们键合的苯环的电子密度以便由捕获得到的和由式（I）代表的化合物衍生的化合物基本上是高度荧光的。荧光探针具有优异的荧光特性。

3. 发明公开

EP1271133A4 MEASURING METHOD USING LONG LIFE FLUORESCENCE OF EXCITATION TYPE 有权
标题翻译：测量方法的刺激long类型的实时荧光
公开(公告)号：EP1271133A4
公开(公告)日：2006-02-08
申请号：EP01908141
申请日：2001-02-28
申请人： DAIICHI PURE CHEMICALS CO LTD , NAGANO TETSUO
发明人： NAGANO TETSUO , KIKUCHI KAZUYA , KORESAWA MITSUNORI , KOJIMA HIROTATSU
IPC分类号： G01N21/78 , C09K11/07 , G01N21/64 , G01N33/50 , G01N33/542
CPC分类号： G01N33/542 , G01N21/6428 , G01N2021/6441
摘要： A method for measuring a substance to be measured by means of a fluorescence, which comprises carrying out a measurement in the presence of (1) a specific fluorescent probe emitting a fluorescence by a specific reaction with the substance to be measured and (2) a donor having a long life fluorescence by itself and being capable of combining with the specific fluorescent probe as an acceptor and of allowing the acceptor to undergo a fluorescence resonance energy transfer (provided that the donor forms no chemical bonding with the specific fluorescent probe), wherein a fluorescence emitted by the reaction of the acceptor with the substance to be measured is converted to a long life fluorescence of excitation type by the fluorescence resonance energy transfer induced in the acceptor.

4. 发明公开

EP1674579A4 FLUORESCENT PROBE 审中-公开
标题翻译：荧光探针
公开(公告)号：EP1674579A4
公开(公告)日：2009-12-02
申请号：EP04772924
申请日：2004-09-03
申请人： DAIICHI PURE CHEMICALS CO LTD , NAGANO TETSUO
发明人： NAGANO TETSUO , KAMIYA MAKO , URANO YASUTERU
IPC分类号： C12Q1/34 , C09B11/08 , G01N21/64 , G01N21/78
CPC分类号： C09B11/08 , C12Q1/34

5. 发明公开

EP1731898A4 FLUORESCENT PROBES 审中-公开
标题翻译： FLUORESZENZSONDEN
公开(公告)号：EP1731898A4
公开(公告)日：2010-04-21
申请号：EP05719873
申请日：2005-03-03
申请人： NAGANO TETSUO , DAIICHI PURE CHEMICALS CO LTD
发明人： NAGANO TETSUO , WADA YOKO , URANO YASUTERU
IPC分类号： G01N21/78 , C07D311/82 , C07D311/90 , C09B11/24 , C09B11/28
CPC分类号： C07D311/82 , C07D311/90 , C09B11/24

6. 发明公开

EP1604994A4 FLUORESCENT PROBES 审中-公开
标题翻译：荧光探针
公开(公告)号：EP1604994A4
公开(公告)日：2009-03-25
申请号：EP04715541
申请日：2004-02-27
申请人： NAGANO TETSUO , DAIICHI PURE CHEMICALS CO LTD
发明人： NAGANO TETSUO , GABE YU , URANO YASUTERU
IPC分类号： C07F5/02 , C09K11/06 , G01N31/22 , G01N21/78
CPC分类号： C07F5/022 , C09K11/06 , C09K2211/1055 , G01N31/22 , Y10T436/145555 , Y10T436/177692
摘要： Compounds represented by the general formula (||) and reagents for measuring nitrogen monoxide which contain the same: (||) [wherein R and R are respectively amino groups present on the phenyl ring at adjacent positions, either of which amino groups may have one alkyl group; R and R are each hydrogen, C1-6 alkyl, or C1-6 alkoxy; R and R are each independently C1-6 alkyl; R and R are each carboxylated C1-6 alkyl, alkoxycarbonyl -substituted C1-6 alkyl, sulfonated C1-6 alkyl, or alkylsulfonated C1-6 alkyl; and R and R are each C1-6 alkyl, aryl, C1-6 alkoxy- carbonyl, vinyl, thienyl, or pyrrolyl]. The invention provides fluorescent substances whose intensities of fluorescence little change within a wide pH region.

7. 发明公开

EP1403268A4 FLUORESCENT PROBES FOR ZINC 审中-公开
标题翻译：荧光探针对锌
公开(公告)号：EP1403268A4
公开(公告)日：2004-11-24
申请号：EP02738686
申请日：2002-06-13
申请人： DAIICHI PURE CHEMICALS CO LTD , NAGANO TETSUO
发明人： NAGANO TETSUO , KIKUCHI KAZUYA , HIRANO TOMOYA , MARUYAMA SATOKO
IPC分类号： C07D405/14 , C07D413/14 , C09K11/06 , G01N31/22 , C07F3/06 , G01N21/78 , G01N31/00
CPC分类号： C07D405/14 , C07D413/14 , C09K11/06 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1033 , C09K2211/1088 , C09K2211/188 , G01N31/22
摘要： Compounds represented by the general formula (I) or salts thereof; and fluorescent probes for zinc containing the compounds or the salts: (I) wherein R1 is hydrogen, alkyl, alkoxy, or hydroxyl; R2 is a group represented by the general formula (A): (A) (wherein X1 to X4 are each hydrogen, alkyl, or 2-pyridylmethyl; and m and n are each 0 or 1); Y is a single bond or -CO-; and R3 is carboxylated aryl, carboxylated heteroaryl, benzothiazol-2-yl, or 5-oxo-2-thioxo-4-imidazolidinylidene- methyl.

8. 发明公开

EP1260508A4 REAGENTS FOR THE QUANTITATION OF ACTIVE OXYGEN 有权
标题翻译：化试剂测定活性氧
公开(公告)号：EP1260508A4
公开(公告)日：2003-06-18
申请号：EP01908143
申请日：2001-02-28
申请人： DAIICHI PURE CHEMICALS CO LTD , NAGANO TETSUO
发明人： NAGANO TETSUO , URANO YASUTERU , SETSUKINAI KEN-ICHI
IPC分类号： C07D311/16 , G01N31/22 , C07D311/82 , G01N31/00
CPC分类号： C07D311/16 , G01N31/225
摘要： Compounds of the general formula (I) or (II) or salts thereof; and reagents for the quantitation of active oxygen, containing the compounds or the salts: wherein R?1 and R2¿ are each independently optionally substituted aryl, e.g., amino- or hydroxyl-substituted phenyl; and R3 is optionally substituted 2-carboxyphenyl.

9. 发明公开

EP1260510A4 FLUORESCENT PROBES FOR THE QUANTITATION OF ZINC 有权
标题翻译：荧光样品锌的定量测定
公开(公告)号：EP1260510A4
公开(公告)日：2003-03-19
申请号：EP01908142
申请日：2001-02-28
申请人： DAIICHI PURE CHEMICALS CO LTD , NAGANO TETSUO
发明人： NAGANO TETSUO , KIKUCHI KAZUYA , HIRANO TOMOYA
IPC分类号： C07D311/82 , C07D493/10 , C09B11/24 , C09B11/28 , C07D405/14 , G01N21/77
CPC分类号： C07D493/10 , C07D311/82 , C09B11/24 , C09B11/245 , C09B11/28 , Y02P20/55
摘要： Compounds of the general formula (IA) or salts thereof, useful as fluorescent probes for the quantitation of zinc: (IA) wherein R?1 and R2¿ are each hydrogen or a group of the general formula (A) (wherein X?1, X2, X3 and X4¿ are each hydrogen, alkyl, 2-pyridylmethyl, or an amino-protective group; and m and n are each 0 or 1), with the proviso that both R?1 and R2¿ must not be hydrogen; R?3 and R4¿ are each hydrogen or halogeno; R?5 and R6¿ are each hydrogen, alkylcarbonyl, or alkylcarbonyloxymethyl; and R7 is hydrogen or alkyl.

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