专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP0740157A3 Immunoassay element comprising both labeled ligand and receptors 失效
标题翻译：与标记的配体和受体Immunoterelement
公开(公告)号：EP0740157A3
公开(公告)日：1998-05-06
申请号：EP96302961
申请日：1996-04-26
申请人： JOHNSON & JOHNSON CLIN DIAG
发明人： DAPPEN GLEN M , HASSETT JAMES W , HEINLE JAMES F
IPC分类号： G01N33/543
CPC分类号： G01N33/54386
摘要： A dry immunoassay analytical element, comprising a coating containing an enzyme labeled ligand over a particulate layer containing a fixed concentration of immobilized receptor for a ligand is described.

2. 发明公开

EP0747708A3 Slide test element holder with minimized Z-axis variability 失效
标题翻译：持有人对具有减小的Z-Achsenveränderlichkeit平坦样品支持
公开(公告)号：EP0747708A3
公开(公告)日：1998-09-23
申请号：EP96304129
申请日：1996-06-05
申请人： JOHNSON & JOHNSON CLIN DIAG
发明人： SHAW JAMES DAVID , JACOBS MERRIT NYLES
IPC分类号： G01N31/22 , G01N1/28 , G01N33/52 , G01N35/00 , G01N35/10 , B01L9/00
CPC分类号： G01N35/00029 , G01N2035/1034 , Y10T436/112499 , Y10T436/114165
摘要： A holder (140) of slide test elements for use in an analyzer at a sample-dispensing station, the holder comprising two opposing holding surfaces for holding generally horizontally a slide test element at opposite side edges of the test element, and a tower (146) extending above the holding surfaces for generally centering a dispensing tip above a held slide test element. The holder is improved in that one of the holding surfaces (160) of the holder extends at least sufficiently for underneath a slide test element held by the holding surfaces to be disposed under an approximate center of the held test element, and includes a raised reference surface located under, and disposed for abutting against, an under-surface of the held slide test element, so that a held slide test element is prevented by the raised reference surface from warping downwardly away from a dispensing tip in the tower.

3. 发明公开

EP0747125A3 Method and apparatus for forming disposable tips in an analyzer 失效
标题翻译：用于在分析仪独特的生产可用移液管尖端的方法和装置
公开(公告)号：EP0747125A3
公开(公告)日：1998-09-09
申请号：EP96304127
申请日：1996-06-05
申请人： JOHNSON & JOHNSON CLIN DIAG
发明人： SHAW JAMES DAVID
IPC分类号： G01N1/00 , B01L3/02 , G01N35/10
CPC分类号： G01N35/1009 , B01L3/0275 , G01N2035/1025 , G01N2035/103
摘要： A method and apparatus for forming in situ a new disposable tip for a dispensing probe within an analyzer, by feeding a continuous stock of tube through two die plates and severing the tube by relative motion of the die plates, while holding the cut portion in the dispensing probe temporarily inserted into one of the die plates. The tip.is ejected from the probe in a direction opposite to the direction of insertion of the tube into the die plates and dispensing probe.

4. 发明公开

EP0718626A3 Calibrating and testing immunoassays to minimize interferences 失效
标题翻译： Kalibrierung undPrüfungvon Immunoassays zur Verminderung vonStörungen
公开(公告)号：EP0718626A3
公开(公告)日：1998-06-10
申请号：EP95309354
申请日：1995-12-21
申请人： JOHNSON & JOHNSON CLIN DIAG
发明人： JACOBS MERRIT N , KILDAL-BRANDT PAUL A , ARTER THOMAS C
IPC分类号： C12Q1/28 , G01N33/543 , G01N33/58 , G01N33/53
CPC分类号： G01N33/54386 , G01N33/581 , Y10S435/962 , Y10S435/97 , Y10S436/805 , Y10S436/815
摘要： A method for reducing interferent bias such as hemoglobin bias in immunoassays using dried slide test elements featuring peroxidase and leuco dye as the labeling mechanism. The method features the steps of:

a) calibrating an immunoassay of a target analyte by ascertaining the time at which the rate of change in density produced by a first set of the test elements for the target analyte on at least one liquid having a known amount of interferent of choice and a known amount of target analyte, crosses over or minimizes the difference compared to the rate of change in density produced by a second set of test elements substantially identical to the first set of test elements, on a liquid having the known amount of target analyte but a negligible amount of interferent of choice, and
b) conducting an assay of a patient sample of unknown amount of the target analyte by reading the rate of change in density in a third set of the test elements substantially identical to the first and second sets, caused by the sample, at a time corresponding to the cross-over time ascertained in step a).
摘要翻译：使用以过氧化物酶和无色染料为特征的干燥载玻片测试元件作为标记机制，减少免疫测定中的血红蛋白偏差等干扰性偏倚的方法。该方法具有以下步骤：a）通过确定由至少一种具有已知量的液体的目标分析物的第一组测试元件产生的密度变化率的时间来校准目标分析物的免疫测定的选择干扰物和已知量的目标分析物，与具有基本上与第一组测试元件基本相同的第二组测试元件产生的密度变化率相比，与已知的量的目标分析物交叉或最小化目标分析物的量，但是可选择的干扰物的量可忽略不计，以及b）通过读取第三组测试元件中的密度变化率来进行对未知量的目标分析物的患者样品的测定，其基本上与在对应于在步骤a）中确定的交叉时间的时间，由样本引起的第一和第二组。

5. 发明公开

EP0747702A3 Method for washing immunoassay elements 失效
标题翻译：洗涤免疫学测试元件的方法
公开(公告)号：EP0747702A3
公开(公告)日：1998-05-06
申请号：EP96304126
申请日：1996-06-05
申请人： JOHNSON & JOHNSON CLIN DIAG
发明人： JACOBS MERRIT NYLES
IPC分类号： G01N33/543 , G01N35/02 , G01N33/558
CPC分类号： G01N33/54386 , Y10S435/962 , Y10S435/969 , Y10S435/97 , Y10S436/808
摘要： A method of separating bound labeled indicator from free labeled indicator in a layer of a test element for immunoassay. The method comprises: a) depositing sample containing a target immunoanalyte capable of binding to the labeled indicator or to an immobilized antibody in competition with the labeled indicator, onto an exterior surface of a test element in the presence of the labeled indicator and b) adding an amount of wash liquid to the exterior surface to form a pool of the liquid having a meniscus on the surface, the liquid penetrating the surface over an area bounded by a closed intersect edge formed between the pool meniscus and the surface, so that penetrating liquid can push free labeled indicator away from bound labeled indicator in a volume of the layer below the bounded area. The method is improved in that the step b) comprises i) depositing a first amount of wash liquid at a first location on the surface in a pool, (ii) allowing at least a portion of the pool to spread out through a first portion of the test element to wash out free labeled indicator, and then (iii) depositing a second amount of wash liquid at a second location on the surface different from the first location to spread out through a second portion of the test element different from the first portion, so that the intersect edge is displaced over the surface over time and the liquid flowing into the test element at the intersect edge sweeps through more of the target read area than is the case when washing from only the first location, thus reducing background signal due to non-separated free labeled indicator remaining in the volume.

6. 发明公开

EP0754761A3 Chemiluminescent analytical method 失效
标题翻译：一种化学发光法
公开(公告)号：EP0754761A3
公开(公告)日：1998-07-01
申请号：EP96305212
申请日：1996-07-16
申请人： JOHNSON & JOHNSON CLIN DIAG
发明人： SUMMERS MALCOLM ROBERT , YEARWOOD GRAHAM DELISLE , BOOTH TRACEY MICHELLE
IPC分类号： G01N21/76 , C12Q1/28 , G01N33/58 , G01N33/76
CPC分类号： G01N33/582 , C12Q1/28 , G01N33/76 , Y10S435/968 , Y10S435/975
摘要： A chemiluminescent analytical method which comprises using a suitable catalyst in a reaction with luminol or a substituted luminol and a perborate in an aqueous solvent and detecting and measuring luminescence produced by the reaction is described. In the method, the aqueous solvent comprises a non-luminescent chelating agent for chelation of an electron-deficient boron atom in the perborate.

7. 发明公开

EP0747704A3 Immunoassay element containing a diaryl telluride compound to increase its stability 失效
标题翻译：包含免疫测定元件的二芳基碲化物，以增加稳定性
公开(公告)号：EP0747704A3
公开(公告)日：1998-06-17
申请号：EP96304211
申请日：1996-06-06
申请人： JOHNSON & JOHNSON CLIN DIAG
发明人： LOGAN MARGARET ELIZABETH , DECANN CAROL ANNE , OENICK MARSHA DENISE BALE , SNODGRASS GARY LOUIS , SNOKE ROY EUEGENE
IPC分类号： G01N33/535 , C07C395/00 , C12Q1/28 , G01N33/543
CPC分类号： G01N33/54386 , C07C395/00 , C12Q1/28 , Y10S435/962 , Y10S435/963 , Y10S435/969 , Y10S435/97
摘要： A dry immunoassay analytical element for assaying a ligand, comprising a support bearing:

1. an enzyme labeled ligand or an enzyme labeled receptor zone;
2. a spreading zone; and
3. a receptor zone containing a fixed concentration of an immobilized receptor for the ligand and the labeled ligand when present and the receptor is covalently bonded to polymeric beads having a diameter in the range of 0.1 to 5 µm;
characterized in that the element contains a diaryl telluride (DAT) compound and the zones can be in the same or separate layers.

8. 发明公开

EP0768519A3 Container for staining of cells and tissues in combination with a roller and a support 失效
标题翻译：容器用于染色的细胞和组织在用辊和保持器连接
公开(公告)号：EP0768519A3
公开(公告)日：1998-06-10
申请号：EP96307500
申请日：1996-10-15
申请人： JOHNSON & JOHNSON CLIN DIAG
发明人： BELLY ROBERT TROCONIS , CHEMELLI JOHN BENJAMIN , STEINMANN MICHELE MCWILLIAMS
IPC分类号： G01N33/48 , B01L3/00 , B01L3/02 , G01N1/31 , G01N35/02 , G01N35/10 , H01J49/04
CPC分类号： B01L3/505 , B01L3/0241 , B01L2300/0867 , B01L2400/0481 , G01N1/31 , G01N35/1002 , G01N2001/317 , Y10S435/81
摘要： A flexible container (10) containing pre-deposited reagents, comprising a plurality of temporarily sealed, breakable compartments (12,14,16,18,20) dispersed in the container, each compartment containing a reagent useful for immuno-assaying, and each compartment comprising opposed confining walls at least one of which is sufficiently flexible as to allow the compartment to be compressed in the presence of an adequate external force, external outlets in the container for the contents of said compartments, passageways (22,24,26,28,30) extending from each of the compartments to the outlets, each of the outlets terminating in a platform (50) that supports a drop of at least 10 µL as a pendant drop, the platforms (50) of at least two of the outlets being adjacent so as to form between them an exterior angle with respect to each other sufficient to cause drops pendant therefrom to substantially uniformly intermix.

9. 发明公开

EP0729029A3 A method for washing immunoassay elements 失效
标题翻译：洗涤免疫测定元件的方法
公开(公告)号：EP0729029A3
公开(公告)日：1998-05-06
申请号：EP96301237
申请日：1996-02-23
申请人： JOHNSON & JOHNSON CLIN DIAG
发明人： JACOBS MERRIT NYLES , MARVIN RUSSEL HUGH , DYCHKO DOUGLAS JOHN
IPC分类号： G01N33/543 , G01N33/558
CPC分类号： G01N33/54386 , Y10S435/962 , Y10S435/968 , Y10S435/969 , Y10S435/97 , Y10S436/825

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式