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1. 发明授权

EP4252002B1 A REUSABLE TEST DEVICE 审中-实审
公开(公告)号：EP4252002B1
公开(公告)日：2024-03-20
申请号：EP22744154.0
申请日：2022-07-01
发明人： MATTSSON, Alice Anna Lovisa , PORTER, Robert Andrew
IPC分类号： G01N33/543 , G01N33/68 , G01N33/74 , G01N33/76

2. 发明公开

EP4293355A2 BIOCOMPATIBLE QUANTUM DOT-POLYMER COMPOSITE AND DIAGNOSTIC KIT USING SAME 审中-公开
公开(公告)号：EP4293355A2
公开(公告)日：2023-12-20
申请号：EP22752998.9
申请日：2022-02-10
申请人： Ulsan National Institute of Science and Technology (UNIST)
发明人： PARK, Jongnam , KIM, Sunghwan
IPC分类号： G01N33/543 , G01N33/545 , G01N33/76 , G01N33/569 , G01N33/58 , C09K11/02 , C09K11/54 , C09K11/56 , C08K9/02 , C08K3/30
摘要： The present disclosure relates to a quantum dot-polymer composite, an immunodetection conjugate including the quantum dot-polymer composite, and a diagnostic kit using the same, the composite including a quantum-bead of a 3D self-assembly structure including one or more quantum dots that has a core-shell structure, a surface-modifying ligand arranged on the surface of the quantum dots, and one or more polymer ligands, wherein the one or more quantum dots are dispersed within the quantum-bead, the core including indium phosphide (InP), and the shell that has a thickness of from 3 nm to 9 nm.

3. 发明授权

EP2715368B2 TSH IMMUNOASSAYS AND PROCESSES FOR PERFORMING TSH IMMUNOASSAYS IN THE PRESENCE OF ENDOGENOUS CONTAMINANTS IN RESTRICTED WASH FORMATS 有权
公开(公告)号：EP2715368B2
公开(公告)日：2021-01-20
申请号：EP11793964.5
申请日：2011-11-29
发明人： WANG, Dan , COLLIER, Gordon, Bruce , SKINNER, Joseph, P. , RUAN, Qiaoqiao , TETIN, Sergey
IPC分类号： G01N33/577 , G01N33/53 , G01N33/76 , G01N33/543 , B01L3/00 , C07K16/26 , G01N33/74

4. 发明公开

EP3077817A1 ASSAY DEVICE 有权
标题翻译：测定装置
公开(公告)号：EP3077817A1
公开(公告)日：2016-10-12
申请号：EP14809373.5
申请日：2014-12-04
申请人： SPD Swiss Precision Diagnostics GmbH
发明人： LEHANE, Kieran Andrew , HART, Steven
IPC分类号： G01N33/543 , G01N33/548 , G01N33/549 , G01N33/558 , G01N33/68 , G01N33/76 , G01N33/52
摘要： The present invention provides an assay device for detecting an analyte in a fluid sample, comprising: a sample receiving member (1), which is fluidically connected to at least two components (2, 3) defining an assay flow path, at least one of which is a detection member (3) comprising an analyte detection zone (31); and a sample detection element (13) adapted to detect fluid at a particular point along the assay flow path. The present invention also provides the use of the assay device of the invention for indicating sample sufficiency when the assay device is exposed to a fluid sample and for indicating to a user after sampling that the device has failed due to insufficient sampling, and a method of alerting a user to the fact that a sufficient sample has been applied to an assay device of the invention.
摘要翻译：本发明提供了用于检测流体样品中的分析物的测定装置，其包括：样品接收构件（1），其流体连接到限定测定流动路径的至少两个部件（2,3），至少一个其是包括分析物检测区（31）的检测构件（3）; 以及样本检测元件（13），其适于检测沿着所述测定流动路径的特定点处的流体。本发明还提供了本发明的测定装置用于当测定装置暴露于流体样品并用于在取样之后向使用者指示由于采样不足而导致装置失效的情况下指示样品充足性的用途，以及提醒用户已经将足够的样品应用于本发明的测定装置。

5. 发明公开

EP3052944A1 IMPROVED PREGNANCY TEST DEVICE AND METHOD 审中-公开
标题翻译： VERBESSERTE SCHWANGERSCHAFSTTESTVORRICHTUNG外展
公开(公告)号：EP3052944A1
公开(公告)日：2016-08-10
申请号：EP14789347.3
申请日：2014-10-01
申请人： SPD Swiss Precision Diagnostics GmbH
发明人： McCARTHY, David , EAPEN, Saji
IPC分类号： G01N33/76 , G01N33/74
CPC分类号： G01N33/689 , G01N33/743 , G01N33/76 , G01N2333/59
摘要： Test devices to detect pregnancy in a human female subject are provided. In various embodiment, test devices include an assay means to measure the absolute or relative amount of hCG in a sample from the subject; an assay means to measure the absolute or relative amount of FSH in a sample from the subject; and an assay means to measure the absolute or relative amount of one or more progesterone metabolites in a sample from the subject.
摘要翻译：公开了一种用于检测人类女性受试者的怀孕的测试装置，该测试装置包括：测量来自受试者的样品中hCG的绝对或相对量的测定装置; 测定方法是测量来自受试者的样品中FSH的绝对量或相对量; 并且测定方法是测量来自受试者的样品中一种或多种孕酮代谢物的绝对或相对量。

6. 发明公开

EP2836839A1 PROCEDE ET TROUSSE DE DETECTION DU PIC PREOVULATOIRE DE LH 有权转让
标题翻译： VERFAHREN UND KIT ZUM NACHWEIS DESPRÄOVULATORISCHENLH-ANSTIEGS
公开(公告)号：EP2836839A1
公开(公告)日：2015-02-18
申请号：EP12723219.7
申请日：2012-04-12
申请人： Repropharm
发明人： DECOURTYE, Jeremy , DUPUY, Laurence , KARA, Elodie , MAUREL, Marie-Christine
IPC分类号： G01N33/68 , G01N33/76
CPC分类号： G01N33/689 , G01N33/76 , G01N2333/59
摘要： The present invention relates to a method for detecting the LH preovulatory surge in a biological sample from mammals and a kit for implementing the detection method. The present invention can be applied, in particular, to the veterinary and medical fields.
摘要翻译：本发明涉及用于检测来自哺乳动物的生物样品中的LH前排波动的方法和用于实施检测方法的试剂盒。本发明特别适用于兽医和医疗领域。

7. 发明公开

EP2715368A1 TSH IMMUNOASSAYS AND PROCESSES FOR PERFORMING TSH IMMUNOASSAYS IN THE PRESENCE OF ENDOGENOUS CONTAMINANTS IN RESTRICTED WASH FORMATS 有权
标题翻译： TSH免疫测定和TSH免疫试验期间内源污染物的出现执行程序在禁止使用手机洗FORMATS
公开(公告)号：EP2715368A1
公开(公告)日：2014-04-09
申请号：EP11793964.5
申请日：2011-11-29
申请人： Abbott Point Of Care, Inc.
发明人： WANG, Dan , COLLIER, Gordon, Bruce , SKINNER, Joseph, P. , RUAN, Qiaoqiao , TETIN, Sergey
IPC分类号： G01N33/577 , G01N33/76
CPC分类号： G01N33/76 , B01L3/50273 , B01L3/502738 , C07K16/26 , C07K2317/33 , G01N33/5302 , G01N33/543 , G01N33/74 , G01N2333/59
摘要： The invention relates to low wash Thyroid Stimulating Hormone (TSH) immunoassays using an ELISA sandwich assay having limited or no wash step between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).
摘要翻译：本发明涉及使用具有有限ELISA夹心测定法或抗原捕获，检测抗体添加和基板引入步骤之间没有洗涤步骤低洗涤促甲状腺激素（TSH）的免疫测定。本发明表现出与生物学上相似的干扰的交叉反应物质，：如促卵泡激素（FSH）低交叉反应性，促黄体激素（LH）和绒毛膜促性腺激素（CG）。

8. 发明公开

EP2545383A1 SPECIFIC DETECTION OF HUMAN CHORIONIC GONADOTROPIN BETA SUBUNIT TYPE II PRODUCED BY TROPHOBLASTIC AND NEOPLASTIC CELLS 审中-公开
标题翻译：人绒毛膜促性腺激素，滋养由β亚基TYPE II的特异性检测和生产的肿瘤细胞
公开(公告)号：EP2545383A1
公开(公告)日：2013-01-16
申请号：EP11709373.2
申请日：2011-03-11
申请人： Université Paris Descartes
发明人： BELLET, Dominique , RICHON, Sophie , ALDAZ-CARROLL, Lydia , PECKING, Alain Paul
IPC分类号： G01N33/574 , G01N33/76 , C07K16/26
CPC分类号： G01N33/57484 , C07K16/26 , C07K2317/33 , C07K2317/34 , G01N33/57407 , G01N33/57415 , G01N33/57423 , G01N33/57434 , G01N33/57476 , G01N33/76 , G01N2333/59 , G01N2800/387
摘要： The present invention provides a novel method to distinguish between HCG β type I and type II gene expression using specific antibody. The specific recognition of HCGβ encoded by type II genes and expressed by trophoblastic and neoplastic cells might improve the clinical usefulness of assays aimed at either diagnosing tumors or screening Down's syndrome. The present invention also provides a diagnostic kit for determining the amount of HCGβ type II in a biological sample. The present invention additionally provides process of preparation and screening hybridoma capable of specifically recognizing HCGβ type II and recombinant antibody thereof. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.

9. 发明公开

EP2322150A3 Method of identifying GLP-1 secretagogues 审中-公开
标题翻译：鉴定GLP-1促分泌素的方法
公开(公告)号：EP2322150A3
公开(公告)日：2011-11-16
申请号：EP10010818.2
申请日：2006-01-09
申请人： Arena Pharmaceuticals, Inc.
发明人： Chu, Zhi-Liang , Leonard, James N. , Al-Shamma, Hussien A. , Jones, Robert M.
IPC分类号： A61K31/00 , A61K31/401 , A61K31/4196 , A61P3/10 , A61K31/415 , A61P3/00 , G01N33/58 , G01N33/566 , C12N15/12 , A61K45/06 , G01N33/76 , A61K9/00
CPC分类号： G01N33/76 , A61K31/00 , A61K31/401 , A61K31/415 , A61K31/4196 , A61K45/06 , G01N33/74 , G01N2333/726 , G01N2800/042 , G01N2800/2814 , G01N2800/2835 , G01N2800/2857 , G01N2800/2871 , A61K2300/00
摘要： The present invention concerns combination of an amount of a GPR1 19 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-l level in a subject over that provided by the amount of the GPR1 19 agonist or the amount of the DPP-FV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions ameliorated by increasing a blood GLP-l level.
The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-l secretagogues.
摘要翻译：本发明涉及一定量的GPR119激动剂与一定量的二肽基肽酶IV（DPP-IV）抑制剂的组合，使得所述组合提供降低血糖水平或增加血液中GLP-1水平的作用超过由GPR119激动剂的量或单独DPP-FV抑制剂的量提供的受试者以及这种组合用于治疗或预防糖尿病及其相关病症或通过增加血液GLP-1水平而改善的病症的用途。本发明还涉及G蛋白偶联受体用于筛选GLP-1促分泌素的用途。

10. 发明公开

EP2282204A1 Early determination of assay results 有权转让
标题翻译： FRÜHERKENNUNGVON测定结果
公开(公告)号：EP2282204A1
公开(公告)日：2011-02-09
申请号：EP10183291.3
申请日：2004-05-25
申请人： Alere Switzerland GmbH
发明人： Sharrock, Stephen Paul , Phelan, Andrew
IPC分类号： G01N33/487 , G01N21/86 , G01N33/543 , G01N33/76
CPC分类号： G01N21/274 , G01N21/4738 , G01N21/78 , G01N21/8483 , G01N31/22 , G01N2021/8488 , G01N2021/8494 , G01N2201/06106 , G01N2201/062
摘要： Disclosed is a device for determining the result of an assay, comprising:
a computation circuit, responsive to an analyte signal representing the amount of an analyte or the rate of accumulation of an analyte, wherein said circuit is capable of comparing the analyte signal to a first threshold and comparing the analyte signal to a second threshold, the second threshold being less than the first threshold, characterised in that:
an output signal is generated if the analyte signal exceeds the first threshold and wherein an output signal is generated if the analyte signal is less than the second threshold, the output signal being indicative of a first result if the analyte signal exceeds the first threshold, and the output signal being indicative of a second result if the analyte signal is less than the second threshold;
and wherein the assay is terminated if the analyte signal exceeds the first threshold; and the assay is terminated if the signal is less than the second threshold.
摘要翻译：公开了一种用于确定测定结果的装置，包括：响应于表示分析物的量的分析物信号或分析物的累积速率的计算电路，其中所述电路能够将分析物信号与第一阈值并将分析物信号与第二阈值进行比较，所述第二阈值小于所述第一阈值，其特征在于：如果所述分析物信号超过所述第一阈值，则生成输出信号，并且如果所述分析物信号如果所述分析物信号超过所述第一阈值，则所述输出信号指示第一结果，并且如果所述分析物信号小于所述第二阈值，则所述输出信号指示第二结果; 并且其中如果所述分析物信号超过所述第一阈值，则所述测定终止; 如果信号小于第二阈值，则终止测定。

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