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1. 发明公开

EP1511445A4 STERILIZED XENOGRAFT TISSUE 有权
标题翻译：消毒的异种
公开(公告)号：EP1511445A4
公开(公告)日：2006-01-25
申请号：EP03753088
申请日：2003-05-16
申请人： CROSSCART INC
发明人： STONE KEVIN R , TUREK THOMAS J
IPC分类号： A01N1/00 , A61F2/08 , A61F2/24 , A61F2/28 , A61F2/30 , A61F2/38 , A61K35/34 , A61L2/00 , A61L2/08 , A61L2/10 , A61L2/20 , A61L27/36 , A61F2/02
CPC分类号： A61L2/0035 , A01N1/00 , A61F2/08 , A61F2/2412 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/38 , A61F2002/2817 , A61F2002/30677 , A61K35/34 , A61L2/0047 , A61L2/007 , A61L2/0094 , A61L2/08 , A61L2/10 , A61L2/20 , A61L2/202 , A61L2/206 , A61L27/3604 , A61L27/3625 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L2430/40
摘要： The invention provides an article of manufacture comprising a substantially non-immunogenic xenograft for implantation into humans. The invention also provides methods for preparing a xenograft by removing at least a portion of a soft tissue from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; subjecting the xenograft to cellular disruption treatment; treating the xenograft with crosslinking agents, and digesting the xenograft with a proteoglycan-depleting factor and/or glycosidase. The invention further provides a method for sterilizing xenograft material, having the steps of obtaining substantially non-immunogenic xenograft material; treating the xenograft material with at least one crosslinking agent; and subjecting the crosslinked xenograft material to radiation treatment.

2. 发明公开

EP1392202A1 SUBMUCOSAL XENOGRAFTS 审中-公开
标题翻译： SUBMUKOSALE XENOTRANSPLANTATE
公开(公告)号：EP1392202A1
公开(公告)日：2004-03-03
申请号：EP02731421.0
申请日：2002-04-18
申请人： Crosscart Inc. , Stone, Kevin R.
发明人： STONE, Kevin, R.
IPC分类号： A61F2/38 , A61F2/28 , A61F2/30
CPC分类号： A61L27/3691 , A61K35/38 , A61L27/3604 , A61L27/3608 , A61L27/3687 , A61L2430/40
摘要： The invention provides a substantially non-immunogenic submucosal xenograft for implantation into humans. The invention further provides methods for preparing the xenograft by removing at least a portion of a submucosa from a non-human animal; washing the xenograft in saline and alcohol; subjecting the xenograft to cellular disruption treatment; and digesting the xenograft with a glycosidase to remove surface carbohydrate moieties. The invention also provides an article of manufacture produced by the above-identified method. The invention further provides a submucosal xenograft for implantation into a human including a portion of a submucosal tissue from a non-human animal, wherein the portion has substantially no surface carbohydrate moieties that are susceptible to glycosidase digestion. Each of the xenografts has substantially the same mechanical properties as native soft tissue.

3. 发明公开

EP1156755A4 ALDEHYDE AND GLYCOSIDASE-TREATED SOFT AND BONE TISSUE XENOGRAFTS 有权
标题翻译：与醛和糖苷酶经处理柔软KNOCHENGEWEBSXENOTRANSPLANTATE
公开(公告)号：EP1156755A4
公开(公告)日：2010-02-03
申请号：EP00910108
申请日：2000-02-08
申请人： CROSSCART INC
发明人： STONE KEVIN R
IPC分类号： A61F2/02 , A61L27/00 , A61F2/08 , A61F2/24 , A61F2/28 , A61F2/30 , A61F2/38 , A61L27/36
CPC分类号： A61L2/10 , A61F2/08 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/38 , A61F2/3872 , A61F2002/2817 , A61F2002/2835 , A61F2002/30677 , A61L2/0035 , A61L27/3604 , A61L27/3608 , A61L27/3625 , A61L27/3645 , A61L27/365 , A61L27/3687 , A61L27/3691 , A61L2430/40

4. 发明公开

EP1061866A4 BONE XENOGRAFTS 审中-公开
标题翻译： KNOCHENXENOTRANSPLANTATE
公开(公告)号：EP1061866A4
公开(公告)日：2003-07-16
申请号：EP99913897
申请日：1999-03-15
申请人： CROSSCART INC
发明人： STONE KEVIN R
IPC分类号： A61F2/28 , A61F2/30 , A61L27/36 , A61L27/00
CPC分类号： A61L27/3691 , A61F2/28 , A61F2/3094 , A61F2002/2835 , A61L2/204 , A61L2/206 , A61L27/36 , A61L27/3608 , A61L27/365 , A61L27/3687 , A61L2430/02
摘要： The invention provides an article of manufacture comprising a substantially non-immunogenic bone xenograft for implantation into humans. The invention further provides a method for preparing a bone xenograft by removing at least a portion of a bone from a non-human animal to provide a xenograft (X); washing the xenograft in saline and alcohol; subjecting the xenograft to a cellular disruption treatment; and treating the xenograft with a glycosidase to remove surface carbohydrate moieties. The invention also provides an article of manufacture produced by the above identified method of invention. The invention further provides a bone xenograft for implantation into a human including a portion (10) of a bone from a nonhuman animal, wherein the portion has substantially no surface carbohydrate moieties which are susceptible to glycosidase digestion. Each xenograft of the invention has substantially the same mechanical properties as a corresponding native bone.

5. 发明公开

EP1061866A1 BONE XENOGRAFTS 审中-公开
标题翻译：骨骼XENOGRAFTS
公开(公告)号：EP1061866A1
公开(公告)日：2000-12-27
申请号：EP99913897.7
申请日：1999-03-15
申请人： Crosscart Inc.
发明人： STONE, Kevin, R.
IPC分类号： A61F2/28
CPC分类号： A61L27/3691 , A61F2/28 , A61F2/3094 , A61F2002/2835 , A61L2/204 , A61L2/206 , A61L27/36 , A61L27/3608 , A61L27/365 , A61L27/3687 , A61L2430/02
摘要： The invention provides an article of manufacture comprising a substantially non-immunogenic bone xenograft for implantation into humans. The invention further provides a method for preparing a bone xenograft by removing at least a portion of a bone from a non-human animal to provide a xenograft (X); washing the xenograft in saline and alcohol; subjecting the xenograft to a cellular disruption treatment; and treating the xenograft with a glycosidase to remove surface carbohydrate moieties. The invention also provides an article of manufacture produced by the above identified method of invention. The invention further provides a bone xenograft for implantation into a human including a portion (10) of a bone from a nonhuman animal, wherein the portion has substantially no surface carbohydrate moieties which are susceptible to glycosidase digestion. Each xenograft of the invention has substantially the same mechanical properties as a corresponding native bone.
摘要翻译：本发明提供了一种制品，其包含用于植入人类的基本上非免疫原性的骨异种移植物。本发明进一步提供了通过从非人类动物移除至少一部分骨以提供异种移植物（X）来制备骨异种移植物的方法; 用盐水和酒精洗涤异种移植物; 使异种移植物经受细胞破裂治疗; 并用糖苷酶处理异种移植物以除去表面碳水化合物部分。本发明还提供了由上述发明方法生产的制品。本发明进一步提供了用于植入人类的骨异种移植物，其包括来自非人动物的骨的一部分（10），其中该部分基本上不具有对糖苷酶消化敏感的表面碳水化合物部分。本发明的每个异种移植物具有与相应天然骨基本相同的机械性质。

6. 发明公开

EP1158930A1 PROTEOGLYCAN-REDUCED SOFT TISSUE XENOGRAFTS 审中-公开
标题翻译：蛋白多糖减少软组织异体移植
公开(公告)号：EP1158930A1
公开(公告)日：2001-12-05
申请号：EP00908532.5
申请日：2000-02-08
申请人： Crosscart Inc.
发明人： STONE, Kevin, R.
IPC分类号： A61F2/02
CPC分类号： A61L27/3691 , A61L27/3604 , A61L27/3687 , A61L2430/40 , Y10S623/915
摘要： The invention provides an article of manufacture comprising a substantially non-immunogenic soft tissue xenograft for implantation into humans. The invention further provides methods for preparing a soft tissue xenograft by removing at least a portion of a soft tissue from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; subjecting the xenograft to cellular disruption treatment; and digesting the xenograft with a proteoglycan-depleting factor and/or glycosidase and optionally following with a capping treatment. The invention also provides an article of manufacture produced by the above-identified method of the invention. The invention further provides a soft tissue xenograft for implantation into a human including a portion of a soft tissue from a non-human animal, wherein the portion has extracellular components and substantially only dead cells. The extracellular components have reduced proteoglycan molecules. Each of the xenografts of the invention are substantially non-immunogenic and have substantially the same mechanical properties as a corresponding native soft tissue.
摘要翻译：本发明提供了一种制品，其包含用于植入人类的基本上非免疫原性的软组织异种移植物。本发明还提供了通过从非人类动物移除至少一部分软组织以提供异种移植物来制备软组织异种移植物的方法; 用盐水和酒精洗涤异种移植物; 使异种移植物经受细胞破裂治疗; 并用蛋白多糖消耗因子和/或糖苷酶消化异种移植物，并任选地进行封闭处理。本发明还提供了由本发明的上述方法生产的制品。本发明进一步提供了用于植入人类的软组织异种移植物，其包括来自非人类动物的软组织的一部分，其中该部分具有细胞外成分并且基本上仅具有死细胞。细胞外成分具有减少的蛋白聚糖分子。本发明的每个异种移植物基本上是非免疫原性的并且具有与相应的天然软组织基本相同的机械性质。

7. 发明公开

EP1156755A1 ALDEHYDE AND GLYCOSIDASE-TREATED SOFT AND BONE TISSUE XENOGRAFTS 有权
标题翻译：与醛和糖苷酶经处理柔软KNOCHENGEWEBSXENOTRANSPLANTATE
公开(公告)号：EP1156755A1
公开(公告)日：2001-11-28
申请号：EP00910108.0
申请日：2000-02-08
申请人： Crosscart Inc.
发明人： STONE, Kevin, R.
IPC分类号： A61F2/02
CPC分类号： A61L2/10 , A61F2/08 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/38 , A61F2/3872 , A61F2002/2817 , A61F2002/2835 , A61F2002/30677 , A61L2/0035 , A61L27/3604 , A61L27/3608 , A61L27/3625 , A61L27/3645 , A61L27/365 , A61L27/3687 , A61L27/3691 , A61L2430/40
摘要： The invention provides articles of manufacture and methods for preparing substantially non-immunogenic soft, and bone tissue xenografts for implantation into humans. The xenografts are prepared by removing at least a portion of a soft or bone tissue from a non-human animal to provide a xenograft; washing the xenograft in saline, and alcohol; subjecting the xenograft to cellular disruption treatment; exposing the xenograft to an aldehyde in an amount ranging from about 0.01 % to about 0.10 %; and digesting the xenograft with a glycosidase, and optionally following with a capping treatment. The invention further provides a soft or bone tissue xenograft for implantation into a human including a portion of a soft or bone tissue from a non-human animal, wherein the portion has extracellular components, and substantially only dead cells. The extracellular components have substantially no surface carbohydrate moieties which are susceptible to glycosidase digestion, and have an aldehyde in an amount ranging from about 0.01 % to about 0.10 % of crosslinking the proteins of the extracellular components. Each of the xenografts of the invention are substantially non-immunogenic, and have substantially the same mechanical properties as a corresponding native soft or bone tissue.

8. 发明公开

EP1065997A1 BONE XENOGRAFTS 有权
标题翻译：骨骼XENOGRAFTS
公开(公告)号：EP1065997A1
公开(公告)日：2001-01-10
申请号：EP99911406.9
申请日：1999-03-15
申请人： Crosscart Inc. , MCP Hahnemann University
发明人： STONE, Kevin, R. , GALILI, Uri
IPC分类号： A61F2/28
CPC分类号： A61L27/3608 , A61F2/28 , A61F2/3094 , A61F2002/2835 , A61L27/365 , A61L2430/02
摘要： The invention provides an article of manufacture comprising a substantially non-immunogenic bone xenograft (X) for implantation into a defect (D) located in a bone portion (10) of a human. The invention further provides methods for preparing a bone xenograft (X) by removing at least a portion of bone from a non-human animal to provide a xenograft (X); washing the xenograft (X) in saline and alcohol; and subjecting the xenograft (X) to at least one of the treatments including exposure to ultraviolet radiation, immersion in alcohol, ozonic, and freeze/thaw cycling. In addition to or in lieu of the above treatments, the methods include a cellular disruption treatment, and digestion of the carbohydrate moieties of the xenograft (X) with a glycosidase followed by treatment for sialylation.
摘要翻译：本发明提供了一种制品，其包含基本上非免疫原性的骨异种移植物（X），用于植入位于人的骨部分（10）中的缺损（D）中。本发明进一步提供了通过从非人动物移除至少一部分骨以提供异种移植物（X）来制备骨异种移植物（X）的方法; 用盐水和酒精洗涤异种移植物（X）; 并使异种移植物（X）经历至少一种处理，包括暴露于紫外线辐射，浸泡在酒精中，臭氧和冷冻/解冻循环中。除上述治疗之外或代替上述治疗，所述方法包括细胞破裂治疗，和用糖苷酶消化异种移植物（X）的碳水化合物部分，然后进行唾液酸化处理。

9. 发明公开

EP1418866A4 XENOGRAFT BONE MATRIX FOR ORTHOPEDIC APPLICATIONS 审中-公开
标题翻译：异种骨基质整形外科应用
公开(公告)号：EP1418866A4
公开(公告)日：2009-09-16
申请号：EP02753794
申请日：2002-03-22
申请人： CROSSCART INC
发明人： STONE KEVIN R , TUREK THOMAS J
IPC分类号： A61L27/00 , A01N1/00 , A61F2/24 , A61F2/28 , A61F2/30 , A61F2/46 , A61K35/34 , A61L27/36 , A61L27/54 , C12N5/08 , C12N5/28
CPC分类号： A61L27/3695 , A01N1/00 , A61F2/2412 , A61F2/28 , A61F2/3094 , A61F2002/2835 , A61F2002/4649 , A61K35/34 , A61L27/3608 , A61L27/365 , A61L27/54 , A61L2300/254
摘要： The invention provides for the use of an improved xenograft bone particulate with respect to osteo-integration and bone remodeling, while diminishing the primate-to-pig immunological response using established bone-processing technique. Work was carried out using undecalcified bone to determine immunocompatibilty and bone remodeling potential of processed porcine bone struts following onlay graft implantation. New bone formation was evident, including the infiltration of cellular materials responsible for fusion and bone reconstruction.

10. 发明授权

EP1065997B1 BONE XENOGRAFTS 有权
标题翻译： KNOCHENXENOTTRANSPLANTATE
公开(公告)号：EP1065997B1
公开(公告)日：2007-11-14
申请号：EP99911406.9
申请日：1999-03-15
申请人： Crosscart Inc. , MCP Hahnemann University
发明人： STONE, Kevin, R. , GALILI, Uri
IPC分类号： A61L27/36
CPC分类号： A61L27/3608 , A61F2/28 , A61F2/3094 , A61F2002/2835 , A61L27/365 , A61L2430/02
摘要： The invention provides an article of manufacture comprising a substantially non-immunogenic bone xenograft (X) for implantation into a defect (D) located in a bone portion (10) of a human. The invention further provides methods for preparing a bone xenograft (X) by removing at least a portion of bone from a non-human animal to provide a xenograft (X); washing the xenograft (X) in saline and alcohol; and subjecting the xenograft (X) to at least one of the treatments including exposure to ultraviolet radiation, immersion in alcohol, ozonic, and freeze/thaw cycling. In addition to or in lieu of the above treatments, the methods include a cellular disruption treatment, and digestion of the carbohydrate moieties of the xenograft (X) with a glycosidase followed by treatment for sialylation.

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