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71. 发明授权

EP1001950B1 FLUORINATED TRIAZINE MONOMERS 失效
标题翻译：氟化单体三嗪
公开(公告)号：EP1001950B1
公开(公告)日：2002-12-04
申请号：EP98935122.6
申请日：1998-07-16
申请人： The Secretary of State for Defence
发明人： WILLIS, Colin, Robert , BREWER, Stuart, Anson , JONES, Brian, George
IPC分类号： C07D251/70 , C08F20/68
CPC分类号： D06M15/277 , C07D251/70 , C08F246/00 , D06M15/353 , D06M15/3562 , D06M15/3566 , Y10T442/2164 , Y10T442/2172 , Y10T442/2189

72. 发明公开

EP1210445A2 RECOMBINANT MICROORGANISMS 有权
标题翻译：重组微生物
公开(公告)号：EP1210445A2
公开(公告)日：2002-06-05
申请号：EP00958787.4
申请日：2000-09-06
申请人： The Secretary of State for Defence
发明人： TITBALL, Richard William , BULLIFENT, Helen Lisa
IPC分类号： C12N15/67 , C12N1/21 , A61K39/02 , C12N1/20
CPC分类号： A61K39/025 , A61K2039/523 , C07K14/24 , C12N15/74 , Y02A50/407 , Y02A50/484
摘要： A method of enhancing expression of a desired protein at mucosal effector sites, said method comprising placing the protein to be expressed under the control of a promoter having SEQ ID NO 2. SEQ ID NO 3 or SEQ ID NO 4 or a fragment or variant or any of these which has promoter activity, and causing expression in mucosal cells. Constructs used in the methods, as well as suitable recombinant gut-colonising microorganisms such as a Salmonella spp . are also described and claimed. Such organisms are useful in the preparation of vaccines.

73. 发明公开

EP1198593A1 AMPLIFICATION METHOD FOR DETECTION OF TARGET NUCLEIC ACIDS INVOLVING FLUORESCENCE ENERGY TRANSFER 有权
标题翻译： AMPLIFIZIERUNGSVERFAHEN FOR靶核酸的检测中荧光能量转移
公开(公告)号：EP1198593A1
公开(公告)日：2002-04-24
申请号：EP00951700.4
申请日：2000-08-03
申请人： The Secretary of State for Defence
发明人： LEE, Martin, Alan , LESLIE, Dario Lyall
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6853 , C12Q1/6818 , C12Q2531/113 , C12Q2531/131 , C12Q2565/101
摘要： A method for detecting the presence of a target nucleic acid sequence in a sample, said method comprising subjecting said sample to an amplification reaction using a set of nucleotides, at least one of which is labelled with a first label, and a reagent comprising an amplification primer which can hybridise to said target sequence when in single stranded form and which is connected at its 5' end to a probe which carries a second label by way of a chemical linking group, said labelled probe being of a sequence which is similar to that of the said target sequence, such that it can hybridise to a complementary region in an amplification product, and wherein one of the first or the second label comprises a donor label and the other comprises an acceptor label, the donor label comprising a fluorescent molecule which is able to donate fluorescent energy to the acceptor label; and monitoring fluorescence of said sample. The method can be used to quantitate the amount of target nucleic acid in the sample as well as to determine sequence characteristics. Kits for effecting the method are also claimed.

74. 发明公开

EP1177559A1 RADIOACTIVE MATERIAL CONTAINER 审中-公开
标题翻译：容器夹杂放射性物质
公开(公告)号：EP1177559A1
公开(公告)日：2002-02-06
申请号：EP00927575.1
申请日：2000-05-12
申请人： THE SECRETARY OF STATE FOR DEFENCE
发明人： Low, Colin Mark , Erskine, Graham John , Awbery, Roy Paul , Allen, Martyn Charles
IPC分类号： G21F5/015
CPC分类号： G21F1/085 , G21F5/002 , G21Y2002/301 , G21Y2002/303 , G21Y2002/501 , G21Y2004/303
摘要： A container for radioactive material which provides protection against the egress of radiation and comprises applying by an electroplating process a layer of lead over a substantial proportion of a receptacle surface. Additional layers of cadmium and copper may be applied to the receptacle by electroplating to provide additional protection. A resilient layer such as an epoxy resin may also be applied to help maintain the structural integrity of the container or limit any leakage of radiation.

75. 发明授权

EP0778945B1 LUCIFERASE LABELLING METHOD 失效
标题翻译：荧光素酶标记方法
公开(公告)号：EP0778945B1
公开(公告)日：2001-10-04
申请号：EP95929977.7
申请日：1995-08-30
申请人： The Secretary of State for Defence
发明人： SQUIRRELL, David, James , MURPHY, Melenie, Jane
IPC分类号： G01N33/535 , C12Q1/68 , G01N33/58 , G01N33/543 , G01N21/84
CPC分类号： C12Q1/6825 , G01N33/535
摘要： A method is provided for conjugating luciferase to a chemical entity, particularly to a specific binding agent such as an antibody, antigen or a nucleic acid, and more particularly an antibody, comprising (a) mixing the luciferase with one or more of D-luciferin, magnesium ions and adenosine triphosphate and (b) performing a covalent coupling reaction between the luciferase and the binding reagent using a covalent coupling reagent wherein the amount of D-luciferin, magnesium ions and/or adenosine triphosphate is sufficient to protect the luciferase activity against inhibition by the covalent coupling reagent. Preferably the step (a) is carried out by mixing the luciferase with its substrates in solution and preferably both magnesium and adenosine triphosphate are present as magnesium adenosine triphosphate (Mg ATP), optionally together with D-luciferin. In a second aspect of the invention there is provided a labelled chemical entity comprising a chemical entity conjugated to active luciferase as provided by the method of the present invention. Preferably the chemical entity is a specific binding agent suitable for use in a specific binding assay, preferably being an antibody, antigen or nucleic acid. When the binding agent is a nucleic acid, it is preferably an oligonucleotide, but may be a polynucleotide or a nucleoside, and may be used as a hybridisation probe or a chain extension primer, e.g. a PCR primer. Most advantageously the entity is an antibody as previous attempts to couple antibodies to luciferase have resulted in inactivity. Test kits are further provided.

76. 发明授权

EP0799491B1 RADIO FREQUENCY ION SOURCE 失效
标题翻译：的射频离子源
公开(公告)号：EP0799491B1
公开(公告)日：2001-09-19
申请号：EP95940374.2
申请日：1995-12-14
申请人： The Secretary of State for Defence
发明人： LANGFORD, Marian Lesley Intellectual Property Dept , TODD, John, Francis, James University of Kent
IPC分类号： H01J49/10 , H01J27/26
CPC分类号： H01J27/16
摘要： An rf ion source suitable for low power operation over a range of pressures in air comprises discharge electrodes having one or more cathodes (1) and an anode (2). Each cathode (1) is connected to an rf signal supply (8) through an associated coupling means (4) and the anode (2) is adapted to provide a surface area over which a plasma discharge may occur that is not substantially greater than the total cathodal area over which the discharge may occur. In this way the anode (2) presents no more useful surface than is required to accommodate the optimum area of the plasma discharge thereby preventing plasma wander and enhancing the stability of the discharge over known ion sources. By configuring the electrodes such that the respective areas of the anode and the cathode(s) over which discharge occurs are separated by no more than 5 mm and by forming the electrodes to have highly curved ends and so creating a higly distorted electric field in the inter-electrode gap when the source is in operation, it is possible to create an effective discharge with very low power input even at atmospheric p ressure.

77. 发明授权

EP0910835B1 METHOD AND APPARATUS FOR IMAGING ARTEFACT REDUCTION 失效
标题翻译：方法和装置形像，伪减少
公开(公告)号：EP0910835B1
公开(公告)日：2001-09-12
申请号：EP97929427.9
申请日：1997-07-03
申请人： The Secretary of State for Defence
发明人： STOYLE, Peter Norman Robertson , HILL, Derek Lionel Glendon, Medical Physics Dept. , ATKINSON, David, Medical Physics Dept.
IPC分类号： G06T11/00
CPC分类号： G06T11/008 , G06T2211/412 , G06T2211/424

78. 发明公开

EP1116170A1 PROGRAMMABLE LENS ASSEMBLIES AND OPTICAL SYSTEMS INCORPORATING THEM 有权
标题翻译：可编程镜头单元和光学系统的这个用途
公开(公告)号：EP1116170A1
公开(公告)日：2001-07-18
申请号：EP99949099.8
申请日：1999-09-24
申请人： THE SECRETARY OF STATE FOR DEFENCE
发明人： LOWANS, Brian, Sinclair
IPC分类号： G06K9/74
CPC分类号： G06K9/74 , G02B26/0808 , G02B26/106 , G06K2209/23
摘要： An imaging system (10) has a fixed lens combination (22), a spatial light modulator (SLM) (20) and a linear detector array (12). A scene image is scanned across a simple array (12) in a direction perpendicular to the array (12) by the SLM (20). This is achieved by displaying a diffraction pattern on the SLM that changes to achieve the scanning. The diffraction pattern displayed typically has a linear element (40) and a quadratic element (42). By having a programmably changed combined chirp pattern (36) displayed on the SLM, and by being able to change it thousands of times a second, an array with fast read out can take the place of a 2-D imaging array.

79. 发明公开

EP1116038A1 FORMATION OF A BRIDGE IN A MICRO-DEVICE 有权
标题翻译：法来制造桥微型器件的
公开(公告)号：EP1116038A1
公开(公告)日：2001-07-18
申请号：EP99946321.9
申请日：1999-09-13
申请人： The Secretary of State for Defence
发明人： MCNIE, Mark, Edward
IPC分类号： G01P1/00
CPC分类号： G01C19/5677 , B81B2203/0109 , B81B2207/07 , B81C1/00095 , G01C19/5712 , G01P15/0802
摘要： A method of micro-machining comprising providing a primary region of at least a first material (AA, BB, 56) which contacts a second material (8, 50, 52, 60, 62) at at least one end portion thereof, the method comprising providing an infill material (34, 36, 38) on to the second material, patterning and etching said infill material to form a hole (40, 42) through the infill material to the second material, depositing the first material on to said infill material so that the at least one portion of the first material contacts the second material through the hole. The method can be used to provide a track bridging suspended portions of micro-machined structures, for example the portion referenced (24). Also, a method of narrowing and sealing top portions of channels cut into a wafer is disclosed.

80. 发明公开

EP1114343A1 FABRICATION OF OPTICAL WAVEGUIDES 有权
标题翻译：生产纤维的
公开(公告)号：EP1114343A1
公开(公告)日：2001-07-11
申请号：EP99946340.9
申请日：1999-09-14
申请人： The Secretary of State for Defence
发明人： SMITH, Peter George Robin , ROSS, Graeme William , HANNA, David Colin , SHEPHERD, David P. , GAWITH, Colin Barry Edmund
IPC分类号： G02B6/12 , G02F1/377
CPC分类号： G02F1/395 , G02B6/12 , G02B6/1342 , G02F1/3558 , G02F1/377 , G02F1/3775 , G02F2201/15 , G02F2202/07 , G02F2202/20
摘要： An optical waveguide comprising at least a guiding lamina (10) of optical material bonded by direct interfacial bonding to a superstructure lamina (20) of optical material, in which regions of the guiding lamina have modified optical properties so as to define a light guiding path along the guiding lamina. In a particular example, a periodically poled LiNbO3 planar waveguide is buried in LiTaO3 by direct interfacial bonding and precision polishing techniques and used in an optical frequency doubling system.

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