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61. 发明授权

EP2374503B1 Dispositif médical implantable actif de stimulation vagale à optimisation du remplissage ventriculaire 有权
标题翻译：与心室的优化迷走神经刺激的主动植入式医疗设备
公开(公告)号：EP2374503B1
公开(公告)日：2012-07-11
申请号：EP10178589.7
申请日：2010-09-23
申请人： Sorin CRM SAS
发明人： Limousin, Marcel M.
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/36114 , A61N1/36139

62. 发明公开

EP2459064A1 MEDICAL DEVICE FOR TREATING HEART FAILURE THROUGH BLOOD VOLUME REDISTRIBUTION 审中-公开
标题翻译：医疗设备，治疗心脏衰竭的再分配血容量
公开(公告)号：EP2459064A1
公开(公告)日：2012-06-06
申请号：EP10742340.2
申请日：2010-07-26
申请人： Cardiac Pacemakers, Inc.
发明人： AVERINA, Viktoria, A. , HAMANN, Jason, J. , RUBLE, Stephen , SHUROS, Allan, C.
IPC分类号： A61B5/08 , A61B5/053
CPC分类号： A61N1/3601 , A61B5/0537 , A61B5/0538 , A61B5/0809 , A61B5/4035 , A61B5/4869 , A61N1/36114 , A61N1/36521 , A61N1/36585
摘要： A first fluid status indicator of a pulmonary fluid status associated with pulmonary edema and a second fluid status indicator of a non-pulmonary fluid status can be used to provide an alert or to control a therapy for pulmonary edema. Additionally, intermittent cardiac blood volume redistribution therapy can be used to provide cardiac conditioning in heart failure patients.

63. 发明公开

EP2453977A2 PHYSIOLOGICL VIBRATION DETECTION IN AN IMPLANTED MEDICAL DEVICE 有权
标题翻译：生理科学家振动科学家北美植物药理学研究所
公开(公告)号：EP2453977A2
公开(公告)日：2012-05-23
申请号：EP10736922.5
申请日：2010-07-13
申请人： Cardiac Pacemakers, Inc.
发明人： TERNES, David, J. , SIEJKO, Krzysztof, Z. , RUBLE, Stephen , HAMANN, Jason, J.
IPC分类号： A61N1/36 , A61B5/024 , A61B5/08 , A61B5/11 , A61N1/365 , A61B7/00 , A61N1/362 , A61B7/04
CPC分类号： A61N1/36585 , A61B5/024 , A61B5/02405 , A61B5/0452 , A61B5/0456 , A61B5/0464 , A61B7/00 , A61B7/003 , A61B2562/0219 , A61N1/3601 , A61N1/36114 , A61N1/36117 , A61N1/36578
摘要： An embodiment of an implantable system configured to be implanted in a patient includes an accelerometer, a neural stimulator, and a controller. The neural stimulator is configured to deliver neural stimulation to a neural target. The controller is configured to use the accelerometer to detect laryngeal vibration or coughing, and is configured to deliver a programmed neural stimulation therapy using the neural stimulator and using detected laryngeal vibration or detected coughing as an input to the programmed neural stimulation therapy.
摘要翻译：被配置为植入患者的可植入系统的实施例包括加速度计，神经刺激器和控制器。神经刺激器被配置为将神经刺激递送到神经靶标。控制器被配置为使用加速度计来检测喉部振动或咳嗽，并且被配置为使用神经刺激器递送编程的神经刺激治疗，并使用检测到的喉部振动或检测到的咳嗽作为编程的神经刺激疗法的输入。

64. 发明公开

EP2448633A1 VAGAL STIMULATION DURING ATRIAL TACHYARRHYTHMIA TO FACILITATE CARDIAC RESYNCHRONIZATION THERAPY 有权
标题翻译：房性心动过速FOR A心脏再同步治疗期间迷走神经刺激
公开(公告)号：EP2448633A1
公开(公告)日：2012-05-09
申请号：EP10729699.8
申请日：2010-06-30
申请人： Bianchi, Stefano , Rossi, Pietro
发明人： Bianchi, Stefano , Rossi, Pietro
IPC分类号： A61N1/365
CPC分类号： A61N1/36507 , A61N1/36114 , A61N1/3627 , A61N1/365 , A61N1/3684
摘要： The disclosure describes techniques for delivering vagal stimulation to decrease the ventricular rate response during an atrial tachyarrhythmia, such as atrial fibrillation. Decreasing the ventricular rate response during an atrial tachyarrhythmia may facilitate increased ventricular pacing for cardiac resynchronization therapy (CRT), and may also reduce the likelihood of inappropriately detecting a ventricular tachyarrhythmia during the atrial tachyarrhythmia. Furthermore, the vagal stimulation may augment vagal tone, which may facilitate long term left ventricular reverse remodeling and decrease atrial and ventricular arrhythmic burden in heart failure patients. An example system that delivers CRT comprises a processor that detects an atrial tachyarrhythmia in one or more atria of the heart, and monitors at least one of a ventricular rate or degree of ventricular pacing subsequent to the detected atrial arrhythmia. The processor controls a stimulation generator to deliver vagal stimulation based on the least one of a ventricular rate or degree of ventricular pacing.

65. 发明公开

EP2410906A1 SYSTEMS FOR ANEMIA DETECTION, MONITORING AND TREATMENT 审中-公开
标题翻译：系统的检测，监测和治疗贫血
公开(公告)号：EP2410906A1
公开(公告)日：2012-02-01
申请号：EP10711804.4
申请日：2010-03-24
申请人： Cardiac Pacemakers, Inc.
发明人： ZHANG, Yunlong , MI, Bin , HATLESTAD, John, D.
IPC分类号： A61B5/00 , A61N1/365 , A61N1/37
CPC分类号： A61N1/3702 , A61B5/0031 , A61B5/02028 , A61B5/02035 , A61B5/0215 , A61B5/14535 , A61B5/417 , A61N1/36007 , A61N1/36114 , A61N1/36135 , A61N1/3627
摘要： Systems for implantably determining a patient's anemia status and treating anemia are described. Blood viscosity is compared to one or more thresholds to determine a patient's anemia status. Therapy, in the form of electrical stimulation therapy or administration of a pharmaceutical delivered to the patient's kidneys or hypothalamus is controlled based on the anemia status.

66. 发明授权

EP2073896B1 SYSTEM FOR NEURAL STIMULATION 有权
标题翻译：系统神经刺激
公开(公告)号：EP2073896B1
公开(公告)日：2011-10-26
申请号：EP07837051.7
申请日：2007-08-20
申请人： Cardiac Pacemakers, Inc.
发明人： LIBBUS, Imad , KRAMER, Andrew, P. , CAPARSO, Anthony V. , JAMES, Kristofer J. , RUBLE, Stephen , ZHAO, Weiying
IPC分类号： A61N1/362
CPC分类号： A61N1/365 , A61N1/36053 , A61N1/36114
摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.

67. 发明公开

EP2374503A1 Dispositif médical implantable actif de stimulation vagale à optimisation du remplissage ventriculaire 有权
标题翻译： Aktive种植体药物VorrichtungfürVagusnervstimulation mit Optimisierung derVentrikelfüllung
公开(公告)号：EP2374503A1
公开(公告)日：2011-10-12
申请号：EP10178589.7
申请日：2010-09-23
申请人： Sorin CRM SAS
发明人： Limousin, Marcel M.
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/36114 , A61N1/36139
摘要： Ce dispositif comprend des moyens de stimulation délivrant au nerf vague du patient des impulsions présentant un niveau d'énergie ajusté. Il comprend en outre un capteur de mesure des paramètres hémodynamiques du cycle cardiaque, notamment un capteur d'accélération endocardiaque, apte à délivrer un paramètre temporel représentatif du temps de remplissage ventriculaire. Les moyens d'ajustement de l'énergie de stimulation vagale opèrent dynamiquement de façon répétée sur plusieurs cycles cardiaques. Ils font varier (50, 56) le niveau de l'énergie de stimulation au cours de cycles cardiaques successifs, évaluent (46) les variations corrélatives du temps de remplissage (FT1, FT2), et établissent l'énergie de stimulation à un niveau ajusté maximisant le temps de remplissage.
摘要翻译：该装置具有用于测量心动周期的血液动力学参数的传感器，用于传递表示心室充盈时间的时间参数。调节单元调节迷走神经刺激能量，其中调节单元在心脏周期上以重复的方式动态地操作。不同的单位在心脏周期内改变刺激能量的水平。不同的单位评估填充时间的相关变化。建立单元提供在调整的水平下的刺激能量，使填充时间最大化。传感器选自心内加速度传感器，内窥镜或心外加速度传感器，壁运动传感器，心内压力传感器，心内生物阻抗传感器，氧饱和度传感器和体积变化测量传感器。

68. 发明公开

EP2370151A1 IMPLANTABLE MEDICAL DEVICE CROSSTALK EVALUATION AND MITIGATION 有权
标题翻译：可植入医疗设备串扰评估和缓解
公开(公告)号：EP2370151A1
公开(公告)日：2011-10-05
申请号：EP09745243.7
申请日：2009-10-30
申请人： Medtronic, Inc.
发明人： DONOFRIO, William, T. , BURNES, John, E. , KRAUSE, Paul, G. , ZHOU, Xiaohong , ARNE, Gerald, P. , PEICHEL, David, J. , REINKE, James, D.
IPC分类号： A61N1/05 , A61N1/37 , A61N1/372 , A61B5/0428
CPC分类号： A61N1/3706 , A61B5/04288 , A61B5/7217 , A61N1/025 , A61N1/0551 , A61N1/36114 , A61N1/36185 , A61N1/3686 , A61N1/3702 , A61N1/3718 , A61N1/37247 , A61N1/37288 , A61N1/3962
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.
摘要翻译：可以评估两个可植入医疗装置或常见可植入医疗装置的两个不同治疗模块之间的电串扰，并且在一些示例中可以减轻。在一些示例中，可植入医疗设备或治疗模块中的一个将电刺激递送至非心肌组织部位或非脉管心脏组织部位，并且另一个可植入医疗设备或治疗模块将心律管理治疗递送至患者的心脏。

69. 发明公开

EP2367596A1 SHUNT-CURRENT REDUCTION HOUSING FOR AN IMPLANTABLE THERAPY SYSTEM 审中-公开
标题翻译：分流电流还原住房的可植入治疗系统
公开(公告)号：EP2367596A1
公开(公告)日：2011-09-28
申请号：EP09753273.3
申请日：2009-10-30
申请人： Medtronic, Inc.
发明人： DONOFRIO, William, T. , HAVEL, William, J. , CHRISTIANSEN, Chris, C. , KRAUSE, Paul, G.
IPC分类号： A61N1/37 , A61N1/375 , A61N1/08 , A61N1/372 , A61N1/39
CPC分类号： A61N1/375 , A61N1/08 , A61N1/36114 , A61N1/37 , A61N1/3718 , A61N1/37211 , A61N1/37288 , A61N1/3925 , A61N1/3962
摘要： Techniques for minimizing interference between first and second medical devices of a therapy system may include providing an outer housing for at least one of the medical devices that comprises an electrically insulative layer formed over at least the electrically conductive portions (e.g., an electrically conductive layer) of the housing, or providing an electrically insulative pouch around an electrically conductive housing of at least the first medical device. The electrically insulative layer or electrically insulative pouch may reduce or even eliminate shunt-current that flows into the medical device via the housing. The shunt-current may be generated by the delivery of electrical stimulation by the second medical device. In some examples, the techniques may also include shunt-current mitigation circuitry that helps minimize or even eliminate shunt-current that feeds into the first medical device via one or more electrodes electrically connected to the first medical device.

70. 发明公开

EP2363165A1 Safety control system for implantable neural stimulator 审中-公开
标题翻译： Sicherheitssteuerungssystemfüreinen implantierbaren神经刺激器
公开(公告)号：EP2363165A1
公开(公告)日：2011-09-07
申请号：EP11166436.3
申请日：2006-05-17
申请人： CARDIAC PACEMAKERS, INC.
发明人： The designation of the inventor has not yet been filed
IPC分类号： A61N1/36
CPC分类号： A61N1/36142 , A61N1/36114 , A61N1/36139 , A61N1/37
摘要： A neural stimulation system includes a safety control system that prevents delivery of neural stimulation pulses from causing potentially harmful effects. The neural stimulation pulses are delivered to one or more nerves to control the physiological functions regulated by the one or more nerves. Examples of such harmful effects include unintended effects in physiological functions associated with autonomic neural stimulation and nerve injuries caused by excessive delivery of the neural stimulation pulses.
摘要翻译：神经刺激系统包括防止神经刺激脉冲传递引起潜在有害影响的安全控制系统。将神经刺激脉冲输送到一个或多个神经以控制由一个或多个神经调节的生理功能。这种有害影响的实例包括与由神经刺激脉冲的过度递送引起的自主神经刺激和神经损伤相关的生理功能中的意想不到的影响。

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