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51. 发明公开

EP1740530A4 SUBSTITUTED PHENOXY- AND PHENYLTHIO- DERIVATIVES FOR TREATING PROLIFERATIVE DISORDERS 有权转让
标题翻译：取代苯氧和PHENYLTHIODERIVATE增殖性疾病的治疗
公开(公告)号：EP1740530A4
公开(公告)日：2008-02-27
申请号：EP05736001
申请日：2005-03-15
申请人： UNIV TEMPLE , ONCONOVA THERAPEUTICS INC
发明人： REDDY E PREMKUMAR , REDDY M V RAMANA , BELL STANLEY C
IPC分类号： C07C233/00 , C07C235/38 , C07C271/44 , C07C311/27 , C07C317/18 , C07C317/28 , C07C321/00 , C07C323/41 , C07C323/49 , C07C323/65 , C07D213/02 , C07D295/088 , C07D295/15 , C07D295/155 , C07F7/18
CPC分类号： C07C235/38 , C07B2200/07 , C07C271/44 , C07C311/27 , C07C317/18 , C07C317/28 , C07C323/41 , C07C323/49 , C07C323/65 , C07D213/02 , C07D295/088 , C07D295/15 , C07D295/155 , C07F7/1852 , C07F7/1856
摘要： Substituted phenol derivatives of Formula (I) are useful as antiproliferative agents including, for example, anticancer agents, and as radioprotective and chemoprotective agents.

53. 发明公开

EP1742908A1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS 有权转让
标题翻译：抑制剂非核苷类逆转录酶抑制剂
公开(公告)号：EP1742908A1
公开(公告)日：2007-01-17
申请号：EP05742851.8
申请日：2005-04-15
申请人： F.HOFFMANN-LA ROCHE AG
发明人： DUNN, James, Patrick , HIRSCHFELD, Donald, Roy , SILVA, Tania , VORA, Harit
IPC分类号： C07C235/38 , A61K31/167 , A61P31/18 , C07C235/78 , C07C255/54 , C07C255/57 , C07C311/08 , C07C311/46 , C07C311/51 , C07C317/32 , C07C317/40 , C07C317/44 , C07C323/49 , C07C323/62 , C07D207/32
CPC分类号： C07C311/46 , C07C311/08 , C07C311/51 , C07C317/32 , C07C317/40 , C07C317/44 , C07C323/49 , C07C323/62 , C07C2601/14 , C07D207/325 , C07D213/75 , C07D213/82 , C07D213/84 , C07D295/108 , C07D295/13 , C07D295/135 , C07D295/26 , C07D307/79
摘要： The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula (I) where Ar, R1-R5, R11c and X1 are as defined herein.

54. 发明公开

EP1565431A1 CANNABINOID RECEPTOR LIGANDS 有权
标题翻译：大麻素受体配体
公开(公告)号：EP1565431A1
公开(公告)日：2005-08-24
申请号：EP03789933.3
申请日：2003-11-21
申请人： SCHERING CORPORATION
发明人： TONG, Ling , CHEN, Lei , SHANKAR, Bandarpalle, B. , KOZLOWSKI, Joseph, A. , SHIH, Neng-Yang
IPC分类号： C07C317/32 , C07C323/49 , C07C323/31 , C07C323/41 , C07D213/70 , C07D401/12 , A61K31/10 , A61P11/00 , A61P35/00 , A61P29/00 , A61P37/00
CPC分类号： C07D401/12 , C07C317/32 , C07C323/31 , C07C323/41 , C07C323/49 , C07C2601/02 , C07C2601/08 , C07C2602/08 , C07D213/71
摘要： A compound of the formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein:R1, R2, L1, L2, M1, M2, n, p, q, A, D, X, Y and Z are as described in the specification; pharmaceutical compositions thereof, methods of making said pharmaceutical compositions; and methods of use thereof.

55. 发明授权

EP0811375B1 GLUTAMIC ACID RECEPTOR AGONIST 失效
标题翻译：谷氨酸受体激动剂
公开(公告)号：EP0811375B1
公开(公告)日：2001-01-03
申请号：EP96902487.6
申请日：1996-02-20
申请人： NIPPON SUISAN KAISHA, LTD.
发明人： TAKEO, Jiro, Nippon Suisan Kaisha, Ltd. , YAMASHITA, Shinya, Nippon Suisan Kaisha, Ltd. , WADA, Keiji , CHIBA, Yoshiyuki, Nippon Suisan Kaisha, Ltd.
IPC分类号： C07C323/49 , C07C317/28 , C07C317/44 , C07C323/20 , C07D213/71 , A61K31/18 , A61K31/195 , A61K31/215 , A61K31/44
CPC分类号： C07C323/62 , A61K31/00 , A61K31/18 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/4035 , A61K31/4406 , C07C317/28 , C07C323/49 , C07C323/56

57. 发明授权

EP0481919B1 Heteroatom containing perfluoroalkyl terminated neopentyl sulfates and salts thereof 失效转让
标题翻译： Neopentylsulfate终止，含杂原子的全氟烷基及其盐。
公开(公告)号：EP0481919B1
公开(公告)日：1995-06-28
申请号：EP91810771.5
申请日：1991-10-01
申请人： CIBA-GEIGY AG
发明人： Karydas, Athanasios , Loh, Yung
IPC分类号： C07C323/12 , C07C323/25 , C07C317/18 , C07C305/10 , C07C311/09 , C07C323/41 , D21H17/11 , D21H17/09 , C07C323/49 , D06M13/265 , D06M13/144 , D06M13/408 , D21H13/16 , D06M13/438 , D06M13/402
CPC分类号： C07C323/25 , C07C305/06 , C07C305/10 , C07C317/18 , C07C317/28 , C07C323/12 , C07C323/41 , C07C323/49 , D06M13/144 , D06M13/265 , D06M13/408 , D21H17/09 , D21H17/11

58. 发明公开

EP0481919A3 Heteroatom containing perfluoroalkyl terminated neopentyl sulfates and salts thereof 失效转让
标题翻译：含有全氟烷基终止的极性硫酸钠及其盐的杂交
公开(公告)号：EP0481919A3
公开(公告)日：1993-11-03
申请号：EP91810771.5
申请日：1991-10-01
申请人： CIBA-GEIGY AG
发明人： Karydas, Athanasios , Loh, Yung
IPC分类号： C07C323/12 , C07C323/25 , C07C317/18 , C07C305/10 , C07C311/09 , C07C323/41 , D21H17/11 , D21H17/09 , C07C323/49 , D06M13/265 , D06M13/144 , D06M13/408 , D21H13/16 , D06M13/438 , D06M13/402
CPC分类号： C07C323/25 , C07C305/06 , C07C305/10 , C07C317/18 , C07C317/28 , C07C323/12 , C07C323/41 , C07C323/49 , D06M13/144 , D06M13/265 , D06M13/408 , D21H17/09 , D21H17/11
摘要： The present invention relates to perfluoroalkyl substituted sulfates and salts thereof of the formulas
(R f X CH₂) x C(CH₂OH) y (CH₂OSO₃-M+) z (I)
or
(R f E X CH₂) x C(CH₂OH) y (CH₂OSO₃-M+) z (II)
which are prepared by sulfation of perfluoroalkyl substituted alcohols of the formulas
(R f X CH₂) x C(CH₂OH) q (III)
or
(R f E X CH₂) x C(CH₂OH) q (IV)
wherein
R f is a straight or branched chain perfluoroalkyl of 1 to 18 carbon atoms or said perfluoroalkyl substituted by perfluoroalkyl of 2 to 6 carbon atoms, or mixtures thereof,
E is branched or straight chain alkylene of 1 to 10 carbon atoms or said alkylene interrupted by one to three groups selected from the group consisting of -NR-, -O-, -S-, -SO₂-, -COO-, -OOC-, -CONR-, -NRCO-, -SO₂NR- and -NRSO₂ or terminated at the R f end with -CONR- or -SO₂NR-, where R f is attached to the carbon or sulfur atom, and
for formula II, X is -S-, -O-, SO₂-, or -NR-, and
for formula I, X is -CONR- or -SO₂NR-, where R f is attached to the carbon or sulfur atom, and where R is independently hydrogen, alkyl of 1 to 6 carbon atoms or hydroxyalkyl of 2 to 6 carbon atoms;
x is 1,2 or 3; y is 0, 1 or 2; z is 1, 2 or 3; q is 1,2 or 3; x+y+z=4 and
x+q=4;
M is independently hydrogen, an alkali metal or organoammonium ion.

59. 发明公开

EP0469901A1 Sulfonamide derivatives 失效转让
标题翻译：磺酰胺衍生物
公开(公告)号：EP0469901A1
公开(公告)日：1992-02-05
申请号：EP91307061.1
申请日：1991-08-01
申请人： TAISHO PHARMACEUTICAL CO. LTD , NIPPON SUISAN KAISHA, LTD.
发明人： Sato, Masakazu , Kawashima, Yutaka , Goto, Jun , Chiba, Yoshiyuki , Satake, Mikio , Iwata, Chuzo , Imanishi, Takeshi
IPC分类号： C07C323/49 , C07C317/28 , C07C317/44 , C07C323/20 , C07D213/71 , A61K31/18
CPC分类号： C07C317/44 , C07C317/28 , C07C323/49 , C07C323/62 , C07D213/71
摘要： Sulfonamide derivative, useful as blood platelet aggregation inhibitors, have the formula:

in which A is a naphthyl group, a pyridyl group, a phenyl group, a phenyl group substituted by 1 to 5 substituents selected from halogen atoms, alkyl groups having 1 to 4 carbon atoms, alkoxy groups having 1 to 4 carbon atoms, nitro groups and acetamido groups, or an alkyl group having 1 to 20 carbon atoms; B is an alkylene group having 1 to 3 carbon atoms, a group -OCH₂- or a group -CH=CH-; X and Y are the same or different, and each is a hydrogen or fluorine atom; R is a carboxy group, an alkyoxycarbonyl group having 2 to 5 carbon atoms, a hydroxymethyl group or a group of the formula
(in which R¹ is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms; R² is a hydrogen atom, a hydroxyl group, an alkyl group having 1 to 3 carbon atoms, a carboxymethyl group or an alkoycarbonylmethyl group having 3 to 6 carbon atoms); m is 0, 1 or 2; n is 0,1,2 or 3; or salts thereof.
This invention also provided intermediates for the preparation of the sulfonamide, which intermediates are thiophenols of the formula:

(in which R, X and Y are as defined above).
摘要翻译：可用作血小板聚集抑制剂的磺酰胺衍生物具有下式：其中A是萘基，吡啶基，苯基，被1至5个选自卤素原子的取代基取代的苯基，具有1至4个碳原子的烷基碳原子，具有1至4个碳原子的烷氧基，硝基和乙酰氨基，或具有1至20个碳原子的烷基; B是具有1-3个碳原子的亚烷基，基团-OCH 2 - 或基团-CH = CH-; X和Y相同或不同，并且各自是氢或氟原子; R为羧基，具有2至5个碳原子的烷氧基羰基，羟甲基或下式基团（其中R 1为氢原子或具有1至3个碳原子的烷基; R 2为氢原子，羟基，碳原子数为1〜3的烷基，羧甲基或碳原子数为3〜6的烷基羰甲基）。 m是0,1或2; n是0,1,2或3; 或其盐。本发明还提供了用于制备磺酰胺的中间体，其中间体是下式的苯硫酚:(其中R，X和Y如上所定义）。

60. 发明公开

EP0312051A2 Tricyclic compounds 失效
标题翻译： Trizyklische Verbindungen。
公开(公告)号：EP0312051A2
公开(公告)日：1989-04-19
申请号：EP88117024.5
申请日：1988-10-13
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Oshima, Etsuo , Obase, Hiroyuki , Karasawa, Akira , Kubo, Kazuhiro , Miki, Ichiro , Ishii, Akio
IPC分类号： C07D313/12 , C07D337/12 , C07D495/04 , C07D405/12 , C07D407/12 , C07C311/16 , C07C323/44 , C07C323/48 , C07C323/49 , C07D409/12 , A61K31/335
CPC分类号： C07D405/12 , C07C311/16 , C07C323/44 , C07C323/48 , C07C323/49 , C07C2603/32 , C07D313/12 , C07D337/12 , C07D407/12 , C07D409/12 , C07D495/04
摘要： Novel tricyclic compounds having a TXA 2 -antagonizing activity represented by formul (I):
which strongly antagonize an action of thromboxane A 2 and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
摘要翻译：具有由配方（I）表示的TXA2拮抗活性的新型三环化合物：，其强烈拮抗血栓烷A2的作用，并预期对缺血性疾病，脑血管疾病等具有预防和治疗作用

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