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1. 发明公开

EP0381439A1 Triazole derivatives 失效
标题翻译：三唑衍。
公开(公告)号：EP0381439A1
公开(公告)日：1990-08-08
申请号：EP90300945.4
申请日：1990-01-30
申请人： TAISHO PHARMACEUTICAL CO. LTD , NIPPON SUISAN KAISHA, LTD.
发明人： Iwata, Chuzo , Imanishi, Takeshi , Chiba, Yoshiyuki , Satake, Mikio , Sato, Masakazu , Kawashima, Yutaka , Goto, Jun
IPC分类号： C07D249/14 , A61K31/41
CPC分类号： C07D249/14
摘要： Triazole derivatices useful as lipid peroxidation inhibitors have the formula:
in which R¹ is a hydrogen atom, a C₁-C₄ alkyl group, an acetyl group, a naphthylmethyl group, an anthrylmethyl group or a group of the formula
(in which X, Y and Z are the same or different and each is a hydrogen or halogen atom, a C₁-C₄ alkyl group, a C₁-C₄ alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a cyano group or a benzyloxy group); R² is a hydrogen atom or an acetyl group; and R³ is a hydrogen atom, an acetyl group or a group of the formula
(in which R¹ and R² have the meanings defined above).
摘要翻译：可用作脂质过氧化抑制剂的三唑衍生物具有下式：其中R 1是氢原子，C 1 -C 4烷基，乙酰基，萘基甲基，蒽基甲基或式 CHEM>（其中X，Y和Z相同或不同，各自为氢或卤素原子，C1-C4烷基，C1-C4烷氧基，羟基，硝基，三氟甲基，氰基或苄氧基）; R 2是氢原子或乙酰基; 和R 3是氢原子，乙酰基或式CHEM的基团（其中R 1和R 2具有上述定义）。一个

2. 发明授权

EP0469901B1 Sulfonamide derivatives 失效转让
标题翻译： Sulfonamidderivate。
公开(公告)号：EP0469901B1
公开(公告)日：1994-10-19
申请号：EP91307061.1
申请日：1991-08-01
申请人： TAISHO PHARMACEUTICAL CO. LTD , NIPPON SUISAN KAISHA, LTD.
发明人： Sato, Masakazu , Kawashima, Yutaka , Goto, Jun , Chiba, Yoshiyuki , Satake, Mikio , Iwata, Chuzo , Imanishi, Takeshi
IPC分类号： C07C323/49 , C07C317/28 , C07C317/44 , C07C323/20 , C07D213/71 , A61K31/18
CPC分类号： C07C317/44 , C07C317/28 , C07C323/49 , C07C323/62 , C07D213/71

3. 发明公开

EP0469901A1 Sulfonamide derivatives 失效转让
标题翻译：磺酰胺衍生物
公开(公告)号：EP0469901A1
公开(公告)日：1992-02-05
申请号：EP91307061.1
申请日：1991-08-01
申请人： TAISHO PHARMACEUTICAL CO. LTD , NIPPON SUISAN KAISHA, LTD.
发明人： Sato, Masakazu , Kawashima, Yutaka , Goto, Jun , Chiba, Yoshiyuki , Satake, Mikio , Iwata, Chuzo , Imanishi, Takeshi
IPC分类号： C07C323/49 , C07C317/28 , C07C317/44 , C07C323/20 , C07D213/71 , A61K31/18
CPC分类号： C07C317/44 , C07C317/28 , C07C323/49 , C07C323/62 , C07D213/71
摘要： Sulfonamide derivative, useful as blood platelet aggregation inhibitors, have the formula:

in which A is a naphthyl group, a pyridyl group, a phenyl group, a phenyl group substituted by 1 to 5 substituents selected from halogen atoms, alkyl groups having 1 to 4 carbon atoms, alkoxy groups having 1 to 4 carbon atoms, nitro groups and acetamido groups, or an alkyl group having 1 to 20 carbon atoms; B is an alkylene group having 1 to 3 carbon atoms, a group -OCH₂- or a group -CH=CH-; X and Y are the same or different, and each is a hydrogen or fluorine atom; R is a carboxy group, an alkyoxycarbonyl group having 2 to 5 carbon atoms, a hydroxymethyl group or a group of the formula
(in which R¹ is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms; R² is a hydrogen atom, a hydroxyl group, an alkyl group having 1 to 3 carbon atoms, a carboxymethyl group or an alkoycarbonylmethyl group having 3 to 6 carbon atoms); m is 0, 1 or 2; n is 0,1,2 or 3; or salts thereof.
This invention also provided intermediates for the preparation of the sulfonamide, which intermediates are thiophenols of the formula:

(in which R, X and Y are as defined above).
摘要翻译：可用作血小板聚集抑制剂的磺酰胺衍生物具有下式：其中A是萘基，吡啶基，苯基，被1至5个选自卤素原子的取代基取代的苯基，具有1至4个碳原子的烷基碳原子，具有1至4个碳原子的烷氧基，硝基和乙酰氨基，或具有1至20个碳原子的烷基; B是具有1-3个碳原子的亚烷基，基团-OCH 2 - 或基团-CH = CH-; X和Y相同或不同，并且各自是氢或氟原子; R为羧基，具有2至5个碳原子的烷氧基羰基，羟甲基或下式基团（其中R 1为氢原子或具有1至3个碳原子的烷基; R 2为氢原子，羟基，碳原子数为1〜3的烷基，羧甲基或碳原子数为3〜6的烷基羰甲基）。 m是0,1或2; n是0,1,2或3; 或其盐。本发明还提供了用于制备磺酰胺的中间体，其中间体是下式的苯硫酚:(其中R，X和Y如上所定义）。

4. 发明公开

EP0365364A3 2-Azetidinone derivatives 失效
标题翻译： 2-氮杂环丁酮衍生物
公开(公告)号：EP0365364A3
公开(公告)日：1991-12-11
申请号：EP89310857.1
申请日：1989-10-20
申请人： TAISHO PHARMACEUTICAL CO. LTD
发明人： Kawashima, Yutaka , Sato, Masakazu , Kawase, Masahiro , Watanabe, Yoshiaki , Hatayama, Katsuo
IPC分类号： C07D205/10 , C07D401/12 , A61K31/395
CPC分类号： C07D401/12 , C07D205/10 , Y10S514/822
摘要： 2-Azetizinone derivatives, useful as blood platelet aggregation inhibiting agents, are those of the formula:
in which R 1 is a halogen atom a C 1 -C 4 alkyl group, a C 1 -C 4 alkoxy group or an alkoxycarbonyl group in which the alkoxy group is a C 1 -C 4 alkoxy group; R 2 is a group of the formula:
(in which R 3 and R 4 are the same or different and each is a hydrogen atom, a C 1 -C 5 alkenyl group, a phenyl group or a benzyl group), a group of the formula:
(in which R 5 is a hydrogen atom, a phenyl group substituted by a halogen atom or a C 1 -C 4 alkoxy group, a phenyl group, a C 1 -C 4 alkyl group or a pyridyl group), a group of the formula:
(in which R 6 is a hydrogen atom, a Ci-C 4 alkyl group or a benzyl group and R 7 is a hydrogen atom or a C 1 -C 4 alkyl group), a group of the formula:
(in which R 8 and R 9 are the same or different and each is a hydrogen atom or C 1 -C 4 alkyl group), a pyrrolidinyl group or a tetrahydroazepinyl group; and n is an integer of from 2 to 10; and salts thereof.
摘要翻译：用作血小板聚集抑制剂的2-氮杂氮酮衍生物是下式的那些：其中R1是卤素原子，C1-C4烷基，C1-C4烷氧基或烷氧基羰基，其中烷氧基是 C1-C4烷氧基; R 2是下式的基团：（其中R 3和R 4相同或不同并且各自是氢原子，C 1 -C 5烯基，苯基或苄基），式其中R5是氢原子，被卤素原子或C1-C4烷氧基取代的苯基，苯基，C1-C4烷基或吡啶基），下式基团（其中R6是氢原子，C 1 -C 4烷基或苄基，并且R 7为氢原子或C 1 -C 4烷基），下式的基团（其中R 8和R 9相同或不同并且各自为氢原子或C1-C4烷基），吡咯烷基或四氢氮杂基; 并且n是2至10的整数; 及其盐。

5. 发明公开

EP0365364A2 2-Azetidinone derivatives 失效
标题翻译： 2 Azetidinonderivate。
公开(公告)号：EP0365364A2
公开(公告)日：1990-04-25
申请号：EP89310857.1
申请日：1989-10-20
申请人： TAISHO PHARMACEUTICAL CO. LTD
发明人： Kawashima, Yutaka , Sato, Masakazu , Kawase, Masahiro , Watanabe, Yoshiaki , Hatayama, Katsuo
IPC分类号： C07D205/10 , C07D401/12 , A61K31/395
CPC分类号： C07D401/12 , C07D205/10 , Y10S514/822
摘要： 2-Azetizinone derivatives, useful as blood platelet aggregation inhibiting agents, are those of the formula:

in which R 1 is a halogen atom a C 1 -C 4 alkyl group, a C 1 -C 4 alkoxy group or an alkoxycarbonyl group in which the alkoxy group is a C 1 -C 4 alkoxy group; R 2 is a group of the formula:

(in which R 3 and R 4 are the same or different and each is a hydrogen atom, a C 1 -C 5 alkenyl group, a phenyl group or a benzyl group), a group of the formula:

(in which R 5 is a hydrogen atom, a phenyl group substituted by a halogen atom or a C 1 -C 4 alkoxy group, a phenyl group, a C 1 -C 4 alkyl group or a pyridyl group), a group of the formula:

(in which R 6 is a hydrogen atom, a Ci-C 4 alkyl group or a benzyl group and R 7 is a hydrogen atom or a C 1 -C 4 alkyl group), a group of the formula:

(in which R 8 and R 9 are the same or different and each is a hydrogen atom or C 1 -C 4 alkyl group), a pyrrolidinyl group or a tetrahydroazepinyl group; and n is an integer of from 2 to 10; and salts thereof.
摘要翻译：可用作血小板聚集抑制剂的2-氮杂酮酮衍生物是下式的那些：其中R 1是卤素原子，C 1 -C 4烷基，C 1 -C 4烷氧基或烷氧羰基其中烷氧基是C1-C4烷氧基; R 2是下式的基团：其中R 3和R 4相同或不同，各自为氢原子，C1-C5烯基，苯基或苄基），下式的基团：其中R 5为氢原子，被卤素原子或C 1 -C 4烷氧基取代的苯基，苯基，C 1 -C 4烷基基或吡啶基），式：CHEM（其中R 6为氢原子，C 1 -C 4烷基或苄基，R 7为氢原子或C 1 -C4烷基），下式的基团：其中R 8和R 9相同或不同，各自为氢原子或C 1 -C 4烷基），吡咯烷基或四氢氮杂基; n为2〜10的整数，及其盐。

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