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1. 发明公开

EP0188802A2 Dibenz (b,e) oxepin derivative and antiallergic agent 失效
标题翻译： Dibenz（b，e）oxepin-Derivat和antiallergisches Mittel。
公开(公告)号：EP0188802A2
公开(公告)日：1986-07-30
申请号：EP85116465.7
申请日：1985-12-23
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Kumazawa, Toshiaki , Oshima, Etsuo , Obase, Hiroyuki , Ohmori, Kanji , Ishii, Hidee , Shuto, Katsuichi
IPC分类号： C07D313/12 , A61K31/335 , A61K31/495 , A61K31/55
CPC分类号： C07D405/04 , C07D313/12
摘要： A dibenz[b,e]oxepin derivative represented by the formula (I):
{wherein A 1 is a hydrogen atom, a methyl group, (CH 2 ) m OR 1 [where m is an integer of 1 to 4, and R 1 is a hydrogen atom, CH 2 CH(OH)CH 2 OCH 2 CH 3 , CH 2 CH(OAc)CH 2 OCH 2 CH 3 or CH 2 OCH 2 CH 2 OCH 3 ], CH(CH 3 )CH 2 OR 1 (where R 1 has the same meaning as defined above), CH = CHC0 2 R 2 (where R 2 is a hydrogen atom or a lower alkyl group), (CH 2 ) n CO 2 R 2 (where n is an integer of 1 to 3, and R has the same meaning as defined above), CH(CH 3 )CO 2 R 2 (where R 2 has the same meaning as defined above), CO 2 (CH 2 )NR 3 R 4 (where is an integer of 1 to 6, and R 3 and R 4 are the same or different lower alkyl groups), CONHR 5 (where R 5 is a lower alkyl group). CO 2 CH 2 CH(OR 6 ),CH 2 OCH 2 CH 3 (where R 6 is a hydrogen atom or an acetyl group), C0 2 CH 2 CH 2 0CH 2 CH 2 0H or CO 2 X 1 (where X 1 is a hydrogen atom or a lower alkyl group). A 2 is a 4-lower alkylpiperazino group, a 4-lower alkylhomopiperazino group or Y-(CH 2 ) p NR 7 R 8 (where Y is NH, O or S, p is an integer of 2 to 5, and R 7 and R 8 are the same or different hydrogen atoms or lower alkyl groups). One of A3 and A4 is COR [where R 9 is a hydroxyl group, a lower alkoxy group, an 1-(ethoxycarbony- loxy)ethoxy group or an amino group] or a cyano group, and the other is a hydrogen atom; or A3 is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms and is a substituent at the 4-position, and A4 is a hydrogen atom.} has antiallergic activity such as antiasthmatic activity.
摘要翻译：由式（I）表示的二苯并[b，e]氧杂七环衍生物：其中A 1是氢原子，甲基，（CH 2）m OR 1 [其中m是整数1 至4，R 1为氢原子，CH 2 CH（OH）CH 2 OCH 2 CH 3，CH 2 CH（OAc）CH 2 OCH 2 CH 3或CH 2 OCH 2 CH 2 OCH 3，CH（CH 3）CH 2 OH（其中R 1具有与上述相同的含义） CH = CHCO 2 R 2（其中R 2是氢原子或低级烷基），（CH 2）n CO 2 R 2（其中n是1至3的整数，并且R 2具有相同的含义如上定义），CH（CH 3）CO 2 R 2（其中R 2具有与上述相同的含义），CO 2（CH 2）n NR 3 R 4（其中@是1至 6，R 3和R 4是相同或不同的低级烷基），CONHR 5（其中R 5是低级烷基），CO 2 CH 2 CH（OR 6），CH 2 OCH 2 CH 3（其中 R 6是氢原子或乙酰基），CO 2 CH 2 CH 2 OCH 2 CH 2 OH或CO 2 X 1（其中X 1是氢原子或低级烷基）。 A 2是4-低级烷基哌嗪基，4-低级烷基高哌啶子基或Y-（CH 2）p NR R R 8（其中Y是NH，O或S，p是2至5的整数 R 7和R 8是相同或不同的氢原子或低级烷基）。 A 3和A 4中的一个是COR 9，其中R 9是羟基，低级烷氧基，1-（乙氧羰基氧基）乙氧基或氨基或氰基，另一个是氢原子; 或A 3为氢原子或碳原子数为1〜3的烷基，为4位的取代基，A 4为氢原子。}具有抗过敏活性，例如抗哮喘活性。

2. 发明公开

EP0312051A3 Tricyclic compounds 失效
标题翻译：三元化合物
公开(公告)号：EP0312051A3
公开(公告)日：1990-07-04
申请号：EP88117024.5
申请日：1988-10-13
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Oshima, Etsuo , Obase, Hiroyuki , Karasawa, Akira , Kubo, Kazuhiro , Miki, Ichiro , Ishii, Akio
IPC分类号： C07D313/12 , C07D337/12 , C07D495/04 , C07D405/12 , C07D407/12 , C07C311/16 , C07C323/44 , C07C323/48 , C07C323/49 , C07D409/12 , A61K31/335
CPC分类号： C07D405/12 , C07C311/16 , C07C323/44 , C07C323/48 , C07C323/49 , C07C2603/32 , C07D313/12 , C07D337/12 , C07D407/12 , C07D409/12 , C07D495/04
摘要： Novel tricyclic compounds having a TXA 2 -antagonizing activity represented by formul (I): which strongly antagonize an action of thromboxane A 2 and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
摘要翻译：具有由配方（I）表示的TXA2拮抗活性的新型三环化合物：，其强烈拮抗血栓烷A2的作用，并预期对缺血性疾病，脑血管疾病等具有预防和治疗作用

3. 发明公开

EP0188802A3 Dibenz (b,e) oxepin derivative and antiallergic agent 失效
标题翻译： DIBENZ（B，E）OXEPIN衍生物和抗癌剂
公开(公告)号：EP0188802A3
公开(公告)日：1986-08-20
申请号：EP85116465
申请日：1985-12-23
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Kumazawa, Toshiaki , Oshima, Etsuo , Obase, Hiroyuki , Ohmori, Kanji , Ishii, Hidee , Shuto, Katsuichi
IPC分类号： C07D313/12 , A61K31/335 , A61K31/495 , A61K31/55
CPC分类号： C07D405/04 , C07D313/12
摘要： A dibenz[b,e]oxepin derivative represented by the formula (I):
{wherein A 1 is a hydrogen atom, a methyl group, (CH 2 ) m OR 1 [where m is an integer of 1 to 4, and R 1 is a hydrogen atom, CH 2 CH(OH)CH 2 OCH 2 CH 3 , CH 2 CH(OAc)CH 2 OCH 2 CH 3 or CH 2 OCH 2 CH 2 OCH 3 ], CH(CH 3 )CH 2 OR 1 (where R 1 has the same meaning as defined above), CH = CHC0 2 R 2 (where R 2 is a hydrogen atom or a lower alkyl group), (CH 2 ) n CO 2 R 2 (where n is an integer of 1 to 3, and R has the same meaning as defined above), CH(CH 3 )CO 2 R 2 (where R 2 has the same meaning as defined above), CO 2 (CH 2 )NR 3 R 4 (where is an integer of 1 to 6, and R 3 and R 4 are the same or different lower alkyl groups), CONHR 5 (where R 5 is a lower alkyl group). CO 2 CH 2 CH(OR 6 ),CH 2 OCH 2 CH 3 (where R 6 is a hydrogen atom or an acetyl group), C0 2 CH 2 CH 2 0CH 2 CH 2 0H or CO 2 X 1 (where X 1 is a hydrogen atom or a lower alkyl group). A 2 is a 4-lower alkylpiperazino group, a 4-lower alkylhomopiperazino group or Y-(CH 2 ) p NR 7 R 8 (where Y is NH, O or S, p is an integer of 2 to 5, and R 7 and R 8 are the same or different hydrogen atoms or lower alkyl groups). One of A3 and A4 is COR [where R 9 is a hydroxyl group, a lower alkoxy group, an 1-(ethoxycarbony- loxy)ethoxy group or an amino group] or a cyano group, and the other is a hydrogen atom; or A3 is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms and is a substituent at the 4-position, and A4 is a hydrogen atom.} has antiallergic activity such as antiasthmatic activity.

4. 发明授权

EP0325755B1 Tricyclic compounds 有权
标题翻译：三环化合物。
公开(公告)号：EP0325755B1
公开(公告)日：1994-03-30
申请号：EP88120889.6
申请日：1988-12-14
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Oshima, Etsuo , Obase, Hiroyuki , Karasawa, Akira , Kubo, Kazuhiro , Miki, Ichiro , Ishii, Akio , Ishii, Hidee , Ohmori, Kenji
IPC分类号： C07D313/12 , C07D337/12 , C07D211/10 , C07D333/34 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/14 , C07D409/12 , C07D471/10 , A61K31/445
CPC分类号： C07D405/06 , C07D211/14 , C07D313/12 , C07D333/34 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D471/10

5. 发明授权

EP0312051B1 Tricyclic compounds 失效
标题翻译：三环化合物。
公开(公告)号：EP0312051B1
公开(公告)日：1994-08-17
申请号：EP88117024.5
申请日：1988-10-13
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Oshima, Etsuo , Obase, Hiroyuki , Karasawa, Akira , Kubo, Kazuhiro , Miki, Ichiro , Ishii, Akio
IPC分类号： C07D313/12 , C07D337/12 , C07D495/04 , C07D405/12 , C07D407/12 , C07C311/16 , C07C323/44 , C07C323/48 , C07C323/49 , C07D409/12 , A61K31/335
CPC分类号： C07D405/12 , C07C311/16 , C07C323/44 , C07C323/48 , C07C323/49 , C07C2603/32 , C07D313/12 , C07D337/12 , C07D407/12 , C07D409/12 , C07D495/04

6. 发明公开

EP0345747A2 Tricyclic compounds 失效
标题翻译：三环化合物
公开(公告)号：EP0345747A2
公开(公告)日：1989-12-13
申请号：EP89110272.5
申请日：1989-06-07
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Oshima, Etsuo , Obase, Hiroyuki , Karasawa, Akira , Kubo, Kazuhiro , Miki, Ichiro , Ishii, Akio
IPC分类号： C07D405/06 , C07D491/04 , C07D405/12 , C07D235/06 , C07D313/12 , C07D409/12 , C07D417/06 , A61K31/41 , A61K31/335
CPC分类号： C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/12 , C07D405/12 , C07D417/12 , C07D471/04 , Y10S514/824 , Y10S514/826
摘要： Novel tricyclic compound represented by formula (I):
possess a TXA 2 biosynthesis inhibiting activity and/or a TXA 2 receptor antagonizing activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
摘要翻译：由式（I）表示的新型三环化合物：具有TXA 2生物合成抑制活性和/或TXA 2受体拮抗活性，并且预期对缺血性疾病，脑血管疾病等具有预防和治疗效果。

7. 发明公开

EP0325755A1 Tricyclic compounds 有权
标题翻译： Tricyclische Verbindungen。
公开(公告)号：EP0325755A1
公开(公告)日：1989-08-02
申请号：EP88120889.6
申请日：1988-12-14
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Oshima, Etsuo , Obase, Hiroyuki , Karasawa, Akira , Kubo, Kazuhiro , Miki, Ichiro , Ishii, Akio , Ishii, Hidee , Ohmori, Kenji
IPC分类号： C07D313/12 , C07D337/12 , C07D211/10 , C07D333/34 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/14 , C07D409/12 , C07D471/10 , A61K31/445
CPC分类号： C07D405/06 , C07D211/14 , C07D313/12 , C07D333/34 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D471/10
摘要： Tricyclic compounds represented by formula (I):
wherein

represents single bond or double bond; X 1 -X 2 represents -CH 2 O-,
wherein t represents 0, 1 or 2, -CH 2 -CH 2 -, or -CH=CH-; W represents -S-or = CH-; n is 1, 2, 3, or 4; one of R A and R B represents hydrogen and the other represents -Y-M wherein Y represents single bond, -CR 1 R 2 -(CH 2 ) m -, or -CR 1 =CR 2 -(CH 2 ) m wherein each of R 1 and R 2 independently represents hydrogen or lower alkyl and m is 0, 1, 2, 3 or 4, in which the left side of each formula is bound to the mother nucleus; and M represents -COOR 3 wherein R 3 represents hydrogen or lower alkyl, -CONR 3a R 3b wherein each of R 3a and R 3b independently has the same significances for R 3 as described above, or tetrazolyl; each of G A and G B independently represents lower alkyl, halogen, hydroxyl, or lower alkoxyl; each of g A and g B independently represents 0, 1, 2 or 3; Z represents N-E 1 -Q wherein E 1 represents single bond, -CO-, -COO- wherein the left side of the formula is bound to the nitrogen atom, or -S0 2 -; and Q represents optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, aromatic heterocyclic group, or

wherein L represents hydrogen, hydroxyl, or lower alkoxy; E 2 represents single bond, -CO-, or - wherein R 4 represents hydrogen or lower alkyl; and Q has the same significance as described above; C = CH-Q wherein Q has the same significance as described above; or
p is 1, 2 or 3; possess a potent antagonizing action against thromboxane A 2 and also an antiallergic and/or antihistaminic activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
摘要翻译：由式（I）表示的三环化合物：其中----表示单键或双键; X1-X2表示-CH2O-，，其中l代表0,1或2，-CH2-CH2-或-CH = CH-; W表示-S-或= CH-; n为1,2,3或4; R A和R B之一表示氢，另一个表示-YM，其中Y表示单键，-CR 1 R 2 - （CH 2）m - 或-CR 1 = CR < 2 - （CH 2）m，其中R 1和R 2各自独立地表示氢或低级烷基，m是0,1,2,3或4，其中每个式的左侧与母核; 并且M表示-COOR 3，其中R 3表示氢或低级烷基-CONR 3a R 3b，其中R 3a和R 3b各自独立地对R 3表示相同的含义，如上所述，或四唑基; G A和G B各自独立地表示低级烷基，卤素，羟基或低级烷氧基; g 和g p为1,2或3; 对血栓素A2具有有效的拮抗作用，还具有抗过敏和/或抗组胺活性，预期对缺血性疾病，脑血管疾病等具有预防和治疗作用。

8. 发明授权

EP0345747B1 Tricyclic compounds 失效
标题翻译：三环化合物
公开(公告)号：EP0345747B1
公开(公告)日：1996-06-26
申请号：EP89110272.5
申请日：1989-06-07
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Oshima, Etsuo , Obase, Hiroyuki , Karasawa, Akira , Kubo, Kazuhiro , Miki, Ichiro , Ishii, Akio
IPC分类号： C07D405/06 , C07D491/04 , C07D405/12 , C07D235/06 , C07D313/12 , C07D409/12 , C07D417/06 , A61K31/41 , A61K31/335
CPC分类号： C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/12 , C07D405/12 , C07D417/12 , C07D471/04 , Y10S514/824 , Y10S514/826

9. 发明公开

EP0345747A3 Tricyclic compounds 失效
标题翻译：三元化合物
公开(公告)号：EP0345747A3
公开(公告)日：1990-07-04
申请号：EP89110272.5
申请日：1989-06-07
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Oshima, Etsuo , Obase, Hiroyuki , Karasawa, Akira , Kubo, Kazuhiro , Miki, Ichiro , Ishii, Akio
IPC分类号： C07D405/06 , C07D491/04 , C07D405/12 , C07D235/06 , C07D313/12 , C07D409/12 , C07D417/06 , A61K31/41 , A61K31/335
CPC分类号： C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/12 , C07D405/12 , C07D417/12 , C07D471/04 , Y10S514/824 , Y10S514/826
摘要： Novel tricyclic compound represented by formula (I):
possess a TXA 2 biosynthesis inhibiting activity and/or a TXA 2 receptor antagonizing activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.

10. 发明公开

EP0312051A2 Tricyclic compounds 失效
标题翻译： Trizyklische Verbindungen。
公开(公告)号：EP0312051A2
公开(公告)日：1989-04-19
申请号：EP88117024.5
申请日：1988-10-13
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Oshima, Etsuo , Obase, Hiroyuki , Karasawa, Akira , Kubo, Kazuhiro , Miki, Ichiro , Ishii, Akio
IPC分类号： C07D313/12 , C07D337/12 , C07D495/04 , C07D405/12 , C07D407/12 , C07C311/16 , C07C323/44 , C07C323/48 , C07C323/49 , C07D409/12 , A61K31/335
CPC分类号： C07D405/12 , C07C311/16 , C07C323/44 , C07C323/48 , C07C323/49 , C07C2603/32 , C07D313/12 , C07D337/12 , C07D407/12 , C07D409/12 , C07D495/04
摘要： Novel tricyclic compounds having a TXA 2 -antagonizing activity represented by formul (I):
which strongly antagonize an action of thromboxane A 2 and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
摘要翻译：具有由配方（I）表示的TXA2拮抗活性的新型三环化合物：，其强烈拮抗血栓烷A2的作用，并预期对缺血性疾病，脑血管疾病等具有预防和治疗作用

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