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51. 发明公开

EP2271935A1 METHOD AND KIT FOR THE EX VIVO EVALUATION OF THE RESPONSE OF A TUMOR TO CONDITIONS TO BE TESTED 有权
标题翻译：方法和试剂盒用于离体评估响应的肿瘤以结束测试条件
公开(公告)号：EP2271935A1
公开(公告)日：2011-01-12
申请号：EP09729792.3
申请日：2009-04-09
申请人： Universität Leipzig , Dietz, Andreas , Tschöp, Katrin , Wichmann, Gunnar , Granzow, Christof
发明人： DIETZ, Andreas , TSCHÖP, Katrin , WICHMANN, Gunnar , GRANZOW, Christof
IPC分类号： G01N33/50
CPC分类号： G01N33/574 , G01N33/5011
摘要： The invention concerns a method and kit for the ex vivo evaluation of the response of a tumor to conditions to be tested, in particular a tumor treatment regime, in an isolated tumor sample. The diagnostic method is suitable for the use in medicine and in pharmacy, in particular for the pretherapeutical evaluation of the responsiveness of a tumor to a tumor treatment regime and the preclinical evaluation of a tumor treatment regime. The method comprises: a.) Placing a freshly isolated tumor sample in a container, which contains antibiotics and preferably antimycotics keeping the sample at a temperature above 10 °C, b.) Breaking up, preferably mechanically disintegrating, the tumor sample, c.) Placing the pieces of the tumor sample into cell culture medium and incubating with collagenase shortly upon isolation of the tumor, d.) Plating the cells and tissue pieces into wells that are coated with extra cellular matrix components, incubating under the conditions of the tumor treatment regime or in presence of a substance to be tested, e.) Determining the number of cells and/or the number of colonies and/or the sum response of cells of epithelial origin, preferably by performing a cytokeratin staining, f.) Using a cell culture medium in the steps c.) to e.) that contains less than 100 nmol/1 flavin and that does not contain phenol red, g.) Performing the steps c.) to e.) in the absence of light of a wavelength below 520 nm.

52. 发明授权

EP2039758B1 Cell culture medium and method for culturing stem cells and progenitor cells 有权
标题翻译：细胞培养基和方法，用于培养干细胞和祖细胞
公开(公告)号：EP2039758B1
公开(公告)日：2010-09-01
申请号：EP07018574.9
申请日：2007-09-21
申请人： Universität Leipzig
发明人： Cross, Michael, Dr. , Alt, Rüdiger
IPC分类号： C12N5/02 , C12N5/0789
CPC分类号： C12N5/0647 , C12N2500/14 , C12N2500/16 , C12N2500/32 , C12N2500/34 , C12N2500/35 , C12N2500/38 , C12N2500/40 , C12N2501/23

53. 发明公开

EP2157171A8 Method for locally modifying the elasticity of a substrate designed for the growth of cells thereon 有权
标题翻译：一种用于的局部弹性的开发为用于细胞生长基底的表面改性方法
公开(公告)号：EP2157171A8
公开(公告)日：2010-04-07
申请号：EP08014921.4
申请日：2008-08-22
申请人： Universität Leipzig
发明人： Ehrlicher, Allen , Käs, Josef , Robitzky, Andrea
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , C12N2535/10
摘要： The present invention describes a method for locally modifying the elasticity of an elastic substrate (1) designed for the growth of living cells thereon and/or therein, comprising:
emitting laser radiation (2a) by a laser (2), locally depositing energy in at least one designated spatial area located inside and/or on the surface of the substrate (1) by focusing (F) the emitted laser radiation (2a) onto at least one spatial area, wherein the amount of locally deposited energy is sufficient to locally modify the elasticity of the substrate (1), and
populating, before, during or after the local energy deposition therein, at least one spatial area in which the elasticity of the substrate (1) has been modified and/or at least one adjacent area of the substrate (1) at least partly with cells.

54. 发明公开

EP2101921A1 VORRICHTUNG UND VERFAHREN ZUM BERÜHRUNGSLOSEN MANIPULIEREN UND AUSRICHTEN VON PROBENTEILCHEN IN EINEM MESSVOLUMEN MIT HILFE EINES INHOMOGENEN ELEKTRISCHEN WECHSELFELDS 审中-公开
标题翻译：装置和方法用于在测量空间非接触操作和样品粒子的取向使用非均匀的交变电场
公开(公告)号：EP2101921A1
公开(公告)日：2009-09-23
申请号：EP07857093.4
申请日：2007-12-21
申请人： Universität Leipzig
发明人： KREYSING, Moritz , GUCK, Jochen , KÄS, Josef
IPC分类号： B03C5/00 , B03C5/02
CPC分类号： B03C5/005 , B03C5/026
摘要： The invention refers to a device for the contactless manipulation and alignment of sample particles in a measurement volume using a nonhomogeneous electric alternating field, with a radiation source for emitting electromagnetic radiation and with optical devices for guiding the electromagnetic radiation into the measurement volume. The device is characterized in that a beam forming device for the production of an intensity profile asymmetrical to a beam axis is present as part of the optical devices, wherein sample particles in the measurement volume can be trapped in a nonhomogeneous field distribution of the electric field produced by the asymmetrical intensity profile, in that a rotating device for rotating the asymmetrical intensity profile around the beam axis relative to the measurement volume is present for carrying sample particles trapped in the nonhomogeneous field distribution, and in that the electromagnetic radiation is not focused in the measurement volume, in particular is divergent. In addition, the device relates to a method for the contactless manipulation and alignment of sample particles in a measurement volume using a nonhomogeneous electric field.

55. 发明公开

EP1951287A2 ARZNEIMITTEL ZUR BEHANDLUNG VON FERTILITÄTS- UND SCHWANGERSCHAFTSSTÖRUNGEN, AUTOIMMUNERKRANKUNGEN UND ZUR INDUKTION EINER IMMUNOLOGISCHEN TOLERANZ BEI TRANSPLANTATIONSPATIENTEN UND VERFAHREN ZUR HERSTELLUNG 审中-公开
标题翻译：药物生育和怀孕的问题，自身免疫性疾病和免疫耐受的诱导移植患者的治疗和制造方法
公开(公告)号：EP1951287A2
公开(公告)日：2008-08-06
申请号：EP06805531.8
申请日：2006-11-21
申请人： Universität Leipzig
发明人： ALEXANDER, Henry , ZIMMERMANN, Gerolf
IPC分类号： A61K38/24 , A61P15/00 , A61P37/00
CPC分类号： A61K38/24
摘要： The invention relates to a medicament, especially for treating problems relating to pregnancy or for inducing an immunological tolerance in patients with auto-immune diseases or having undergone a transplant. Said medicament contains at least one beta6 or beta7 precursor or mature sub-unit of the endometrial or decidual human choriongonadotropin (hCG), and an alpha precursor or mature sub-unit of the human choriongonadotropin or the glycolysed fragments of said sub-units. Unlike the trophoblast hCG with the sub-units beta3, beta5 and beta8, the function of the non-trophoblast hCG beta6 oder beta7 expressed in the endometrium and the decidua has hardly been examined.

56. 发明授权

EP1597554B1 VERFAHREN ZUR FESTSTELLUNG WENIGSTENS EINES ZUSTANDSPARAMETERS EINES DICHTUNGSSYSTEMS SOWIE DICHTUNGSSYSTEM 有权
标题翻译：一种用于确定密封系统和密封系统的至少一个条件参数
公开(公告)号：EP1597554B1
公开(公告)日：2008-01-30
申请号：EP04708336.5
申请日：2004-02-05
申请人： Universität Leipzig
发明人： KREMER, Friedrich
IPC分类号： G01L1/14 , G01M3/18 , F16L23/16
CPC分类号： G01L1/142 , G01M3/40
摘要： The invention relates to a method for determining at least one state parameter of a sealing system (10, 110) comprising at least one sealing element (12, 112) and at least one dielectric element (24, 124) containing dielectric material (26, 126). The invention is characterised in that the real part and/or the imaginary part of the complex dielectric function of the dielectric element is measured.

57. 发明公开

EP1876449A1 Cell cycle-based blood test to diagnose Alzheimer's disease 审中-公开
标题翻译： Zellzyklusbasierter Bluttest zur Diagnose von Alzheimer
公开(公告)号：EP1876449A1
公开(公告)日：2008-01-09
申请号：EP06014144.7
申请日：2006-07-07
申请人： Universität Leipzig
发明人： Arendt, Thomas , Stieler, Jens , Gartner, William J. , Grimes, F. Randall , Weber, Donald F.
IPC分类号： G01N33/68
CPC分类号： G01N33/5091 , G01N2333/70589 , G01N2333/70596 , G01N2800/2821 , G01N2800/2835
摘要： Described is a method of diagnosing Alzheimer's Disease (AD), an early stage or predisposition for said disease in a blood sample obtained from a patient comprising: (a) quantitatively determining (i) expression of blood cell surface marker CD69 prior to and after stimulation of the cells of the blood sample by a mitogen and (ii) the ratio of CD45RO/CD45RA; (b) comparing the expression values of said surface markers of the blood cells with referenc expression values of the same surface markers; and (c) relating the determined expression of CD69 and the ratio of CD45RO/CD45RA to an assessment of the risk of developing the disease, a diagnosis of the disease, or a measure of the progression of the disease. Also described are methods for distinguishing between AD patients and non-AD patients, preferably Parkinson's Disease (PD) patients.
摘要翻译：描述了一种诊断阿尔茨海默病（AD）的方法，该方法是从患者获得的血液样品中的所述疾病的早期或倾向性，包括：（a）定量测定（i）在刺激之前和之后血细胞表面标志物CD69的表达的血液样品的细胞由丝裂原和（ii）CD45RO / CD45RA的比例; （b）将所述血细胞的所述表面标志物的表达值与相同表面标志物的参考表达值进行比较; 和（c）将确定的CD69的表达与CD45RO / CD45RA的比例与评估疾病发展的风险，疾病的诊断或疾病进展的度量相关联。还描述了区分AD患者和非AD患者，优选帕金森病（PD）患者的方法。

58. 发明公开

EP1655289A1 Quinazoline derivatives, process for their preparation, their use as antimitotics and pharmaceutical compositions comprising said derivatives 审中-公开
标题翻译：喹唑啉衍生物，它们的制备，它们作为抗有丝分裂剂使用过程中，以及含有这些医药Zusammensetzunegen
公开(公告)号：EP1655289A1
公开(公告)日：2006-05-10
申请号：EP04026190.1
申请日：2004-11-04
申请人： EMBL , Universität Leipzig , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人： Surrey, Thomas , Athanassios, Giannis , Vernos, Isabelle , Gartner, Michael , Sunder-Plassmann, Nils , Vasiliki, Sarli , Mayer, Thomas , Huemmer, Stefan
IPC分类号： C07D239/78 , A61K31/505 , A61P35/00
CPC分类号： C07D239/82 , C07D239/78
摘要： The invention relates to quinazoline derivatives of formula (I)

in which R 1 , X and A have the meanings as indicated, or to a pharmaceutically acceptable salt thereof, e.g.

Such compounds are useful as modulators, in particular inhibitors, of the mitotic kinesin Eg5. i.e. the human protein (also called KSP), the Xenopus laevis homologue, further homologues from other species as well as allelic variants and functionally related proteins.
The invention also relates to processes for their preparation, pharmaceutical compositions comprising said quinazoline derivatives, and the use of said quinazoline derivatives, in particular for treating diseases such as cancer.
摘要翻译：本发明涉及喹唑啉的式（I）其中R 1，X和A的含义的衍生物如所指出的，或者其药学上可接受的盐，如搜索化合物可用作调节剂，特别是抑制剂，的期驱动蛋白Eg5。即人蛋白（所谓的KSP），非洲爪蟾同源物，来自其它物种以及等位基因变体和功能上相关的蛋白质。此外同系物。因此，本发明涉及它们的制备方法，药物组合物包含所述喹唑啉衍生物，以及使用所述喹唑啉衍生物，特别是用于治疗疾病：如癌症。

59. 发明公开

EP1636594A2 VERFAHREN UND MITTEL ZUR BESTIMMUNG VON DEFINIERTEN ZUSTÄNDEN ODER VERÄNDERUNGEN IN DER UTERUSSCHLEIMHAUT ODER IM EPITHEL ANDERER ORGANE 有权
标题翻译：方式和途径定义的状态或更改子宫粘膜上皮或其他机构测定
公开(公告)号：EP1636594A2
公开(公告)日：2006-03-22
申请号：EP04738662.8
申请日：2004-06-04
申请人： Universität Leipzig
发明人： ALEXANDER, Henry , ZIMMERMANN, Gerolf
IPC分类号： G01N33/76 , C07K14/59
CPC分类号： G01N33/76 , C07K14/59 , C07K16/26 , C07K2317/34
摘要： The invention relates to a method and means for the determination of defined states or modifications in the mucus of the uterus or in the epithelium of other organs, especially for the diagnosis of pregnancy and diagnosis of embryo-implantation. In a biological sample, the concentration of human endometrial chorionic gonadotropin (eßhCG/ehCG) and/or non-trophoblastic hCG (hCG type I, ß6, ß7) is determined in a specific manner, wherein the hCG (hCG type II, tßhCG) which is to be trophoblastic is different. The invention also relates to the sequence of the ß sub-unit of human endometrial chorionic gonadotropin of eßhCG, and anti-bodies which are specifically different from eßhCG/ehCG and hCG type II, tßhCG, and to a test kit for carrying out said method.

60. 发明公开

EP4180550A1 MASK-ASSISTED RADIALLY SEGMENTED TARGET PHYSICAL VAPOR DEPOSITION 审中-实审
公开(公告)号：EP4180550A1
公开(公告)日：2023-05-17
申请号：EP21208007.1
申请日：2021-11-12
申请人： Universität Leipzig
发明人： Wenckstern, Holger von , Kneiß, Max , Splith, Daniel Thomas , Grundmann, Marius
IPC分类号： C23C14/04 , C23C14/08 , C23C14/28
摘要： In a first aspect, the invention relates to a method of producing a thin film material composition on a substrate comprising providing an ablation source, the substrate and a target comprising target material which is inhomogeneous and to be deposited onto the substrate, wherein the ablation source is emitting an ablation beam onto the target at an ablation point and/or along an ablation track by means of the ablation source, such that the target material is ablated and deposited on the substrate forming the thin film material composition. The chemical composition of the material flux of target material towards the substrate is defined by a composition of target material at the ablation point and/or by an average composition of target material along the ablation track. The method is characterized in that a mask comprising at least one aperture is located between the target and the substrate, wherein the mask and the substrate are presently positioned moveable with respect to each other allowing for selectively depositing the chemical composition of the material flux of target material on the substrate to yield a desired material distribution.
In further aspects, the invention refers to a thin film material produced by the method according to the invention and the use of the process according to the invention to produce a thin film material composition.

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