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1. 发明公开

EP2614135A2 VERFAHREN UND VORRICHTUNG ZUR HERSTELLUNG VON METHAN IN EINEM PHOTOBIOREAKTOR 审中-公开
标题翻译：方法和装置甲烷在光生物反应器中生产
公开(公告)号：EP2614135A2
公开(公告)日：2013-07-17
申请号：EP11755317.2
申请日：2011-09-08
申请人： Universität Leipzig , Sächsisches Institut für Angewandte Biotechnologie an der Universität Leipzig e.V. , Karlsruher Institut für Technologie , Universität Bremen
发明人： WILHELM, Christian , POSTEN, Clemens , RÄBIGER, Norbert
IPC分类号： C12M1/00 , C12M1/113 , C12M1/12 , C12M1/18 , C12P5/02 , C12N9/02 , C12R1/89
CPC分类号： C12M21/02 , C12M21/04 , C12M23/34 , C12N9/0004 , C12N9/0006 , C12N9/16 , C12N9/88 , C12P5/023 , C12P7/42 , C12P39/00 , C12Y101/01026 , C12Y101/03015 , C12Y101/99014 , C12Y301/03018 , C12Y401/01039 , Y02E50/343
摘要： The invention relates to a method for producing methane by culturing algae and methanogenic microorganisms, and to a facility for carrying out the process. The essence of the invention is a photobioreactor which directly generates methane from two zones composed of sunlight and an oxygen-enriched and carbon-dioxide-depleted gas mixture. The reaction is carried out in two sub steps which take place in two different zones. In the first, aerobic part, glycolate is synthesized in algal cells by photosynthesis, and this glycolate is excreted by the cells. The algae form a biofilm on a support material, which biofilm is firstly supplied by nutrients with the aid of a continuous or semicontinuous stream of liquid and secondly transfers the excreted glycolate into the second zone. This compartment is anaerobic due to an oxygen-impermeable membrane and comprises methanogenic bacteria, which directly convert the introduced glycolate into methane.

2. 发明公开

EP4332240A1 RNA-BIOMARKERS FOR DIAGNOSIS OF PROSTATE CANCER 审中-公开
公开(公告)号：EP4332240A1
公开(公告)日：2024-03-06
申请号：EP22193923.4
申请日：2022-09-05
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. , Universität Leipzig
发明人： Reiche, Kirstin , Buschmann, Tilo , Bartsch, Sophie , Bertram, Catharina , Horn, Friedemann , Blumert, Conny , Wirth, Manfred , Füssel, Susanne , Fröhner, Michael , Kreuz, Markus , Dominik, Otto
IPC分类号： C12Q1/6886
摘要： The present invention involves methods for the ex-vivo diagnosis of prostate cancer comprising the steps of i) providing a sample from a patient suspected of having prostate cancer and ii) analysing the expression level of at least one newly identified biomarker for prostate cancer in the sample, wherein, if the expression level of said biomarker is above a threshold value, the sample is designated as prostate cancer positive. Further, the invention involves stringent sample and method quality control criteria to ensure a reliable and specific method of diagnosing prostate cancer.

3. 发明公开

EP4115885A1 A PHARMACEUTICAL COMPOSITION COMPRISING BAY 86-5277 AND SALTS THEREOF FOR USE IN THE TREATMENT OF VIRAL INFECTIONS AND HYPERINFLAMMATION 无效
公开(公告)号：EP4115885A1
公开(公告)日：2023-01-11
申请号：EP21183823.0
申请日：2021-07-05
申请人： Charité - Universitätsmedizin Berlin , Universität Leipzig
发明人： LEHMANN, Irina , LANDMESSER, Ulf , CONRAD, Christian , EILS, Roland , TRUMP, Saskia , CHUA, Robert Lorenz , LUKASSEN, Sören , LIEBIG, Johannes , THÜRMANN, Loreen , HENNIG, Bianca , LAUDI, Sven
IPC分类号： A61K31/495 , A61P31/14
摘要： The invention relates to a pharmaceutical composition comprising BAY 86-5277 or salt thereof for use in the treatment and/or prevention of a medical condition associated with a viral infection and comprising hyperinflammation in a human subject. The invention further relates to a combination of BAY 86-5277 or a salt thereof and at least one other treatment, such as a guideline treatment for severe respiratory disease, for example recommended by the S3 guideline on in-patient treatment of COVID-19, preferably a glucocorticoid, more preferably dexamethasone. The invention further relates to a pharmaceutical composition comprising BAY 86-5277 or salt thereof or said combination with a glucocorticoid, and use of the combination or composition, in the treatment and/or prevention of a viral infection in a subject and/or a medical condition associated with hyperinflammation, preferably hyperinflammation in the respiratory tract, acute respiratory failure, pneumonia, acute respiratory distress syndrome and/or multiorgan failure. In preferred embodiments, the invention relates to the treatment and/or prevention of a medical condition associated with a SARS-CoV infection, preferably SARS-CoV-2 infection.

4. 发明公开

EP3967220A1 VERARBEITEN UND VISUALISIEREN VON DATEN EINER ELEKTRISCHEN IMPEDANZTOMOGRAPHIE 有权
公开(公告)号：EP3967220A1
公开(公告)日：2022-03-16
申请号：EP21195954.9
申请日：2021-09-10
申请人： Universität Leipzig
发明人： Schneider, Dominic , Neumuth, Thomas , Salz, Peter , Reske, Andreas
IPC分类号： A61B5/0536 , A61B5/08 , A61B5/091 , A61B5/00
摘要： Ein Verfahren zum Verarbeiten und Visualisieren von Daten einer elektrischen Impedanztomographie einer Lunge umfasst die Schritte: Aufnehmen (8) von Daten mittels eines Elektro-Impedanz-Tomographie-Geräts (3) oder Bereitstellen von mit dem Elektro-Impedanz-Tomographie-Gerät (3) aufgenommenen Daten, Generieren (9) einer visuellen Darstellung der Daten, Bilden (10) mindestens eines Tidalbilds (12) eines Atemzyklus und Transformieren (11) jedes Pixels des mindestens einen Tidalbilds (12) anhand einer vorab definierten Funktion, wobei durch das Transformieren jedem der Pixel des mindestens einen Tidalbilds (12) ein Absolutwert zugeordnet wird, der einer Wahrscheinlichkeit für ein Auftreten einer Belüftungsstörung entspricht.

5. 发明授权

EP2750689B1 MODIFIZIERTE APIDAECINDERIVATE ALS ANTIBIOTISCHE PEPTIDE 失效转让
公开(公告)号：EP2750689B1
公开(公告)日：2019-08-21
申请号：EP12774981.0
申请日：2012-09-21
申请人： Universität Leipzig
发明人： HOFFMANN, Ralf , KNAPPE, Daniel , HILPERT, Kai , MIKUT, Ralf , RUDEN, Serge
IPC分类号： A61K38/10

6. 发明授权

EP2771454B1 METHOD FOR DERIVING MELANOCYTES FROM THE HAIR FOLLICLE OUTER ROOT SHEATH AND PREPARATION FOR GRAFTING 失效
公开(公告)号：EP2771454B1
公开(公告)日：2019-07-24
申请号：EP12780487.0
申请日：2012-10-29
申请人： Universität Leipzig
发明人： SAVKOVIC, Vuk , DIECKMANN, Christina , SIMON, Jan-Christoph , SCHULZ-SIEGMUND, Michaela , HACKER, Michael
IPC分类号： C12N5/071 , A61L27/36 , A61K35/12

7. 发明授权

EP3155433B1 A NOVEL SOLUBLE BIOMARKER FOR INSULIN RESISTANCE 有权
公开(公告)号：EP3155433B1
公开(公告)日：2018-10-10
申请号：EP15728513.1
申请日：2015-06-11
申请人： SANOFI , Universität Leipzig
发明人： KANNT, Aimo , PFENNINGER, Anja , BLÜHER, Matthias
IPC分类号： G01N33/68 , G01N33/82
CPC分类号： G01N33/82 , G01N33/6893 , G01N2800/042 , G01N2800/52
摘要： The present invention relates to a novel soluble biomarker for insulin resistance: 1-methyl nicotinamide (MNA). The invention relates to methods of determining the degree of insulin resistance in a patient. The invention further relates to methods for determining whether a subject with insulin resistance or type 2 diabetes will benefit from a treatment with an inhibitor of nicotinamide-N-methyltransferase (NNMT) or whether a subject responds to a therapeutic treatment with an NNMT inhibitor. The invention also relates to methods of adjusting the dose of an NNMT inhibitor applied for therapeutic treatment of insulin resistance or type-2 diabetes

8. 发明公开

EP3349811A1 PEPTID ZUR BESCHICHTUNG VON OBERFLÄCHEN 有权
公开(公告)号：EP3349811A1
公开(公告)日：2018-07-25
申请号：EP16767250.0
申请日：2016-09-16
申请人： Universität Leipzig
发明人： BECK-SICKINGER, Annette , PAGEL, Mareen , HASSERT, Rayk
IPC分类号： A61L27/28 , A61L27/50 , A61L27/54 , A61K6/00 , C07K7/06 , C07K17/14 , C07K5/087
CPC分类号： C07K5/0812 , A61K6/0017 , A61K47/65 , A61L27/28 , A61L27/50 , A61L27/54 , A61L2300/25 , A61L2300/606 , A61L2420/00 , C07K7/06 , C07K17/14 , C07K2319/00
摘要： The invention relates to a peptide, comprising (i) a main chain comprising at least one L-3,4-dihydroxyphenylalanine (DOPA), (ii) at least one integrin-binding peptide, and (iii) at least one heparin-binding peptide. The invention further relates to a coating of metal surfaces, comprising the peptide according to the invention, and a coated metal surface that can be obtained by reacting the peptide according to the invention with a metal surface.

9. 发明公开

EP3164696A1 VERFAHREN UND VORRICHTUNG ZUR RAMANSPEKTROSKOPISCHEN IN-OVO GESCHLECHTSBESTIMMUNG VON BEFRUCHTETEN UND BEBRÜTETEN VOGELEIERN 有权
标题翻译：方法和设备IN-拉曼光谱OVO性别鉴定和受精孵化鸟蛋
公开(公告)号：EP3164696A1
公开(公告)日：2017-05-10
申请号：EP15759358.3
申请日：2015-07-03
申请人： Technische Universität Dresden , Universität Leipzig
发明人： GALLI, Roberta , PREUSSE, Grit , KOCH, Edmund , STEINER, Gerald , KRAUTWALD-JUNGHANNS, Maria-Elisabeth , BARTELS, Thomas
IPC分类号： G01N21/65 , G01N33/08
CPC分类号： G01N21/65 , A01K45/007 , G01N33/08 , G01N33/4833 , G01N2021/653 , G01N2201/06113
摘要： The invention relates to a method for the Raman spectroscopic, in ovo sex determination of fertilised and hatched birds' eggs (1), wherein the embryo, including the extra-embryonic structures, can move in the egg, and is not yet attached to the shell at the time of measuring. In addition, the following steps are carried out: monitoring the time course of the hatched egg until forming at least one recognisable blood vessel (21); creating a hole (2) in the shell in the region near to the attached bloody vessel, using a hole-generating unit; finding the blood vessel forming in the egg, using a vision system (19, 13) and a coaxial or lateral illumination with light (10a) in the visible wavelength range; positioning at least one blood vessel in the laser focus of a laser source (3), either by moving the egg or moving a lens (6) of a device (5) for introducing the laser light (3a), and detecting the Raman scattered radiation (7); registering the Raman scattered radiation of the irradiated blood vessel using the device for introducing the laser light, and for detecting the Raman scattered radiation, wherein, during the measuring process, a movement of the blood vessel out of the focus can be avoided by tracking using the vision system; evaluating the Raman scattered radiation in an evaluation unit; determining and displaying the sex of the embryo in the bird's egg.
摘要翻译：本发明涉及一种拉曼光谱的方法，在卵内性别决定受精和孵化的鸟蛋（1）的，worin胚胎，包括胚外的结构，可在蛋移动，并且还没有被附连到壳在测量的时间。此外，下面的步骤被执行：监测蛋孵出的时间过程，直至形成至少一个可识别的血管（21）; 创建在该区域壳中的孔（2）接近附血性容器，使用空穴产生单元; 找到血管在卵形成，使用视觉系统（19，13）和在可见光波长范围内的光（10A）同轴或侧向照明; 定位至少一个血管中的激光源（3）任一的激光焦点通过移动卵或移动透镜（6）用于将激光（3a）中，并检测拉曼的装置（5）的散辐射（7）; 注册拉曼使用该装置用于将激光光散射所照射的血管的辐射，并且用于检测拉曼散射辐射，worin，在测量过程中，可以通过使用跟踪来避免使血管的移动出来的焦点的视觉系统; 评价拉曼至评估单元的散射辐射; 确定性的挖掘和展示在鸟的蛋胚胎的性别。

10. 发明公开

EP3128966A1 A DEVICE FOR A MEDICAL TREATMENT OF A SCLERA 审中-公开
标题翻译： VORRICHTUNG ZUR MEDIZINISCHEN BEHANDLUNG EINER SKLERA
公开(公告)号：EP3128966A1
公开(公告)日：2017-02-15
申请号：EP15716003.7
申请日：2015-04-02
申请人： Universität Leipzig , Iseli, Hans Peter
发明人： ISELI, Hans Peter , FRANCKE, Mike , WIEDEMANN, Peter
IPC分类号： A61F9/00 , A61F9/007
CPC分类号： A61F9/00821 , A61F9/0017 , A61F9/008 , A61F2009/00853 , A61F2009/00865
摘要： The invention provides a device for a medical treatment of a sclera, the device comprising a single applicator connected to a shaft, wherein the applicator is configured to be placed into the Tenon's space; the applicator has a first surface, wherein the first surface of the applicator is superficially contactable to the surface of an area of the sclera so as to superficially cover said area; and the applicator comprises a single optical outlet connected to a single optical guiding element extending from a proximal end of the shaft to the single distal optical outlet at the first surface of the applicator, the optical guiding element being configured for guiding electromagnetic waves towards the optical outlet, wherein the optical guiding element is configured to guide electromagnetic waves of a wavelength adapted for thermal treatment of the sclera by protein coagulation.
摘要翻译：本发明提供了一种用于治疗巩膜的装置，所述装置包括连接到轴的单个施用器，其中所述施用器被配置成放置在所述Tenon的空间中; 所述施用器具有第一表面，其中所述施用器的第一表面与所述巩膜的区域的表面表面接触，以便表面覆盖所述区域; 并且所述施加器包括单个光学出口，所述单个光学出口连接到从所述轴的近端延伸到所述施用器的第一表面处的所述单个远端光学出口的单个光学引导元件，所述光学引导元件被配置为用于将电磁波引向所述光学出口，其中所述光导元件被构造成通过蛋白质凝结来引导适合于对所述巩膜进行热处理的波长的电磁波。

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