专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明公开

EP0876617A4 PORTABLE FERTILITY TESTER 失效
标题翻译：便携式测试仪生育
公开(公告)号：EP0876617A4
公开(公告)日：1999-09-08
申请号：EP96936931
申请日：1996-10-24
申请人： RAUSNITZ GERALD J
发明人： RAUSNITZ GERALD J
IPC分类号： G01N33/48 , A61B10/00 , G01N33/50 , G01N33/543 , G01N33/74
CPC分类号： G01N33/54386 , A61B10/0012 , A61B2010/0025 , G01N33/74 , Y10S436/809 , Y10S436/814 , Y10S436/906
摘要： A portable fertility tester (1) for identifying the days during the menstrual cycle when a woman is most likely to conceive. The tester has a circular disk (19) with transparent regions (23) indexed to each day of the month.

42. 发明公开

EP0933637A1 Prenatal detection of chromosomal abnormality 有权
标题翻译：产品名称Nachweis einerChromosomabnormalität
公开(公告)号：EP0933637A1
公开(公告)日：1999-08-04
申请号：EP99300756.6
申请日：1999-02-02
申请人： WAKO PURE CHEMICAL INDUSTRIES, LTD
发明人： Yamamoto, Ritsu , Satomura, Shinji, Wako Pure Chemical Ind., Ltd.
IPC分类号： G01N33/68
CPC分类号： G01N33/689 , G01N33/6893 , G01N2800/368 , G01N2800/387 , Y10S435/973 , Y10S436/811 , Y10S436/814 , Y10S436/817 , Y10S436/818 , Y10S436/827 , Y10S436/906
摘要： An increased risk of a fetal chromosomal abnormality, for example, fetal Down syndrome can be detected by separating or discriminating α-fetoproteins present in the body fluid of a pregnant woman, and measuring the proportion of one or more of the α-fetoproteins which have a specific sugar chain structure, relative to the total α-fetoproteins.
摘要翻译：胎儿染色体异常增加的风险，例如胎儿唐氏综合征可以通过分离或鉴别存在于孕妇体液中的α-蛋白质来检测，并测量一种或多种具有相对于总α-蛋白质的特定糖链结构。

43. 发明授权

EP0566695B1 A ONE-STEP LATERAL FLOW ASSAY AND NONBIBULOUS SUPPORT USED THEREIN 失效
标题翻译：单级横流分析方法和本文中所使用NICHTSAUGFÄHIGERCARRIER
公开(公告)号：EP0566695B1
公开(公告)日：1999-06-02
申请号：EP92905452.6
申请日：1992-01-09
申请人： QUIDEL CORPORATION
发明人： PAWLAK, Catherine , PRONOVOST, Allan, D. , GOINS, Keren, A.
IPC分类号： G01N33/53 , G01N33/543 , G01N33/549 , G01N33/546 , G01N33/538 , G01N21/00
CPC分类号： G01N33/54366 , G01N33/558 , G01N33/76 , Y10S436/807 , Y10S436/81 , Y10S436/814 , Y10S436/829
摘要： A particularly efficient design for a nonbibulous lateral flow one step assay for an analyte in a biological sample is disclosed. In the improved device of the invention, three zones which are in nonbibulous lateral flow contact are employed: a sample receiving zone, a labeling zone, and a capture zone. The sample containing analyte is carried through the labeling zone and interacts with an assay label comprising visible moieties, preferably particles, which are coupled to specific binding reagent for analyte or to a competitor with analyte for a capture reagent. The flow continues into the capture zone where the visible moieties to which analyte or competitor are coupled are captured. Excess fluid is absorbed into an absorbent zone in contact with the capture zone. A positive result is obtained by visualizing the visible moieties in the capture zone. An additional improvement comprises obtaining the nonbibulous lateral flow by converting a bibulous support to a nonbibulous support through coating with a blocking agent, such as methylated BSA. Control label comprising visible moieties (preferably, visually distinguishable from those of the assay label) may also be included in the labeling zone and captured in a separate control portion of the capture zone to verify that the flow of liquid is as expected.

44. 发明公开

EP0824697A4 ONE STEP IMMUNOCHROMATOGRAPHIC DEVICE AND METHOD OF USE 失效
标题翻译： STAGE免疫色谱装置及使用方法
公开(公告)号：EP0824697A4
公开(公告)日：1999-04-07
申请号：EP96911611
申请日：1996-04-04
申请人： WYNTEK DIAGNOSTICS INC
发明人： HUANG CHING , FAN EUGENE
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , Y10S435/805 , Y10S435/81 , Y10S435/967 , Y10S435/97 , Y10S435/971 , Y10S436/81 , Y10S436/814 , Y10S436/818
摘要： This invention relates to a lateral flow immunochromatographic assay device without a plastic housing. The assay includes a sample receiving region (3a), analyte detection region (2), and end region (4) all made of porous material and capable of lateral flow. The analyte detection region (2) includes labelling reagents (2a), a capture reagent (26), and a control reagent (2c). The back of the porous material is laminated with a semi-rigid material (1) with adequate mechanical strength. The top is partially covered with a thin plastic material (5) so as to leave a portion of the sample receiving region exposed for sample application.

45. 发明公开

EP0897540A1 PROCEDE DE DETECTION ET/OU DE QUANTIFICATION D'UN HAPTENE DANS UNE PHASE HOMOGENE ET DISPOSITIF POUR SA MISE EN OEUVRE 失效
标题翻译：在均相及其装置方法用于检测和/或半抗原的定量
公开(公告)号：EP0897540A1
公开(公告)日：1999-02-24
申请号：EP97917955.0
申请日：1997-04-30
申请人： LA REGION WALLONNE
发明人： KOHL, Michel , RENOTTE, Roger , GHITTI, Gianangelo , SARLET, Guy , LEJEUNE, Robert
IPC分类号： C12Q1 , G01N33
CPC分类号： C12Q1/34 , G01N33/53 , G01N33/581 , G01N2333/986 , G01N2415/00 , Y10S435/805 , Y10S435/81 , Y10S436/814
摘要： The invention discloses a method for detecting and/or quantifying a hapten in a homogeneous phase, comprising the following steps: adding a known quantity of a hapten inhibitor complex to the solution containing the hapten to be detected and/or quantified; adding to the solution a quantity of antibodies corresponding to the quantiy of the hapten/inhibitor complex; adding to the solution a type C β-lactamase having an active site for two substrates in antigenic competition in the said active site, the first substrate being a reporter substrate capable of being transformed into a detectable and/or quantifiable product, preferably by visible UV radiation measurement, the second substrate being the hapten/inhibitor complex acting on the hydrolysis rate of the reporter substrate; detecting and/or quantifying the concentration of the product resulting from the transformation of the reporter substrate, the Km constant of the reporter substrate being at least a hundred times higher than the Km constant of the hapten/inhibitor complex, and the kcat constant being at least ten times higher than the kcat constant of the hapten/inhibitor complex.

46. 发明授权

EP0782707B1 ASSAY DEVICES WITH NON-WOVEN SAMPLE COLLECTION ZONE 无效
标题翻译：与无纺布样品收集区测试设备
公开(公告)号：EP0782707B1
公开(公告)日：1998-11-25
申请号：EP95934087.8
申请日：1995-09-21
申请人： UNILEVER PLC , UNILEVER N.V.
发明人： CUNNINGHAM, Carole, Robinson , WILSON, Stewart, John
IPC分类号： G01N33/543 , G01N33/52
CPC分类号： G01N33/54366 , B01L3/5023 , B01L2200/16 , B01L2300/0816 , B01L2300/161 , G01N33/521 , Y10S435/805 , Y10S435/97 , Y10S436/81 , Y10S436/814
摘要： An assay device comprises a sample-collecting wick made from non-woven fabric material laminated to plastics sheet. Preferably, the fabric is a 30:70 blend of viscose and polyester, and has a fibrous structure in which more than two-thirds of the fibres run substantially parallel to the intended direction of liquid flow in the wick.

47. 发明公开

EP0813064A1 Method for amplification of the response signal in a sandwich immunoassay 失效
标题翻译： Methode zurVerstärkungdes Antwortsignals bei einem Sandwich-Immunoassay
公开(公告)号：EP0813064A1
公开(公告)日：1997-12-17
申请号：EP97108863.8
申请日：1997-06-03
申请人： Bayer Corporation
发明人： Kuo, Hai Hang
IPC分类号： G01N33/543 , G01N33/541 , G01N33/76
CPC分类号： G01N33/54306 , Y10S436/814
摘要： Disclosed is an improvement to a sandwich type immunoassay in which there is immobilized to a solid support an antibody which is specific to an epitope of the analyte whose presence or concentration is being sought and a first labeled antibody which is specific to another epitope of the analyte. The improvement involves providing a second labeled antibody which is specific to the first labeled antibody to thereby form a chain of two or more labeled antibodies which results in amplification of the signal generated upon formation of the sandwich.
摘要翻译：披露了对夹心型免疫测定的改进，其中将固定在固体支持物上的抗体是特异于分析物的表位的抗体，所述分析物的存在或浓度正在寻求，并且第一标记抗体对分析物的另一表位是特异性的。该改进涉及提供对第一标记抗体特异性的第二标记抗体，从而形成两个或更多个标记抗体的链，其导致在形成夹心物时产生的信号的扩增。

48. 发明公开

EP0702233A1 SIMPLE IMMUNOCHEMICAL SEMIQUANTITATIVE ASSAY METHOD AND APPARATUS 失效
标题翻译：美食免疫组化免疫组织免疫组织化学
公开(公告)号：EP0702233A1
公开(公告)日：1996-03-20
申请号：EP94916429.7
申请日：1994-05-31
申请人： TEIKOKU HORMONE MFG. CO., LTD.
发明人： MANITA, Hideaki
IPC分类号： G01N33/543
CPC分类号： A47J27/08 , G01N33/54306 , G01N33/558 , Y10S436/81 , Y10S436/814 , Y10S436/818 , Y10S436/829
摘要： Simple chromatographic immunochemical assay method and apparatus, characterized by reducing the concentration of an object present in a sample before the immunochemical qualitative analysis thereof by trapping the object in such an amount as to correspond to the amount of an antibody against the object, said antibody having been immobilized in a predetermined amount.
摘要翻译：简单的色谱免疫化学测定方法和装置，其特征在于通过以对应于针对物体的抗体的量捕获对象的量来免疫化学定性分析之前，降低样品中存在的物体的浓度，所述抗体具有以预定量固定。

49. 发明公开

EP0362809A1 Device and method for the detection of an analyte 失效
标题翻译： Vorrichtung und Verfahren zur Bestimmung eines分析。
公开(公告)号：EP0362809A1
公开(公告)日：1990-04-11
申请号：EP89118378.2
申请日：1989-10-04
申请人： BOEHRINGER BIOCHEMIA ROBIN S.p.A.
发明人： Corti, Angelo , Piro, Paola , Carta, Emanuela , Rovelli, Cesare , Bassi, Rosa Angela , Lamponi, Alessandro , Morgese, Nicola , Rurali, Carlo , Tognella, Sergio
IPC分类号： G01N33/543 , G01N33/558 , G01N33/76
CPC分类号： G01N33/558 , G01N33/76 , Y10S435/97 , Y10S436/81 , Y10S436/814 , Y10S436/818
摘要： A device to determine human chorionic gonadotropin (hCG) in urine is described. It includes:

a) a first area, consisting of a material able to draw urine by capillarity, on which an hCG bioselective colored agent is absorbed, an end of said first area, to be dipped in urine, while the other end contacts with the following b) area;
b) a reading area which contacts the previous one and an area of a material able to assure the capillary flow of urine, on which there is bound:

1) a protein able to selectively bind hCG and possibly;
2) hCG (positive reagent control) and
3) an inert protein (negative reagent control) disposed so as to form, after the reaction with the bioselective colored reagent present in a), two different figures which can be visually detected according to the positivity of the analysis;

c) a further area, an end of wich contacts the previous one, of a material able to assure the capillary flow of urine towards the other end containing an indicator revealing the occured passage of urine through the A device.

According to the invention, pregnancy analysis becomes easier because the a device is dipped just once in the sample to be tested and because the results are simple to read.
摘要翻译：描述了测定尿中人绒毛膜促性腺激素（hCG）的装置。它包括：a）第一区域，由能够通过毛细管吸引尿液的材料组成，其上吸收hCG生物选择性着色剂，所述第一区域的末端被浸入尿液中，而另一端与以下b）区域; b）与前一个接触的读取区域和能够确保尿液的毛细血管流动的材料的区域，在该区域上结合有：1）能够选择性地结合hCG并且可能的蛋白质; 2）hCG（阳性试剂对照）和3）设置为在与a）中存在的生物反应性有色试剂反应后形成的惰性蛋白质（阴性试剂对照），可以根据阳性视觉检测两个不同的图的分析; c）与前一个接触的另一个区域，一个能够确保尿液朝向另一端的毛细血管流动的材料，该指示器露出通过A装置的尿液的通过。根据本发明，怀孕分析变得更容易，因为一个装置在待测试样品中仅浸渍一次，并且因为结果很容易阅读。

50. 发明授权

EP0132750B1 Novel antigen associated with early detection of mammalian pregnancy 失效
标题翻译：与早期检测妈妈怀孕相关的新型抗原
公开(公告)号：EP0132750B1
公开(公告)日：1990-04-04
申请号：EP84108365.2
申请日：1984-07-16
申请人： IDAHO RESEARCH FOUNDATION, INC.
发明人： Sasser, R. Garth , Hamilton, William Clark
IPC分类号： G01N33/53 , G01N33/534 , G01N33/68
CPC分类号： G01N33/689 , G01N33/68 , G01N2800/368 , Y10S436/804 , Y10S436/814 , Y10S436/815

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式